Chandra Tucker, PhD

Publications

• Pathak, G.P., Vrana, J.D., and Tucker, C.L. (2013) Optogenetic control of cell function using engineered photoreceptors. Biol Cell 105, 59-72.
• Pathak GP, Strickland D, Vrana JD, Tucker CL. Benchmarking of optical dimerizer systems. ACS Synth Biol. 2014 Nov 21;3(11):832-8. PubMed PMID: 25350266
• Taslimi A, Vrana JD, Chen D, Borinskaya S, Mayer BJ, Kennedy MJ, Tucker CL. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun. 2014 Sep 18;5:4925. PubMed PMID: 25233328
• Tucker CL, Vrana JD, Kennedy MJ. Tools for controlling protein interactions using light. Curr Protoc Cell Biol. 2014 Sep 2;64:17.16.1-17.16.20. PubMed PMID: 25181301
• Hanson MG, Fregoso VL, Vrana JD, Tucker CL, Niswander LA. Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95. PubMed PMID: 25176044
• Lage MD, Pittman AM, Roncador A, Cellini B, Tucker CL. Allele-specific characterization of alanine: glyoxylate aminotransferase variants associated with primary hyperoxaluria. PLoS One. 2014;9(4):e94338. PubMed PMID: 24718375
• Spiltoir JI, Strickland D, Glotzer M, Tucker CL. Optical Control of Peroxisomal Trafficking. ACS Synth Biol. 2015 Nov 2. [Epub ahead of print] PubMed PMID: 26513473
• Schindler SE, McCall JG, Yan P, Hyrc KL, Li M, Tucker CL, Lee JM, Bruchas MR, Diamond MI. Photo-activatable Cre recombinase regulates gene expression in vivo. Sci Rep. 2015 Sep 9;5:13627. PubMed PMID: 26350769
• Spiltoir JI, Strickland D, Glotzer M, Tucker CL. Optical Control of Peroxisomal Trafficking. ACS Synth Biol. 2016 Jul 15;5(7):554-60. PubMed PMID: 26513473
• Taslimi A, Zoltowski B, Miranda JG, Pathak GP, Hughes RM, Tucker CL. Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase. Nat Chem Biol. 2016 Jun;12(6):425-30. PubMed PMID: 27065233
• Liu Q, Tucker CL. Engineering genetically-encoded tools for optogenetic control of protein activity. Curr Opin Chem Biol. 2017 Oct;40:17-23. PubMed PMID: 28527343
• Pathak GP, Spiltoir JI, Höglund C, Polstein LR, Heine-Koskinen S, Gersbach CA, Rossi J, Tucker CL. Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2. Nucleic Acids Res. 2017 Nov 16;45(20):e167. PubMed PMID: 28431041
• Locke C, Machida K, Tucker CL, Wu Y, Yu J. Correction: Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase. Biol Open. 2018 Apr 23;7(4). PubMed PMID: 29685998
• Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ß splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 Apr 3;8(1):5448. PubMed PMID: 29615706
• Meador K, Wysoczynski CL, Norris AJ, Aoto J, Bruchas MR, Tucker CL. Achieving tight control of a photoactivatable Cre recombinase gene switch: new design strategies and functional characterization in mammalian cells and rodent. Nucleic Acids Res. 2019 Sep 26;47(17):e97. PubMed PMID: 31287871
• Hernández-Candia CN, Wysoczynski CL, Tucker CL. Advances in optogenetic regulation of gene expression in mammalian cells using cryptochrome 2 (CRY2). Methods. 2019 Jul 15;164-165:81-90. PubMed PMID: 30905749
• Spiltoir JI, Tucker CL. Photodimerization systems for regulating protein-protein interactions with light. Curr Opin Struct Biol. 2019 Aug;57:1-8. PubMed PMID: 30818200
• Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 Mar 6;101(5):863-875.e6. PubMed PMID: 30704911
• Hernández-Candia CN, Tucker CL. Optogenetic Control of Gene Expression Using Cryptochrome 2 and a Light-Activated Degron. Methods Mol Biol. 2020;2173:151-158. PubMed PMID: 32651916
• Cleveland JD, Tucker CL. Photo-SNAP-tag, a Light-Regulated Chemical Labeling System. ACS Chem Biol. 2020 Aug 21;15(8):2212-2220. PubMed PMID: 32623878
• Pearce S, Tucker CL. Dual Systems for Enhancing Control of Protein Activity through Induced Dimerization Approaches. Adv Biol (Weinh). 2021 May;5(5):e2000234. PubMed PMID: 34028215
• Hernández-Candia CN, Pearce S, Tucker CL. A modular tool to query and inducibly disrupt biomolecular condensates. Nat Commun. 2021 Mar 22;12(1):1809. PubMed PMID: 33753744
• Taslimi A, Fields KM, Dahl KD, Liu Q, Tucker CL. Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains. Cell Death Discov. 2022 Nov 29;8(1):469. PubMed PMID: 36446770
• Cleveland JD, Taslimi A, Liu Q, Van Keuren AM, Churchill MEA, Tucker CL. Reprogramming the Cleavage Specificity of Botulinum Neurotoxin Serotype B1. ACS Synth Biol. 2022 Oct 21;11(10):3318-3329. PubMed PMID: 36153971
• Hernandez-Candia CN, Brady BR, Harrison E, Tucker CL. A platform to induce and mature biomolecular condensates using chemicals and light. Nat Chem Biol. 2024 Apr;20(4):452-462. PubMed PMID: 38191942
• Rumian NL, Barker CM, Larsen ME, Tullis JE, Freund RK, Taslimi A, Coultrap SJ, Tucker CL, Dell'Acqua ML, Bayer KU. LTP expression mediated by autonomous activity of GluN2B-bound CaMKII. Cell Rep. 2024 Oct 22;43(10):114866. PubMed PMID: 39395168