Luisa Mestroni, MD

Professor, Medicine-Cardiology

FacultyPhoto

Download CV

Website

Medical School
  • MD, University of Trieste, School of Medicine, Italy (1979)
Undergraduate School
  • BS, University of Trieste, School of Medicine, Italy (1979)
Internship
  • University of Trieste, School of Medicine, Italy (1980)
Residency
  • University of Trieste, School of Medicine, Italy, Cardiology (1980)
Fellowships
  • University of Trieste, School of Medicine, Italy, Interventional Cardiology (1984)
Languages
English, Italian
Department
Medicine-Cardiology

Professional Titles

  • Professor of Medicine/Cardiology
  • Co-Director, Molecular Genetics Program, University of Colorado Cardiovascular Institute
  • Principal Investigator, International Familial Cardiomyopathy Registry

Recognitions

  • 2018 Distinguished Fellowship Award, International Academy of Cardiology (2018)
  • Fondation Leducq Transatlantic Network of Excellence, Fondation Leducq (2014)
    Prestigious International Award to conduct research on inherited arrhythmogenic cardiomyopathies.
  • Academic Achievement Award, Western Society of Clinical Investigation (2014)
  • Permanent Study Section Member, NIH/CRS/CCHF (2011)
    Cardiac Contractility, Hypertrophy, and Failure ( CCHF), from 2011-2017
  • Dean’s Mentoring Award in Recognition of Exemplary Thesis Advising, Graduate School, University of Colorado Health Sciences Center (2005)

Research Interests

My research is dedicated to the study of genetics of heart muscle diseases, called cardiomyopathies. Since 1991, we have collected clinical information and DNA of over 2000 subjects from families with cardiomyopathies, initially in Italy and subsequently in the USA. Data and materials are collected in the International Familial Registry which has been supported by various grants of the NIH, AHA, UN, MDA. Through our researches on the molecular genetics of cardiomyopathies and analysis on genotype-phenotype correlations, several genes and pathways causing heart disease have been investigated in my laboratory, from cytoskeletal and sarcomeric genes, to ion channels. We are interested in the genes causing dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia, left ventricular noncompaction and hypertrophic cardiomyopathy. Our ongoing research has shown that specific genes may have a different prognosis and may suggest different management strategies. Functional studies of mutant cardiomyopathy genes are also performed to evaluate the consequences of the defective proteins on cellular models. We are currently exploring applications of nanotechnology, biophysics and bioengineering to the study of heart function and cardiomyopathies.

