Wendy Tzou, MD, FACC, FHRS
Professor, Medicine-Cardiology

Professional Titles

• Director, Cardiac Electrophysiology
• Director, Cardiology Platinum Service

Recognition & Awards

• 5280 Top Doctor, 5280 Magazine (2020)
• 5280 Top Doctor, 5280 Magazine (2019)
• 5280 Top Doctor, 5280 Magazine (2017)

Teaching

Publications

• Zghaib T, Allison JD, Barrett C, Arkles J, D'Souza B, Luebbert J, Garcia F, Heist EK, Tzou W, Callans D, Marchlinski FE, Frankel DS. Multicenter experience with andexanet alfa for refractory pericardial bleeding during catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2023 Jan 4. [Epub ahead of print] PubMed PMID: 36598431
• Aksu T, De Potter T, John L, Osorio J, Singh D, Alyesh D, Baysal E, Kumar K, Mikaeili J, Dal Forno A, Yalin K, Akdemir B, Woods CE, Salcedo J, Eftekharzadeh M, Akgun T, Sundaram S, Aras D, Tzou WS, Gopinathannair R, Winterfield J, Gupta D, Davila A. Procedural and short-term results of electroanatomic-mapping-guided ganglionated plexus ablation by first-time operators: A multicenter study. J Cardiovasc Electrophysiol. 2022 Jan;33(1):117-122. PubMed PMID: 34674347
• Varela DL, Rosenberg MA, Borne RT, Sandhu A, Zipse MM, Tzou WS, Sauer WH, Scheinman MM, Nguyen DT. Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation. J Interv Card Electrophysiol. 2022 Apr;63(3):581-589. PubMed PMID: 34532821
• Scott M, Baykaner T, Bunch TJ, Piccini JP, Russo AM, Tzou WS, Zeitler EP, Steinberg BA. Contemporary Trends in Cardiac Electrophysiology Procedures in the United States, and Impact of a Global Pandemic. Heart Rhythm O2. 2022 Dec 21. [Epub ahead of print] PubMed PMID: 36569386
• Amin DR, Behan S, Pengshung M, Khanna A, Tzou WS, Mantini N, Henao-Martinez AF, Tumolo A, Groves DW. Sustained monomorphic ventricular tachycardia as the presenting sign of Chagas' cardiomyopathy in a low prevalence setting, diagnosis and management challenges. A case report. Ther Adv Infect Dis. 2022 Jan-Dec;9:20499361221141772. PubMed PMID: 36506697
• Sandhu A, Varosy PD, Du C, Aleong RG, Tumolo AZ, West JJ, Tzou WS, Curtis JP, Freeman JV, Friedman DJ, Hess PL. Device-Sizing and Associated Complications With Left Atrial Appendage Occlusion: Findings From the NCDR LAAO Registry. Circ Cardiovasc Interv. 2022 Dec;15(12):e012183. PubMed PMID: 36472194
• Piccini JP, Russo AM, Sharma PS, Kron J, Tzou W, Sauer W, Park DS, Birgersdotter-Green U, Frankel DS, Healey JS, Hummel J, Koruth J, Linz D, Mittal S, Nair DG, Nattel S, Noseworthy PA, Steinberg BA, Trayanova NA, Wan EY, Wissner E, Zeitler EP, Wang PJ. Advances in Cardiac Electrophysiology. Circ Arrhythm Electrophysiol. 2022 Dec;15(12):e009911. PubMed PMID: 36441565
• Knoepke CE, Wallace BC, Allen LA, Lewis CL, Gupta SK, Peterson PN, Kramer DB, Brancato SC, Varosy PD, Mandrola JM, Tzou WS, Matlock DD. Experiences Implementing a Suite of Decision Aids for Implantable Cardioverter Defibrillators: Qualitative Insights From the DECIDE-ICD Trial. Circ Cardiovasc Qual Outcomes. 2022 Nov;15(11):e009352. PubMed PMID: 36378770
• Edward JA, Chang SC, Gill EA, Tzou WS, Aleong RG. Esophago-Pericardial Fistula as a Rare and Life-Threatening Complication of Epicardial Ventricular Tachycardia Ablation. JACC Case Rep. 2022 Sep 21;4(18):1180-1185. PubMed PMID: 36213880
