Christopher Evans, PhD

Professional Titles

• Professor
• Associate Division Head - Research

Research Interests

Research in the Evans lab focuses on how airway mucins regulate respiratory health and disease. Two secreted mucins--MUC5AC and MUC5B--are the predominant macromolecular components of airway mucus. MUC5AC and MUC5B regulate host mucosal defense in health, but their excessive or aberrant expression is associated with transient infections and with a wide range of lung diseases such as asthma, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer. Using genetic and respiratory challenge models, our group has pioneered efforts to determine the significance of Muc5ac and Muc5b in mouse lungs (‘MUC’ in humans, ‘Muc’ in mice). We have discovered critical beneficial roles for Muc5b in homeostasis and responses to infection. Conversely, we have identified required detrimental roles for Muc5ac in airflow obstruction and lung injury. Current research programs involve investigating how these two mucins perform their specific functions. Efforts are underway to determine whether and how the effects of MUC5AC/Muc5ac and MUC5B/Muc5b are mediated intrinsically by their differential expression and structural heterogeneity. Additional projects focus on how Muc5ac and Muc5b interact with leukocytes and structural cells in the lungs to regulate tissue inflammation, injury, and repair. These projects use of genetically engineered mice, including over-expressing, knockout, and gene-edited lines, to address how Muc5ac and Muc5b function singly and in combination. Projects include studies of the mucin proteins, their assembly, and their glycosylation.

Publications

• Hasnain SZ, Evans CM, Roy MG, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Muc5ac: A critical component mediating the rejection of enteric nematodes. J Exp Med 208(5):893-900 2011. (Cover Art; Research Highlight in Nature, 5 May 2011.) PMID: 21502330.
• Roy MG, Alexander SN, Ehre C, Ho SB, Evans CM. Muc5ac and Muc5b are the major secreted polymeric gel-forming mucins expressed during mouse lung development. Am J Respir Cell Mol Biol, 2011. 44:755-60. PMID: 21653907.
• Kelada SN, Wilson MS, Tavarez U, Borate B, Kubalanza K,Carpenter DE, Whitehead G, Maruoka S, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS. Strain-dependent genomic factors affect allergen-induced airway hyper-responsiveness in mice. Am J Respir Cell Mol Biol, 2011. 45:817-24. PMID: 21378263.
• Piccotti L, Dickey BF, Evans CM. Assessment of intracellular mucin content in vivo. Methods Mol Biol. 2012;842:279-95. (Cover art) PubMed PMID: 22259143.
• Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16;505(7483):412-6. PubMed PMID: 24317696
• Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA. Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol. 2013 Jun 15;190(12):6360-7. PubMed PMID: 23667110
• Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE. TGF-ß2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res. 2013 Feb;39(1):39-47. PubMed PMID: 23249391
• Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Muc5ac during ventilator induced lung injury Mucosal Immunology. (MI-12-066). Submitted.
• Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul;6(4):762-75. PubMed PMID: 23187315
• Harrop C, Gore R, Evans CM, Thronton D, Herrick S. TGF-ß2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Am J Physiol Lung Cell Mol Biol. (L-00089-2012). Submitted.
• Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol. 2014 Dec 11. [Epub ahead of print] PubMed PMID: 25497369
• Kim K, Scott BL, Nigam R, Petrova YM, Agrawal A, Adachie R, Evans CM, Azzegagh Z, Olkkonen VM, Bagirzadeh R, Piccotti L, Yoon JH, McNew JA, Tuvim MJ, Dickey BF. Munc18B is an essential gene in mice whose expression is limiting for airway mucin secretion. J. Biol. Chem (JBC/2011/290833) Resubmitted.