Publications

  • Mestroni L,J, Gilbert EM, Lowes BL, Bristow RM. Dilated Cardiomyopathies. In Hurst’s The Heart 12th edition, Fuster VI et al, eds, The McGraw-Hill Companies, Inc., New York 2008, page 803
  • Mestroni L, Miyamoto SD, Taylor, MRG. Genetics of Dilated Cardiomyopathy Conduction Disease. Progress in Pediatric Cardiology 2007;24:3-13.
  • Sinagra G, Di Lenarda A, Moretti M, Mestroni L, Pinamonti B, Perkan A, Salvi A, Pyxaras S, Bussani R, Silvestri F, Camerini F. The challenge of cardiomyopathies in 2007. JCM 2008.
  • Mestroni L,J, Gilbert EM, Lowes BL, Bristow RM. Dilated Cardiomyopathies. In Hurst’s the Heart Manual of Cardiology, 12th edition, Ch. 40. O’Rourke R.A, Walsh R. & Fuster VI, eds., The McGraw-Hill Companies, Inc., New York,
  • Taylor MRG, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek M, Ferguson DA, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Mestroni L. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation 2007; 115;1244-1251
  • Taylor MRG, Ku L, Slavov D, Cavanaugh J, Boucek M, Zhu X, Graw SL, Carniel E, Barnel C, Quan D, Prall RF, Lovell MA, Mierau G, Mandava G, Bristow MR, Towbin JA, Mestroni L. A LAMP2 mutation presenting with dilated cardiomyopathy and a complex phenotype. J Hum Genet 2007;52:830–835
  • Zecchin M, Di Lenarda A, Gregori D, Merlo M, Pivetta A, Vitrella G, Sabbadini G, Mestroni L, Sinagra G. Are non sustained ventricular tachycardias predictive of major arrhythmias in patients with dilated cardiomyopathy on optimal medical treatment ? PACE 2008;31:290-299
  • Amat di San Filippo C, Taylor MRG, Mestroni L, Lorenzo D Botto, Longo N. Cardiomyopathy and carnitine deficiency Molecular Genetics and Metabolism 2008 (in press)
  • Zecchin M, Di Lenarda A, Gregori D, Merlo M, Pivetta A, Vitrella G, Sabbadini G, Mestroni L, Sinagra G. Are non sustained ventricular tachycardias predictive of major arrhythmias in patients with dilated cardiomyopathy on optimal medical treatment ? PACE 2008; 31:290–299
  • Amat di San Filippo C, Taylor MRG, Mestroni L, Lorenzo D Botto, Longo N. Cardiomyopathy and carnitine deficiency. Molecular Genetics and Metabolism 2008;94:162-6.
  • Mestroni L, Taylor MRG. Lamin A/C gene and the heart: how genetics may impact clinical care (Invited Editorial). J Am Coll Cardiol 2008;52:1261-2.
  • Taylor MRG, Slavov D, Humphrey K, Zhao L, Cockroft J, Zhu X, Lavori P, Bristow MR, Mestroni L, Lazzeroni L. A pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure. Pharmacogenomics & Genomics 2009;19:35-43
  • Hershberger RE, Lindenfeld J, Mestroni L, Seidman CE, Taylor MR, Tobwin JR. Genetic Evaluation of Cardiomyopathy: A HFSA Comprehensive Heart Failure Practice Guideline. Journal of Cardiac Failure 2009;15(2):83-97
  • Sinagra G, Di Lenarda A, Moretti M, Mestroni L, Pinamonti B, Perkan A, Salvi A, Pyxaras S, Bussani R, Silvestri F, Camerini F. The challenge of cardiomyopathies in 2007. Journal of Cardiovascular Medicine 2008, 9:545–554
  • Mestroni L,J, Gilbert EM, Lowes BL, Bristow RM. Dilated Cardiomyopathies. In Hurst’s the Heart Manual of Cardiology, 12th edition, Ch. 40. O’Rourke R.A, Walsh R. & Fuster VI, eds., The McGraw-Hill Companies, Inc., New York, 2008
  • Mestroni L. Mechanisms and genetics in Adult Cardiomyopathies: whats new? Menarini Foundation Symposia "HEART FAILURE AND CARDIOMYOPATHIES 2009 CONTROVERSIAL ISSUES", Trieste, Italy
  • Taylor MRG, Slavov D, Humphrey K, Zhao L, Cockroft J, Zhu X, Lavori P, Bristow MR, Mestroni L, Lazzeroni L. A pharmacogenetic effect of an endothelin-1 haplotype on response to bucindolol therapy in chronic heart failure. Pharmacogenomics & Genomics 2009;19:35-43.
