Janine Higgins, PhD
Professor, Medicine-Admin Research

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Graduate School :
  • PhD, University of Sydney (1995)
Languages: English
Department: Medicine-Admin Research


  • Cox RC, Blumenstein AB, Burke TM, Depner CM, Guerin MK, Hay-Arthur E, Higgins J, Knauer OA, Lanza SM, Markwald RR, Melanson EL, McHill AW, Morton SJ, Ritchie HK, Smith MR, Smits AN, Sprecher KE, Stothard ER, Withrow D, Wright KP Jr. Distribution of dim light melatonin offset (DLMOff) and phase relationship to waketime in healthy adults and associations with chronotype. Sleep Health. 2023 Sep 28. [Epub ahead of print] PubMed PMID: 37777359
  • Hernandez TL, Farabi SS, Fosdick BK, Hirsch N, Dunn EZ, Rolloff K, Corbett JP, Haugen E, Marden T, Higgins J, Friedman JE, Barbour LA. Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Mellitus Results in Similar Newborn Adiposity. Diabetes Care. 2023 Nov 1;46(11):1931-1940. PubMed PMID: 37643311
  • Ghosh T, McCrory MA, Marden T, Higgins J, Anderson AK, Domfe CA, Jia W, Lo B, Frost G, Steiner-Asiedu M, Baranowski T, Sun M, Sazonov E. I2N: image to nutrients, a sensor guided semi-automated tool for annotation of images for nutrition analysis of eating episodes. Front Nutr. 2023;10:1191962. PubMed PMID: 37575335
  • Breit M, Padia J, Marden T, Forjan D, Zhaoxing P, Zhou W, Ghosh T, Thomas G, McCrory MA, Sazonov E, Higgins J. The spectrum of eating environments encountered in free living adults documented using a passive capture food intake wearable device. Front Nutr. 2023;10:1119542. PubMed PMID: 37252243
  • Gandica R, Weinstock RS, Gunaratne M, Arslanian S, Doherty L, Geffner ME, Laffel L, Higgins J. Long-Term Retention of Young Adult Study Participants with Youth-Onset Type 2 Diabetes: Results from the TODAY2 Study. Horm Res Paediatr. 2023;96(3):325-331. PubMed PMID: 36412631
  • Doulah A, Ghosh T, Hossain D, Marden T, Parton JM, Higgins JA, McCrory MA, Sazonov E. Energy intake estimation using a novel wearable sensor and food images in a laboratory (pseudo-free-living) meal setting: quantification and contribution of sources of error. Int J Obes (Lond). 2022 Nov;46(11):2050-2057. PubMed PMID: 36192533
  • Rynders CA, Bowen AE, Cooper E, Brinton JT, Higgins J, Nadeau KJ, Wright KP Jr, Simon SL. A Naturalistic Actigraphic Assessment of Changes in Adolescent Sleep, Light Exposure, and Activity Before and During COVID-19. J Biol Rhythms. 2022 Sep 20;:7487304221123455. [Epub ahead of print] PubMed PMID: 36124632
  • Simon SL, Pan Z, Marden T, Zhou W, Ghosh T, Hossain D, Thomas JG, McCrory MA, Sazonov E, Higgins J. Body mass index and variability in meal duration and association with rate of eating. Front Nutr. 2022;9:941001. PubMed PMID: 35958246
  • Pan Z, Forjan D, Marden T, Padia J, Ghosh T, Hossain D, Thomas JG, McCrory MA, Sazonov E, Higgins JA. Improvement of Methodology for Manual Energy Intake Estimation From Passive Capture Devices. Front Nutr. 2022;9:877775. PubMed PMID: 35811954
  • Higgins J, Zeitler P, Drews KL, Arslanian S, Copeland K, Goland R, Klingensmith G, Lipman TH, Tollefsen S. ZnT8 autoantibody prevalence is low in youth with type 2 diabetes and associated with higher insulin sensitivity, lower insulin secretion, and lower disposition index. J Clin Transl Endocrinol. 2022 Sep;29:100300. PubMed PMID: 35601597
  • Elizabeth A. Wellberg, Karen A. Corleto, L. Allyson Checkley, Sonali Jindal, Ginger Johnson, Janine A. Higgins, Sarina Obeid, Steven M. Anderson, Ann D. Thor, Pepper J. Schedin, Paul S. MacLean, Erin D. Giles Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer (2022) Breast Cancer Res. 24: 42. PMCID: PMC9208221
  • Long-term Outcomes Among Young Adults With Type 2 Diabetes Based on Durability of Glycemic Control: Results From the TODAY Cohort Study. Diabetes Care. 2022 Nov 1;45(11):2689-2697. PubMed PMID: 36190810
