Jordan Jacobelli, PhD

Publications

• Beemiller P.J., Jacobelli J., Krummel M.F. 'Integration of the movement of signaling microclusters with cellular motility in immunological synapses.' Nature Immunology. 2012. Aug; 13(8):787-95.
• Huang Y., Aydintug M.K., Loomis J., Macleod M.K., McKee A.S., Kirchenbaum G., Jakubzick C.V., Kedl R.M., Sun D., Jacobelli J., O'Brien R.L., Born W.K. 'Antigen-Specific Regulation of IgE Antibodies by Non-Antigen-Specific ?d T Cells.' Journal of Immunology. 2012 Dec 28.
• McKee A., Burchill M.A., Munks M.W., Jin L., Kappler J.W., Friedman R.S., Jacobelli J., Marrack P. 'Host DNA released in response to aluminum adjuvant prolongs CD4 T cell interactions with dendritic cells.' PNAS. 2013 in press.
• Jacobelli J., Lindsay R.S., Friedman R.S. 'Peripheral tolerance and autoimmunity: Lessons from in vivo imaging.' Immunologic Research. 2013 Mar; 55(1-3):146-54.
• Gerard A., Beemiller P., Friedman R.S., Jacobelli J., Krummel M.F. 'Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses.' Immunological Reviews 2013 Jan; 251(1):80-96.
• Jacobelli J, Lindsay RS, Friedman RS. Peripheral tolerance and autoimmunity: lessons from in vivo imaging. Immunol Res. 2013 Mar;55(1-3):146-54. PubMed PMID: 22956468
• Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 1;190(3):913-21. PubMed PMID: 23275606
• Gérard A, Beemiller P, Friedman RS, Jacobelli J, Krummel MF. Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev. 2013 Jan;251(1):80-96. PubMed PMID: 23278742
• McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31. PubMed PMID: 23447566
• Jacobelli J, Estin Matthews M, Chen S, Krummel MF. Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. PLoS One. 2013;8(9):e75151. PubMed PMID: 24069389
• Krummel MF, Friedman RS, Jacobelli J. Modes and mechanisms of T cell motility: roles for confinement and Myosin-IIA. Curr Opin Cell Biol. 2014 Jun 3;30C:9-16. [Epub ahead of print] PubMed PMID: 24905977
• Friedman RS, Lindsay RS, Lilly JK, Nguyen V, Sorensen CM, Jacobelli J, Krummel MF. An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9223-8. PubMed PMID: 24927530
• Sandor AM, Jacobelli J, Friedman RS. Immune cell trafficking to the islets during type 1 diabetes. Clin Exp Immunol. 2019 Jul 25. [Epub ahead of print] PubMed PMID: 31343073
• Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c( ) Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Front Immunol. 2019;10:99. PubMed PMID: 30766536
• Thompson SB, Sandor AM, Lui V, Chung JW, Waldman MM, Long RA, Estin ML, Matsuda JL, Friedman RS, Jacobelli J. Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity. Elife. 2020 Jun 8;9. PubMed PMID: 32510333
• Lindsay RS, Whitesell JC, Dew KE, Rodriguez E, Sandor AM, Tracy D, Yannacone SF, Basta BN, Jacobelli J, Friedman RS. MERTK on mononuclear phagocytes regulates T cell antigen recognition at autoimmune and tumor sites. J Exp Med. 2021 Oct 4;218(10). PubMed PMID: 34415994
• Thompson SB, Waldman MM, Jacobelli J. Polymerization power: effectors of actin polymerization as regulators of T lymphocyte migration through complex environments. FEBS J. 2021 Jul 17. [Epub ahead of print] PubMed PMID: 34273243
• Jha V, Nicholson LK, Gardner EM, Rahkola JT, Pratap H, Scott J, Borgeson M, Jacobelli J, Janoff EN. Impact of HIV-1 Infection and Antigen Class on T Follicular Helper Cell Responses to Pneumococcal Polysaccharide-Protein Conjugate Vaccine-13. J Immunol. 2021 May 15;206(10):2402-2411. PubMed PMID: 33931485
• Waldman MM, Rahkola JT, Sigler AL, Chung JW, Willett BAS, Kedl RM, Friedman RS, Jacobelli J. Ena/VASP Protein-Mediated Actin Polymerization Contributes to Naïve CD8( ) T Cell Activation and Expansion by Promoting T Cell-APC Interactions In Vivo . Front Immunol. 2022;13:856977. PubMed PMID: 35757762
• Kremer KN, Buser A, Thumkeo D, Narumiya S, Jacobelli J, Pelanda R, Torres RM. LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2118816119. PubMed PMID: 35394866
• Jacobelli J, Buser AE, Heiden DL, Friedman RS. Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging. Immunol Rev. 2022 Mar;306(1):181-199. PubMed PMID: 34825390
• Thompson SB, Waldman MM, Jacobelli J. Polymerization power: effectors of actin polymerization as regulators of T lymphocyte migration through complex environments. FEBS J. 2022 Oct;289(20):6154-6171. PubMed PMID: 34273243
• Abdelazeem KNM, Nguyen D, Corbo S, Darragh LB, Matsumoto MW, Van Court B, Neupert B, Yu J, Olimpo NA, Osborne DG, Gadwa J, Ross RB, Nguyen A, Bhatia S, Kapoor M, Friedman RS, Jacobelli J, Saviola AJ, Knitz MW, Pasquale EB, Karam SD. Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HNSCC. Oncogene. 2024 Nov 3. [Epub ahead of print] PubMed PMID: 39489818
• Sigler AL, Thompson SB, Ellwood-Digel L, Kandasamy A, Michaels MJ, Thumkeo D, Narumiya S, Del Alamo JC, Jacobelli J. FMNL1 and mDia1 promote efficient T cell migration through complex environments via distinct mechanisms. Front Immunol. 2024;15:1467415. PubMed PMID: 39430739
• Pierce SA, Jacobelli J, Given KS, Macklin WB, Gopinath JT, Siemens ME, Restrepo D, Gibson EA. OpenSTED: open-source dynamic intensity minimum system for stimulated emission depletion microscopy. Neurophotonics. 2024 Jul;11(3):034311. PubMed PMID: 38867758
• Haist KC, Gibbings SL, Jacobelli J, Mould KJ, Henson PM, Bratton DL. A LTB(4)/CD11b self-amplifying loop drives pyogranuloma formation in chronic granulomatous disease. iScience. 2024 Apr 19;27(4):109589. PubMed PMID: 38623335

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000