  • Hershberger RE, Lindenfeld J, Mestroni L, Seidman CE, Taylor MR, Tobwin JR. Genetic Evaluation of Cardiomyopathy: A HFSA Comprehensive Heart Failure Practice Guideline. Journal of Cardiac Failure 2009;15(2):83-97.
  • Mestroni L. Phenotypic heterogeneity of sarcomeric gene mutations: a matter of gain and loss? J Am Coll Cardiol 2009; 54(4):343-5
  • Moretti M, Merlo M, Barbati G, Di Lenarda A, Brun B, Pinamont B, Gregori D, Mestroni L, Sinagra G. Prognostic impact of familial screening in Dilated Cardiomyopathy. Eur J Heart Fail 2010 (in press)
  • Mestroni L, Merlo M, Taylor MRG, Camerini F, Sinagra G. Scompenso cardiaco e terapie personalizzate: dalle malattie monogeniche alla farmacogenomica. [Heart failure and personalized therapies: from monogenic diseases to pharmacogenomics]. In: Conoscere e curare il cuore 2010, F. Prati editor, Edizioni Urban, Saronno 2010, page 313-322
  • Mestroni L,J, Gilbert EM, Lowes BL, Bristow RM. Dilated Cardiomyopathies. In Hurst’s the Heart Manual of Cardiology, 13th edition, Ch. 40. Fuster VI, Walsh R. & Harrington R, eds., The McGraw-Hill Companies, Inc., New York (in press).
  • Mestroni L. Mechanisms And Genetics In Adult Cardiomyopathies: What’s New? Menarini Foundation Symposia "HEART FAILURE AND CARDIOMYOPATHIES 2009 CONTROVERSIAL ISSUES", March 2009, Trieste, Italy
  • Merlo M, Carniel E, Slavov D, Zhu X, Ferguson D, Salcedo E, Cavanaugh J, Sinagra G, Di Lenarda A, Mestroni L, Taylor MRG.  Mutation screening of sarcomere genes MYH7, MYBPC3, LDB3, and TNNT2 in a large cohort of dilated cardiomyopathy families.  American Society of Human Genetics 2009 (Honolulu, HA)
  • oucek D, Jirikowic J, Wells C, Mestroni L, Taylor MRG. Natural history of the Danon disease phenotype in a large affected population. American Society of Human Genetics 2009 (Honolulu, HA)
  • Taylor MRG, Slavov D, Zhu X, Ferguson D, Jirikowic J, Di Lenarda A, Sinagra G, Mestroni L. Barth syndrome is not a common cause of dilated cardiomyopathy in adults. American Society of Human Genetics 2009 (Honolulu, HA)
  • Mestroni L, Merlo M, Carniel E, Slavov D, Zhu X, Ferguson D, Salcedo EE, Cavanaugh J, Di Lenarda A, Sinagra G, Taylor MRG. Mutation Screening Of Sarcomere Genes MYH7, MYBPC3, LDB3, And TNNT2 In A Large Cohort Of Dilated Cardiomyopathy Families. American College of Cardiology 59th Annual Scientific Session Atlanta March 2010
  • Mestroni L, Boucek D, Jirikowic J, Wells C, Taylor MRG. Natural History of the Danon Disease Phenotype in a Large Affected Population. American College of Cardiology 59th Annual Scientific Session Atlanta March 2010
  • Mestroni L, McNair W, Sinagra G, Di Lenarda A, Ferguson D, Salcedo EE, Slavov D, Zhu X, Caldwell J, Taylor MRG. SCN5A Mutations Associated With Dilated Cardiomyopathy Commonly Localize To The Voltagesensing Mechanism. American College of Cardiology 59th Annual Scientific Session Atlanta March 2010.
  • Mestroni L, Merlo M, Taylor MR, Camerini F, Sinagra G. Heart failure and personalized medicine. J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):6-12. PMID: 20814312
  • Moretti M, Merlo M, Barbati G, Di Lenarda A, Brun F, Pinamonti B, Gregori D, Mestroni L, Sinagra G. Prognostic impact of familial screening in dilated cardiomyopathy. Eur J Heart Fail. 2010 Sep;12(9):922-7. Epub 2010 Jun 4. PMID: 20525703
  • 21. Pinamonti B, Dragos AM, Pyxaras SA, Merlo M, Pivetta M, Barbati G, Di Lenarda A, Morgera, T, Mestroni L, Sinagra G. Prognostic predictors in Arrhythmogenic Right Ventricular Cardiomyopathy: results from a 10 year Registry. Eur H J 2011(in publication)
  • 20. Mestroni L,J, Gilbert EM, Lowes BL, Bristow RM. Dilated Cardiomyopathies. In Hurst s the Heart Manual of Cardiology, 13th edition, Ch. 40. Fuster VI, Walsh R. & Harrington R, eds., The McGraw-Hill Companies, Inc., New York, 2010
