Amrut Ambardekar, MD
Associate Professor, Medicine-Cardiology

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Medical School:
  • MD, Northwestern University The Feinberg School of Medicine (2003)
Undergraduate School:
  • BSE, University of Iowa (IA) (1999)
Internship:
  • University of Colorado (2004)
Residencies:
  • University of Colorado, Chief Resident, Internal Medicine (2007)
  • University of Colorado, Internal Medicine (2006)
Fellowships:
  • University of Colorado, Cardiovascular Disease (2010)
  • University of Colorado, Advanced Heart Failure and Transplant Cardiology (2011)
Languages: English
Department: Medicine-Cardiology

Professional Titles

  • Director Cardiac Transplantation
  • Director Cardiac Amyloidosis Program

Recognition & Awards

  • Top Docs: Advanced Heart Failure Transplant Cardiology, 5280 Magazine (2019)
  • Strength in Healthcare Award Nominee, Denver Post (2014)
  • Clinical Research Program Award, National Institutes of Health (2010)
  • Samuel A. Levine Young Clinical Investigator Award Finalist, American Heart Association (2010)
  • Jay N. Cohn Integrative Physiology/Clinical Research New Investigator Award Finalist, Heart Failure Society of America (2010)
  • Outstanding Cardiology Research Fellow Award, University of Colorado (2010)
  • S. Gilbert Blount Research Fellowship Award, University of Colorado (2009)
  • Outstanding Clinical Cardiology Fellow Award, University of Colorado (2009)
  • Division of Cardiology Chief Fellow, University of Colorado (2009)
  • Research Fellowship Award, Heart Failure Society of America (2009)
  • Thorkildsen Research Fellowship, University of Colorado School of Medicine (2009)
  • Chief Resident-Internal Medicine, University of Colorado (2006)

Publications

  • Ambardekar AV, Sailer C. SGLT2 Inhibitors and Blood Pressure in Heart Failure: A Misunderstanding of Our Understanding?. JACC Heart Fail. 2023 Jan;11(1):90-92. PubMed PMID: 36599554
  • Ambardekar AV, Fontana M, Maurer MS, Trachtenberg B, Kittleson M. How to Identify Cardiac Amyloidosis Patients Who Might Benefit From Cardiac Transplantation. JACC Heart Fail. 2023 Jan;11(1):115-120. PubMed PMID: 36599538
  • Rubino M, Travers JG, Headrick AL, Enyart BT, Lemieux ME, Cavasin MA, Schwisow JA, Hardy EJ, Kaltenbacher KJ, Felisbino MB, Jonas E, Ambardekar AV, Bristow MR, Koch KA, McKinsey TA. Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart. Circ Res. 2023 Jan 6;132(1):10-29. PubMed PMID: 36475698
  • Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25;8(8):eabk0052. PubMed PMID: 35196083
  • Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, Gonzalez-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 Feb 4. [Epub ahead of print] PubMed PMID: 35114812
  • Kittleson MM, Ambardekar AV, Stevenson LW, Gilotra NA, Shah P, Ewald GA, Thibodeau JT, Stehlik J, Palardy M, Estep JD, Cascino TM, Baldwin JT, Jeffries N, Khalatbari S, Yosef M, Peters WT, Richards B, Mann DL, Aaronson KD, Stewart GC. An early relook identifies high-risk trajectories in ambulatory advanced heart failure. J Heart Lung Transplant. 2022 Jan;41(1):104-112. PubMed PMID: 34629234
  • Ambardekar AV, Hoffman JRH. Newton's laws of heart transplant allocation. J Heart Lung Transplant. 2022 Nov 9. [Epub ahead of print] PubMed PMID: 36456407
