Rachel McMahan, PhD

Publications

• Bile-Acid Receptor Activation Shifts Hepatic Monocytes/Macrophages Towards an Anti-Inflammatory Phenotype and Improves Non-Alcoholic Fatty Liver Disease. American Association for the Study of Liver Diseases (AASLD) Annual Meeting, Boston, MA 2011
• Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, He Z, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Am J Physiol Renal Physiol. 2012 Feb;302(4):F421-32.
• Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time. Li H, Hughes AL, Bano N, McArdle S, Livingston S, Deubner H, McMahon BJ, Townshend-Bulson L, McMahan R, Rosen HR, Gretch DR. PLoS One. 2011 May 5;6(5):e19562.
• McMahan, R., Wang, X. X., Cheng, L. L., Krisko, T., Smith, M., El Kasmi, K., Pruzanski, M., Adorini, L., Golden-Mason, L., Levi, M., and Rosen, H. R. (2013) Bile-acid receptor activation modulates hepatic monocyte activity and improves non-alcoholic fatty liver disease. J Biol Chem
• Golden-Mason, L., McMahan, R. H., Strong, M., Reisdorph, R., Mahaffey, S., Palmer, B. E., Cheng, L., Kulesza, C., Hirashima, M., Niki, T., and Rosen, H. R. (2013) Galectin-9 functionally impairs natural killer (NK) cells in humans and mice. J Virol
• Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872
• McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, El Kasmi K, Pruzanski M, Adorini L, Golden-Mason L, Levi M, Rosen HR. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem. 2013 Apr 26;288(17):11761-70. PubMed PMID: 23460643
• Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013 May;87(9):4835-45. PubMed PMID: 23408620
• Liver Sinusoidal Endothelial Cells (LSECs) in Nonalcoholic Fatty Liver Disease (NAFLD) demonstrate compensatory transcriptional changes Rachel McMahan, Silvia Giugliano, Cara Porsche, Lucy Golden- Mason, Hugo R. Rosen. AASLD Liver Meeting 2013.
• Human placenta contains memory T cells with stem-cell like properties (TSCM) that specifically target HCV: Novel insights into protective immunity in pregnancy Rachel McMahan, Christine Waasdorp Hurtado, Lucy Golden- Mason, Mona Krull, Michael R. Narkewicz, Hugo R. Rosen. AASLD Liver Meeting 2013.
• McMahan RH, Porsche C, Edwards M, Adorini L, Levi M, Rosen HR. Downregulation of pro-fibrotic and pro-inflammatory genes in liver sinusoidal endothelial cells following activation of the bile acid receptors FXR and TGR5. AASLD Liver Meeting Nov. 7-11, Boston MA.
• McGettigan BM, McMahan RH, Porsche C, Orlicky D, Wang X, Luo Y, Levi M, Rosen HR. Sevelamer improves hepatic steatosis and modulates inflammation in a Western Diet mouse model of non-alcoholic fatty liver disease (NAFLD). AASLD Liver Meeting, Nov. 7-11 Boston MA.
• McMahan RH, Porsche CE, Edwards MG, Rosen HR. Correction: Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease. PLoS One. 2016 Dec 8;11(12):e0168301. PubMed PMID: 27930747
• McGettigan BM, McMahan RH, Luo Y, Wang XX, Orlicky DJ, Porsche C, Levi M, Rosen HR. Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease. J Biol Chem. 2016 Oct 28;291(44):23058-23067. PubMed PMID: 27605663
• Truong LD, Trostel J, McMahan R, Chen JF, Garcia GE. Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury. Am J Pathol. 2016 Oct;186(10):2601-13. PubMed PMID: 27520357
• Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI. Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. J Leukoc Biol. 2016 Sep;100(3):545-57. PubMed PMID: 26921345
• Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM. How an alloreactive T-cell receptor achieves peptide and MHC specificity. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. PubMed PMID: 28572406
• Orlicky DJ, Libby AE, Bales ES, McMahan RH, Monks J, La Rosa FG, McManaman JL. Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. J Physiol. 2018 Dec 8. [Epub ahead of print] PubMed PMID: 30536914
• McMahan R*, McGettigan B*, Orlicky D, Burchill M, Danhorn T, Francis P, Cheng LL, Golden-Mason L, Jakubzick C, Rosen H. Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages. Hepatology. 2018 Dec 5. [Epub ahead of print] PubMed PMID: 30516830
