Elan Eisenmesser, PhD

Associate Professor, Biochemistry & Molecular Genetics


Publications

  • Schlegel J, Redzic JS, Porter CC, Yurchenko V, Bukrinsky M, Armstrong GS, Zhang F, Isern NG, DeGregori J, Hodges R, Eisenmesser EZ. Solution characterization of the extracellular region of EMMPRIN/CD147 and its interaction with its enzyme ligand cyclophilin-A. J Mol Biol., 18, 518-535 (2009).
  • Schlegel J, Armstrong G, Redzic JS, Zhang F, and Eisenmesser EZ. Characterizing and controlling the inherent dynamics of cyclophilin-A Protein Science 18, 811-824 (2009).
  • Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Mapping of the C3D ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. J. Biol Chem. 284, 9513-9520 (2009).
  • Gardino AK, Villali J, Kivenson A, Lei M, Liu CF, Steindel P, Eisenmesser EZ, Labeikovsky W, Wolf-Watz M, Clarkson MW, Kern D. Transient non-native hydrogen bonds promote activation of a signaling protein. Cell 11:139(6):1049-1051.
  • Clarkson MW, Lei M, Eisenmesser EZ, Labeikovsky W, Redfield A, Kern D Mesodynamics in the SARS nucleocapsid measured by NMR field cycling J. Biomol. NMR 45:217-225 (2009).
  • 22. Yurchenko V, Constant S, Eisenmesser EZ, Bukrinsky M. “Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics.” Clin Exp Immunol. 160(3):305-317 (2010).
  • 23. Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. “Biophysical investigations of complement receptor 2-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. “ J. Biol Chem. 285(35), 27251-8 (2010).
  • 24. Davis TL, Walker JR, Campagna-Slater V, Finerty PJ, Paramanathan R, Bernstein G, MacKenzie F, Tempel W, Ouyang H, Lee WH, Eisenmesser EZ, Dhe-Paganon S. “Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.” PLoS Biol. 8(7):e1000439 (2010).
  • 25. Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D. “Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological substrate HIV capsid by NMR.” J. Mol Biol. PMID:20708627 (2010).
  • 25. Bosco DA, Eisenmesser EZ, Clarkson MW, Wolf-Watz M, Labeikovsky W, Millet O, Kern D. “Dissecting the microscopic steps of the cyclophilin A enzymatic cycle on the biological substrate HIV capsid by NMR.” J. Mol Biol. PMID:20708627 (2010).
  • The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. Redzic JS, Armstrong GS, Isern NG, Jones DN, Kieft JS, Eisenmesser EZ. J Mol Biol. 2011 Aug 5;411(1):68-82. Epub 2011 May 19.
  • Extracellular Cyclophilin-A induces ERK1/2 phosphorylation in some cell types but NFkB activation in multiple cell types. Cancer Cell Internationa. Karim Bahmed, Curtis Henry, Michael Holliday, Jasmina S Redzic, Madalina Ciobanu, Fengli Zhang, Colin Weekes, Robert A Sclafani, James DeGregori and Elan Z Eisenmesser
  • Bahmed, K., Henry, C., Holliday, M., Redzic, J. S., Ciobanu, M., Zhang, F. L., Weekes, C., Sclafani, R. A., DeGregori, J., and Eisenmesser, E. Z. (2012) Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B, Cancer Cell International (2012)
  • 1. Holliday M, Zhang F, Isern NG, Armstrong GS, Eisenmesser EZ. “1H, 13C and 15N backbone and side chain resonance assignments of thermophilic Geobacillus Kaustophilus cyclophilin-A.” Biomolecular NMR Assignments 3(1): DOI 10.1007/s12104-012-9445-3
  • Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-ß1 and EMMPRIN. Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ. PLoS One. 2013 Aug 1;8(8):e71225. doi: 10.1371/journal.pone.0071225. Print 2013.
  • The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide. Kendrick AA, Holliday MJ, Isern NG, Zhang F, Camilloni C, Huynh C, Vendruscolo M, Armstrong G, Eisenmesser EZ. Protein Sci. 2014 Apr;23(4):464-80. doi: 10.1002/pro.2430. Epub 2014 Feb 12.
  • Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems. Holliday MJ, Armstrong GS, Eisenmesser EZ. Biochemistry. 2015 Sep 29;54(38):5815-27. doi: 10.1021/acs.biochem.5b00746. Epub 2015 Sep 11. PMID: 26335054
  • Networks of Dynamic Allostery Regulate Enzyme Function. Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Structure. 2016 Dec 27. pii: S0969-2126(16)30393-8. doi: 10.1016/j.str.2016.12.003. [Epub ahead of print] PMID: 28089447 Similar articles Select item 28039486
  • CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, Alessandro AD, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. Oncotarget. 2016 Dec 27. doi: 10.18632/oncotarget.14272. [Epub ahead of print] PMID: 28039486 Free Article Similar articles Select item 28028839 3. Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro. Chi YC, Rahkola JT, Kendrick AA, Holliday MJ, Paukovich N, Roberts TS, Janoff EN, Eisenmesser EZ. Protein Sci. 2016 Dec 28. doi: 10.1002/pro.3110. [Epub ahead of print] PMID: 28028839
  • Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro. Chi YC, Rahkola JT, Kendrick AA, Holliday MJ, Paukovich N, Roberts TS, Janoff EN, Eisenmesser EZ. Protein Sci. 2016 Dec 28. doi: 10.1002/pro.3110. [Epub ahead of print] PMID: 28028839
  • Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures. Holliday MJ, Camilloni C, Armstrong GS, Isern NG, Zhang F, Vendruscolo M, Eisenmesser EZ. Biochemistry. 2015 May 26;54(20):3207-17. doi: 10.1021/acs.biochem.5b00263. Epub 2015 May 14. PMID: 25923019
  • Inherent dynamics within the Crimean-Congo Hemorrhagic fever virus protease are localized to the same region as substrate interactions. Eisenmesser EZ, Capodagli GC, Armstrong GS, Holliday MJ, Isern NG, Zhang F, Pegan SD. Protein Sci. 2015 May;24(5):651-60. doi: 10.1002/pro.2637. Epub 2015 Jan 28. PMID: 25564798
  • J Mol Biol. 2018 Jan 5;430(1):33-40. doi: 10.1016/j.jmb.2017.11.002. Epub 2017 Nov 11. The Mechanism of HdeA Unfolding and Chaperone Activation. Salmon L1, Stull F2, Sayle S3, Cato C4, Akgül S5, Foit L2, Ahlstrom LS2, Eisenmesser EZ6, Al-Hashimi HM7, Bardwell JCA8, Horowitz S9.
  • Biochem J. 2017 Oct 25;474(21):3689-3704. doi: 10.1042/BCJ20170366. The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding. Rajiv C1, Jackson SR1, Cocklin S1, Eisenmesser EZ2, Davis TL3,4.
  • Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance. Cavalli G, Justice JN, Boyle KE, D'Alessandro A, Eisenmesser EZ, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Garlanda C, Mantovani A, Seals DR, Dagna L, Joosten LA, Ballak DB, Dinarello CA. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2313-2318. doi: 10.1073/pnas.1619011114. Epub 2017 Feb 13.
  • Networks of Dynamic Allostery Regulate Enzyme Function. Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Structure. 2017 Feb 7;25(2):276-286. doi: 10.1016/j.str.2016.12.003. Epub 2017 Jan 12.
  • Oncotarget. 2017 Jan 24;8(4):6742-6762. doi: 10.18632/oncotarget.14272. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Kendrick AA1, Schafer J1, Dzieciatkowska M1, Nemkov T1, D'Alessandro A1, Neelakantan D2, Ford HL2, Pearson CG3, Weekes CD4, Hansen KC1, Eisenmesser EZ1.
  • 4. Paukovich, N, Xue M, Elder JR, Redzic JS, Blue A, Pike H, Miller BG, Pitts TM, Pollock DD, Hansen K, D’Alessandro A, Eisenmesser EZ, JMB (2018) 430: 3234-3235.
  • IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, Dinarello CA, Albanesi C, Madonna S. Cell Death Dis. 2018 Oct 30;9(11):1104. doi: 10.1038/s41419-018-1143-3.
  • Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D'Alessandro A. Transfusion. 2018 Dec;58(12):2978-2991. doi: 10.1111/trf.14936. Epub 2018 Oct 12.
  • The Mechanism of HdeA Unfolding and Chaperone Activation. Salmon L, Stull F, Sayle S, Cato C, Akgül S, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S. J Mol Biol. 2018 Jan 5;430(1):33-40. doi: 10.1016/j.jmb.2017.11.002. Epub 2017 Nov 11.
  • Elan Z. Eisenmesser et al., The interleukin-37 monomer is the active form for reducing innate immunity, PNAS
  • Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. “Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice”. Aging Cell (2020) 19(10):e13074. Doi. 10.1111/acel.13074
  • Klück V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, Cri?an TO, Tausche AK, Riches P, Dalbeth N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M, Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea MG, Dinarello CA, Joosten LA. “Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout”. Ann. Rheum. Dis. (2020) 79(4):536-544.
  • Iverson DB, Xiao Y, Jones DN, Eisenmesser EZ, Ahn NG.” Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2”. Biochemistry (2020) 59(29): 2698-2706.
  • Amo-Aparicio J, Sanchez-Fernandez A, Li S, Eisenmesser EZ, Garlanda C, Dinarello CA, Lopez-Vales R. “Extracellular and nuclear roles of IL-37 after spinal cord injury”. Brain Behav. Immun. (2020) 91:194-201.
  • Duff M, Redzic JS, Ryan LP, Paukovich N, Zhao R, Nix JC, Pitts TM, Agarwal P, Eisenmesser EZ. “Structure, dynamics, and function of the evolutionarily changing BLVRB family”. J. Biochem. (2020) 168(2):191-202.