• Howard B, Verma A, Tzou WS, Mattison L, Kos B, Miklavcic D, Onal B, Stewart MT, Sigg DC. Effects of Electrode-Tissue Proximity on Cardiac Lesion Formation Using Pulsed Field Ablation. Circ Arrhythm Electrophysiol. 2022 Oct;15(10):e011110. PubMed PMID: 36166690
• Tzou WS. Insights From the Dilated Cardiomyopathy Ventricular Tachycardia Ablation Study: Wisdom Through Humility. J Am Coll Cardiol. 2022 Sep 13;80(11):1057-1059. PubMed PMID: 36075674
• Garg L, Tzou WS. A Force Awakens: Return of Needle Catheter Radiofrequency Ablation for Targeting Intramural Ventricular Arrhythmias. Circ Arrhythm Electrophysiol. 2022 Sep;15(9):e011309. PubMed PMID: 36006297
• Sabzwari SRA, Rosenberg MA, Mann J, Cerbin L, Barrett C, Garg L, Aleong RG, Sandhu A, West J, Tumolo AZ, Varosy PD, Sauer WH, Zipse MM, Tzou WS. Limitations of Unipolar Signals in Guiding Successful Outflow Tract Premature Ventricular Contraction Ablation. JACC Clin Electrophysiol. 2022 Jul;8(7):843-853. PubMed PMID: 35643806
• Markman TM, John L, Kalluri AG, Tzou WS, Badertscher P, Winterfield J, Partington SL, Santangeli P, Chung FP. Catheter Ablation of Ventricular Arrhythmias With Indirect Evidence of Critical Substrate Elements Protected by Prosthetic Material. JACC Clin Electrophysiol. 2022 May;8(5):677-679. PubMed PMID: 35589181
• Barrett C, Tzou WS. Endocardial and Epicardial Scar Homogenization: Is It Time to See the Light?. JACC Clin Electrophysiol. 2022 Apr;8(4):462-464. PubMed PMID: 35450600
• Aksu T, De Potter T, John L, Osorio J, Singh D, Alyesh D, Baysal E, Kumar K, Mikaeili J, Dal Forno A, Yalin K, Akdemir B, Woods CE, Salcedo J, Eftekharzadeh M, Akgun T, Sundaram S, Aras D, Tzou WS, Gopinathannair R, Winterfield J, Gupta D, Davila A. Procedural and short-term results of electroanatomic-mapping-guided ganglionated plexus ablation by first-time operators: A multicenter study. J Cardiovasc Electrophysiol. 2022 Jan;33(1):117-122. PubMed PMID: 34674347
• Kim RS, Simon S, Powers B, Sandhu A, Sanchez J, Borne RT, Tumolo A, Zipse M, West JJ, Aleong R, Tzou W, Rosenberg MA. Machine Learning Methodologies for Prediction of Rhythm-Control Strategy in Patients Diagnosed With Atrial Fibrillation: Observational, Retrospective, Case-Control Study. JMIR Med Inform. 2021 Dec 6;9(12):e29225. PubMed PMID: 34874889
• Sabzwari SRA, Tzou WS. Systemic Diseases and Heart Block. Card Electrophysiol Clin. 2021 Dec;13(4):721-740. PubMed PMID: 34689899
• Barrett C, Sandhu A, Tzou W. Electrophysiologic Implications of Transcatheter Aortic Valve Replacement: Incidence, Outcomes, and Current Management Strategies. Curr Cardiol Rep. 2021 Oct 1;23(11):167. PubMed PMID: 34599417
• Al-Ahmad A, Knight B, Tzou W, Schaller R, Yasin O, Padmanabhan D, Zagrodzky J, Bassiouny M, Burkhardt JD, Gallinghouse GJ, Mansour M, McLeod C, Natale A. Evaluation of a novel cardiac signal processing system for electrophysiology procedures: The PURE EP 2.0 study. J Cardiovasc Electrophysiol. 2021 Nov;32(11):2915-2922. PubMed PMID: 34554634
• Varela DL, Rosenberg MA, Borne RT, Sandhu A, Zipse MM, Tzou WS, Sauer WH, Scheinman MM, Nguyen DT. Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation. J Interv Card Electrophysiol. 2021 Sep 17. [Epub ahead of print] PubMed PMID: 34532821