• Chandler JD, Min E, Huang J, McElroy CS, Dickerhof N, Mocatta T, Fletcher AA, Evans CM, Liang L, Patel M, Kettle AJ, Nichols DP, Day BJ. Anti-Inflammatory and Anti-Microbial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model. Am J Respir Cell Mol Biol. 2014 Dec 9. [Epub ahead of print] PubMed PMID: 25490247
• Piccotti L, Dickey BF, Evans CM. Assessment of intracellular mucin content in vivo. Methods Mol Biol. 2012. 842:279-95. (Cover Art)
• Weng T, Poth JM, Karmouty-Quintana H, Garcia-Morales LJ, Melicoff E, Luo F, Chen NY, Evans CM, Bunge RR, Bruckner BA, Loebe M, Volcik KA, Eltzschig HK, Blackburn MR. Hypoxia-induced deoxycytidine kinase contributes to epithelial proliferation in pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Dec 15;190(12):1402-12. PubMed PMID: 25358054
• Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen V, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim M, Dickey BF. Munc18b Is an Essential Gene in Mice Whose Expression Is Limiting for Secretion by Airway Epithelial and Mast Cells. Biochem J. 2012. 446:383-94.
• Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE. TGF-ß2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res. 2013. 39:39-47
• Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2012. In press.
• Floyd AM, Zhou X, Evans CM, Rompala OJ, Zhu L, Wang M, Chen Y. Mucin deficiency causes functional and structural changes of the ocular surface.PLoS One. 2012. 7:e50704.
• Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16;505(7483):412-6. PubMed PMID: 24317696
• Marko CK, Tisdale AS, Spurr-Michaud S, Evans C, Gipson IK. The ocular surface phenotype of Muc5ac and Muc5b null mice. Invest Ophthalmol Vis Sci. 2014 Jan 15;55(1):291-300. PubMed PMID: 24327612
• Jing J, Hui L, O'Connor BP, Evans CM, Perikeris R, Kobzik L, Yanb IV, Schwartz DA. Role of MARCO in Innate Immune Tolerance. Submitted.
• Kindrachuk KN, Ramalingam RE, Mentink-Kane MM, Fletcher AA, Phillips AG, Roy MG, Barron L, Vannella KM, Kindradchuk J, White S, Thompson R, DeClercq C, Williams C, Hubeau C, Cheever A, Evans CM, Wynn TA. A cell intrinsic role for Muc5ac in the TH2-response. Submitted to Nature, 11/2012. Currently in revision for resubmission.
• Roy MG, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova Y, Tuvim MJ, Adachi R, Romo R, Bordt AS, Bowden MG, Sisson JH, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, Livraghi-Butrico A, O’Neal WK, Fletcher AA, Yang IV, Woodruff PG, Boucher RC, Dickey BF, Evans CM. Required Barrier and Immunomodulatory Roles for Muc5b in Host Defense. Submitted to Nature, 11/2012. Currently in revision for resubmission.
• Yang IV, Fingerlin TE, Evans CM, Schwarz MI, Schwartz DA. MUC5B and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S193-9. PubMed PMID: 26595739
• Steele MP, Luna LG, Coldren CD, Murphy E, Hennessy CE, Heinz D, Evans CM, Groshong S, Cool C, Cosgrove GP, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Yang IV. Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. BMC Genomics. 2015 Oct 26;16(1):869. PubMed PMID: 26503507
• Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, Chen J, Davis CW, Tuvim MJ, Dickey BF. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Biosci Rep. 2015 Apr 28;35(3). PubMed PMID: 26182382
• Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May;8(3):699. PubMed PMID: 25943416