• Trostel J, Truong LD, Roncal-Jimenez C, Miyazaki M, Miyazaki-Anzai S, Kuwabara M, McMahan R, Andres-Hernando A, Sato Y, Jensen T, Lanaspa MA, Johnson RJ, Garcia GE. Different effects of global osteopontin and macrophage osteopontin in glomerular injury. Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F759-F768. PubMed PMID: 29717936
• Golden-Mason L, McMahan RH, Kriss MS, Kilgore AL, Cheng L, Dran RJ, Wieland A, Rosen HR. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018 Apr;2(4):364-375. PubMed PMID: 29619416
• McMahan R*, McGettigan B*, Orlicky D, Burchill M, Danhorn T, Francis P, Cheng LL, Golden-Mason L, Jakubzick CV, Rosen HR. Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages. Hepatology. 2019 Jul;70(1):67-83. PubMed PMID: 30516830
• Orlicky DJ, Libby AE, Bales ES, McMahan RH, Monks J, La Rosa FG, McManaman JL. Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. J Physiol. 2019 Mar;597(6):1565-1584. PubMed PMID: 30536914
• Idrovo JP, Boe DM, Kaahui S, Walrath T, McMahan RH, Kovacs EJ. Advanced age heightens hepatic damage in a murine model of scald burn injury. J Trauma Acute Care Surg. 2020 Dec 9. [Epub ahead of print] PubMed PMID: 33306599
• Walrath T, Dyamenahalli KU, Hulsebus HJ, McCullough RL, Idrovo JP, Boe DM, McMahan RH, Kovacs EJ. Age-related changes in intestinal immunity and the microbiome. J Leukoc Biol. 2020 Oct 5. [Epub ahead of print] PubMed PMID: 33020981
• Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jirón Tamburini BA. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2020 Sep 19. [Epub ahead of print] PubMed PMID: 32961356
• McMahan RH, Afshar M, Amedee AM, Bishehsari F, Carr RM, Coleman LG, Herrnreiter CJ, Lewis SL, Mandrekar P, McCullough RL, Morris NL, Vasiliou V, Wang HJ, Yeligar SM, Choudhry MA, Kovacs EJ. Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. Alcohol. 2020 Sep;87:89-95. PubMed PMID: 32353591
• Najarro KM, Boe DM, Walrath TM, Mullen JE, Paul MT, Frankel JH, Hulsebus HJ, Idrovo JP, McMahan RH, Kovacs EJ. Advanced age exacerbates intestinal epithelial permeability after burn injury in mice. Exp Gerontol. 2021 Dec 13;158:111654. [Epub ahead of print] PubMed PMID: 34915110
• McMahan RH, Najarro KM, Mullen JE, Paul MT, Orlicky DJ, Hulsebus HJ, Kovacs EJ. Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age. Immun Ageing. 2021 Oct 21;18(1):39. PubMed PMID: 34674721
• Idrovo JP, Boe DM, Kaahui S, Walrath T, McMahan RH, Kovacs EJ. Advanced age heightens hepatic damage in a murine model of scald burn injury. J Trauma Acute Care Surg. 2021 Apr 1;90(4):731-737. PubMed PMID: 33306599
• Walrath T, Dyamenahalli KU, Hulsebus HJ, McCullough RL, Idrovo JP, Boe DM, McMahan RH, Kovacs EJ. Age-related changes in intestinal immunity and the microbiome. J Leukoc Biol. 2021 Jun;109(6):1045-1061. PubMed PMID: 33020981
• Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jirón Tamburini BA. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2021;11(2):573-595. PubMed PMID: 32961356
• Crotty K, Anton P, Coleman LG, Morris NL, Lewis SA, Samuelson DR, McMahan RH, Hartmann P, Kim A, Ratna A, Mandrekar P, Wyatt TA, Choudhry MA, Kovacs EJ, McCullough R, Yeligar SM. A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues. Alcohol Clin Exp Res. 2022 Nov 22. [Epub ahead of print] PubMed PMID: 36446606
• Walrath T, McMahan RH, Idrovo JP, Quillinan N, Kovacs EJ. Cutaneous burn injury induces neuroinflammation and reactive astrocyte activation in the hippocampus of aged mice. Exp Gerontol. 2022 Nov;169:111975. PubMed PMID: 36208823
• McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Kovacs EJ. Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice. Alcohol. 2022 Sep 20. [Epub ahead of print] PubMed PMID: 36150609
• Boe DM, Hulsebus HJ, Najarro KM, Mullen JE, Kim H, Tan AC, McMahan RH, Kovacs EJ. Advanced age is associated with changes in alveolar macrophages and their responses to the stress of traumatic injury. J Leukoc Biol. 2022 Dec;112(6):1371-1386. PubMed PMID: 36120937
• McMahan RH, Boe DM, Walrath TM, Idrovo JP, Kovacs EJ. Aging, Cutaneous Burn Injury and Multi-Organ Complications: The Role of the Gut. Adv Geriatr Med Res. 2022;4(2). PubMed PMID: 35913894
• Khair S, Brenner LA, Koval M, Samuelson D, Cucinello-Regland JA, Anton P, Piano MR, Simon L, Crotty K, Sharieh F, Travers JB, Singh V, Cannon A, Kim A, McCullough RL, Yeligar SM, Wyatt TA, McMahan RH, Choudhry MA, Kovacs EJ. New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2022 Sep;103:1-7. PubMed PMID: 35659577