• Kunkel M, Rothstein P, Sauer P, Zipse MM, Sandhu A, Tumolo AZ, Borne RT, Aleong RG, Cleveland JC Jr, Fullerton D, Pal JD, Davies AS, Lane C, Nguyen DT, Sauer WH, Tzou WS. Open surgical ablation of ventricular tachycardia: Utility and feasibility of contemporary mapping and ablation tools. Heart Rhythm O2. 2021 Jun;2(3):271-279. PubMed PMID: 34337578
• Sanchez JM, Farasat M, Levy AE, Douglas IS, Stauffer BL, Tzou WS, West JJ. A novel approach to electrocardiography in the prone patient. Heart Rhythm O2. 2021 Feb;2(1):107-109. PubMed PMID: 34113910
• Barrett C, Tzou WS. Utility of Intracardiac Echocardiography for Guiding Ablation of Ventricular Tachycardia in Nonischemic Cardiomyopathy. Card Electrophysiol Clin. 2021 Jun;13(2):337-343. PubMed PMID: 33990272
• Tzou W, Sauer W. Letter from the Program Directors. J Innov Card Rhythm Manag. 2021 Apr;12(4):4457-4458. PubMed PMID: 33936860
• Sandhu A, Tzou WS. A Disruptive Technology: Determining Need for Permanent Pacing After TAVR. Curr Cardiol Rep. 2021 Apr 16;23(5):53. PubMed PMID: 33871728
• Sanchez JM, Tzou WS. Amiodarone during ventricular tachycardia ablation: A total eclipse of the heart?. Heart Rhythm. 2021 Jun;18(6):894-895. PubMed PMID: 33753276
• Darden D, Hsu JC, Tzou WS, von Alvensleben JC, Brooks M, Hoffmayer KS, Brambatti M, Sauer WH, Feld GK, Adler E. Fasciculoventricular and atrioventricular accessory pathways in patients with Danon disease and preexcitation: A multicenter experience. Heart Rhythm. 2021 Jul;18(7):1194-1202. PubMed PMID: 33737230
• Tschabrunn CM, Tzou WS. The Evolution of Ventricular Scar Substrate Assessment by Using High-Resolution Mapping Platforms: Ongoing Quest for "Ground Truth". JACC Clin Electrophysiol. 2021 Feb;7(2):206-209. PubMed PMID: 33602401
• Cerbin L, Tzou WS. Open-irrigation for radiofrequency ablation for atrial fibrillation: Worth its salt?. J Cardiovasc Electrophysiol. 2021 Apr;32(4):982-983. PubMed PMID: 33556989
• Aguilar M, Tedrow UB, Tzou WS, Tung R, Frankel DS, Santangeli P, Vaseghi M, Bunch TJ, Di Biase L, Tholakanahalli VN, Lakkireddy D, Dickfeld T, Weiss JP, Mathuria N, Vergara P, Nakahara S, Bradfield JS, Burkhardt JD, Stevenson WG, Callans DJ, Della Bella P, Natale A, Shivkumar K, Marchlinski FE, Sauer WH. Catheter ablation of ventricular tachycardia in patients with prior cardiac surgery: An analysis from the International VT Ablation Center Collaborative Group. J Cardiovasc Electrophysiol. 2021 Feb;32(2):409-416. PubMed PMID: 33355965
• Sandhu A, Tzou WS, Borne RT, Zipse MM, Nguyen DT, Sauer WH. Uncovering a unique path: Antidromic AVRT utilizing a left anteroseptal Mahaim-like accessory pathway. Pacing Clin Electrophysiol. 2021 Jan;44(1):185-188. PubMed PMID: 32794265
• Sandhu A, Tzou W, Ream K, Valle J, Tompkins C, Nguyen DT, Sauer WH, Carroll JD, Messenger J, Aleong RG. Heart Block After Discharge in Patients Undergoing TAVR With Latest-Generation Valves. J Am Coll Cardiol. 2018 Feb 6;71(5):577-578. PubMed PMID: 29406864
• Vergara P, Tung R, Vaseghi M, Brombin C, Frankel D, Di Biase L, Nagashima K, Tedrow U, Tzou WS, Sauer WH, Mathuria N, Nakahara S, Vakil K, Tholakanahalli V, Bunch TJ, Weiss JP, Dickfeld T, Vunnam R, Lakireddy D, Burkhardt JD, Correra A, Santangeli P, Callans D, Natale A, Marchlinski F, Stevenson WG, Shivkumar K, Della Bella P. Successful ventricular tachycardia ablation in patients with electrical storm reduces recurrences and improves survival. Heart Rhythm. 2018 Jan;15(1):48-55. PubMed PMID: 28843418