  • Depner CM, Rice JD, Tussey EJ, Eckel RH, Bergman BC, Higgins JA, Melanson EL, Kohrt WM, Wright KP Jr, Swanson CM. Bone turnover marker responses to sleep restriction and weekend recovery sleep. Bone. 2021 Nov;152:116096. PubMed PMID: 34216838
  • Depner CM, Melanson EL, Eckel RH, Higgins JA, Bergman BC, Perreault L, Knauer OA, Birks BR, Wright KP Jr. Effects of ad libitum food intake, insufficient sleep and weekend recovery sleep on energy balance. Sleep. 2021 Jun 1. [Epub ahead of print] PubMed PMID: 34059916
  • Armstrong AJS, Quinn K, Fouquier J, Li SX, Schneider JM, Nusbacher NM, Doenges KA, Fiorillo S, Marden TJ, Higgins J, Reisdorph N, Campbell TB, Palmer BE, Lozupone CA. Systems Analysis of Gut Microbiome Influence on Metabolic Disease in HIV-Positive and High-Risk Populations. mSystems. 2021 May 18;6(3). PubMed PMID: 34006628
  • Presby DM, Rudolph MC, Sherk VD, Jackman MR, Foright RM, Jones KL, Houck JA, Johnson GC, Higgins JA, Neufer PD, Eckel RH, MacLean PS. Lipoprotein Lipase Overexpression in Skeletal Muscle Attenuates Weight Regain by Potentiating Energy Expenditure. Diabetes. 2021 Apr;70(4):867-877. PubMed PMID: 33536195
  • Simon SL, Higgins J, Melanson E, Wright KP Jr, Nadeau KJ. A Model of Adolescent Sleep Health and Risk for Type 2 Diabetes. Curr Diab Rep. 2021 Jan 15;21(2):4. PubMed PMID: 33449241
  • Patrick A. Flume, Elie F. Berbari, Laura Viera, Rachel Hess, Janine Higgins, Jennifer Armstrong, Linda Rice, Laura True, Reza Shaker, John B. Buse and Reynold A. Panettieri Jr. (2021) Managing the risks and benefits of clinical research in response to a pandemic. Journal of Clinical and Translational Science , Volume 5, 2021 , e105 DOI: https://doi.org/10.1017/cts.2021.14
  • Jennifer Armstrong, Alison Lakin, Laurie Blumberg-Romero, Thomas Campbell, John Heldens, Christopher Lieu, Jenae Neiman, Erin Sandene, Matthew Steinbeiss, Darcy Thompson, Jason Tregellas, Thomas Flaig, and Janine Higgins (2021) Clinical Research Reactivation During the COVID-19 Pandemic at University of Colorado Anschutz Medical Campus. J Clin Trans Sci
  • How to keep a diet diary: https://www.youtube.com/watch?v=BKKwH9MK9n8&t=66s
  • Fontana JM, Pan Z, Sazonov ES, McCrory MA, Thomas JG, McGrane KS, Marden T, Higgins JA. Reproducibility of Dietary Intake Measurement From Diet Diaries, Photographic Food Records, and a Novel Sensor Method. Front Nutr. 2020;7:99. PubMed PMID: 32760735
  • Stothard ER, Ritchie HK, Birks BR, Eckel RH, Higgins J, Melanson EL, Wright KP Jr, McHill AW. Early Morning Food Intake as a Risk Factor for Metabolic Dysregulation. Nutrients. 2020 Mar 13;12(3). PubMed PMID: 32182981
  • Kaar JL, Schmiege SJ, Drews K, Higgins J, Walders-Abramson N, Isganaitis E, Willi SM, Marcus MD, Zeitler PS, Kelsey MM. Evaluation of the longitudinal change in health behavior profiles across treatment groups in the TODAY clinical trial. Pediatr Diabetes. 2020 Mar;21(2):224-232. PubMed PMID: 31886931
  • Alex Anderson, Megan McCrory, Matilda Steiner-Asiedu, Richard Ansong, Clara Lewis, Tonmoy Ghosh, Janine Higgins, Edward Sazonov (2020) Household Food-Related Assessment Using an Innovative Passive Dietary Assessment Device in Ghana. Curr Dev Nutr. 2020 Jun; 4(Suppl 2): 1157. PMCID: PMC7259030
  • Modou L Jobarteh, Megan A McCrory, Benny Lo, Mingui Sun, Edward Sazonov, Alex K Anderson, Wenyan Jia, Kathryn Maitland, Jianing Qiu, Matilda Steiner-Asiedu, Janine A Higgins, Tom Baranowski, Peter Olupot-Olupot, Gary Frost (2020) Development and Validation of an Objective, Passive Dietary Assessment Method for Estimating Food and Nutrient Intake in Households in Low- and Middle-Income Countries: A Study Protocol. Curr Dev Nutr. 4(2): 020. PMCID: PMC7031207
  • Presby DM, Checkley LA, Jackman MR, Higgins JA, Jones KL, Giles ED, Houck JA, Webb P, Steig AJ, Johnson GC, Rudolph MC, MacLean PS. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 25. [Epub ahead of print] PubMed PMID: 31553623