• Liptzin DR, Watson AM, Murphy E, Kroehl ME, Dishop MK, Galambos C, Evans CM, Schwarz MI, Deterding RR, Schwartz DA. MUC5B expression and location in surfactant protein C mutations in children. Pediatr Pulmonol. 2015 Dec;50(12):1270-6. PubMed PMID: 25858779
• Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov;8(6):1324-38. PubMed PMID: 25850656
• Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015 Feb 17;6:6281. PubMed PMID: 25687754
• Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol. 2015 May;135(5):1329-40.e1-9. PubMed PMID: 25497369
• Chandler JD, Min E, Huang J, McElroy CS, Dickerhof N, Mocatta T, Fletcher AA, Evans CM, Liang L, Patel M, Kettle AJ, Nichols DP, Day BJ. Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model. Am J Respir Cell Mol Biol. 2015 Aug;53(2):193-205. PubMed PMID: 25490247
• Nakano Y, Yang IV, Walts AD, Watson AM, Helling BA, Fletcher AA, Lara AR, Schwarz MI, Evans CM, Schwartz DA. MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Feb 15;193(4):464-6. PubMed PMID: 26871673
• Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol. 2016 Jul 20. [Epub ahead of print] PubMed PMID: 27435107
• Gong L, da Silva Caetano M, Cumpian AM, Daliri S, Garza Flores A, Chang SH, Ochoa CE, Evans CM, Yu Z, Moghaddam SJ. Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment. Oncoimmunology. 2016 Sep 2;5(10):e1229724. PubMed PMID: 27853654
• Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D. Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016 Nov;13(11):2103-2104. PubMed PMID: 27831803
• Evans CM, Fingerlin TE, Schwarz MI, Lynch D, Kurche J, Warg L, Yang IV, Schwartz DA. Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways. Physiol Rev. 2016 Oct;96(4):1567-91. PubMed PMID: 27630174
• Janssen WJ, Stefanski AL, Bochner BS, Evans CM. Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions. Eur Respir J. 2016 Oct;48(4):1201-1214. PubMed PMID: 27587549
• Evans CM, Dickey BF, Schwartz DA. E-Cigarettes: Mucus Measurements Make Marks. Am J Respir Crit Care Med. 2017 Nov 21. [Epub ahead of print] PubMed PMID: 29161057
• Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657
• Monte AA, Sun H, Rapp-Olsson AM Ms, Mohamed F, Gawarammana I, Buckley NA, Evans CM, Yang IV, Schwartz DA. The Plasma Concentration of MUC5B is Associated with Clinical Outcomes in Paraquat Poisoned Patients. Am J Respir Crit Care Med. 2017 Jul 18. [Epub ahead of print] PubMed PMID: 28719757
• Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30;8:15494. PubMed PMID: 28555642
• Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F553-F559. PubMed PMID: 28515178
• Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol. 2017 May;10(3):829. PubMed PMID: 28435155
• Helling BA, Gerber AN, Kadiyala V, Sasse SK, Pedersen BS, Sparks L, Nakano Y, Okamoto T, Evans CM, Yang IV, Schwartz DA. Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 Jul;57(1):91-99. PubMed PMID: 28272906
• Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol. 2017 Mar;10(2):395-407. PubMed PMID: 27435107
• Hancock LA, Hennessy CE, Solomon GM, Dobrinskikh E, Estrella A, Hara N, Hill DB, Kissner WJ, Markovetz MR, Grove Villalon DE, Voss ME, Tearney GJ, Carroll KS, Shi Y, Schwarz MI, Thelin WR, Rowe SM, Yang IV, Evans CM, Schwartz DA. Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice. Nat Commun. 2018 Dec 18;9(1):5363. PubMed PMID: 30560893
• Benam KH, Vladar EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S210-S215. PubMed PMID: 30431350
• Kim V, Evans CM, Dickey BF. Dawn of a New Era in the Diagnosis and Treatment of Airway Mucus Dysfunction. Am J Respir Crit Care Med. 2019 Jan 15;199(2):133-134. PubMed PMID: 30252497