  • 19. Bortot B, Athanasakis E, Brun F, Rizzotti D, Mestroni L, Sinagra G, Severini GM. High-throughput genotyping robot-assisted method for mutation detection in patients with Hypertrophic Cardiomyopathy. Diagnostic Molecular Pathology (in press)
  • 17. McNair WP, Sinagra G, Taylor MRG, Di Lenarda A, Ferguson DA, Salcedo EE, Slavov D, Zhu X, Caldwell J, Mestroni L. SCN5A Mutations Associate with Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism. J Am Coll Cardiol (in press)
  • Mutation Screening Of Sarcomere Genes MYH7, MYBPC3, LDB3, And TNNT2 In A Large Cohort Of Dilated Cardiomyopathy Families
  • SCN5A Mutations Associated With Dilated Cardiomyopathy Commonly Localize To The Voltage-sensing Mechanism
  • Natural History of the Danon Disease Phenotype in a Large Affected Population
  • AHA-Titin Mutations Cause Arrhythmogenic Right Ventricular Cardiomyopathy
  • 95. Mestroni L, Taylor M. Hearing the Noise: The Challenges of Human Genome Variation in Genetic Testing. Invited Editorial. J Am Coll Cardiol 2011(in press).
  • Bortot B, Athanasakis E, Brun F, Rizzotti D, Mestroni L, Sinagra G, Severini GM. High-throughput genotyping robot-assisted method for mutation detection in patients with Hypertrophic Cardiomyopathy. Diagn Mol Pathol. 2011 Sep;20(3):175-9. PMID: 21817903
  • Mestroni L, Taylor M. Hearing the Noise: The Challenges of Human Genome Variation in Genetic Testing. Invited Editorial. J Am Coll Cardiol. 2011 Jun 7;57(23):2328-9. PMID: 21636033
  • Taylor M, Graw S, Sinagra S, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE,Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, Mestroni L. Titin mutations in arrhythmogenic right ventricular cardiomyopathy: a new player in disease pathogenesis. Circulation. 2011 Aug 23;124(8):876-85. PMID: 21810661
  • Pinamonti B, Dragos AM, Pyxaras SA, Merlo M, Pivetta M, Barbati G, Di Lenarda A, Morgera, T, Mestroni L, Sinagra G. Prognostic predictors in Arrhythmogenic Right Ventricular Cardiomyopathy: results from a 10 year Registry. Eur H J Eur Heart J. 2011;32(9):1105-13. PMID: 21362707
  • Mestroni L, Taylor, MRG. Personalized medicine and heart failure. Discov Med. 2011 Jun;11(61):551-61. PMID: 21712021
  • Taylor MGR, Slavov D, Salcedo EE, Zhu X, Ferguson D, Jirikowic J, Di Lenarda A, Sinagra G, Mestroni L. Tafazzin gene mutations are uncommon causes of dilated cardiomyopathy in adults. Cardiogenetics 2011.e4
  • Herman DS, Lam L, Taylor MRG, Wang L, Conner L, Teekakirikul P, DePalma SR, McDonough B, Sparks E, Lin Teodorescu D, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncation of sarcomeric titin: a common cause of dilated cardiomyopathy. New Eng J Med 2012;366:619-28. PMID: 22335739
  • Miani D, Taylor, M, Mestroni L, D’Aurizio F, Finato N, Fanin, M, Brigido S, Proclemer A. Sudden Death Associated With Danon Disease In Women. Am J Cardiol. 2012 Feb 1;109(3):406-11. PMID: 22074992.
  • Herman DS, Lam L, Taylor MRG, Wang L, Bos JM, Ackerman MJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Structural mutations of the sarcomere protein titin are a common cause of dilated cardiomyopathy. ASCI / AAP Chicago 2011
  • Steckman D, Schneider P, Schuller JL, Varosy PD, Aleong RG, Nguyen DT, Mestroni L, Sauer WH. Cardiac MRI findings can be used to Differentiate Arrhythmogenic Right Ventricular Cardiomyopathy from Cardiac Sarcoidosis. AHA Scientific Sessions Orlando 2011
  • Brun F, Taylor MRG, Pinamonti B, Sinagra G, Mestroni L. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: novel insights in a life-threatening disorder. In: Proceedings (N723) of the 16th World Congress on Heart Disease (July 23-26, 2011, Vancouver).