  • Altman NL, Berning AA, Saxon CE, Adamek KE, Wagner JA, Slavov D, Quaife RA, Gill EA, Minobe WA, Jonas ER, Carroll IA, Huebler SP, Raines J, Messenger JC, Ambardekar AV, Mestroni L, Rosenberg RM, Rove J, Campbell TB, Bristow MR. Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination. JACC Basic Transl Sci. 2022 Oct 19. [Epub ahead of print] PubMed PMID: 36281440
  • Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF. Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. Mol Cell. 2022 Oct 6;82(19):3661-3676.e8. PubMed PMID: 36206740
  • Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
  • Gökler J, Aliabadi-Zuckermann AZ, Kaider A, Ambardekar AV, Antretter H, Artemiou P, Bertolotti AM, Boeken U, Brossa V, Copeland H, Generosa Crespo-Leiro M, Eixeré-Esteve A, Epailly E, Farag M, Hulman M, Khush KK, Masetti M, Patel J, Ross HJ, Rudež I, Silvestry S, Suarez SM, Vest A, Zuckermann AO. Indications, Complications, and Outcomes of Cardiac Surgery After Heart Transplantation: Results From the Cash Study. Front Cardiovasc Med. 2022;10:879612. PubMed PMID: 35756840
  • Lin YH, Major JL, Liebner T, Hourani Z, Travers JG, Wennersten SA, Haefner KR, Cavasin MA, Wilson CE, Jeong MY, Han Y, Gotthardt M, Ferguson SK, Ambardekar AV, Lam MP, Choudhary C, Granzier HL, Woulfe KC, McKinsey TA. HDAC6 modulates myofibril stiffness and diastolic function of the heart. J Clin Invest. 2022 May 16;132(10). PubMed PMID: 35575093
  • Ambardekar AV, Weiser-Evans MCM, McKinsey TA. Arterial wall rejuvenation: the potential of targeting matrix metalloprotease 2 to treat vascular aging. Cardiovasc Res. 2022 Jul 27;118(10):2229-2230. PubMed PMID: 35512358
  • Peters LL, Raymer DS, Pal JD, Ambardekar AV. Association of COVID-19 Vaccination With Risk of COVID-19 Infection, Hospitalization, and Death in Heart Transplant Recipients. JAMA Cardiol. 2022 Jun 1;7(6):651-654. PubMed PMID: 35475896
  • Ambardekar AV, Stratton MS, Weiser-Evans MCM, Moulton KS, McKinsey TA. Reply: Aortic Valve Remodeling in CF-LVAD: Beyond the Arterial Wall. J Am Coll Cardiol. 2022 Mar 29;79(12):e223. PubMed PMID: 35331421
  • Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25;8(8):eabk0052. PubMed PMID: 35196083
  • Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, González-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 Apr 19;145(16):1218-1233. PubMed PMID: 35114812
  • Kittleson MM, Ambardekar AV, Stevenson LW, Gilotra NA, Shah P, Ewald GA, Thibodeau JT, Stehlik J, Palardy M, Estep JD, Cascino TM, Baldwin JT, Jeffries N, Khalatbari S, Yosef M, Peters WT, Richards B, Mann DL, Aaronson KD, Stewart GC. An early relook identifies high-risk trajectories in ambulatory advanced heart failure. J Heart Lung Transplant. 2022 Jan;41(1):104-112. PubMed PMID: 34629234
  • Knoepke CE, Chaussee EL, Matlock DD, Thompson JS, McIlvennan CK, Ambardekar AV, Schaffer EM, Khazanie P, Scherer L, Arnold RM, Allen LA. Changes over Time in Patient Stated Values and Treatment Preferences Regarding Aggressive Therapies: Insights from the DECIDE-LVAD Trial. Med Decis Making. 2022 Apr;42(3):404-414. PubMed PMID: 34296623
  • Lala A, Shah KB, Lanfear DE, Thibodeau JT, Palardy M, Ambardekar AV, McNamara DM, Taddei-Peters WC, Baldwin JT, Jeffries N, Khalatbari S, Spino C, Richards B, Mann DL, Stewart GC, Aaronson KD, Mancini DM. Predictive Value of Cardiopulmonary Exercise Testing Parameters in Ambulatory Advanced Heart Failure. JACC Heart Fail. 2021 Jan 28. [Epub ahead of print] PubMed PMID: 33549559
