Clyde Wright, MD

Recognitions

• Distinguished Teaching Award, Resident, Awarded by Medical Student Body (2004)
  
• Outstanding Resident Teaching Award, Awarded by Pediatric Residents (2004)
  
• Outstanding Pediatric Resident Award, Awarded by 4th Year Medical Students (2006)
  
• Thomas R. Boggs, Jr. Neonatal-Perinatal Research Award, Philadelphia Perinatal Society (2009)
  

Publications

• Wright CJ, Agboke F, Muthu M, Michaelis KA, Mundy MA, La P, Yang G, Dennery PA. Nuclear factor-?B (NF-?B) inhibitory protein I?Bß determines apoptotic cell death following exposure to oxidative stress. J Biol Chem. 2012 Feb 24;287(9):6230-9. PubMed PMID: 22223647
• Yang G, Hinson MD, Bordner JE, Lin QS, Fernando AP, La P, Wright CJ, Dennery PA. Silencing hyperoxia-induced C/EBPa in neonatal mice improves lung architecture via enhanced proliferation of alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L187-96. PubMed PMID: 21571903
• Stewart MS, Dietz RM, Landman MP, Moulton SL, Wright CJ. Abdominal Radiograph with Intravesical Air and Possible Small Bowel Atresia. J Pediatr. 2014 Jan 25. [Epub ahead of print] PubMed PMID: 24472230
• Yang G, Wright CJ, Hinson MD, Fernando AP, Sengupta S, Biswas C, La P, Dennery PA. Oxidative stress and inflammation modulate Rev-erba signaling in the neonatal lung and affect circadian rhythmicity. Antioxid Redox Signal. 2013 Nov 19. [Epub ahead of print] PubMed PMID: 24252172
• The NF-?B inhibitory proteins I?Ba and I?Bß mediate disparate responses to inflammation in fetal pulmonary endothelial cells. Tang JR, Michaelis KA, Nozik-Grayck E, Seedorf GJ, Hartman-Filson M, Abman SH, Wright CJ. J Immunol. 2013 Mar 15;190(6):2913-23. doi: 10.4049/jimmunol.1202670. Epub 2013 Feb 15.
• Thin catheter surfactant administration during spontaneous breathing in very low birth weight infants is associated with reduced need for mechanical ventilation. Benjamin J, Wright CJ. J Pediatr. 2013 Sep;163(3):923-4. doi: 10.1016/j.jpeds.2013.06.049. No abstract available. PMID: 23973239 [PubMed - indexed for MEDLINE]
• OHRP and SUPPORT: lessons in balancing safety and improving the way we care for patients. Wright CJ, Saugstad OD. J Pediatr. 2013 Nov;163(5):1495-7. doi: 10.1016/j.jpeds.2013.08.061. Epub 2013 Sep 17. No abstract available. PMID: 24050739 [PubMed - indexed for MEDLINE]
• I?Bß-Mediated NF-?B Activation Confers Protection against Hyperoxic Lung Injury. Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ. Am J Respir Cell Mol Biol. 2014 Feb;50(2):429-38. doi: 10.1165/rcmb.2013-0303OC. PMID: 24066808 [PubMed - in process]
• DeMauro SB, Wright CJ. Acetaminophen: a possible alternative to ibuprofen in patent ductus arteriosus closure. J Pediatr. 2014 Jul;165(1):209-10. PubMed PMID: 24973162
• McKenna S, Michaelis KA, Agboke F, Liu T, Han K, Yang G, Dennery PA, Wright CJ. Sustained hyperoxia-induced NF-?B activation improves survival and preserves lung development in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1078-89. PubMed PMID: 24748603
• Stewart MS, Dietz RM, Landman MP, Moulton SL, Wright CJ. Abdominal radiograph with intravesical air and possible small bowel atresia. J Pediatr. 2014 May;164(5):1238-1238.e1. PubMed PMID: 24472230
• Michaelis KA, Agboke F, Liu T, Han K, Muthu M, Galambos C, Yang G, Dennery PA, Wright CJ. I?Bß-mediated NF-?B activation confers protection against hyperoxic lung injury. Am J Respir Cell Mol Biol. 2014 Feb;50(2):429-38. PubMed PMID: 24066808
• Yang G, Wright CJ, Hinson MD, Fernando AP, Sengupta S, Biswas C, La P, Dennery PA. Oxidative stress and inflammation modulate Rev-erba signaling in the neonatal lung and affect circadian rhythmicity. Antioxid Redox Signal. 2014 Jul 1;21(1):17-32. PubMed PMID: 24252172
• McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ. Endotoxemia Induces I?Bß/NF-?B-Dependent Endothelin-1 Expression in Hepatic Macrophages. J Immunol. 2015 Oct 15;195(8):3866-79. PubMed PMID: 26342031
• McKenna S, Wright CJ. Inhibiting I?Bß-NF?B signaling attenuates the expression of select pro-inflammatory genes. J Cell Sci. 2015 Jun 1;128(11):2143-55. PubMed PMID: 25908863
• Wright CJ, Permar SR. Preventing postnatal cytomegalovirus infection in the preterm infant: should it be done, can it be done, and at what cost?. J Pediatr. 2015 Apr;166(4):795-8. PubMed PMID: 25662832
