Christy Smith-Anderson, MD

Associate Professor, Pediatrics-Infectious Diseases


FacultyPhoto
Medical School
  • MD, University of Florida College of Medicine (2008)
Graduate School
  • MSc, University of Colorado Health Sciences Center (2017)
Undergraduate School
  • BS, University of Florida (FL) (2004)
Residency
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2011)
Fellowships
  • University of Colorado, Pediatric Infectious Diseases (2016)
Languages
English
Department
Pediatrics-Infectious Diseases

Professional Titles

  • Physician

Research Interests

My research focuses on pediatric HIV infection, the prevention of transmission of HIV from mother to child, and the immune consequences of HIV exposure.

Publications

  • Smith C, McFarland EJ. Update on Pediatric Human Immunodeficiency Virus Infection: Paradigms in Treatment and Prevention. Adv Pediatr. 2016 Aug;63(1):147-71. PubMed PMID: 27426899
  • Abuogi LL, Smith C, McFarland EJ. Retention of HIV-Infected Children in the First 12 Months of Anti-Retroviral Therapy and Predictors of Attrition in Resource Limited Settings: A Systematic Review. PLoS One. 2016 Jun 9;11(6):e0156506. PubMed PMID: 27280404
  • Smith C, Weinberg A, Forster JE, Levin MJ, Davies J, Pappas J, Kinzie K, Barr E, Paul S, McFarland EJ. Maternal Lopinavir/Ritonavir Is Associated with Fewer Adverse Events in Infants than Nelfinavir or Atazanavir. Infect Dis Obstet Gynecol. 2016;2016:9848041. PubMed PMID: 27127401
  • Cantey PT, Weeks J, Edwards M, Rao S, Ostovar GA, Dehority W, Alzona M, Swoboda S, Christiaens B, Ballan W, Hartley J, Terranella A, Weatherhead J, Dunn JJ, Marx DP, Hicks MJ, Rauch RA, Smith C, Dishop MK, Handler MH, Dudley RW, Chundu K, Hobohm D, Feiz-Erfan I, Hakes J, Berry RS, Stepensaski S, Greenfield B, Shroeder L, Bishop H, de Almeida M, Mathison B, Eberhard M. The Emergence of Zoonotic Onchocerca lupi Infection in the United States--A Case-Series. Clin Infect Dis. 2016 Mar 15;62(6):778-83. PubMed PMID: 26611778
  • Smith, C, McFarland, EJ. Remaining Challenges in Pediatric HIV-1 Infection. Curr Pediatr Rep 2016.
  • Smith C, Jalbert E, de Almeida V, Canniff J, Lenz LL, Mussi-Pinhata MM, Cohen RA, Yu Q, Amaral FR, Pinto J, Alarcon JO, Siberry G, Weinberg A. Altered Natural Killer Cell Function in HIV-Exposed Uninfected Infants. Front Immunol. 2017;8:470. PubMed PMID: 28484464
  • Smith, C., & Weinberg, A. The Neonatal Immune System: General Concepts and Clinical Correlations. Cur Immunol Rev 2017; 13, doi: 10.2174/1573395513666170706123452 (E-pub ahead of print).
  • Weinberg A, Mussi-Pinhata MM, Yu Q, Cohen RA, Almeida VC, Amaral FR, Freimanis L, Harris DR, Smith C, Siberry G. Factors Associated with Lower Respiratory Tract Infections in HIV-Exposed Uninfected Infants. AIDS Res Hum Retroviruses. 2018 Jun;34(6):527-535. PubMed PMID: 29620934
  • Moraka NO, Moyo S, Mayondi G, Leidner J, Ibrahim M, Smith C, Weinberg A, Li S, Thami PK, Kammerer B, Ajibola G, Musonda R, Shapiro R, Gaseitsiwe S, Lockman S. Cytomegalovirus Viremia in HIV-1 Subtype C Positive Women at Delivery in Botswana and Adverse Birth/Infant Health Outcomes. J Acquir Immune Defic Syndr. 2019 May 1;81(1):118-124. PubMed PMID: 30964806
  • Kalata KE, Osborne C, Willis A, Navarro K, Fenton LZ, Smith C. Disseminated Histoplasmosis as an AIDS-Defining Illness Presenting as Fever of Unknown Origin in an 11-Year-Old Female. Case Rep Pediatr. 2019;2019:9417102. PubMed PMID: 31214373
  • Labuda SM, Huo Y, Kacanek D, Patel K, Huybrechts K, Jao J, Smith C, Hernandez-Diaz S, Scott G, Burchett S, Kakkar F, Chadwick EG, Van Dyke RB. Rates of Hospitalization and Infection-Related Hospitalization Among HIV-Exposed Uninfected Children Compared to HIV-Unexposed Uninfected Children in the United States, 2007-2016. Clin Infect Dis. 2019 Aug 22. [Epub ahead of print] PubMed PMID: 31504291