  • Sherk VD, Jackman MR, Higgins JA, Giles ED, Foright RM, Presby DM, Carpenter RD, Johnson GC, Oljira R, Houck JA, MacLean PS. Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health PostOVX. Med Sci Sports Exerc. 2019 Jul 3. [Epub ahead of print] PubMed PMID: 31274683
  • Dhaliwal R, Shepherd JA, El Ghormli L, Copeland KC, Geffner ME, Higgins J, Levitsky LL, Nadeau KJ, Weinstock RS, White NH. Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study. Diabetes Care. 2019 Aug;42(8):1549-1559. PubMed PMID: 31167889
  • Presby DM, Jackman MR, Rudolph MC, Sherk VD, Foright RM, Houck JA, Johnson GC, Orlicky DJ, Melanson EL, Higgins JA, MacLean PS. Compensation for cold-induced thermogenesis during weight loss maintenance and regain. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E977-E986. PubMed PMID: 30912962
  • Depner CM, Melanson EL, Eckel RH, Snell-Bergeon JK, Perreault L, Bergman BC, Higgins JA, Guerin MK, Stothard ER, Morton SJ, Wright KP Jr. Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep. Curr Biol. 2019 Mar 18;29(6):957-967.e4. PubMed PMID: 30827911
  • Giles ED, Brown IL, MacLean PS, Pan Z, Melanson EL, Heard KJ, Cornier MA, Marden T, Higgins JA. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019 Oct 16;11(10). PubMed PMID: 31623184
  • Farooq M, Doulah A, Parton J, McCrory MA, Higgins JA, Sazonov E. Validation of Sensor-Based Food Intake Detection by Multicamera Video Observation in an Unconstrained Environment. Nutrients. 2019 Mar 13;11(3). PubMed PMID: 30871173
  • Yang X, Doulah A, Farooq M, Parton J, McCrory MA, Higgins JA, Sazonov E. Statistical models for meal-level estimation of mass and energy intake using features derived from video observation and a chewing sensor. Sci Rep. 2019 Jan 10;9(1):45. PubMed PMID: 30631094
  • Liu J, Johnson R, Dillon S, Kroehl M, Frank DN, Tuncil YE, Zhang X, Ir D, Robertson CE, Seifert S, Higgins J, Hamaker B, Wilson CC, Erlandson KM. Among older adults, age-related changes in the stool microbiome differ by HIV-1 serostatus. EBioMedicine. 2019 Feb;40:583-594. PubMed PMID: 30685386
  • Melanson EL, Ritchie HK, Dear TB, Catenacci V, Shea K, Connick E, Moehlman TM, Stothard ER, Higgins J, McHill AW, Wright KP Jr. Daytime bright light exposure, metabolism, and individual differences in wake and sleep energy expenditure during circadian entrainment and misalignment. Neurobiol Sleep Circadian Rhythms. 2018 Jan;4:49-56. PubMed PMID: 29876528
  • Foright RM, Presby DM, Sherk VD, Kahn D, Checkley LA, Giles ED, Bergouignan A, Higgins JA, Jackman MR, Hill JO, MacLean PS. Is regular exercise an effective strategy for weight loss maintenance?. Physiol Behav. 2018 May 1;188:86-93. PubMed PMID: 29382563
  • Sherk VD, Jackman MR, Giles ED, Higgins JA, Foright RM, Presby DM, Johnson GC, Houck JA, Houser JL, Oljira R, MacLean PS. Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function. Physiol Rep. 2017 May;5(10). PubMed PMID: 28533263
  • Kriska A, El Ghormli L, Copeland KC, Higgins J, Ievers-Landis CE, Levitt Katz LE, Trief PM, Wauters AD, Yasuda PM, Delahanty LM. Impact of lifestyle behavior change on glycemic control in youth with type 2 diabetes. Pediatr Diabetes. 2017 Apr 4. [Epub ahead of print] PubMed PMID: 28378429
  • Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, Maclean PS. Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training. Med Sci Sports Exerc. 2017 May;49(5):888-895. PubMed PMID: 28079706
  • Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Lindstrom RC, MacLean PS. Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss. Front Physiol. 2016 Feb 10;7:32. PubMed PMID: 26903882
  • Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, Higgins J, Melanson EL, Wright KP Jr. Morning Circadian Misalignment during Short Sleep Duration Impacts Insulin Sensitivity. Curr Biol. 2015 Nov 16;25(22):3004-10. PubMed PMID: 26549253