• De la Garza MM, Cumpian AM, Daliri S, Castro-Pando S, Umer M, Gong L, Khosravi N, Caetano MS, Ramos-Castañeda M, Flores AG, Beltran EC, Tran HT, Tuvim MJ, Ostrin EJ, Dickey BF, Evans CM, Moghaddam SJ. COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1a mediated tumor angiogenesis and proliferation. Oncotarget. 2018 Aug 31;9(68):32972-32983. PubMed PMID: 30250643
• Fernández-Blanco JA, Fakih D, Arike L, Rodríguez-Piñeiro AM, Martínez-Abad B, Skansebo E, Jackson S, Root J, Singh D, McCrae C, Evans CM, Åstrand A, Ermund A, Hansson GC. Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. JCI Insight. 2018 Sep 6;3(17). [Epub ahead of print] PubMed PMID: 30185674
• Bauer AK, Umer M, Richardson VL, Cumpian AM, Harder AQ, Khosravi N, Azzegagh Z, Hara NM, Ehre C, Mohebnasab M, Caetano MS, Merrick DT, van Bokhoven A, Wistuba II, Kadara H, Dickey BF, Velmurugan K, Mann PR, Lu X, Barón AE, Evans CM, Moghaddam SJ. Requirement for MUC5AC in KRAS-dependent lung carcinogenesis. JCI Insight. 2018 Aug 9;3(15). [Epub ahead of print] PubMed PMID: 30089720
• Stefanski AL, Raclawska DS, Evans CM. Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches. Methods Mol Biol. 2018;1809:169-201. PubMed PMID: 29987791
• Symmes BA, Stefanski AL, Magin CM, Evans CM. Role of mucins in lung homeostasis: regulated expression and biosynthesis in health and disease. Biochem Soc Trans. 2018 Jun 19;46(3):707-719. PubMed PMID: 29802217
• Evans CM, Seibold MA, Gerber AN. SPDEFending the Lung through Mucin Expression. Am J Respir Cell Mol Biol. 2018 Sep;59(3):287-288. PubMed PMID: 29723043
• Zhang C, Jones JT, Chand HS, Wathelet MG, Evans CM, Dickey B, Xiang J, Mebratu YA, Tesfaigzi Y. Noxa/HSP27 complex delays degradation of ubiquitylated IkBa in airway epithelial cells to reduce pulmonary inflammation. Mucosal Immunol. 2018 May;11(3):741-751. PubMed PMID: 29363670
• Evans CM, Dickey BF, Schwartz DA. E-Cigarettes: Mucus Measurements Make Marks. Am J Respir Crit Care Med. 2018 Feb 15;197(4):420-422. PubMed PMID: 29161057
• Monte AA, Sun H, Rapp-Olsson AM, Mohamed F, Gawarammana I, Buckley NA, Evans CM, Yang IV, Schwartz DA. The Plasma Concentration of MUC5B Is Associated with Clinical Outcomes in Paraquat-poisoned Patients. Am J Respir Crit Care Med. 2018 Mar 1;197(5):663-665. PubMed PMID: 28719757
• Jaramillo AM, Evans CM. It Takes 1 for Type 2: IL-1 Receptor Mediates Eosinophilia in Scnn1b Transgenic Mice. Am J Respir Cell Mol Biol. 2019 Oct 10. [Epub ahead of print] PubMed PMID: 31600081
• Campbell L, Hepworth MR, Whittingham-Dowd J, Thompson S, Bancroft AJ, Hayes KS, Shaw TN, Dickey BF, Flamar AL, Artis D, Schwartz DA, Evans CM, Roberts IS, Thornton DJ, Grencis RK. ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites. J Exp Med. 2019 Dec 2;216(12):2714-2723. PubMed PMID: 31582416
• Kurche JS, Dobrinskikh E, Hennessy CE, Huber J, Estrella A, Hancock LA, Schwarz MI, Okamoto T, Cool CD, Yang IV, Evans CM, Schwartz DA. Muc5b Enhances Murine Honeycomb-like Cyst Formation. Am J Respir Cell Mol Biol. 2019 Oct;61(4):544-546. PubMed PMID: 31573335
• Fryer AD, Stein LH, Nie Z, Curtis DE, Evans CM, Hodgson ST, Jose PJ, Belmonte KE, Fitch E, Jacoby DB. Neuronal eotaxin and the effects of CCR3 antagonist on airway hyperreactivity and M2 receptor dysfunction. J Clin Invest. 2006 Jan;116(1):228-36. PubMed PMID: 16374515
