My research focuses on pediatric HIV infection, the prevention of transmission of HIV from mother to child, and the immune consequences of HIV exposure.
Publications
Smith C, Silveira L, Crotteau M, Garth K, Canniff J, Fetters KB, Lazarus S, Capraro S, Weinberg A. Congenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States. Front Pediatr. 2022;10:894627. PubMed PMID: 35783327
Jalbert E, Ghosh T, Smith C, Amaral FR, Mussi-Pinhata MM, Weinberg A. Impaired functionality of antigen presenting cells in HIV- exposed uninfected infants in the first six months of life. Front Immunol. 2022;13:960313. PubMed PMID: 36032106
Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Smith C, Abuogi L, Kistler A, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children. Nat Commun. 2022 Jul 8;13(1):3937. PubMed PMID: 35803954
Graff K, Smith C, Silveira L, Jung S, Curran-Hays S, Jarjour J, Carpenter L, Pickard K, Mattiucci M, Fresia J, McFarland EJ, Dominguez SR, Abuogi L. Risk Factors for Severe COVID-19 in Children. Pediatr Infect Dis J. 2021 Apr 1;40(4):e137-e145. PubMed PMID: 33538539
Smith C, Huo Y, Patel K, Fetters K, Hegemann S, Burchett S, Van Dyke R, Weinberg A. Immunologic and Virologic Factors Associated With Hospitalization in Human Immunodeficiency Virus-Exposed, Uninfected Infants in the United States. Clin Infect Dis. 2021 Sep 15;73(6):1089-1096. PubMed PMID: 34157096
Kociolek LK, Muller WJ, Yee R, Dien Bard J, Brown CA, Revell P, Wardell H, Savage TJ, Jung S, Dominguez S, Parikh BA, Jerris RC, Kehl SC, Campigotto A, Bender JM, Zheng X, Muscat E, Linam M, Abuogi L, Smith C, Graff K, Hernandez-Leyva A, Williams D, Pollock NR. Comparison of upper respiratory viral load distributions in asymptomatic and symptomatic children diagnosed with SARS-CoV-2 infection in pediatric hospital testing programs. J Clin Microbiol. 2020 Oct 22. [Epub ahead of print] PubMed PMID: 33093026
Moraka NO, Moyo S, Smith C, Ibrahim M, Mayondi G, Leidner J, Powis KM, Cassidy AR, Kammerer B, Ajibola G, Williams PL, Weinberg A, Musonda R, Shapiro R, Gaseitsiwe S, Lockman S. Child HIV Exposure and CMV Seroprevalence in Botswana: No Associations With 24-Month Growth and Neurodevelopment. Open Forum Infect Dis. 2020 Oct;7(10):ofaa373. PubMed PMID: 33072807
Smith C, Moraka NO, Ibrahim M, Moyo S, Mayondi G, Kammerer B, Leidner J, Gaseitsiwe S, Li S, Shapiro R, Lockman S, Weinberg A. Human Immunodeficiency Virus Exposure but Not Early Cytomegalovirus Infection Is Associated With Increased Hospitalization and Decreased Memory T-Cell Responses to Tetanus Vaccine. J Infect Dis. 2020 Mar 16;221(7):1167-1175. PubMed PMID: 31711179
Labuda SM, Huo Y, Kacanek D, Patel K, Huybrechts K, Jao J, Smith C, Hernandez-Diaz S, Scott G, Burchett S, Kakkar F, Chadwick EG, Van Dyke RB. Rates of Hospitalization and Infection-Related Hospitalization Among Human Immunodeficiency Virus (HIV)-Exposed Uninfected Children Compared to HIV-Unexposed Uninfected Children in the United States, 2007-2016. Clin Infect Dis. 2020 Jul 11;71(2):332-339. PubMed PMID: 31504291
Moraka NO, Moyo S, Mayondi G, Leidner J, Ibrahim M, Smith C, Weinberg A, Li S, Thami PK, Kammerer B, Ajibola G, Musonda R, Shapiro R, Gaseitsiwe S, Lockman S. Cytomegalovirus Viremia in HIV-1 Subtype C Positive Women at Delivery in Botswana and Adverse Birth/Infant Health Outcomes. J Acquir Immune Defic Syndr. 2019 May 1;81(1):118-124. PubMed PMID: 30964806