• Wright CJ, Polin RA. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia?. Clin Perinatol. 2016 Dec;43(4):783-798. PubMed PMID: 27837759
• Wright CJ. More is not always better, at least when it comes to oxygen saturation target goals. J Pediatr. 2016 Nov;178:2. PubMed PMID: 27788834
• Wright CJ. Working backwards: Can variations in neonatal outcomes help identify best practice?. J Pediatr. 2016 Oct;177:1. PubMed PMID: 27666070
• Wright CJ. Blunted response: smoke, illicit substances, and how babies breathe. J Pediatr. 2016 Aug;175:1-4. PubMed PMID: 27507312
• Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the delivery room and how high should we go?. Acta Paediatr. 2016 Aug;105(8):868-70. PubMed PMID: 27383516
• McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016;8(4):386-99. PubMed PMID: 27160391
• Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve?. J Pediatr. 2016 Jun;173:17-24.e2. PubMed PMID: 27025910
• Dietz RM, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Hypothermia and the Resuscitation of Asphyxiated Fetal Rhesus Monkeys. J Pediatr. 2016 Jan;168:87. PubMed PMID: 26719178
• Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 1;595(21):6595-6596. PubMed PMID: 28925540
• McKenna S, Butler B, Jatana L, Ghosh S, Wright CJ. Inhibition of I?Bß/NF?B signaling prevents LPS-induced IL1ß expression without increasing apoptosis in the developing mouse lung. Pediatr Res. 2017 Aug 23. [Epub ahead of print] PubMed PMID: 28753596
• Wright CJ. Lessons from Goldilocks: maternal weight gain and neurocognitive outcomes of ELGAN. J Pediatr. 2017 Aug;187:1-2. PubMed PMID: 28750756
• Wright CJ. Is more oxygen better for our smallest babies, or maybe just our smallest babies?. J Pediatr. 2017 Jul;186:3. PubMed PMID: 28648280
• Ratcliffe SJ, Sherlock LG, Wright CJ. Oral paracetamol or oral ibuprofen to close the ductus arteriosus: both 'work', but do we know when to use them?. Acta Paediatr. 2017 Sep;106(9):1539. PubMed PMID: 28370568
• Sherlock LG, Wright CJ. Preventing extubation failure in preterm infants: nasal CPAP remains the standard of care. Acta Paediatr. 2017 Aug;106(8):1364. PubMed PMID: 28370320
• Sherlock LG, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Pneumomediastinum, a Silent Lesion in the Newborn. J Pediatr. 2017 Apr;183:93. PubMed PMID: 28343537
• Wright CJ. Is preventing BPD the target, or should we strive for something else?. J Pediatr. 2017 Apr;183:2. PubMed PMID: 28343533
• Palau MA, Winters A, Liang X, Nuss R, Niermeyer S, Gossling M, Wright C. Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. Case Rep Pediatr. 2017;2017:7628946. PubMed PMID: 28280644
• Wright CJ. Oxygen saturation targets: The wrinkle in the pulse oximeter calibration software provides another wrinkle. J Pediatr. 2017 Mar;182:3-4. PubMed PMID: 28237449
• Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta Paediatrica: a new collaboration to advance evidence-based neonatology. Acta Paediatr. 2017 Mar;106(3):358. PubMed PMID: 28186374
• Wright CJ. Too salty: biochemical markers to validate maternal concern of breastmilk supply. J Pediatr. 2017 Feb;181:3. PubMed PMID: 28129875
• Wright CJ, Polin RA. Noninvasive Support: Does It Really Decrease Bronchopulmonary Dysplasia?. Clin Perinatol. 2016 Dec;43(4):783-798. PubMed PMID: 27837759
• Wright CJ. More is not always better, at least when it comes to oxygen saturation target goals. J Pediatr. 2016 Nov;178:2. PubMed PMID: 27788834
• Wright CJ. Working backwards: Can variations in neonatal outcomes help identify best practice?. J Pediatr. 2016 Oct;177:1. PubMed PMID: 27666070
• Wright CJ. Blunted response: smoke, illicit substances, and how babies breathe. J Pediatr. 2016 Aug;175:1-4. PubMed PMID: 27507312
• Wright CJ, Kirpalani H. When should we start continuous positive airway pressure in the delivery room and how high should we go?. Acta Paediatr. 2016 Aug;105(8):868-70. PubMed PMID: 27383516
• McKenna S, Eckman M, Parker A, Bok R, Hurt KJ, Wright CJ. Perinatal Endotoxemia Induces Sustained Hepatic COX-2 Expression through an NF?B-Dependent Mechanism. J Innate Immun. 2016;8(4):386-99. PubMed PMID: 27160391
• Wright CJ, Polin RA, Kirpalani H. Continuous Positive Airway Pressure to Prevent Neonatal Lung Injury: How Did We Get Here, and How Do We Improve?. J Pediatr. 2016 Jun;173:17-24.e2. PubMed PMID: 27025910
• Dietz RM, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Hypothermia and the Resuscitation of Asphyxiated Fetal Rhesus Monkeys. J Pediatr. 2016 Jan;168:87. PubMed PMID: 26719178