  • Smith C, Moraka NO, Ibrahim M, Moyo S, Mayondi G, Kammerer B, Leidner J, Gaseitsiwe S, Li S, Shapiro R, Lockman S, Weinberg A. HIV Exposure but Not Early CMV Infection is Associated with Increased Hospitalization and Decreased Memory T-cell Responses to Tetanus Vaccine. J Infect Dis. 2019 Nov 10. [Epub ahead of print] PubMed PMID: 31711179
  • Kociolek LK, Muller WJ, Yee R, Dien Bard J, Brown CA, Revell P, Wardell H, Savage TJ, Jung S, Dominguez S, Parikh BA, Jerris RC, Kehl SC, Campigotto A, Bender JM, Zheng X, Muscat E, Linam M, Abuogi L, Smith C, Graff K, Hernandez-Leyva A, Williams D, Pollock NR. Comparison of upper respiratory viral load distributions in asymptomatic and symptomatic children diagnosed with SARS-CoV-2 infection in pediatric hospital testing programs. J Clin Microbiol. 2020 Oct 22. [Epub ahead of print] PubMed PMID: 33093026
  • Moraka NO, Moyo S, Smith C, Ibrahim M, Mayondi G, Leidner J, Powis KM, Cassidy AR, Kammerer B, Ajibola G, Williams PL, Weinberg A, Musonda R, Shapiro R, Gaseitsiwe S, Lockman S. Child HIV Exposure and CMV Seroprevalence in Botswana: No Associations With 24-Month Growth and Neurodevelopment. Open Forum Infect Dis. 2020 Oct;7(10):ofaa373. PubMed PMID: 33072807
  • Smith C, Moraka NO, Ibrahim M, Moyo S, Mayondi G, Kammerer B, Leidner J, Gaseitsiwe S, Li S, Shapiro R, Lockman S, Weinberg A. Human Immunodeficiency Virus Exposure but Not Early Cytomegalovirus Infection Is Associated With Increased Hospitalization and Decreased Memory T-Cell Responses to Tetanus Vaccine. J Infect Dis. 2020 Mar 16;221(7):1167-1175. PubMed PMID: 31711179
  • Labuda SM, Huo Y, Kacanek D, Patel K, Huybrechts K, Jao J, Smith C, Hernandez-Diaz S, Scott G, Burchett S, Kakkar F, Chadwick EG, Van Dyke RB. Rates of Hospitalization and Infection-Related Hospitalization Among Human Immunodeficiency Virus (HIV)-Exposed Uninfected Children Compared to HIV-Unexposed Uninfected Children in the United States, 2007-2016. Clin Infect Dis. 2020 Jul 11;71(2):332-339. PubMed PMID: 31504291
  • Graff K, Smith C, Silveira L, Jung S, Curran-Hays S, Jarjour J, Carpenter L, Pickard K, Mattiucci M, Fresia J, McFarland EJ, Dominguez SR, Abuogi L. Risk Factors for Severe COVID-19 in Children. Pediatr Infect Dis J. 2021 Apr 1;40(4):e137-e145. PubMed PMID: 33538539
  • Smith C, Huo Y, Patel K, Fetters K, Hegemann S, Burchett S, Van Dyke R, Weinberg A. Immunologic and Virologic Factors Associated With Hospitalization in Human Immunodeficiency Virus-Exposed, Uninfected Infants in the United States. Clin Infect Dis. 2021 Sep 15;73(6):1089-1096. PubMed PMID: 34157096
  • Smith C, Silveira L, Crotteau M, Garth K, Canniff J, Fetters KB, Lazarus S, Capraro S, Weinberg A. Congenital Co-infections Among HIV-Exposed Infants Born to Mothers on Antiretroviral Treatment in the United States. Front Pediatr. 2022;10:894627. PubMed PMID: 35783327
  • Jalbert E, Ghosh T, Smith C, Amaral FR, Mussi-Pinhata MM, Weinberg A. Impaired functionality of antigen presenting cells in HIV- exposed uninfected infants in the first six months of life. Front Immunol. 2022;13:960313. PubMed PMID: 36032106
  • Mick E, Tsitsiklis A, Spottiswoode N, Caldera S, Serpa PH, Detweiler AM, Neff N, Pisco AO, Li LM, Retallack H, Ratnasiri K, Williamson KM, Soesanto V, Simões EAF, Smith C, Abuogi L, Kistler A, Wagner BD, DeRisi JL, Ambroggio L, Mourani PM, Langelier CR. Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children. Nat Commun. 2022 Jul 8;13(1):3937. PubMed PMID: 35803954