• Tzou WS, Tung R, Frankel DS, Vaseghi M, Bunch TJ, Di Biase L, Tholakanahalli VN, Lakkireddy D, Dickfeld T, Saliaris A, Weiss JP, Mathuria N, Tedrow U, Afzal MR, Vergara P, Nagashima K, Patel M, Nakahara S, Vakil K, Burkhardt JD, Tseng CH, Natale A, Shivkumar K, Callans DJ, Stevenson WG, Della Bella P, Marchlinski FE, Sauer WH. Ventricular Tachycardia Ablation in Severe Heart Failure: An International Ventricular Tachycardia Ablation Center Collaboration Analysis. Circ Arrhythm Electrophysiol. 2017 Jan;10(1). PubMed PMID: 28082527
• Vakil K, Garcia S, Tung R, Vaseghi M, Tedrow U, Della Bella P, Frankel DS, Vergara P, Di Biase L, Nagashima K, Nakahara S, Tzou WS, Burkhardt JD, Dickfeld T, Weiss JP, Bunch J, Callans D, Lakkireddy D, Natale A, Sauer WH, Stevenson WG, Marchlinski F, Shivkumar K, Tholakanahalli VN. Ventricular Tachycardia Ablation in the Elderly: An International Ventricular Tachycardia Center Collaborative Group Analysis. Circ Arrhythm Electrophysiol. 2017 Dec;10(12). PubMed PMID: 29254946
• Doherty JU, Kort S, Mehran R, Schoenhagen P, Soman P, Dehmer GJ, Doherty JU, Schoenhagen P, Amin Z, Bashore TM, Boyle A, Calnon DA, Carabello B, Cerqueira MD, Conte J, Desai M, Edmundowicz D, Ferrari VA, Ghoshhajra B, Mehrotra P, Nazarian S, Reece TB, Tamarappoo B, Tzou WS, Wong JB, Doherty JU, Dehmer GJ, Bailey SR, Bhave NM, Brown AS, Daugherty SL, Dean LS, Desai MY, Duvernoy CS, Gillam LD, Hendel RC, Kramer CM, Lindsay BD, Manning WJ, Mehrotra P, Patel MR, Sachdeva R, Wann LS, Winchester DE, Wolk MJ, Allen JM. ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for Multimodality Imaging in Valvular Heart Disease: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Am Soc Echocardiogr. 2017 Oct 20. [Epub ahead of print] PubMed PMID: 29066081
• Lip GYH, Coca A, Kahan T, Boriani G, Manolis AS, Olsen MH, Oto A, Potpara TS, Steffel J, Marín F, de Oliveira Figueiredo MJ, de Simone G, Tzou WS, Chiang CE, Williams B, Dan GA, Gorenek B, Fauchier L, Savelieva I, Hatala R, van Gelder I, Brguljan-Hitij J, Erdine S, Lovic D, Kim YH, Salinas-Arce J, Field M. Hypertension and cardiac arrhythmias: a consensus document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE). Europace. 2017 Jun 1;19(6):891-911. PubMed PMID: 28881872
• Zipse MM, Tzou WS. Sudden cardiac death in nonischemic cardiomyopathy: Refining risk assessment. J Cardiovasc Electrophysiol. 2017 Nov;28(11):1361-1366. PubMed PMID: 28670752
• Lip GYH, Coca A, Kahan T, Boriani G, Manolis AS, Olsen MH, Oto A, Potpara TS, Steffel J, Marín F, de Oliveira Figueiredo MJ, de Simone G, Tzou WS, En Chiang C, Williams B. Hypertension and cardiac arrhythmias: executive summary of a consensus document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE). Eur Heart J Cardiovasc Pharmacother. 2017 Oct 1;3(4):235-250. PubMed PMID: 28541499