• McKenna S, Burey T, Sandoval J, Nguyen L, Castro O, Gudipati S, Gonzalez J, El Kasmi KC, Wright CJ. Immunotolerant p50/NF?B Signaling and Attenuated Hepatic IFNß Expression Increases Neonatal Sensitivity to Endotoxemia. Front Immunol. 2018;9:2210. PubMed PMID: 30319651
• Hwang SS, Burris HH, Collins JW Jr, Kirpalani H, Wright CJ. Moving beyond race and ethnicity to understand the effect of inhaled nitric oxide on bronchopulmonary dysplasia prevention. J Pediatr. 2018 Oct;201:298-300. PubMed PMID: 30029858
• Wright CJ. Paracetamol for ductal closure: Inching closer, but cautiously!. J Pediatr. 2018 Jul;198:4. PubMed PMID: 29936969
• Stremming JE, Wright CJ, Brown LD. Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants?. Acta Paediatr. 2018 Oct;107(10):1836. PubMed PMID: 29873417
• Wright CJ. Midlife crisis? In its 50th year, BPD redefines itself. J Pediatr. 2018 Jun;197:3. PubMed PMID: 29801543
• Wright CJ, Sherlock LG, Sahni R, Polin RA. Preventing Continuous Positive Airway Pressure Failure: Evidence-Based and Physiologically Sound Practices from Delivery Room to the Neonatal Intensive Care Unit. Clin Perinatol. 2018 Jun;45(2):257-271. PubMed PMID: 29747887
• Bourque SL, Roberts RS, Wright CJ, Kirpalani H, Lemyre B, Millar D, Bamat NA. Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure to Prevent Primary Noninvasive Ventilation Failure in Extremely Low Birthweight Infants. J Pediatr. 2019 Oct 8. [Epub ahead of print] PubMed PMID: 31604630
• Burris HH, Wright CJ, Kirpalani H, Collins JW Jr, Lorch SA, Elovitz MA, Hwang SS. The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth. Pediatr Res. 2019 Aug 5. [Epub ahead of print] PubMed PMID: 31382269
• Wright CJ. Hey baby, slow down-what happens now matters!. J Pediatr. 2018 May;196:2-3. PubMed PMID: 29703356
• Butler B, De Dios R, Nguyen L, McKenna S, Ghosh S, Wright CJ. Developmentally Regulated Innate Immune NF?B Signaling Mediates IL-1a Expression in the Perinatal Murine Lung. Front Immunol. 2019;10:1555. PubMed PMID: 31354715
• Wright CJ. Using blood we've got to save blood we need. J Pediatr. 2019 Aug;211:1-3. PubMed PMID: 31349912
• Lohmann P, Wright C. Does permissive hypercapnia carry increased risk for neurodevelopmental sequelae?. Acta Paediatr. 2019 Aug;108(8):1547. PubMed PMID: 31222809
• Nguyen L, Castro O, De Dios R, Sandoval J, McKenna S, Wright CJ. Sex-differences in LPS-induced neonatal lung injury. Sci Rep. 2019 Jun 11;9(1):8514. PubMed PMID: 31186497
• Marrs LK, Zenge JP, Barry JS, Wright CJ. Achieving Procedural Competency during Neonatal Fellowship Training: Can Trainees Teach Us How to Teach?. Neonatology. 2019;116(1):17-19. PubMed PMID: 30889581
• Wright CJ. The metabolic costs 30 years after preterm birth. J Pediatr. 2019 Mar;206:1-2. PubMed PMID: 30798821
• Burris HH, Hwang SS, Collins JW Jr, Kirpalani H, Wright CJ. Re-conceptualizing Associations between Race and Morbidities of Extreme Prematurity. J Pediatr. 2019 Apr;207:10-14.e1. PubMed PMID: 30723017
• Nguyen L, Sandoval J, De Dios R, Yihdego E, Zarate M, Castro O, McKenna S, Wright CJ. The hepatic innate immune response is lobe-specific in a murine model endotoxemia. Innate Immun. 2019 Feb;25(2):144-154. PubMed PMID: 30774009
• El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 Apr 11;9(1):1393. PubMed PMID: 29643332
• McKenna S, Burey T, Sandoval J, Nguyen L, Castro O, Gudipati S, Gonzalez J, El Kasmi KC, Wright CJ. Immunotolerant p50/NF?B Signaling and Attenuated Hepatic IFNß Expression Increases Neonatal Sensitivity to Endotoxemia. Front Immunol. 2018;9:2210. PubMed PMID: 30319651
• Jensen EA, Wright CJ. Bronchopulmonary Dysplasia: The Ongoing Search for One Definition to Rule Them All. J Pediatr. 2018 Jun;197:8-10. PubMed PMID: 29605396
• Sherlock LG, Trumpie A, Hernandez-Lagunas L, McKenna S, Fisher S, Bowler R, Wright CJ, Delaney C, Nozik-Grayck E. Redistribution of Extracellular Superoxide Dismutase Causes Neonatal Pulmonary Vascular Remodeling and PH but Protects Against Experimental Bronchopulmonary Dysplasia. Antioxidants (Basel). 2018 Mar 14;7(3). PubMed PMID: 29538340
• Glaser K, Wright CJ. Aerosolized Calfactant in Infants With RDS: Surfactant Replacement 2.0?. Pediatrics. 2020 Oct 15. [Epub ahead of print] PubMed PMID: 33060257