  • Thomas EA, Higgins J, Bessesen DH, McNair B, Cornier MA. Usual breakfast eating habits affect response to breakfast skipping in overweight women. Obesity (Silver Spring). 2015 Apr;23(4):750-9. PubMed PMID: 25755093
  • MacLean PS, Higgins JA, Giles ED, Sherk VD, Jackman MR. The role for adipose tissue in weight regain after weight loss. Obes Rev. 2015 Feb;16 Suppl 1:45-54. PubMed PMID: 25614203
  • Fontana JM, Higgins JA, Schuckers SC, Bellisle F, Pan Z, Melanson EL, Neuman MR, Sazonov E. Energy intake estimation from counts of chews and swallows. Appetite. 2015 Feb;85:14-21. PubMed PMID: 25447016
  • Higgins JA. Resistant starch and energy balance: impact on weight loss and maintenance. Crit Rev Food Sci Nutr. 2014;54(9):1158-66. PubMed PMID: 24499148
  • McHill AW, Melanson EL, Higgins J, Connick E, Moehlman TM, Stothard ER, Wright KP Jr. Impact of circadian misalignment on energy metabolism during simulated nightshift work. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17302-7. PubMed PMID: 25404342
  • Walders-Abramson N, Venditti EM, Ievers-Landis CE, Anderson B, El Ghormli L, Geffner M, Kaplan J, Koontz MB, Saletsky R, Payan M, Yasuda P, Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study Group. Relationships among stressful life events and physiological markers, treatment adherence, and psychosocial functioning among youth with type 2 diabetes. J Pediatr. 2014 Sep;165(3):504-508.e1. PubMed PMID: 24948348
  • McHill AW, Melanson EL, Higgins J, Connick E, Moehlman TM, Stothard ER, Wright KP Jr. Impact of circadian misalignment on energy metabolism during simulated nightshift work. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17302-7. PubMed PMID: 25404342
  • Higgins J, Hagman J, Pan Z, MacLean P. Increased physical activity not decreased energy intake is associated with inpatient medical treatment for anorexia nervosa in adolescent females. PLoS One. 2013;8(4):e61559. PubMed PMID: 23637854
  • Higgins JA, Brown IL. Resistant starch: a promising dietary agent for the prevention/treatment of inflammatory bowel disease and bowel cancer. Curr Opin Gastroenterol. 2013 Mar;29(2):190-4. PubMed PMID: 23385525
  • Markwald RR, Melanson EL, Smith MR, Higgins J, Perreault L, Eckel RH, Wright KP Jr. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5695-700. PubMed PMID: 23479616
  • TODAY Study Group, Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, Arslanian S, Cuttler L, Nathan DM, Tollefsen S, Wilfley D, Kaufman F. A clinical trial to maintain glycemic control in youth with type 2 diabetes. N Engl J Med. 2012 Jun 14;366(24):2247-56. PubMed PMID: 22540912
  • Laffel L, Chang N, Grey M, Hale D, Higgins L, Hirst K, Izquierdo R, Larkin M, Macha C, Pham T, Wauters A, Weinstock RS, TODAY Study Group. Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study. Pediatr Diabetes. 2012 Aug;13(5):369-75. PubMed PMID: 22369102
  • Bacha F, Pyle L, Nadeau K, Cuttler L, Goland R, Haymond M, Levitsky L, Lynch J, Weinstock RS, White NH, Caprio S, Arslanian S, TODAY Study Group. Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study. Pediatr Diabetes. 2012 Aug;13(5):376-83. PubMed PMID: 22332798
  • Maahs DM, Higgins J. Is carbohydrate counting enough? Towards perfection or unwanted complexity?. Diabetes Technol Ther. 2012 Jan;14(1):3-5. PubMed PMID: 22066526
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Professional Memberships

  • American Diabetes Association, Member
  • American Society for Nutrition, Member
  • The Obesity Society, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital
Center Affiliations

Specialty Information

  • Pediatric Endocrinology

General Information

Graduate Schools:
  • PhD, University of Sydney (1995)
Download CV
Languages: English
Department: Medicine-Admin Research
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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