Matthew Kennedy, PhD

Publications

• Fox, P.D., Haberkorn, C.J., Weigel, A.V., Higgin, J.L., Akin, E.J., Kennedy, M.J., Krapf, D., Tamkun, M.M. (2013) Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs. Molecular Biology of the Cell, 24:2703-13.
• Chen, D., Gibson, E.S., Kennedy, M.J. (2013) A light-triggered protein secretion system. Journal of Cell Biology, 201:631-40.
• Sinnen BL, Bowen AB, Gibson ES, Kennedy MJ. Local and Use-Dependent Effects of ß-Amyloid Oligomers on NMDA Receptor Function Revealed by Optical Quantal Analysis. J Neurosci. 2016 Nov 9;36(45):11532-11543. PubMed PMID: 27911757
• Sinnen, B.L., Bowen, A.B., Forte, J.S., Hiester, B.G., Crosby, K.C., Gibson, E.S., Dell’Acqua, M.L., Kennedy, M.J. (2017) Optogenetic control of synaptic composition and function. Neuron. 93: In Press
• Zimmerman SP, Hallett RA, Bourke AM, Bear JE, Kennedy MJ, Kuhlman B. Tuning the Binding Affinities and Reversion Kinetics of a Light Inducible Dimer Allows Control of Transmembrane Protein Localization. Biochemistry. 2016 Sep 20;55(37):5264-71. PubMed PMID: 27529180
• Bowen AB, Bourke AM, Hiester BG, Hanus C, Kennedy MJ. Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines. Elife. 2017 Sep 6;6. PubMed PMID: 28875935
• Hiester BG, Bourke AM, Sinnen BL, Cook SG, Gibson ES, Smith KR, Kennedy MJ. L-Type Voltage-Gated Ca(2 ) Channels Regulate Synaptic-Activity-Triggered Recycling Endosome Fusion in Neuronal Dendrites. Cell Rep. 2017 Nov 21;21(8):2134-2146. PubMed PMID: 29166605
• Bourke AM, Bowen AB, Kennedy MJ. New approaches for solving old problems in neuronal protein trafficking. Mol Cell Neurosci. 2018 Sep;91:48-66. PubMed PMID: 29649542
• Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 8;93(3):646-660.e5. PubMed PMID: 28132827
• Hiester BG, Becker MI, Bowen AB, Schwartz SL, Kennedy MJ. Mechanisms and Role of Dendritic Membrane Trafficking for Long-Term Potentiation. Front Cell Neurosci. 2018;12:391. PubMed PMID: 30425622
• Liu, Q*, Sinnen, B.L.*, Boxer, E.E, Schneider, M.W., Grybko, M.J., Buchta, W.C., Gibson, E.S., Wysoczynski, C.L., Ford, C.P., Gottschalk, A., Aoto, J., Tucker, C.L., Kennedy, M.J. A light activated botulinum neurotoxin for inducible control of neurotransmission, Neuron (accepted for publication)
• Chander, P., Kennedy, M.J., Winckler, B., Weick, J.P. (2019) Neuron-Specific Gene 2 (NSG2) encodes an AMPA receptor interacting protein that modulates excitatory neurotransmission. eNeuro ENEURO.0292-18.2018.