• Beard L, Wright CJ. Does non-invasive ventilation confer a lung protective effect and improve long-term pulmonary outcomes?. Acta Paediatr. 2018 Jun;107(6):1102. PubMed PMID: 29517827
• Zarate MA, Nguyen LM, De Dios RK, Zheng L, Wright CJ. Maturation of the Acute Hepatic TLR4/NF-?B Mediated Innate Immune Response Is p65 Dependent in Mice. Front Immunol. 2020;11:1892. PubMed PMID: 32973783
• Wright CJ. Tiny babies can be sugary sweet-how hard should we work to control this?. J Pediatr. 2018 Feb;193:2. PubMed PMID: 29389447
• Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by I?B/NF?B Signaling. Reprod Sci. 2020 Nov;27(11):2063-2074. PubMed PMID: 32542534
• Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 Oct;26(7):549-564. PubMed PMID: 32538259
• Wright CJ. Hyperbilirubinemia: Not always as simple as plugging numbers into an app. J Pediatr. 2020 Apr;219:1-3. PubMed PMID: 32204797
• Delaney C, Sherlock L, Fisher S, Maltzahn J, Wright C, Nozik-Grayck E. Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L871-L881. PubMed PMID: 29345193
• Butler B, Wright CJ. Does hydrocortisone reduce death and BPD in preterm infants who remain intubated beyond a week of life?. Acta Paediatr. 2020 Jul;109(7):1495-1496. PubMed PMID: 32167184
• De Dios R, Nguyen L, Ghosh S, McKenna S, Wright CJ. CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NF?B inhibitory protein I?Bß to drive IL1a and IL1ß expression. Immunology. 2020 May;160(1):64-77. PubMed PMID: 32064589
• Wright C. Is it the baby or the beds?. J Pediatr. 2018 Jan;192:2. PubMed PMID: 29246342
• Dietz RM, Wright CJ. Oxidative stress diseases unique to the perinatal period: A window into the developing innate immune response. Am J Reprod Immunol. 2018 May;79(5):e12787. PubMed PMID: 29194835
• Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 1;595(21):6595-6596. PubMed PMID: 28925540
• Sherlock LG, Wright CJ, Kinsella JP, Delaney C. Inhaled nitric oxide use in neonates: Balancing what is evidence-based and what is physiologically sound. Nitric Oxide. 2020 Feb 1;95:12-16. PubMed PMID: 31866361
• McKenna S, Butler B, Jatana L, Ghosh S, Wright CJ. Inhibition of I?Bß/NF?B signaling prevents LPS-induced IL1ß expression without increasing apoptosis in the developing mouse lung. Pediatr Res. 2017 Dec;82(6):1064-1072. PubMed PMID: 28753596
• Bourque SL, Roberts RS, Wright CJ, Kirpalani H, Lemyre B, Millar D, Bamat NA. Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure to Prevent Primary Noninvasive Ventilation Failure in Extremely Low Birthweight Infants. J Pediatr. 2020 Jan;216:218-221.e1. PubMed PMID: 31604630
• Wright CJ. Lessons from Goldilocks: maternal weight gain and neurocognitive outcomes of ELGAN. J Pediatr. 2017 Aug;187:1-2. PubMed PMID: 28750756
• Burris HH, Wright CJ, Kirpalani H, Collins JW Jr, Lorch SA, Elovitz MA, Hwang SS. The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth. Pediatr Res. 2020 Jan;87(2):221-226. PubMed PMID: 31382269
• Wright CJ. Is more oxygen better for our smallest babies, or maybe just our smallest babies?. J Pediatr. 2017 Jul;186:3. PubMed PMID: 28648280
• Shay R, Wright CJ. Can a predictive model for extubation readiness in preterm infants improve rates of successful extubation?. Acta Paediatr. 2020 Oct 29. [Epub ahead of print] PubMed PMID: 33118635
• Ratcliffe SJ, Sherlock LG, Wright CJ. Oral paracetamol or oral ibuprofen to close the ductus arteriosus: both 'work', but do we know when to use them?. Acta Paediatr. 2017 Sep;106(9):1539. PubMed PMID: 28370568
• Sherlock LG, Wright CJ. Preventing extubation failure in preterm infants: nasal CPAP remains the standard of care. Acta Paediatr. 2017 Aug;106(8):1364. PubMed PMID: 28370320
• Sherlock LG, Wright CJ. 50 Years Ago in The Journal of Pediatrics: Pneumomediastinum, a Silent Lesion in the Newborn. J Pediatr. 2017 Apr;183:93. PubMed PMID: 28343537
• Dobrinskikh E, Al-Juboori S, Zarate M, Zheng L, de Dios R, Balasubramaniyan D, Sherlock LG, Orlicky D, Wright CJ. Pulmonary implications of acetaminophen exposures independent of hepatic toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 Sep 29. [Epub ahead of print] PubMed PMID: 34585971
• Zarate MA, De Dios RK, Balasubramaniyan D, Zheng L, Sherlock LG, Rozance PJ, Wright CJ. The Acute Hepatic NF-?B-Mediated Proinflammatory Response to Endotoxemia Is Attenuated in Intrauterine Growth-Restricted Newborn Mice. Front Immunol. 2021;12:706774. PubMed PMID: 34539638
