Elan Eisenmesser, PhD
Associate Professor, Biochemistry & Molecular Genetics


  • 67. Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze T, Hansen KC, Zhao R, Ahn R, Sluchanko NN, Eisenmesser EZ. “Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein.” Protein Sci. (2023) 32(4):e4603. Doi: 10.10002/pro.4603.
  • 68. Lee E, McLeod MJ, Redzic JS, Marcolin B, Thorne RE, Agarwal P, Eisenmesser EZ. “Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle.” Front Mol Biosci. (2023) 10:12444587. Doi: 10.3389/fmolb.2023.1244587.
  • 69. Lee E, Redzic JS, Marcolin B, Eisenmesser EZ. “Relaxation and single site multiple mutations to identify and control allosteric networks”. Methods (2023) 216:51-57. Doi:10.1016/j.ymeth.2023.06002.
  • 70. Klontz E, Obi JO, Wang Y, Glendening G, Carr J, Tsibouris C, Buddula S, Nallar S, Soares AS, Beckett D,, Redzic Js, Eisenmesser EZ, Palm C, Shmidt K, Scudder AH, Obiorah T, Esssuman K, Milbrandt J, Diantonia A, Ray K, Snyder MLD, Derdge D,, Snyder GA. “The structure of NAD consuming protein Acietobacter baumannii TIR domain shows unique kinetics and conformations.” J Biol Chem. (2023) doi:1016/j.jbc.2023.105290.
  • 71. Dinarello A, May M, Amo-Aparicio J, Azam T, Gaballa JM, Marchetti C, Tesoriere A, Ghirardo R, Redzic JS, Webber WS 3rd, Atif SM, Li S, Eisenmesser EZ, de Graaf DM, Dinarello CA. “IL-38 regulates interstinal step cell homeostasis by inducing WNT signaling and beneficial IL-1beta secretion”. PNAS (2023) 120(45):e2306476120. Doi:10.1073/pnas.2306476120.
  • 72. Fulte S, Atto B, McCarty A, Horn K, Redzic J, Eisenmesser EZ, Yang M, March R, Tristram S, Clark S. “Heme sequestration by haemophilin from Haemophilus haemolyticus reduces respiratory tract colonization and infection with non-typeable Haemophilus influenzae.” mSphere, (2024) in press.
  • Redzic JS, Rahkola J, Tran N, Holyoak T, Lee E, Martín-Galiano AJ, Meyer N, Zheng H, Eisenmesser E. A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. Commun Biol. 2022 Nov 7;5(1):1190. PubMed PMID: 36336763
  • Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14;27(14). PubMed PMID: 35889366
  • Nemkov T, Stefanoni D, Bordbar A, Issaian A, Palsson BO, Dumont LJ, Hay AM, Song A, Xia Y, Redzic JS, Eisenmesser EZ, Zimring JC, Kleinman S, Hansen KC, Busch M, D'Alessandro A. “Blood donor exposome and impact of common drugs on red blood cell metabolism” (2021) Doi: 10.1172/jci.insight.146175.
  • Sánchez-Fernández A, Zandee S, Amo-Aparicio J, Charabati M, Prat A, Garlanda C, Eisenmesser EZ, Dinarello CA, López-Vales R. “IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8”. Theranostics (2021) 11(1):1-13.
  • Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. “Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds”. Aging Cell (2021) e13309. Doi 10.1111/acel.13309.
  • "The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region" JMB (2021)
  • "Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase "B Front Mol Biosci (2021)
  • "Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage" Transfusion (2021)
  • "A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling" J Biol Chem (2021)
  • "Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA" J Clin Microbiol (2021)
  • Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. “Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice”. Aging Cell (2020) 19(10):e13074. Doi. 10.1111/acel.13074
  • Klück V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, Cri?an TO, Tausche AK, Riches P, Dalbeth N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M, Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea MG, Dinarello CA, Joosten LA. “Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout”. Ann. Rheum. Dis. (2020) 79(4):536-544.
  • Iverson DB, Xiao Y, Jones DN, Eisenmesser EZ, Ahn NG.” Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2”. Biochemistry (2020) 59(29): 2698-2706.
  • Amo-Aparicio J, Sanchez-Fernandez A, Li S, Eisenmesser EZ, Garlanda C, Dinarello CA, Lopez-Vales R. “Extracellular and nuclear roles of IL-37 after spinal cord injury”. Brain Behav. Immun. (2020) 91:194-201.
  • Duff M, Redzic JS, Ryan LP, Paukovich N, Zhao R, Nix JC, Pitts TM, Agarwal P, Eisenmesser EZ. “Structure, dynamics, and function of the evolutionarily changing BLVRB family”. J. Biochem. (2020) 168(2):191-202.
  • Wang Z, Rahkola J, Janoff J, Redzic JS, Chi Y-C, Tran N, Holyoak T, Zheng H, Eisenmesser EZ. “Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease”. Nature Communications (2020) 11(1): 6063-6070.
  • de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser EZ, Redzic JS, Helsen MM, Powers NE, Li S, Kalabokis V, Gresnigt MS, Joosten LAB, Dinarello CA, van de Veerdonk FL. “Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease”. Cytokine (2021) 137:155334.
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Department: Biochemistry & Molecular Genetics
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