• Williams OW, Sharafkhaneh A, Kim V, Dickey BF, Evans CM. Airway mucus: From production to secretion. Am J Respir Cell Mol Biol. 2006 May;34(5):527-36. PubMed PMID: 16415249
• Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P. Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles. JCI Insight. 2019 Aug 8;5. PubMed PMID: 31393853
• Adler KB, Shapiro SD, Gallup M, Wu R, Randell SH, Holtzman MJ, Evans CM, Jacoby DB, Tesfaigzi Y, Rose MC, Mossman BT, Prince A, Reddy SP, Davis CW, Matthay MA. Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol. 2006 May;34(5):523-6. PubMed PMID: 16618787
• Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS. The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nat Immunol. 2019 May;20(5):571-580. PubMed PMID: 30936493
• Young HW, Sun CX, Evans CM, Dickey BF, Blackburn MR. A3 adenosine receptor signaling contributes to airway mucin secretion after allergen challenge. Am J Respir Cell Mol Biol. 2006 Nov;35(5):549-58. PubMed PMID: 16763221
• Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol. 2007 Sep;37(3):273-90. PubMed PMID: 17463395
• Jaramillo AM, Piccotti L, Velasco WV, Delgado ASH, Azzegagh Z, Chung F, Nazeer U, Farooq J, Brenner J, Parker-Thornburg J, Scott BL, Evans CM, Adachi R, Burns AR, Kreda SM, Tuvim MJ, Dickey BF. Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 Mar 21;4(6). PubMed PMID: 30721150
• Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF, Davis CW. Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways. J Physiol. 2008 Apr 1;586(7):1977-92. PubMed PMID: 18258655
• Kim V, Kelemen SE, Abuel-Haija M, Gaughan JP, Sharafkaneh A, Evans CM, Dickey BF, Solomides CC, Rogers TJ, Criner GJ. Small airway mucous metaplasia and inflammation in chronic obstructive pulmonary disease. COPD. 2008 Dec;5(6):329-38. PubMed PMID: 19353346
• Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res. 2008 Feb 15;68(4):1119-27. PubMed PMID: 18281487
• Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF. Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype. Am J Respir Cell Mol Biol. 2008 Jun;38(6):629-38. PubMed PMID: 18096867
• Li H, Cho SN, Evans CM, Dickey BF, Jeong JW, DeMayo FJ. Cre-mediated recombination in mouse Clara cells. Genesis. 2008 Jun;46(6):300-7. PubMed PMID: 18543320
• Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 2008 Jun 15;177(12):1322-30. PubMed PMID: 18388354
• Kim V, Evans CM, Dickey BF. Dawn of a New Era in the Diagnosis and Treatment of Airway Mucus Dysfunction. Am J Respir Crit Care Med. 2019 Jan 15;199(2):133-134. PubMed PMID: 30252497
• Evans CM, Kim K, Tuvim MJ, Dickey BF. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med. 2009 Jan;15(1):4-11. PubMed PMID: 19077699
• Evans CM, Koo JS. Airway mucus: the good, the bad, the sticky. Pharmacol Ther. 2009 Mar;121(3):332-48. PubMed PMID: 19059283
• Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis. 2009 Nov;30(11):1949-56. PubMed PMID: 19793800
• Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009 Oct;136(19):3347-56. PubMed PMID: 19710174
• Seibold MA, Wise AL, Speer MC, Steele MP, Brown KK, Loyd JE, Fingerlin TE, Zhang W, Gudmundsson G, Groshong SD, Evans CM, Garantziotis S, Adler KB, Dickey BF, du Bois RM, Yang IV, Herron A, Kervitsky D, Talbert JL, Markin C, Park J, Crews AL, Slifer SH, Auerbach S, Roy MG, Lin J, Hennessy CE, Schwarz MI, Schwartz DA. A common MUC5B promoter polymorphism and pulmonary fibrosis. N Engl J Med. 2011 Apr 21;364(16):1503-12. PubMed PMID: 21506741