• Palau MA, Winters A, Liang X, Nuss R, Niermeyer S, Gossling M, Wright C. Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature. Case Rep Pediatr. 2017;2017:7628946. PubMed PMID: 28280644
• Keir A, Bamat N, Hennebry B, King B, Patel R, Wright C, Scrivens A, ElKhateeb O, Mitra S, Roland D. Building a community of practice through social media using the hashtag #neoEBM. PLoS One. 2021;16(5):e0252472. PubMed PMID: 34048469
• Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21;10(5). PubMed PMID: 33919055
• Glaser K, Wright CJ. Indications for and Risks of Noninvasive Respiratory Support. Neonatology. 2021;118(2):235-243. PubMed PMID: 33902052
• Wright CJ, McKenna S, De Dios R, Boehmer BH, Nguyen L, Ghosh S, Sandoval J, Rozance PJ. Lower threshold to NF?B activity sensitizes murine ß-cells to streptozotocin. J Endocrinol. 2021 May 6;249(3):163-175. PubMed PMID: 33764312
• Wright CJ. Is preventing BPD the target, or should we strive for something else?. J Pediatr. 2017 Apr;183:2. PubMed PMID: 28343533
• Dobrinskikh E, Sherlock LG, Orlicky DJ, Zheng L, De Dios R, Balasubramaniyan D, Sizemore T, Butler B, Wright CJ. The developing murine lung is susceptible to acetaminophen toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L969-L978. PubMed PMID: 33759579
• Glaser K, Wright CJ. EBNEO Review: aerosolised Calfactant in infants with RDS: A feasible route of surfactant administration?. Acta Paediatr. 2021 May;110(5):1699-1700. PubMed PMID: 33682175
• Wright CJ. Oxygen saturation targets: The wrinkle in the pulse oximeter calibration software provides another wrinkle. J Pediatr. 2017 Mar;182:3-4. PubMed PMID: 28237449
• Sherlock LG, Balasubramaniyan D, Zheng L, Zarate M, Sizemore T, Delaney C, Tipple TE, Wright CJ, Nozik-Grayck E. Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency. Antioxidants (Basel). 2021 Feb 14;10(2). PubMed PMID: 33672905
• Kirkley MJ, Wright CJ. Rapid synthesis of a changing evidence base during the COVID-19 pandemic: the NeoCLEAR Project. J Perinatol. 2021 Apr;41(4):898-900. PubMed PMID: 33664470
• Wright CJ, Norman M, Kirpalani H, Johansson S. EBNEO commentaries in Acta Paediatrica: a new collaboration to advance evidence-based neonatology. Acta Paediatr. 2017 Mar;106(3):358. PubMed PMID: 28186374
• Wright CJ. Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?. J Pediatr. 2021 Aug;235:264-276.e1. PubMed PMID: 33617854
• Wright CJ. Too salty: biochemical markers to validate maternal concern of breastmilk supply. J Pediatr. 2017 Feb;181:3. PubMed PMID: 28129875
• Keir A, Bamat N, Boyle E, ElKhateeb O, Wright C. EBNEO commentaries: An ongoing collaboration advancing evidence-based neonatal care. Acta Paediatr. 2021 May;110(5):1398-1400. PubMed PMID: 33475179
• Burris HH, Wright CJ, Kirpalani H, Collins JW Jr, Lorch SA, Elovitz MA, Hwang SS. The promise and pitfalls of precision medicine to resolve black-white racial disparities in preterm birth. Pediatr Res. 2020 Jan;87(2):221-226. PubMed PMID: 31382269
• Bourque SL, Roberts RS, Wright CJ, Kirpalani H, Lemyre B, Millar D, Bamat NA. Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure to Prevent Primary Noninvasive Ventilation Failure in Extremely Low Birthweight Infants. J Pediatr. 2020 Jan;216:218-221.e1. PubMed PMID: 31604630
• Sherlock LG, Wright CJ, Kinsella JP, Delaney C. Inhaled nitric oxide use in neonates: Balancing what is evidence-based and what is physiologically sound. Nitric Oxide. 2020 Feb 1;95:12-16. PubMed PMID: 31866361
• Glaser K, Speer CP, Wright CJ. Fine Tuning Non-invasive Respiratory Support to Prevent Lung Injury in the Extremely Premature Infant. Front Pediatr. 2019;7:544. PubMed PMID: 31998672
• De Dios R, Nguyen L, Ghosh S, McKenna S, Wright CJ. CpG-ODN-mediated TLR9 innate immune signalling and calcium dyshomeostasis converge on the NF?B inhibitory protein I?Bß to drive IL1a and IL1ß expression. Immunology. 2020 May;160(1):64-77. PubMed PMID: 32064589
• Butler B, Wright CJ. Does hydrocortisone reduce death and BPD in preterm infants who remain intubated beyond a week of life?. Acta Paediatr. 2020 Jul;109(7):1495-1496. PubMed PMID: 32167184
• Wright CJ. Hyperbilirubinemia: Not always as simple as plugging numbers into an app. J Pediatr. 2020 Apr;219:1-3. PubMed PMID: 32204797
• Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 Oct;26(7):549-564. PubMed PMID: 32538259