  • Riordan M, Oreschak K, Peters LL, Aquilante CL, Ambardekar AV. Bariatric Surgery Is Associated With Decreased Calcineurin Inhibitor Time in Therapeutic Range After Heart Transplantation. Transplant Proc. 2021 Feb 3. [Epub ahead of print] PubMed PMID: 33549348
  • Sailer C, Edelmann H, Buchanan C, Giro P, Babcock M, Swanson C, Spotts M, Schulte M, Pratt-Cordova A, Coe G, Beindorff M, Page RL 2nd, Ambardekar AV, Pal JD, Kohrt W, Wolfel E, Lawley JS, Tarumi T, Cornwell WK 3rd. Impairments in Blood Pressure Regulation and Cardiac Baroreceptor Sensitivity Among Patients With Heart Failure Supported With Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail. 2021 Jan;14(1):e007448. PubMed PMID: 33464953
  • Tran T, Muralidhar A, Hunter K, Buchanan C, Coe G, Hieda M, Tompkins C, Zipse M, Spotts MJ, Laing SG, Fosmark K, Hoffman J, Ambardekar AV, Wolfel EE, Lawley J, Levine B, Kohrt WM, Pal J, Cornwell WK 3rd. Right ventricular function and cardiopulmonary performance among patients with heart failure supported by durable mechanical circulatory support devices. J Heart Lung Transplant. 2021 Feb;40(2):128-137. PubMed PMID: 33281029
  • Ambardekar AV, Stratton MS, Dobrinskikh E, Hunter KS, Tatman PD, Lemieux ME, Cleveland JC, Tuder RM, Weiser-Evans MCM, Moulton KS, McKinsey TA. Matrix-Degrading Enzyme Expression and Aortic Fibrosis During Continuous-Flow Left Ventricular Mechanical Support. J Am Coll Cardiol. 2021 Nov 2;78(18):1782-1795. PubMed PMID: 34711337
  • Knoepke CE, Chaussee EL, Matlock DD, Thompson JS, McIlvennan CK, Ambardekar AV, Schaffer EM, Khazanie P, Scherer L, Arnold RM, Allen LA. Changes over Time in Patient Stated Values and Treatment Preferences Regarding Aggressive Therapies: Insights from the DECIDE-LVAD Trial. Med Decis Making. 2021 Jul 23;:272989X211028234. [Epub ahead of print] PubMed PMID: 34296623
  • Oreschak K, Saba LM, Rafaels N, Ambardekar AV, Deininger KM, PageII R, Lindenfeld J, Aquilante CL. Variants in mycophenolate and CMV antiviral drug pharmacokinetic and pharmacodynamic genes and leukopenia in heart transplant recipients. J Heart Lung Transplant. 2021 Sep;40(9):917-925. PubMed PMID: 34253456
  • Oreschak K, Saba LM, Rafaels N, Ambardekar AV, Deininger KM, Page RL 2nd, Lindenfeld J, Aquilante CL. Association Between Variants in Calcineurin Inhibitor Pharmacokinetic and Pharmacodynamic Genes and Renal Dysfunction in Adult Heart Transplant Recipients. Front Genet. 2021;12:658983. PubMed PMID: 33868389
  • Ambardekar AV, Raymer DS. Reverse Remodeling the Transplanted Heart by Remodeling Immunosuppression?. JACC Heart Fail. 2021 Apr;9(4):314-316. PubMed PMID: 33795117
  • Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC Jr, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 Mar 9;16(3):519-533. PubMed PMID: 33636116
  • Lala A, Shah KB, Lanfear DE, Thibodeau JT, Palardy M, Ambardekar AV, McNamara DM, Taddei-Peters WC, Baldwin JT, Jeffries N, Khalatbari S, Spino C, Richards B, Mann DL, Stewart GC, Aaronson KD, Mancini DM. Predictive Value of Cardiopulmonary Exercise Testing Parameters in Ambulatory Advanced Heart Failure. JACC Heart Fail. 2021 Mar;9(3):226-236. PubMed PMID: 33549559