• Ochoa CE, Mirabolfathinejad SG, Ruiz VA, Evans SE, Gagea M, Evans CM, Dickey BF, Moghaddam SJ. Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis. Cancer Prev Res (Phila). 2011 Jan;4(1):51-64. PubMed PMID: 21098042
• Roy MG, Rahmani M, Hernandez JR, Alexander SN, Ehre C, Ho SB, Evans CM. Mucin production during prenatal and postnatal murine lung development. Am J Respir Cell Mol Biol. 2011 Jun;44(6):755-60. PubMed PMID: 21653907
• Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011 May 9;208(5):893-900. PubMed PMID: 21502330
• Raclawska DS, Ttofali F, Fletcher AA, Harper DN, Bochner BS, Janssen WJ, Evans CM. Mucins and Their Sugars. Critical Mediators of Hyperreactivity and Inflammation. Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S98-9. PubMed PMID: 27027967
• Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen VM, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim MJ, Dickey BF. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15;446(3):383-94. PubMed PMID: 22694344
• Piccotti L, Dickey BF, Evans CM. Assessment of intracellular mucin content in vivo. Methods Mol Biol. 2012;842:279-95. PubMed PMID: 22259143
• Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS. Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2011 Oct;45(4):817-24. PubMed PMID: 21378263
• Evans CM, Brody SL. Airway Biology. In: Murray & Nadel’s Textbook of Respiratory Medicine 7th Edition. Elsevier, Inc, In press.
• Fakih D, Rodriguez-Piñeiro AM, Trillo-Muyo S, Evans CM, Ermund A, Hansson GC. Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1270-L1279. PubMed PMID: 32348677
• Olli KE, Rapp C, O'Connell L, Collins CB, McNamee EN, Jensen O, Jedlicka P, Allison KC, Goldberg MS, Gerich ME, Frank DN, Ir D, Robertson CE, Evans CM, Aherne CM. Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis. Inflamm Bowel Dis. 2020 Aug 20;26(9):1353-1367. PubMed PMID: 32385500
• Laube BL, Carson KA, Evans CM, Richardson VL, Sharpless G, Zeitlin PL, Mogayzel PJ Jr. Changes in mucociliary clearance over time in children with cystic fibrosis. Pediatr Pulmonol. 2020 Sep;55(9):2307-2314. PubMed PMID: 32427408
• Cruz-Hernandez A, Mendoza RP, Nguyen K, Harder A, Evans CM, Bauer AK, Tewari-Singh N, Brown JM. Mast Cells Promote Nitrogen Mustard-Mediated Toxicity in the Lung Associated With Proinflammatory Cytokine and Bioactive Lipid Mediator Production. Toxicol Sci. 2021 Oct 27;184(1):127-141. PubMed PMID: 34453837
• McShane A, Bath J, Jaramillo AM, Ridley C, Walsh AA, Evans CM, Thornton DJ, Ribbeck K. Mucus. Curr Biol. 2021 Aug 9;31(15):R938-R945. PubMed PMID: 34375594
• Laube BL, Carson KA, Evans CM, Aksit MA, Collaco JM, Richardson VL, Sharpless G, Zeitlin PL, Cutting GR, Mogayzel PJ. Characterizing mucociliary clearance in young children with cystic fibrosis. Pediatr Res. 2021 Mar 22. [Epub ahead of print] PubMed PMID: 33753897
• Evans CM, McCubbrey AL. Can Eosinophils Prevent Lung Injury? Ask PHIL. Am J Respir Cell Mol Biol. 2021 May;64(5):523-524. PubMed PMID: 33651669
• Morgan LE, Jaramillo AM, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ, NeeDell JC, Hennessy CE, El-Batal HM, Magin CM, Grove Villalon DE, Duncan G, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. Disulfide disruption reverses mucus dysfunction in allergic airway disease. Nat Commun. 2021 Jan 11;12(1):249. PubMed PMID: 33431872
• Jaramillo MA, Harder AQ, Holguin F, Evans CM. Vagal Reflexes in Airway Hyperreactivity: Novel Pathways and a Note of Caution for Studies in Mice. Am J Respir Cell Mol Biol. 2022. In press.