Chandra Tucker, PhD
Professor, Pharmacology

Department: Pharmacology


  • Taslimi A, Fields KM, Dahl KD, Liu Q, Tucker CL. Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains. Cell Death Discov. 2022 Nov 29;8(1):469. PubMed PMID: 36446770
  • Cleveland JD, Taslimi A, Liu Q, Van Keuren AM, Churchill MEA, Tucker CL. Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1. ACS Synth Biol. 2022 Oct 21;11(10):3318-3329. PubMed PMID: 36153971
  • Pearce S, Tucker CL. Dual Systems for Enhancing Control of Protein Activity through Induced Dimerization Approaches. Adv Biol (Weinh). 2021 May;5(5):e2000234. PubMed PMID: 34028215
  • Hernández-Candia CN, Pearce S, Tucker CL. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun. 2021 Mar 22;12(1):1809. PubMed PMID: 33753744
  • Hernández-Candia CN, Tucker CL. Optogenetic Control of Gene Expression Using Cryptochrome 2 and a Light-Activated Degron. Methods Mol Biol. 2020;2173:151-158. PubMed PMID: 32651916
  • Cleveland JD, Tucker CL. Photo-SNAP-tag, a Light-Regulated Chemical Labeling System. ACS Chem Biol. 2020 Aug 21;15(8):2212-2220. PubMed PMID: 32623878
  • Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res. 2019 Sep 26;47(17):e97. PubMed PMID: 31287871
  • Hernández-Candia CN, Wysoczynski CL, Tucker CL. Advances in optogenetic regulation of gene expression in mammalian cells using cryptochrome 2 (CRY2). Methods. 2019 Jul 15;164-165:81-90. PubMed PMID: 30905749
  • Spiltoir JI, Tucker CL. Photodimerization systems for regulating protein-protein interactions with light. Curr Opin Struct Biol. 2019 Aug;57:1-8. PubMed PMID: 30818200
  • Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 Mar 6;101(5):863-875.e6. PubMed PMID: 30704911
  • Locke C, Machida K, Tucker CL, Wu Y, Yu J. Correction: Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open. 2018 Apr 23;7(4). PubMed PMID: 29685998
  • Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ß splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 Apr 3;8(1):5448. PubMed PMID: 29615706
  • Liu Q, Tucker CL. Engineering genetically-encoded tools for optogenetic control of protein activity. Curr Opin Chem Biol. 2017 Oct;40:17-23. PubMed PMID: 28527343
  • Pathak GP, Spiltoir JI, Höglund C, Polstein LR, Heine-Koskinen S, Gersbach CA, Rossi J, Tucker CL. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res. 2017 Nov 16;45(20):e167. PubMed PMID: 28431041
  • Spiltoir JI, Strickland D, Glotzer M, Tucker CL. Optical Control of Peroxisomal Trafficking. ACS Synth Biol. 2016 Jul 15;5(7):554-60. PubMed PMID: 26513473
  • Taslimi A, Zoltowski B, Miranda JG, Pathak GP, Hughes RM, Tucker CL. Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol. 2016 Jun;12(6):425-30. PubMed PMID: 27065233
  • Spiltoir JI, Strickland D, Glotzer M, Tucker CL. Optical Control of Peroxisomal Trafficking. ACS Synth Biol. 2015 Nov 2. [Epub ahead of print] PubMed PMID: 26513473
  • Schindler SE, McCall JG, Yan P, Hyrc KL, Li M, Tucker CL, Lee JM, Bruchas MR, Diamond MI. Photo-activatable Cre recombinase regulates gene expression in vivo. Sci Rep. 2015 Sep 9;5:13627. PubMed PMID: 26350769
  • Hanson MG, Fregoso VL, Vrana JD, Tucker CL, Niswander LA. Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95. PubMed PMID: 25176044
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General Information

Department: Pharmacology
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13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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