  • Riordan M, Oreschak K, Peters LL, Aquilante CL, Ambardekar AV. Bariatric Surgery Is Associated With Decreased Calcineurin Inhibitor Time in Therapeutic Range After Heart Transplantation. Transplant Proc. 2021 Mar;53(2):681-685. PubMed PMID: 33549348
  • Sailer C, Edelmann H, Buchanan C, Giro P, Babcock M, Swanson C, Spotts M, Schulte M, Pratt-Cordova A, Coe G, Beindorff M, Page RL 2nd, Ambardekar AV, Pal JD, Kohrt W, Wolfel E, Lawley JS, Tarumi T, Cornwell WK 3rd. Impairments in Blood Pressure Regulation and Cardiac Baroreceptor Sensitivity Among Patients With Heart Failure Supported With Continuous-Flow Left Ventricular Assist Devices. Circ Heart Fail. 2021 Jan;14(1):e007448. PubMed PMID: 33464953
  • Tran T, Muralidhar A, Hunter K, Buchanan C, Coe G, Hieda M, Tompkins C, Zipse M, Spotts MJ, Laing SG, Fosmark K, Hoffman J, Ambardekar AV, Wolfel EE, Lawley J, Levine B, Kohrt WM, Pal J, Cornwell WK 3rd. Right ventricular function and cardiopulmonary performance among patients with heart failure supported by durable mechanical circulatory support devices. J Heart Lung Transplant. 2021 Feb;40(2):128-137. PubMed PMID: 33281029
  • Peters LL, Ambardekar AV, Rosenthal LD, McIlvennan CK. Universal Depression Screen of Ambulatory Heart Transplant Recipients With Referral for Mental Health Intervention: A Quality Improvement Project. J Nurs Care Qual. 2021 Jul-Sep 01;36(3):236-241. PubMed PMID: 32956136
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Jan 17. [Epub ahead of print] PubMed PMID: 31958463
  • Stehlik J, Mountis M, Haas D, Palardy M, Ambardekar AV, Estep JD, Ewald G, Russell SD, Robinson S, Jorde U, Taddei-Peters WC, Jeffries N, Richards B, Khalatbari S, Spino C, Baldwin JT, Mann D, Stewart GC, Aaronson KD. Quality of life and treatment preference for ventricular assist device therapy in ambulatory advanced heart failure: A report from the REVIVAL study. J Heart Lung Transplant. 2020 Jan;39(1):27-36. PubMed PMID: 31822442
  • Abraham WT, Psotka MA, Fiuzat M, Filippatos G, Lindenfeld J, Mehran R, Ambardekar AV, Carson PE, Jacob R, Januzzi JL Jr, Konstam MA, Krucoff MW, Lewis EF, Piccini JP, Solomon SD, Stockbridge N, Teerlink JR, Unger EF, Zeitler EP, Anker SD, O'Connor CM. Standardized Definitions for Evaluation of Heart Failure Therapies: Scientific Expert Panel From the Heart Failure Collaboratory and Academic Research Consortium. JACC Heart Fail. 2020 Dec;8(12):961-972. PubMed PMID: 33199251
  • Peters LL, Ambardekar AV. An immunosuppression tightrope: Successful heart transplantation after giant cell myocarditis in a patient with HIV complicated by recurrent giant cell myocarditis and Kaposi sarcoma. J Heart Lung Transplant. 2020 Dec;39(12):1506-1508. PubMed PMID: 33067104
  • Abraham WT, Psotka MA, Fiuzat M, Filippatos G, Lindenfeld J, Mehran R, Ambardekar AV, Carson PE, Jacob R, Januzzi JL Jr, Konstam MA, Krucoff MW, Lewis EF, Piccini JP, Solomon SD, Stockbridge N, Teerlink JR, Unger EF, Zeitler EP, Anker SD, O'Connor CM. Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium. Eur J Heart Fail. 2020 Dec;22(12):2175-2186. PubMed PMID: 33017862
  • Peters LL, Ambardekar AV, Rosenthal LD, McIlvennan CK. Universal Depression Screen of Ambulatory Heart Transplant Recipients With Referral for Mental Health Intervention: A Quality Improvement Project. J Nurs Care Qual. 2020 Sep 14. [Epub ahead of print] PubMed PMID: 32956136