• Tzou WS, Tung R, Frankel DS, Di Biase L, Santangeli P, Vaseghi M, Bunch TJ, Weiss JP, Tholakanahalli VN, Lakkireddy D, Vunnam R, Dickfeld T, Mathuria N, Tedrow U, Vergara P, Vakil K, Nakahara S, Burkhardt JD, Stevenson WG, Callans DJ, Della Bella P, Natale A, Shivkumar K, Marchlinski FE, Sauer WH. Outcomes after repeat ablation of ventricular tachycardia in structural heart disease: An analysis from the International VT Ablation Center Collaborative Group. Heart Rhythm. 2017 Jul;14(7):991-997. PubMed PMID: 28506710
• Santangeli P, Frankel DS, Tung R, Vaseghi M, Sauer WH, Tzou WS, Mathuria N, Nakahara S, Dickfeldt TM, Lakkireddy D, Bunch TJ, Di Biase L, Natale A, Tholakanahalli V, Tedrow UB, Kumar S, Stevenson WG, Della Bella P, Shivkumar K, Marchlinski FE, Callans DJ. Early Mortality After Catheter Ablation of Ventricular Tachycardia in Patients With Structural Heart Disease. J Am Coll Cardiol. 2017 May 2;69(17):2105-2115. PubMed PMID: 28449770
• Tzou WS, Tung R, Frankel DS, Vaseghi M, Bunch TJ, Di Biase L, Tholakanahalli VN, Lakkireddy D, Dickfeld T, Saliaris A, Weiss JP, Mathuria N, Tedrow U, Afzal MR, Vergara P, Nagashima K, Patel M, Nakahara S, Vakil K, Burkhardt JD, Tseng CH, Natale A, Shivkumar K, Callans DJ, Stevenson WG, Della Bella P, Marchlinski FE, Sauer WH. Ventricular Tachycardia Ablation in Severe Heart Failure: An International Ventricular Tachycardia Ablation Center Collaboration Analysis. Circ Arrhythm Electrophysiol. 2017 Jan;10(1). PubMed PMID: 28082527
• Zipse MM, Tzou WS. Resynchronization Therapy in Cardiac Sarcoidosis and Severe Heart Failure: When Good May Not Be Good Enough. J Cardiovasc Electrophysiol. 2017 Feb;28(2):182-184. PubMed PMID: 27925330
• Zipse MM, Tzou WS. Resynchronization Therapy in Cardiac Sarcoidosis and Severe Heart Failure: When Good May Not Be Good Enough. J Cardiovasc Electrophysiol. 2016 Dec 7. [Epub ahead of print] PubMed PMID: 27925330
• Nguyen DT, Tzou WS, Brunnquell M, Zipse M, Schuller JL, Zheng L, Aleong RA, Sauer WH. Clinical and biophysical evaluation of variable bipolar configurations during radiofrequency ablation for treatment of ventricular arrhythmias. Heart Rhythm. 2016 Nov;13(11):2161-2171. PubMed PMID: 27424078
• Frankel DS, Tung R, Santangeli P, Tzou WS, Vaseghi M, Di Biase L, Nagashima K, Tedrow U, Bunch TJ, Tholakanahalli VN, Dendi R, Reddy M, Lakkireddy D, Dickfeld T, Weiss JP, Mathuria N, Vergara P, Patel M, Nakahara S, Vakil K, Sauer WH, Callans DJ, Natale A, Stevenson WG, Della Bella P, Shivkumar K, Marchlinski FE. Sex and Catheter Ablation for Ventricular Tachycardia: An International Ventricular Tachycardia Ablation Center Collaborative Group Study. JAMA Cardiol. 2016 Nov 1;1(8):938-944. PubMed PMID: 27556589
• Flint K, Tzou WS. Pacing-Induced Cardiomyopathy: "It's Tough to Make Predictions, Especially About the Future"*. J Cardiovasc Electrophysiol. 2016 Oct;27(10):1180-1182. PubMed PMID: 27502329
• Nguyen DT, Tzou WS, Zheng L, Barham W, Schuller JL, Shillinglaw B, Quaife RA, Sauer WH. Enhanced Radiofrequency Ablation With Magnetically Directed Metallic Nanoparticles. Circ Arrhythm Electrophysiol. 2016 May;9(5). PubMed PMID: 27162034
• Gonzalez JE, Tzou W, Sauer WH, Nguyen DT. Ventricular Tachycardia in a Patient with Biventricular Noncompaction. Card Electrophysiol Clin. 2016 Mar;8(1):139-44. PubMed PMID: 26920182

Professional Memberships

• Heart Rhythm Society (HRS), Fellow
• American College of Cardiology, Fellow
• American Heart Association (AHA), Member