Liudmila Kulik, PhD

Publications

• Whelan R, Feemster A, Laskowski J, Renner B, Kulik L, Poppelaars F, Lee C, Holers VM, Thurman JM. Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury. J Immunol. 2023 Oct 15;211(8):1240-1248. PubMed PMID: 37682538
• Renner B, Poppelaars F, Laskowski J, Serkova NJ, Kulik L, Holers VM, Thurman JM. Noninvasive Detection of iC3b/C3d Deposits in the Kidney Using a Novel Bioluminescent Imaging Probe. J Am Soc Nephrol. 2023 Jul 1;34(7):1151-1154. PubMed PMID: 36995143
• Kulik L., Renner B., Laskowski J., Thurman J.M., Holers V.M. Highly pathogenic natural monoclonal antibody B4-IgM recognizes a post-translational modification comprised of acetylated N-terminal methionine followed by aspartic or glutamic acid. Mol Immunol. PMID: 37018938
• Gordon L, Mabbott N, Wells J, Kulik L, Juleff N, Charleston B, Perez-Martin E. Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1). PLoS Pathog. 2022 May;18(5):e1009942. PubMed PMID: 35512014
• Trachtman H, Laskowski J, Lee C, Renner B, Feemster A, Parikh S, Panzer SE, Zhong W, Cravedi P, Cantarelli C, Kulik L, You Z, Satchell S, Rovin B, Liu F, Kalled SL, Holers VM, Jalal D, Thurman JM. Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F505-F516. PubMed PMID: 34459222
• Li C, Patel K, Tu Z, Yang X, Kulik L, Alawieh A, Allen P, Cheng Q, Wallace C, Kilkenny J, Kwon J, Gibney B, Cantu E, Sharma A, Pipkin M, Machuca T, Emtiazjoo A, Goddard M, Holers VM, Nadig S, Christie J, Tomlinson S, Atkinson C. A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Am J Transplant. 2021 Jun;21(6):2067-2078. PubMed PMID: 33210808
• Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Insights Into the Structure-Function Relationships of Dimeric C3d Fragments. Front Immunol. 2021;12:714055. PubMed PMID: 34434196
• Banda NK, Tomlinson S, Scheinman RI, Ho N, Ramirez JR, Mehta G, Wang G, Vu VP, Simberg D, Kulik L, Holers VM. C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice. Front Immunol. 2020;11:575154. PubMed PMID: 33178202
• Li C, Patel K, Tu Z, Yang X, Kulik L, Alawieh A, Allen P, Cheng Q, Wallace C, Kilkenny J, Kwon J, Gibney B, Cantu E, Sharma A, Pipkin M, Machuca T, Emtiazjoo A, Goddard M, Holers VM, Nadig S, Christie J, Tomlinson S, Atkinson C. A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. Am J Transplant. 2020 Nov 19. [Epub ahead of print] PubMed PMID: 33210808
• Kulik L, Laskowski J, Renner B, Woolaver R, Zhang L, Lyubchenko T, You Z, Thurman JM, Holers VM. Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus. J Immunol. 2019 Dec 15;203(12):3136-3147. PubMed PMID: 31732528
• He YG, Pappworth IY, Rossbach A, Paulin J, Mavimba T, Hayes C, Kulik L, Holers VM, Knight AM, Marchbank KJ. A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice. Immunobiology. 2018 Jan;223(1):125-134. PubMed PMID: 29017821
• Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 May;48(5):791-802. PubMed PMID: 29389016
• He YG, Pappworth IY, Rossbach A, Paulin J, Mavimba T, Hayes C, Kulik L, Holers VM, Knight AM, Marchbank KJ. Immunobiology. 2018 Jan;223(1):125-134 A novel C3d-containing oligomeric vaccine provides insight into the viability of testing human C3d-based vaccines in mice.
• Narang A, Qiao F, Atkinson C, Zhu H, Yang X, Kulik L, Holers VM, Tomlinson S. J Neuroinflammation. 2017 Jun 19;14(1):120 Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.