  • Hughes DL, Rice JD, Burton JR, Jin Y, Peterson RA, Ambardekar AV, Pomposelli JJ, Pomfret EA, Kriss MS. Presence of any degree of coronary artery disease among liver transplant candidates is associated with increased rate of post-transplant major adverse cardiac events. Clin Transplant. 2020 Nov;34(11):e14077. PubMed PMID: 32939833
  • Kittleson MM, Maurer MS, Ambardekar AV, Bullock-Palmer RP, Chang PP, Eisen HJ, Nair AP, Nativi-Nicolau J, Ruberg FL. Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association. Circulation. 2020 Jul 7;142(1):e7-e22. PubMed PMID: 32476490
  • Cornwell WK, Tran T, Cerbin L, Coe G, Muralidhar A, Hunter K, Altman N, Ambardekar AV, Tompkins C, Zipse M, Schulte M, O'Gean K, Ostertag M, Hoffman J, Pal JD, Lawley JS, Levine BD, Wolfel E, Kohrt WM, Buttrick P. New insights into resting and exertional right ventricular performance in the healthy heart through real-time pressure-volume analysis. J Physiol. 2020 Jul;598(13):2575-2587. PubMed PMID: 32347547
  • Oreschak K, Wolfel EE, Saba LM, Ambardekar AV, Lindenfeld J, Aquilante CL. Relationship between nocturnal blood pressure patterns and end organ damage and diastolic dysfunction in heart transplant recipients. Clin Transplant. 2020 May;34(5):e13842. PubMed PMID: 32090364
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC, Fritz KS. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 2020 Jan;138:304-317. PubMed PMID: 31836543
  • Stehlik J, Mountis M, Haas D, Palardy M, Ambardekar AV, Estep JD, Ewald G, Russell SD, Robinson S, Jorde U, Taddei-Peters WC, Jeffries N, Richards B, Khalatbari S, Spino C, Baldwin JT, Mann D, Stewart GC, Aaronson KD. Quality of life and treatment preference for ventricular assist device therapy in ambulatory advanced heart failure: A report from the REVIVAL study. J Heart Lung Transplant. 2020 Jan;39(1):27-36. PubMed PMID: 31822442
  • Lee JW, Koeppen M, Seo SW, Bowser JL, Yuan X, Li J, Sibilia M, Ambardekar AV, Zhang X, Eckle T, Yoo SH, Eltzschig HK. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology. 2020 Apr;132(4):763-780. PubMed PMID: 31794514
  • Cornwell WK 3rd, Ambardekar AV, Tran T, Pal JD, Cava L, Lawley J, Tarumi T, Cornwell CL, Aaronson K. Stroke Incidence and Impact of Continuous-Flow Left Ventricular Assist Devices on Cerebrovascular Physiology. Stroke. 2019 Feb;50(2):542-548. PubMed PMID: 30602359
  • Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC, Fritz KS. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 2019 Dec 10;138:304-317. [Epub ahead of print] PubMed PMID: 31836543
  • Lee JW, Koeppen M, Seo SW, Bowser JL, Yuan X, Li J, Sibilia M, Ambardekar AV, Zhang X, Eckle T, Yoo SH, Eltzschig HK. Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion. Anesthesiology. 2019 Nov 26. [Epub ahead of print] PubMed PMID: 31794514
  • Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
  • Ambardekar AV. When You Hear Hoof Beats, Think of the Treatable Zebras. JACC Heart Fail. 2019 Nov;7(11):967-969. PubMed PMID: 31606363
  • Grady KL, Andrei AC, Shankel T, Chinnock R, Miyamoto SD, Ambardekar AV, Anderson A, Addonizio L, Latif F, Lefkowitz D, Goldberg LR, Hollander SA, Pham M, Van't Hof K, Weissberg-Benchell J, Yancy C, Liu M, Melody N, Pahl E. Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Feasibility of a Pilot Randomized Controlled Trial. J Card Fail. 2019 Dec;25(12):948-958. PubMed PMID: 31276804
  • Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr;4(2):147-157. PubMed PMID: 31061916
  • Ambardekar AV, Kittleson MM, Palardy M, Mountis MM, Forde-McLean RC, DeVore AD, Pamboukian SV, Thibodeau JT, Teuteberg JJ, Cadaret L, Xie R, Taddei-Peters W, Naftel DC, Kirklin JK, Stevenson LW, Stewart GC. Outcomes with ambulatory advanced heart failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry. J Heart Lung Transplant. 2019 Apr;38(4):408-417. PubMed PMID: 30948210
  • Cornwell WK 3rd, Ambardekar AV, Tran T, Pal JD, Cava L, Lawley J, Tarumi T, Cornwell CL, Aaronson K. Stroke Incidence and Impact of Continuous-Flow Left Ventricular Assist Devices on Cerebrovascular Physiology. Stroke. 2019 Feb;50(2):542-548. PubMed PMID: 30602359
  • Cornwell WK 3rd, Tarumi T, Lawley J, Ambardekar AV. Rebuttal from William K. Cornwell III, Takashi Tarumi, Justin Lawley and Amrut V. Ambardekar. J Physiol. 2019 Jan;597(2):363-364. PubMed PMID: 30560588
  • Cornwell WK 3rd, Tarumi T, Lawley J, Ambardekar AV. CrossTalk opposing view: Blood flow pulsatility in left ventricular assist device patients is not essential to maintain normal brain physiology. J Physiol. 2019 Jan;597(2):357-359. PubMed PMID: 30560586
  • Jeong MY, Lin YH, Wennersten SA, Demos-Davies KM, Cavasin MA, Mahaffey JH, Monzani V, Saripalli C, Mascagni P, Reece TB, Ambardekar AV, Granzier HL, Dinarello CA, McKinsey TA. Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism. Sci Transl Med. 2018 Feb 7;10(427). PubMed PMID: 29437146
  • Grady KL, Hof KV, Andrei AC, Shankel T, Chinnock R, Miyamoto S, Ambardekar AV, Anderson A, Addonizio L, Latif F, Lefkowitz D, Goldberg L, Hollander SA, Pham M, Weissberg-Benchell J, Cool N, Yancy C, Pahl E. Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Baseline Findings. Pediatr Cardiol. 2018 Feb;39(2):354-364. PubMed PMID: 29098353
  • Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018 Nov 12;19(1):812. PubMed PMID: 30419824
  • Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PubMed PMID: 30140897
  • Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
  • Moulton KS, Li M, Strand K, Burgett S, McClatchey P, Tucker R, Furgeson SB, Lu S, Kirkpatrick B, Cleveland JC, Nemenoff RA, Ambardekar AV, Weiser-Evans MC. PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. JCI Insight. 2018 Feb 22;3(4). [Epub ahead of print] PubMed PMID: 29467331
  • Jeong MY, Lin YH, Wennersten SA, Demos-Davies KM, Cavasin MA, Mahaffey JH, Monzani V, Saripalli C, Mascagni P, Reece TB, Ambardekar AV, Granzier HL, Dinarello CA, McKinsey TA. Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism. Sci Transl Med. 2018 Feb 7;10(427). PubMed PMID: 29437146
  • Grady KL, Hof KV, Andrei AC, Shankel T, Chinnock R, Miyamoto S, Ambardekar AV, Anderson A, Addonizio L, Latif F, Lefkowitz D, Goldberg L, Hollander SA, Pham M, Weissberg-Benchell J, Cool N, Yancy C, Pahl E. Pediatric Heart Transplantation: Transitioning to Adult Care (TRANSIT): Baseline Findings. Pediatr Cardiol. 2018 Feb;39(2):354-364. PubMed PMID: 29098353
  • Stewart GC, Ambardekar AV, Kittleson MM. Defining Ambulatory Advanced Heart Failure: MedaMACS and Beyond. Curr Heart Fail Rep. 2017 Dec;14(6):498-506. PubMed PMID: 28952014
  • Cobretti MR, Page RL 2nd, Linnebur SA, Deininger KM, Ambardekar AV, Lindenfeld J, Aquilante CL. Medication regimen complexity in ambulatory older adults with heart failure. Clin Interv Aging. 2017;12:679-686. PubMed PMID: 28442898