Labuda SM, Huo Y, Kacanek D, Patel K, Huybrechts K, Jao J, Smith C, Hernandez-Diaz S, Scott G, Burchett S, Kakkar F, Chadwick EG, Van Dyke RB. Rates of Hospitalization and Infection-Related Hospitalization Among HIV-Exposed Uninfected Children Compared to HIV-Unexposed Uninfected Children in the United States, 2007-2016. Clin Infect Dis. 2019 Aug 22. [Epub ahead of print] PubMed PMID: 31504291
Smith C, Moraka NO, Ibrahim M, Moyo S, Mayondi G, Kammerer B, Leidner J, Gaseitsiwe S, Li S, Shapiro R, Lockman S, Weinberg A. HIV Exposure but Not Early CMV Infection is Associated with Increased Hospitalization and Decreased Memory T-cell Responses to Tetanus Vaccine. J Infect Dis. 2019 Nov 10. [Epub ahead of print] PubMed PMID: 31711179
Weinberg A, Mussi-Pinhata MM, Yu Q, Cohen RA, Almeida VC, Amaral FR, Freimanis L, Harris DR, Smith C, Siberry G. Factors Associated with Lower Respiratory Tract Infections in HIV-Exposed Uninfected Infants. AIDS Res Hum Retroviruses. 2018 Jun;34(6):527-535. PubMed PMID: 29620934
Smith C, Jalbert E, de Almeida V, Canniff J, Lenz LL, Mussi-Pinhata MM, Cohen RA, Yu Q, Amaral FR, Pinto J, Alarcon JO, Siberry G, Weinberg A. Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants. Front Immunol. 2017;8:470. PubMed PMID: 28484464
Smith, C., Fought, A.J., Sung, J.F., McKinney, J.R., Metz, T.D., Fetters, K.B., Lazarus, S., Hegemann, S., Barr, E., Glenny, C., Buehler, J., and Weinberg, A. Congenital Malformations and Preeclampsia Associated with Integrase Inhibitor Use in Pregnancy. Preprint:https://medrxiv.org/cgi/content/short/2022.10.10.22280923v1. (in revision, PLoS One)
Jelic, M., Silveira, L., Graff, K., Boyer, S., Lang, S., Curran-Hays, S., Carter, B., Fresia, J., Nerguizian, D., Choi, Y., Maeda, L.C., Abuogi, L., and Smith, C. Changing Characteristics of Children with COVID-19 in Colorado Admitted During Different Variant Periods. (in revision, PIDJ)
Lang, S., Silveira, L., Smith, C., Abuogi, L., and DeCamp, L. Variation Over Time in Individual and Neighborhood Characteristics Associated with Pediatric COVID-19. (under review, Health Equity)
Child and Teen Health - Pediatric Diseases and Conditions
Child and Teen Health
Infections - Viral Infections
Infections - Sexually Transmitted Diseases
Infections - Influenza
Infections - Pneumonia
Infections - Fungal Infections
Infections - Bacterial Infections
Clinical Interests
I am interested in pediatric infectious diseases, including common infections such as osteomyelitis, pneumonia, and skin infections. I have a special interest in caring for children who are HIV-infected or HIV-exposed.
Care Philosophy
I was drawn to pediatrics because it allows me to develop rewarding relationships with my patients and families. I strive to practice evidence-based medicine while treating patients and their families as integral members of the health care team.
Volunteer Activities
I volunteer every year at Roundup River Ranch, a summer camp that gives kids with serious illnesses the chance to have fun and experience the great outdoors.
General Information
Medical Schools:
MD, University of Florida College of Medicine
(2008)
Graduate Schools:
MSc, University of Colorado Health Sciences Center
(2017)
Undergraduate Schools:
BS, University of Florida (FL)
(2004)
Residency Programs:
University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2011)
Fellowships:
University of Colorado, Pediatric Infectious Diseases
(2016)