• Holers VM, Tomlinson S, Kulik L, Atkinson C, Rohrer B, Banda N, Thurman JM. New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities. Semin Immunol. 2016 Jun;28(3):260-7. PubMed PMID: 27282113
• International Complement Workshop. Treatment of a Murine Model of Human Lupus with a mAb that Blocks Binding of C3d to Receptors Decreases Anti-DNA Autoantibodies and Proteinuria: Implications for the CR2:C3d Interaction as a Therapeutic Target in Lupus/Autoimmune Diseases
• ALR. Treatment of MRL/lpr mice with a mAb blocking binding of C3d to its receptors decreases anti-DNA autoantibodies and proteinuria: support for targeting the CR2:C3d interaction as a therapeutic strategy in SLE
• LUPUS 21st century. Treatment of MRL/lpr Mice with a mAb Blocking Binding of C3d to Its Receptors Decreases Anti-DNA Autoantibodies and Proteinuria: Support for Targeting the CR2:C3d Interaction as a Therapeutic Strategy in SLE
• Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney Int. 2015 Sep;88(3):528-37. PubMed PMID: 25945405
• Atkinson C, Qiao F, Yang X, Zhu P, Reaves N, Kulik L, Goddard M, Holers VM, Tomlinson S. Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 2015 Mar 31;131(13):1171-80. PubMed PMID: 25825397
• Kulik L, Hewitt FB, Willis VC, Rodriguez R, Tomlinson S, Holers VM. A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease. Mol Immunol. 2015 Feb;63(2):479-88. PubMed PMID: 25457881
• Neher MD, Rich MC, Keene CN, Weckbach S, Bolden AL, Losacco JT, Patane J, Flierl MA, Kulik L, Holers VM, Stahel PF. Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury. J Neuroinflammation. 2014 May 24;11:95. PubMed PMID: 24885042
• IgM Contributes to Glomerular Injury in FSGS Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanovic D, Holers VM, Thurman JM. J Am Soc Nephrol. 2013
• Detection of complement activation using epitope-specific monoclonal antibodies to C3d. J. M. Thurman, L. Kulik, H.Orth, M.Wong, B. Renner, S. A. Sargsyan, L. M. Mitchell, D. E. Hourcade, J.P. Hannan, J. M. Kovacs, B. Coughlin, A. S. Woodell, M. C. Pickering, B. Rohrer, V. M. Holers. JCI.
• Oxidative Stress Sensitizes RPE Cells To Complement-Mediated Injury In A Natural Antibody-, Lectin Pathway- And Phospholipid Epitope-Dependent Manner. K. Joseph, L. Kulik, B.Coughlin, M. Bandyopadhyay, K. Kunchithapautham, S. Thiel, N.M. Thielens, V. M. Holers, and B. Rohrer, JBC
• Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun;24(7):1063-72. PubMed PMID: 23641055
• Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013 May 1;123(5):2218-30. PubMed PMID: 23619360
• Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J Biol Chem. 2013 May 3;288(18):12753-65. PubMed PMID: 23493397
• Novel mouse anti-mouse monoclonal antibodies that block either the ligand or receptor member of the CR2-C3d interaction pair impair antigen-specific humoral immune responses to model antigens. Liudmila Kulik1, Joshua M. Thurman1, Jonathan P. Hannan1, Stephen Tomlinson2, V. Michael Holers. XXIV International Complement Workshop
• 1. Weckbach S., Neher M., Losacco J., Bolden A., Kulik L., Flierl M., Bell S., Holers VM., Stahel P. Challenging the role of adaptive immunity in neurotrauma: Rag1-/- mice lacking mature B and T cells do not show neuroprotection after closed head injury. J Neurotrauma. 2012, in press
• 2. Elvington A, Atkinson C, Kulik L, Zhu H, Yu J, Kindy MS, Holers VM, Tomlinson S. Pathogenic Natural antibodies propagate cerebral injury following ischemic stroke in mice.. J Immunol. 2012;.188: 1460-1468
• 3. Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM. N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis., J Immunol. 2011; 186:4396-4404
• Kulik L, Chen K, Huber BT, Holers VM. Human complement receptor type 2 (CR2/CD21) transgenic mice provide an in vivo model to study immunoregulatory effects of receptor antagonists.Mol Immunol. 2011 Mar;48(6-7):883-94.
• Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM.N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis.J Immunol. 2011 Feb 23
• Renner B, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Botto M, Takahashi K, Stahl GL, Carroll MC, Holers VM, and Thurman JM. B Cell Subsets Contribute to Both Renal Injury and Renal Protection after Ischemia/Reperfusion- Submitted
• Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion., J Immunol. 2010 Oct 1;185(7):4393-400
• I.Y.Pappworth, L.Kulik, C.Haluszczak, J.W.Reuter, V.M.Holers and K.J.Marchbank. Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21).Mol Immunol. In press
• L.Kulik, S.D.Fleming, C.Moratz, J.W.Reuter, A.Novikov, K.Chen, K.A.Andrews, A.Markaryan, R.J.Quigg, G.J.Silverman¶, G.C.Tsokos and V.M.Holers. Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury. J.Immun. Accepted
• Twohig JP, Pappworth IY, Sivasankar B, Kulik L, Bull M, Holers VM, Wang EC, Marchbank KJ. Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice. Mol Immunol. 2009
• 2 Twohig J., Kulik L., Haluszczak C., ReuterJ., Rossbach A., Bull M., Holers V.M., and Marchbank K.J. Defective B cell ontogeny and immune response in human complement receptor 2 (CR2, CD21). transgenic mice is partially recovered in the absence of C3. Mol Immunol. 2007, 44:3434-44.