• Wright CJ, Cari EL, Sandoval J, Bales E, Sam PK, Zarate MA, Polotsky AJ, Kallen AN, Johnson J. Control of Murine Primordial Follicle Growth Activation by I?B/NF?B Signaling. Reprod Sci. 2020 Nov;27(11):2063-2074. PubMed PMID: 32542534
• Zarate MA, Nguyen LM, De Dios RK, Zheng L, Wright CJ. Maturation of the Acute Hepatic TLR4/NF-?B Mediated Innate Immune Response Is p65 Dependent in Mice. Front Immunol. 2020;11:1892. PubMed PMID: 32973783
• Shay R, Wright CJ. Can a predictive model for extubation readiness in preterm infants improve rates of successful extubation?. Acta Paediatr. 2021 Feb;110(2):722-723. PubMed PMID: 33118635
• Glaser K, Wright CJ. Aerosolized Calfactant in Infants With RDS: Surfactant Replacement 2.0?. Pediatrics. 2020 Nov;146(5). PubMed PMID: 33060257
• Sherlock LG, Sjostrom K, Sian L, Delaney C, Tipple TE, Krebs NF, Nozik-Grayck E, Wright CJ. Hepatic-Specific Decrease in the Expression of Selenoenzymes and Factors Essential for Selenium Processing After Endotoxemia. Front Immunol. 2020;11:595282. PubMed PMID: 33224150
• Jhaveri Sanghvi U, Wright CJ, Hernandez TL. Pulmonary Resilience: Moderating the Association between Oxygen Exposure and Pulmonary Outcomes in Extremely Preterm Newborns. Neonatology. 2022;119(4):433-442. PubMed PMID: 35551136
• McCulley DJ, Jensen EA, Sucre JMS, McKenna S, Sherlock LG, Dobrinskikh E, Wright CJ. Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L1-L13. PubMed PMID: 35503238
• Wright CJ, Glaser K, Speer CP, Härtel C, Roehr CC. Noninvasive Ventilation and Exogenous Surfactant in Times of Ever Decreasing Gestational Age: How Do We Make the Most of These Tools?. J Pediatr. 2022 Aug;247:138-146. PubMed PMID: 35429507
• Wright CJ, Glaser K, Bamat NA. EBNEO Commentary: OPTIMIST-ically moving towards targeted noninvasive surfactant therapy?. Acta Paediatr. 2022 May;111(5):1091-1092. PubMed PMID: 35100470
• Wright CJ, Jensen EA. EBNEO Commentary: Paracetamol/acetaminophen to avoid PDA ligation: How to interpret impact on 18- to 24-month outcomes. Acta Paediatr. 2022 Apr;111(4):901-902. PubMed PMID: 35099086
• Bamat N, Fierro J, Mukerji A, Wright CJ, Millar D, Kirpalani H. Nasal continuous positive airway pressure levels for the prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev. 2021 Nov 30;11:CD012778. PubMed PMID: 34847243
• Sherlock LG, Balasubramaniyan D, Zheng L, Grayck M, McCarthy WC, De Dios RC, Zarate MA, Orlicky DJ, De Dios R, Wright CJ. APAP-Induced I?Bß/NF?B Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation. Toxicol Sci. 2022 Jan 24;185(2):158-169. PubMed PMID: 34726736
• Shay RL, Goldberg A, Sundaram SS, Browne LP, Wright CJ, Annam A. Neonatal Presentation of Congenital Portosystemic Shunt. J Pediatr. 2022 Feb;241:261-262. PubMed PMID: 34687689
• Dobrinskikh E, Al-Juboori SI, Zarate MA, Zheng L, De Dios R, Balasubramaniyan D, Sherlock LG, Orlicky DJ, Wright CJ. Pulmonary implications of acetaminophen exposures independent of hepatic toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L941-L953. PubMed PMID: 34585971
• Zarate MA, De Dios RK, Balasubramaniyan D, Zheng L, Sherlock LG, Rozance PJ, Wright CJ. The Acute Hepatic NF-?B-Mediated Proinflammatory Response to Endotoxemia Is Attenuated in Intrauterine Growth-Restricted Newborn Mice. Front Immunol. 2021;12:706774. PubMed PMID: 34539638
• Keir A, Bamat N, Hennebry B, King B, Patel R, Wright C, Scrivens A, ElKhateeb O, Mitra S, Roland D. Building a community of practice through social media using the hashtag #neoEBM. PLoS One. 2021;16(5):e0252472. PubMed PMID: 34048469
• Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21;10(5). PubMed PMID: 33919055
• Glaser K, Wright CJ. Indications for and Risks of Noninvasive Respiratory Support. Neonatology. 2021;118(2):235-243. PubMed PMID: 33902052
• Wright CJ, McKenna S, De Dios R, Boehmer BH, Nguyen L, Ghosh S, Sandoval J, Rozance PJ. Lower threshold to NF?B activity sensitizes murine ß-cells to streptozotocin. J Endocrinol. 2021 May 6;249(3):163-175. PubMed PMID: 33764312
• Glaser K, Wright CJ. EBNEO Review: aerosolised Calfactant in infants with RDS: A feasible route of surfactant administration?. Acta Paediatr. 2021 May;110(5):1699-1700. PubMed PMID: 33682175
• Dobrinskikh E, Sherlock LG, Orlicky DJ, Zheng L, De Dios R, Balasubramaniyan D, Sizemore T, Butler B, Wright CJ. The developing murine lung is susceptible to acetaminophen toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L969-L978. PubMed PMID: 33759579