• Hulsebus HJ, Najarro KM, McMahan RH, Boe DM, Orlicky DJ, Kovacs EJ. Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection. Front Immunol. 2022;13:884719. PubMed PMID: 35603143
• McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Orlicky DJ, Kovacs EJ. Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice. Front Aging. 2022;3. PubMed PMID: 35392033
• Dyamenahalli K, Choy K, Frank DN, Najarro K, Boe D, Colborn KL, Idrovo JP, Wagner AL, Wiktor AJ, Afshar M, Burnham EL, McMahan RH, Kovacs EJ. Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients. J Burn Care Res. 2022 Sep 1;43(5):1145-1153. PubMed PMID: 35020913
• Najarro KM, Boe DM, Walrath TM, Mullen JE, Paul MT, Frankel JH, Hulsebus HJ, Idrovo JP, McMahan RH, Kovacs EJ. Advanced age exacerbates intestinal epithelial permeability after burn injury in mice. Exp Gerontol. 2022 Feb;158:111654. PubMed PMID: 34915110
• Zillich L, Wagner J, McMahan RH, Park LM, Hodgkinson C, Kovacs EJ, Lohoff FW. Multi-omics analysis of alcohol effects on the liver in young and aged mice. Addict Biol. 2023 Dec;28(12):e13342. PubMed PMID: 38017640
• Khair S, Walrath TM, Curtis BJ, Orlicky DJ, McMahan RH, Kovacs EJ. Ethanol exacerbates pulmonary complications after burn injury in mice, regardless of frequency of ethanol exposures. Burns. 2023 Dec;49(8):1935-1943. PubMed PMID: 37574341
• Walrath T, Najarro KM, Giesy LE, Khair S, Frank DN, Robertson CE, Orlicky DJ, Quillinan N, Idrovo JP, McMahan RH, Kovacs EJ. REMOTE BURN INJURY IN AGED MICE INDUCES COLONIC LYMPHOID AGGREGATE EXPANSION AND DYSBIOSIS OF THE FECAL MICROBIOME WHICH CORRELATES WITH NEUROINFLAMMATION. Shock. 2023 Oct 1;60(4):585-593. PubMed PMID: 37548929
• McMahan RH, Anton P, Coleman LG, Cresci GAM, Crews FT, Crotty KM, Luck ME, Molina PE, Vachharajani V, Weinberg J, Yeligar SM, Choudhry MA, McCullough RL, Kovacs EJ. Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting. Alcohol. 2023 Aug;110:57-63. PubMed PMID: 37061143
• Choy K, Dyamenahalli KU, Khair S, Colborn KL, Wiktor AJ, Idrovo JP, McMahan RH, Burnham EL, Kovacs EJ. Aberrant inflammatory responses in intoxicated burn-injured patients parallel impaired cognitive function. Alcohol. 2023 Jun;109:35-41. PubMed PMID: 36690221
• Crotty K, Anton P, Coleman LG, Morris NL, Lewis SA, Samuelson DR, McMahan RH, Hartmann P, Kim A, Ratna A, Mandrekar P, Wyatt TA, Choudhry MA, Kovacs EJ, McCullough R, Yeligar SM. A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues. Alcohol Clin Exp Res (Hoboken). 2023 Jan;47(1):36-44. PubMed PMID: 36446606
• Walrath T, Najarro KM, Giesy LE, Khair S, Orlicky DJ, McMahan RH, Kovacs EJ. Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome. FASEB J. 2024 Sep 30;38(18):e70065. PubMed PMID: 39305117
• McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Kovacs EJ. Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice. Alcohol. 2023 Mar;107:136-143. PubMed PMID: 36150609
• Sugino KY, Janssen RC, McMahan RH, Zimmerman C, Friedman JE, Jonscher KR. Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response. Nutrients. 2024 Jun 8;16(12). PubMed PMID: 38931163
• McMahan RH, Boe D, Giesy LE, Najarro KM, Khair S, Walrath T, Frank DN, Kovacs EJ. Advanced age worsens respiratory function and pulmonary inflammation after burn injury and this correlates with changes in the fecal microbiome in mice. J Burn Care Res. 2024 Jun 5. [Epub ahead of print] PubMed PMID: 38837704
• Hoisington AJ, Choy K, Khair S, Dyamenahalli KU, Najarro KM, Wiktor AJ, Frank DN, Burnham EL, McMahan RH, Kovacs EJ. Recent alcohol intake impacts microbiota in adult burn patients. Alcohol. 2024 Aug;118:25-35. PubMed PMID: 38604285
• Rutt LN, Liu M, Melamed E, Twardy S, Sturgill JL, Brenner LA, Hardesty J, Weinman SA, Tschann MM, Travers J, Welsh DA, Chichetto N, Crotty KM, Mackowiak B, Yeligar SM, Wyatt TA, McMahan RH, Choudry MA, Kovacs EJ, McCullough RL. Emerging concepts in alcohol, infection & immunity: A summary of the 2023 alcohol and immunology research interest group (AIRIG) meeting. Alcohol. 2024 Aug;118:9-16. PubMed PMID: 38582261