• Kennedy MJ, Hanus C. Architecture and Dynamics of the Neuronal Secretory Network. Annu Rev Cell Dev Biol. 2019 Oct 6;35:543-566. PubMed PMID: 31283381
• Wild AR, Sinnen BL, Dittmer PJ, Kennedy MJ, Sather WA, Dell'Acqua ML. Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca(2 ) Channel Ca(2 ) Spike Propagation to the Soma. Cell Rep. 2019 Mar 26;26(13):3537-3550.e4. PubMed PMID: 30917310
• Liu Q, Sinnen BL, Boxer EE, Schneider MW, Grybko MJ, Buchta WC, Gibson ES, Wysoczynski CL, Ford CP, Gottschalk A, Aoto J, Tucker CL, Kennedy MJ. A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Neuron. 2019 Mar 6;101(5):863-875.e6. PubMed PMID: 30704911
• Chander P, Kennedy MJ, Winckler B, Weick JP. Neuron-Specific Gene 2 (NSG2) Encodes an AMPA Receptor Interacting Protein That Modulates Excitatory Neurotransmission. eNeuro. 2019 Jan-Feb;6(1). PubMed PMID: 30680309
• Restrepo S, Schwartz SL, Kennedy MJ, Aoto J. Measuring Transcellular Interactions through Protein Aggregation in a Heterologous Cell System. J Vis Exp. 2020 May 22;(159). PubMed PMID: 32510501
• Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, Kennedy MJ. Precision Mapping of Amyloid-ß Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits. eNeuro. 2021 Nov 17. [Epub ahead of print] PubMed PMID: 34789478
• Tullis JE, Buonarati OR, Coultrap SJ, Bourke AM, Tiemeier EL, Kennedy MJ, Herson PS, Bayer KU. GluN2B S1303 phosphorylation by CaMKII or DAPK1: no indication for involvement in ischemia or LTP. iScience. 2021 Oct 22;24(10):103214. PubMed PMID: 34704002
• Bourke AM, Schwartz SL, Bowen AB, Kleinjan MS, Winborn CS, Kareemo DJ, Gutnick A, Schwarz TL, Kennedy MJ. zapERtrap: A light-regulated ER release system reveals unexpected neuronal trafficking pathways. J Cell Biol. 2021 Sep 6;220(9). PubMed PMID: 34241635
• Garcia, J.D., Gookin, S., Crosby, K.C., Schwartz, S.L., Tiemeier, E., Kennedy, M.J., Dell'Acqua, M.L., Herson, P.S., Quillinan, N., Smith, K. Step-wise disassembly of GABAergic synapses during pathogenic excitotoxicity Cell Reports
• Boxer, E.E., Seng, C., Lukacsovich, D., Kim, J., Schwartz, S.L., Kennedy, M.J., Foldy, C., Aoto, J. Neurexin-3 defines synapse- and sex-dependent diversity of GABAergic inhibition in ventral subiculum
• Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, Franco SJ, Harris KM, Oh WC, Kennedy MJ. Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk. Neuron. 2023 Feb 1;111(3):362-371.e6. PubMed PMID: 36395772
• Barcomb K, Olah SS, Kennedy MJ, Ford CP. Properties and modulation of excitatory inputs to the locus coeruleus. J Physiol. 2022 Nov;600(22):4897-4916. PubMed PMID: 36156249
• Bourke AM, Kennedy MJ. Spatial and Temporal Control of Protein Secretion with Light. Methods Mol Biol. 2022;2473:29-45. PubMed PMID: 35819757
• Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR. Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses. Front Synaptic Neurosci. 2022;14:852227. PubMed PMID: 35463850
• Welle TM, Rajgor D, Garcia JD, Kareemo D, Zych SM, Gookin SE, Martinez TP, Dell'Acqua ML, Ford CP, Kennedy MJ, Smith KR. miRNA-mediated control of gephyrin synthesis drives sustained inhibitory synaptic plasticity. bioRxiv. 2023 Dec 12. PubMed PMID: 38168421
• Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, Smith KR, Kennedy MJ. Acute reorganization of postsynaptic GABA(A) receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses. Cell Rep. 2023 Nov 28;42(11):113331. PubMed PMID: 37910506
• Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ. AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Front Mol Neurosci. 2023;16:1232795. PubMed PMID: 37602191
• Kleinjan MS, Buchta WC, Ogelman R, Hwang IW, Kuwajima M, Hubbard DD, Kareemo DJ, Prikhodko O, Olah SL, Gomez Wulschner LE, Abraham WC, Franco SJ, Harris KM, Chan Oh W, Kennedy MJ. Dually innervated dendritic spines develop in the absence of excitatory activity and resist plasticity through tonic inhibitory crosstalk. Neuron. 2023 May 3;111(9):1517. PubMed PMID: 37141861
• Wang S, Chen X, Crisman L, Dou X, Winborn CS, Wan C, Puscher H, Yin Q, Kennedy MJ, Shen J. Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module. Sci Adv. 2023 Feb 22;9(8):eade2540. PubMed PMID: 36812304