  • Hooker JM, Strebl MG, Schroeder FA, Wey HY, Ambardekar AV, McKinsey TA, Schoenberger M. Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine. Sci Rep. 2017 Feb 16;7:42136. PubMed PMID: 28205593
  • Jurgens PT, Allen LA, Ambardekar AV, McIlvennan CK. Chronic Norovirus Infections in Cardiac Transplant Patients. Prog Transplant. 2017 Mar;27(1):69-72. PubMed PMID: 27881814
  • Jurgens PT, Allen LA, Ambardekar AV, McIlvennan CK. Chronic Norovirus Infections in Cardiac Transplant Patients: Considerations for Evaluation and Management. Prog Transplant. 2016 Nov 23. [Epub ahead of print] PubMed PMID: 27881814
  • Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 Aug 2;16(5):1366-78. PubMed PMID: 27425608
  • Allen LA, Ambardekar AV. Hashing It Out Over Cannabis: Moving Toward a Standard Guideline on Substance Use for Cardiac Transplantation Eligibility That Includes Marijuana. Circ Heart Fail. 2016 Jul;9(7). PubMed PMID: 27413033
  • Bryant BM, Libby AM, Metz KR, Page RL 2nd, Ambardekar AV, Lindenfeld J, Aquilante CL. Evaluating Patient-Level Medication Regimen Complexity Over Time in Heart Transplant Recipients. Ann Pharmacother. 2016 Nov;50(11):926-934. PubMed PMID: 27371949
  • Deininger KM, Vu A, Page RL 2nd, Ambardekar AV, Lindenfeld J, Aquilante CL. CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients. Clin Transplant. 2016 Sep;30(9):1074-81. PubMed PMID: 27314545
  • McIlvennan CK, Babu AN, Brieke A, Ambardekar AV. Concomitant surgical cryoablation for refractory ventricular tachycardia and left ventricular assist device placement: a dual remedy but a recipe for thrombosis?. J Cardiothorac Surg. 2016 Apr 11;11(1):53. PubMed PMID: 27067868
  • Ambardekar AV, Forde-McLean RC, Kittleson MM, Stewart GC, Palardy M, Thibodeau JT, DeVore AD, Mountis MM, Cadaret L, Teuteberg JJ, Pamboukian SV, Cantor RS, Lindenfeld J. High early event rates in patients with questionable eligibility for advanced heart failure therapies: Results from the Medical Arm of Mechanically Assisted Circulatory Support (Medamacs) Registry. J Heart Lung Transplant. 2016 Jun;35(6):722-30. PubMed PMID: 26987599
  • Lindenfeld J, Cleveland JC Jr, Kao DP, White M, Wichman S, Bristow JC, Peterson V, Rodegheri-Brito J, Korst A, Blain-Nelson P, Sederberg J, Hunt SA, Gilbert EM, Ambardekar AV, Minobe W, Port JD, Bristow MR. Sex-related differences in age-associated downregulation of human ventricular myocardial ß1-adrenergic receptors. J Heart Lung Transplant. 2016 Mar;35(3):352-61. PubMed PMID: 26970472
  • Ambardekar AP, Singh D, Lockman JL, Rodgers DL, Hales RL, Gurnaney HG, Nathan A, Deutsch ES. Pediatric anesthesiology fellow education: is a simulation-based boot camp feasible and valuable?. Paediatr Anaesth. 2016 May;26(5):481-7. PubMed PMID: 26948074
  • Breathett K, Allen LA, Ambardekar AV. Patient-centered care for left ventricular assist device therapy: current challenges and future directions. Curr Opin Cardiol. 2016 May;31(3):313-20. PubMed PMID: 26890085
  • Ambardekar AV, Alluri N, Patel AC, Lindenfeld J, Dorosz JL. Myocardial Strain and Strain Rate from Speckle-Tracking Echocardiography are Unable to Differentiate Asymptomatic Biopsy-Proven Cellular Rejection in the First Year after Cardiac Transplantation. J Am Soc Echocardiogr. 2015 Apr;28(4):478-85. PubMed PMID: 25622999