• Sherlock LG, Balasubramaniyan D, Zheng L, Zarate M, Sizemore T, Delaney C, Tipple TE, Wright CJ, Nozik-Grayck E. Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency. Antioxidants (Basel). 2021 Feb 14;10(2). PubMed PMID: 33672905
• Kirkley MJ, Wright CJ. Rapid synthesis of a changing evidence base during the COVID-19 pandemic: the NeoCLEAR Project. J Perinatol. 2021 Apr;41(4):898-900. PubMed PMID: 33664470
• Wright CJ. Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?. J Pediatr. 2021 Aug;235:264-276.e1. PubMed PMID: 33617854
• Keir A, Bamat N, Boyle E, ElKhateeb O, Wright C. EBNEO commentaries: An ongoing collaboration advancing evidence-based neonatal care. Acta Paediatr. 2021 May;110(5):1398-1400. PubMed PMID: 33475179
• Shay R, Wright CJ. Can a predictive model for extubation readiness in preterm infants improve rates of successful extubation?. Acta Paediatr. 2021 Feb;110(2):722-723. PubMed PMID: 33118635
• Gallagher LT, Wright CJ, Lehmann T, Khailova L, Zarate M, Lyttle BD, Liechty KW, Derderian SC. Angiogenic and Inflammatory microRNA Regulation in a Mouse Model of Fetal Growth Restriction. J Surg Res. 2023 Aug 30;292:234-238. [Epub ahead of print] PubMed PMID: 37657141
• Harding E, Hill LR, Black JO, Annam A, Wright CJ. Term Neonate with Progressive Respiratory Distress. J Pediatr. 2023 Aug 26;263:113704. [Epub ahead of print] PubMed PMID: 37640231
• Ramaswamy VV, Bandyopadhyay T, Abiramalatha T, Pullattayil S AK, Szczapa T, Wright CJ, Roehr CC. Clinical decision thresholds for surfactant administration in preterm infants: a systematic review and network meta-analysis. EClinicalMedicine. 2023 Aug;62:102097. PubMed PMID: 37538537
• Bhandari V, Black R, Gandhi B, Hogue S, Kakkilaya V, Mikhael M, Moya F, Pezzano C, Read P, Roberts KD, Ryan RM, Stanford RH, Wright CJ. RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS. J Perinatol. 2023 Aug;43(8):982-990. PubMed PMID: 37188774
• Wright CJ, McCulley DJ, Mitra S, Jensen EA. Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated?. J Perinatol. 2023 Oct;43(10):1230-1237. PubMed PMID: 37169914
• McCarthy WC, Sherlock LG, Grayck MR, Zheng L, Lacayo OA, Solar M, Orlicky DJ, Dobrinskikh E, Wright CJ. Innate Immune Zonation in the Liver: NF-?B (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific. J Immunol. 2023 May 1;210(9):1372-1385. PubMed PMID: 36946778
• Glaser K, Kern D, Speer CP, Schlegel N, Schwab M, Thome UH, Härtel C, Wright CJ. Imbalanced Inflammatory Responses in Preterm and Term Cord Blood Monocytes and Expansion of the CD14( )CD16( ) Subset upon Toll-like Receptor Stimulation. Int J Mol Sci. 2023 Mar 3;24(5). PubMed PMID: 36902350
• Wright CJ, Glaser K, Speer CP, Härtel C, Roehr CC. Reply. J Pediatr. 2023 Jun;257:113363. PubMed PMID: 36828344
• Mues N, Martin RJ, Alam R, Schaunaman N, Dimasuay KG, Kolakowski C, Wright CJ, Zheng L, Chu HW. Bacterial DNA amplifies neutrophilic inflammation in IL-17-exposed airways. ERJ Open Res. 2023 Jan;9(1). PubMed PMID: 36699649
• Wright CJ, Glaser K, Speer CP, Härtel C, Roehr CC. Corrigendum to Non-Invasive Ventilation and Exogenous Surfactant in Times of Ever Decreasing Gestational Age: How Do We Make the Most of These Tools? The Journal of Pediatrics 247(2022):138-146. J Pediatr. 2023 Apr;255:264. PubMed PMID: 36599711
• Shay RL, Goldberg A, Sundaram SS, Browne LP, Wright CJ, Annam A. Neonatal Presentation of Congenital Portosystemic Shunt. J Pediatr. 2022 Feb;241:261-262. PubMed PMID: 34687689
• Sherlock LG, Balasubramaniyan D, Zheng L, Grayck M, McCarthy WC, De Dios RC, Zarate MA, Orlicky DJ, De Dios R, Wright CJ. APAP-Induced I?Bß/NF?B Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation. Toxicol Sci. 2022 Jan 24;185(2):158-169. PubMed PMID: 34726736
• Wright CJ, Jensen EA. EBNEO Commentary: Paracetamol/acetaminophen to avoid PDA ligation: How to interpret impact on 18- to 24-month outcomes. Acta Paediatr. 2022 Apr;111(4):901-902. PubMed PMID: 35099086
• Wright CJ, Glaser K, Bamat NA. EBNEO Commentary: OPTIMIST-ically moving towards targeted noninvasive surfactant therapy?. Acta Paediatr. 2022 May;111(5):1091-1092. PubMed PMID: 35100470
• Wright CJ, Glaser K, Speer CP, Härtel C, Roehr CC. Noninvasive Ventilation and Exogenous Surfactant in Times of Ever Decreasing Gestational Age: How Do We Make the Most of These Tools?. J Pediatr. 2022 Aug;247:138-146. PubMed PMID: 35429507