  • Smith, C., Fought, A.J., Sung, J.F., McKinney, J.R., Metz, T.D., Fetters, K.B., Lazarus, S., Hegemann, S., Barr, E., Glenny, C., Buehler, J., and Weinberg, A. Congenital Malformations and Preeclampsia Associated with Integrase Inhibitor Use in Pregnancy. Preprint:https://medrxiv.org/cgi/content/short/2022.10.10.22280923v1. (in revision, PLoS One)
  • Jelic, M., Silveira, L., Graff, K., Boyer, S., Lang, S., Curran-Hays, S., Carter, B., Fresia, J., Nerguizian, D., Choi, Y., Maeda, L.C., Abuogi, L., and Smith, C. Changing Characteristics of Children with COVID-19 in Colorado Admitted During Different Variant Periods. (in revision, PIDJ)
  • Lang, S., Silveira, L., Smith, C., Abuogi, L., and DeCamp, L. Variation Over Time in Individual and Neighborhood Characteristics Associated with Pediatric COVID-19. (under review, Health Equity)
  • Tyler S, Abuogi L, Vannoni V, Silveira L, Lang S, Smith C, DeCamp LR. Mixed Methods Evaluation of the Impact of the COVID-19 Pandemic on Immigrant Families. Hisp Health Care Int. 2023 Nov 19;:15404153231214707. [Epub ahead of print] PubMed PMID: 37981744
  • Lang S, Silveira L, Smith C, Abuogi L, DeCamp LR. Variation over Time in Child and Neighborhood Characteristics Associated with COVID-19. Health Equity. 2023;7(1):676-684. PubMed PMID: 37908402
  • Smith C, Silveira L, Crotteau M, Garth K, Canniff J, Fetters KB, Lazarus S, Capraro S, Weinberg A. Modern antiretroviral regimens in pregnant women: virologic outcomes and durability. AIDS. 2024 Jan 1;38(1):21-29. PubMed PMID: 37289582
  • Smith C, Fought AJ, Sung JF, McKinney JR, Metz TD, Fetters KB, Lazarus S, Capraro S, Barr E, Glenny C, Buehler J, Weinberg A. Congenital malformations and preeclampsia associated with integrase inhibitor use in pregnancy: A single-center analysis. PLoS One. 2023;18(6):e0276473. PubMed PMID: 37307279
  • Abuogi L, Smith C, Kinzie K, Barr E, Bonham A, Johnson RL, Dinnebeil M, McFarland E, Weinberg A. Development and Implementation of an Interdisciplinary Model for the Management of Breastfeeding in Women With HIV in the United States: Experience From the Children's Hospital Colorado Immunodeficiency Program. J Acquir Immune Defic Syndr. 2023 Aug 15;93(5):395-402. PubMed PMID: 37104739
  • Jelic M, Silveira L, Lang S, Curran-Hays S, Boyer S, Carter B, Choi YJ, Fresia J, Maeda LC, Nerguizian D, Graff K, Abuogi L, Smith C. Changing Characteristics of Children With COVID-19 in Colorado Admitted During Different Variant Periods. Pediatr Infect Dis J. 2023 Aug 1;42(8):679-684. PubMed PMID: 37079565

Professional Memberships

  • Pediatric Infectious Disease Society, member
  • Infectious Diseases Society of America, member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatrics, Board Certification (2011)
  • Pediatric Infectious Diseases (2017)
Conditions & Treatments
  • Kawasaki Disease
  • Infections
  • Child and Teen Health - Pediatric Diseases and Conditions
  • Child and Teen Health
  • Infections - Viral Infections
  • Infections - Sexually Transmitted Diseases
  • Infections - Influenza
  • Infections - Pneumonia
  • Infections - Fungal Infections
  • Infections - Bacterial Infections
Clinical Interests
I am interested in pediatric infectious diseases, including common infections such as osteomyelitis, pneumonia, and skin infections. I have a special interest in caring for children who are HIV-infected or HIV-exposed.

Care Philosophy
I was drawn to pediatrics because it allows me to develop rewarding relationships with my patients and families. I strive to practice evidence-based medicine while treating patients and their families as integral members of the health care team.

Volunteer Activities
I volunteer every year at Roundup River Ranch, a summer camp that gives kids with serious illnesses the chance to have fun and experience the great outdoors.