  • Ambardekar AV, Hunter KS, Babu AN, Tuder RM, Dodson RB, Lindenfeld J. Changes in Aortic Wall Structure, Composition, and Stiffness With Continuous-Flow Left Ventricular Assist Devices: A Pilot Study. Circ Heart Fail. 2015 Sep;8(5):944-52. PubMed PMID: 26136459
  • Ambardekar AV, Alluri N, Patel AC, Lindenfeld J, Dorosz JL. Myocardial strain and strain rate from speckle-tracking echocardiography are unable to differentiate asymptomatic biopsy-proven cellular rejection in the first year after cardiac transplantation. J Am Soc Echocardiogr. 2015 Apr;28(4):478-85. PubMed PMID: 25622999
  • Allen LA, Ambardekar AV, Devaraj KM, Maleszewski JJ, Wolfel EE. Clinical problem-solving. Missing elements of the history. N Engl J Med. 2014 Feb 6;370(6):559-66. PubMed PMID: 24499215
  • Herod JW, Ambardekar AV. Right ventricular systolic and diastolic function as assessed by speckle-tracking echocardiography improve with prolonged isolated left ventricular assist device support. J Card Fail. 2014 Jul;20(7):498-505. PubMed PMID: 24785158
  • McIlvennan CK, Magid KH, Ambardekar AV, Thompson JS, Matlock DD, Allen LA. Clinical outcomes after continuous-flow left ventricular assist device: a systematic review. Circ Heart Fail. 2014 Nov;7(6):1003-13. PubMed PMID: 25294625
  • McIlvennan CK, Page RL 2nd, Ambardekar AV, Brieke A, Lindenfeld J. Activated partial thromboplastin time overestimates anti-coagulation in left ventricular assist device patients. J Heart Lung Transplant. 2014 Dec;33(12):1312-4. PubMed PMID: 25443872
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Professional Memberships

  • American Heart Association (AHA), Fellow
  • American College of Cardiology, Fellow
  • Heart Failure Society of America, Fellow
  • American Society of Transplantation, Member
  • International Society of Heart Lung Transplantation, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Heart Failure Program - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

UCHealth Transplant Center - Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0005

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2006)
  • Cardiovascular Disease, Board Certification (2010)
  • Cardiology, Board Certification (2010)
  • Advanced Heart Failure and Transplant Cardiology, Board Certification (2012)
Conditions & Treatments
  • Heart and Circulation - Cardiomyopathy
  • Heart and Circulation - Heart Failure
  • Heart and Circulation - Heart Valve Diseases
  • Heart and Circulation - Coronary Disease
  • Heart and Circulation
  • Surgery - Heart Transplant Surgery
  • Surgery

General Information

Medical Schools:
  • MD, Northwestern University The Feinberg School of Medicine (2003)
Undergraduate Schools:
  • BSE, University of Iowa (IA) (1999)
Internships:
  • University of Colorado (2004)
Residency Programs:
  • University of Colorado, Chief Resident, Internal Medicine (2007)
  • University of Colorado, Internal Medicine (2006)
Fellowships:
  • University of Colorado, Cardiovascular Disease (2010)
  • University of Colorado, Advanced Heart Failure and Transplant Cardiology (2011)
Languages: English
Department: Medicine-Cardiology
SOM Resources
CU Resources
Contact Us
CU Anschutz
Fitzsimons Building
13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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