  • Wang Z, Rahkola J, Janoff J, Redzic JS, Chi Y-C, Tran N, Holyoak T, Zheng H, Eisenmesser EZ. “Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease”. Nature Communications (2020) 11(1): 6063-6070.
  • de Graaf DM, Maas RJA, Smeekens SP, Eisenmesser EZ, Redzic JS, Helsen MM, Powers NE, Li S, Kalabokis V, Gresnigt MS, Joosten LAB, Dinarello CA, van de Veerdonk FL. “Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease”. Cytokine (2021) 137:155334.
  • Nemkov T, Stefanoni D, Bordbar A, Issaian A, Palsson BO, Dumont LJ, Hay AM, Song A, Xia Y, Redzic JS, Eisenmesser EZ, Zimring JC, Kleinman S, Hansen KC, Busch M, D'Alessandro A. “Blood donor exposome and impact of common drugs on red blood cell metabolism” (2021) Doi: 10.1172/jci.insight.146175.
  • Sánchez-Fernández A, Zandee S, Amo-Aparicio J, Charabati M, Prat A, Garlanda C, Eisenmesser EZ, Dinarello CA, López-Vales R. “IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8”. Theranostics (2021) 11(1):1-13.
  • Hamilton JAG, Lee MY, Hunter R, Ank RS, Story JY, Talekar G, Sisroe T, Ballak DB, Fedanov A, Porter CC, Eisenmesser EZ, Dinarello CA, Raikar SS, DeGregori J, Henry CJ. “Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds”. Aging Cell (2021) e13309. Doi 10.1111/acel.13309.
  • Redzic JS, Rahkola J, Tran N, Holyoak T, Lee E, Martín-Galiano AJ, Meyer N, Zheng H, Eisenmesser E. A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases. Commun Biol. 2022 Nov 7;5(1):1190. PubMed PMID: 36336763
  • Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14;27(14). PubMed PMID: 35889366
  • "The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region" JMB (2021)
  • "Modulating Enzyme Function via Dynamic Allostery within Biliverdin Reductase "B Front Mol Biosci (2021)
  • "Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage" Transfusion (2021)
  • 67. Lee E, Redzic JS, Saviola AJ, Li X, Ebmeier CC, Kutateladze T, Hansen KC, Zhao R, Ahn R, Sluchanko NN, Eisenmesser EZ. “Molecular insight into the specific interactions of the SARS-Coronavirus-2 nucleocapsid with RNA and host protein.” Protein Sci. (2023) 32(4):e4603. Doi: 10.10002/pro.4603.
  • 68. Lee E, McLeod MJ, Redzic JS, Marcolin B, Thorne RE, Agarwal P, Eisenmesser EZ. “Identifying structural and dynamic changes during the Biliverdin Reductase B catalytic cycle.” Front Mol Biosci. (2023) 10:12444587. Doi: 10.3389/fmolb.2023.1244587.
  • 69. Lee E, Redzic JS, Marcolin B, Eisenmesser EZ. “Relaxation and single site multiple mutations to identify and control allosteric networks”. Methods (2023) 216:51-57. Doi:10.1016/j.ymeth.2023.06002.
  • 70. Klontz E, Obi JO, Wang Y, Glendening G, Carr J, Tsibouris C, Buddula S, Nallar S, Soares AS, Beckett D,, Redzic Js, Eisenmesser EZ, Palm C, Shmidt K, Scudder AH, Obiorah T, Esssuman K, Milbrandt J, Diantonia A, Ray K, Snyder MLD, Derdge D,, Snyder GA. “The structure of NAD consuming protein Acietobacter baumannii TIR domain shows unique kinetics and conformations.” J Biol Chem. (2023) doi:1016/j.jbc.2023.105290.
  • 71. Dinarello A, May M, Amo-Aparicio J, Azam T, Gaballa JM, Marchetti C, Tesoriere A, Ghirardo R, Redzic JS, Webber WS 3rd, Atif SM, Li S, Eisenmesser EZ, de Graaf DM, Dinarello CA. “IL-38 regulates interstinal step cell homeostasis by inducing WNT signaling and beneficial IL-1beta secretion”. PNAS (2023) 120(45):e2306476120. Doi:10.1073/pnas.2306476120.
  • 72. Fulte S, Atto B, McCarty A, Horn K, Redzic J, Eisenmesser EZ, Yang M, March R, Tristram S, Clark S. “Heme sequestration by haemophilin from Haemophilus haemolyticus reduces respiratory tract colonization and infection with non-typeable Haemophilus influenzae.” mSphere, (2024) in press.
  • "A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling" J Biol Chem (2021)
  • "Development and Validation of a Multiplex Microsphere Immunoassay Using Dried Blood Spots for SARS-CoV-2 Seroprevalence: Application in First Responders in Colorado, USA" J Clin Microbiol (2021)