• McCulley DJ, Jensen EA, Sucre JMS, McKenna S, Sherlock LG, Dobrinskikh E, Wright CJ. Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures. Am J Physiol Lung Cell Mol Physiol. 2022 Jul 1;323(1):L1-L13. PubMed PMID: 35503238
• Jhaveri Sanghvi U, Wright CJ, Hernandez TL. Pulmonary Resilience: Moderating the Association between Oxygen Exposure and Pulmonary Outcomes in Extremely Preterm Newborns. Neonatology. 2022;119(4):433-442. PubMed PMID: 35551136
• Solar M, Grayck MR, McCarthy WC, Zheng L, Lacayo OA, Sherlock LG, Zhou R, Orlicky DJ, Wright CJ. Absence of I?Bß/NF?B signaling does not attenuate acetaminophen-induced hepatic injury. Anat Rec (Hoboken). 2022 Nov 25. [Epub ahead of print] PubMed PMID: 36426684
• Sherlock LG, McCarthy WC, Grayck MR, Solar M, Hernandez A, Zheng L, Delaney C, Tipple TE, Wright CJ, Nozik ES. Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development. Antioxidants (Basel). 2022 Dec 7;11(12). PubMed PMID: 36552625
• Glaser K, Bamat NA, Wright CJ. Can we balance early exogenous surfactant therapy and non-invasive respiratory support to optimise outcomes in extremely preterm infants? A nuanced review of the current literature. Arch Dis Child Fetal Neonatal Ed. 2022 Dec 7. [Epub ahead of print] PubMed PMID: 36600473
• Gilley SP, Ruebel ML, Chintapalli SV, Wright CJ, Rozance PJ, Shankar K. Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice. Front Endocrinol (Lausanne). 2024;15:1423464. PubMed PMID: 39429739
• Jensen EA, DeMauro SB, Rysavy MA, Patel RM, Laughon MM, Eichenwald EC, Do BT, Das A, Wright CJ. Acetaminophen for Patent Ductus Arteriosus and Risk of Mortality and Pulmonary Morbidity. Pediatrics. 2024 Aug 1;154(2). PubMed PMID: 39011550
• King WE, Sanghvi UJ, Ambalavanan N, Shukla VV, Travers CP, Schelonka RL, Wright C, Carlo WA. Heart rate characteristics predict risk of mortality in preterm infants in low and high target oxygen saturation ranges. ERJ Open Res. 2024 Jul;10(4). PubMed PMID: 39010885
• Glaser K, Jensen EA, Wright CJ. Prevention of Inflammatory Disorders in the Preterm Neonate: An Update with a Special Focus on Bronchopulmonary Dysplasia. Neonatology. 2024;121(5):636-645. PubMed PMID: 38870912
• Gallagher LT, Bardill J, Sucharov CC, Wright CJ, Karimpour-Fard A, Zarate M, Breckenfelder C, Liechty KW, Derderian SC. Dysregulation of miRNA-mRNA expression in fetal growth restriction in a caloric restricted mouse model. Sci Rep. 2024 Mar 7;14(1):5579. PubMed PMID: 38448721
• Grayck MR, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Orlicky DJ, Wright CJ. Implications of neonatal absence of innate immune mediated NF?B/AP1 signaling in the murine liver. Pediatr Res. 2024 Jun;95(7):1791-1802. PubMed PMID: 38396130
• Grayck MR, McCarthy WC, Solar M, Golden E, Balasubramaniyan N, Zheng L, Sherlock LG, Wright CJ. GSK3ß/NF-?B -dependent transcriptional regulation of homeostatic hepatocyte Tnf production. Am J Physiol Gastrointest Liver Physiol. 2024 Apr 1;326(4):G374-G384. PubMed PMID: 38193163
• Gilley SP, Zarate MA, Zheng L, Jambal P, Yazza DN, Chintapalli SV, MacLean PS, Wright CJ, Rozance PJ, Shankar K. Metabolic and fecal microbial changes in adult fetal growth restricted mice. Pediatr Res. 2024 Feb;95(3):647-659. PubMed PMID: 37935884
• Harding E, Hill LR, Black JO, Annam A, Wright CJ. Term Neonate with Progressive Respiratory Distress. J Pediatr. 2023 Dec;263:113704. PubMed PMID: 37640231
• Gallagher LT, Wright CJ, Lehmann T, Khailova L, Zarate M, Lyttle BD, Liechty KW, Derderian SC. Angiogenic and Inflammatory microRNA Regulation in a Mouse Model of Fetal Growth Restriction. J Surg Res. 2023 Dec;292:234-238. PubMed PMID: 37657141

Professional Memberships

• American Academy of Pediatrics (AAP), Member
• Section of Perinatal Pediatrics, AAP, Member
• Eastern Society of Pediatric Research, Member
• Philadelphia Perinatal Society, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado
• University of Colorado Hospital

Center Affiliations

• Perinatal Research Center

Specialty Information

Specialties

• Pediatrics, Board Certification (2004)
• Neonatal-Perinatal Medicine, Board Certification (2010)

Conditions & Treatments

• Pregnancy and Reproduction - Neonatal Intensive Care
• Pregnancy and Reproduction - Prenatal Care
• Pregnancy and Reproduction - Prenatal Testing
• Pregnancy and Reproduction