  • Mestroni L. Genomic prediction of individual drug response. In: Heart and Metabolism no. 55 - New Therapeutic Approaches, Marber & Marzilli editors, Springer Verlag France 2012 (in press)
  • Sinagra G, Mestroni L, Camerini F. Genetic cardiomyopathies. Springer Heidelberg, New York. 2012
  • Herman DS, Lam L, Taylor MRG, Wang L, Conner L, Teekakirikul P, DePalma SR, McDonough B, Sparks E, Lin Teodorescu D, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncation of sarcomeric titin: a common cause of dilated cardiomyopathy. New Eng J Med 2012;366:619-28. PMID: 22335739
  • Miani D, Taylor, M, Mestroni L, D’Aurizio F, Finato N, Fanin, M, Brigido S, Proclemer A. Sudden Death Associated With Danon Disease In Women. Am J Cardiol. 2012 Feb 1;109(3):406-11. PMID: 22074992
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes promote growth and spontaneous electrical activity in cultured cardiac myocytes. Nano Letters 2012;12(4):1831-8. PMID: 22432413
  • Steckman DA, Schneider LM, Schuller JL, Aleong RG, Nguyen DT, Sinagra G, Vitrella G, Brun F, Cova, MA, Pagnan L, Mestroni L, Varosy PD, Sauer WH. Utility of Cardiac Magnetic Resonance Imaging to Differentiate Cardiac Sarcoidosis from Arrhythmogenic Right Ventricular Cardiomyopathy. American Journal of Cardiology 2012; 110(4):575-9. PMID: 22595349
  • Fabris E, Brun F, Porto AG, Losurdo P, Vitali Serdoz L, Zecchin M, Severini GM, Mestroni L, Di Chiara A, Sinagra G. Cardiac Hypertrophy, Accessory Pathway and Conduction System Disease in an Adolescent: the PRKAG2 Cardiac Syndrome. J Am Coll Cardiol 2013 (in press)
  • Codan B, Maggiolino S, Martinelli V, Mestroni L, Sbaizero O. Influence of different fixation reagents on NIH 3T3 fibroblasts morphology: an AFM study. Applied Cell Biology 2012 (in press)
  • Mestroni L, Taylor MR. Genetics and genetic testing of dilated cardiomyopathy: a new perspective. Discov Med 15(80):43-49, 2013. PMID: 23375013
  • Brun F, Taylor MRG, Pinamonti B, Sinagra G, Mestroni L. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: novel insights in a life-threatening disorder. In: “New frontiers in heart Disease”, Kimchi A. ed., Proceedings of the 16th World Congress on Heart Disease of the International Academy of Cardiology (Vancouver, CA, July 23-26, 2011). Medimond, Bologna (Italy) 2012, page 223-230. ISBN:978-88-7587-652-4
  • Mestroni L. Genomic prediction of individual drug response. Heart Metab 2012;55:18-24. ISSN: 1566-0338
  • B. Codan, L. Mestroni, O. Sbaizero. Grafting of Pluronic F127 to pyrolytic carbon surfaces using UV radiation. NanotechItaly 2012
  • O. Sbaizero, B. Codan, V. Martinelli, D. Slavov, C. Long, L. Mestroni, M.R.G. Taylor. Mechanical properties of cells with laminopathies: an AFM study. Nanotech Italy 2012
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes as a synthetic substrate for in vitro physiological heart tissue engineering. Frontiers in Cardiac and Vascular Regeneration, 2012, Trieste (Italy) May 2012, page 78
  • Steckman DA, Schneider PM, Schuller JL, Aleong RG, Nguyen DT, Sinagra G, Vitrella G, Brun F, Cova MA, Pagnan L, Mestroni L, Varosy PD, Sauer WH. Heart Rhythm Society, Boston 2012
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes for physiological heart tissue engineering. Florence Cardiomyopathies 2012, Florence Italy 2012
  • Mestroni L, Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L. Carbon Nanotubes Instruct Physiological Growth and Functionally Mature Syncytia: Non-Genetic Engineering of Cardiac Myocytes. American College of Cardiology 62nd Annual Scientific Session, San Francisco, CA, March 11, 2013
  • Mestroni Campbell N, Sinagra G, Jones K, Slavov D, Gowan K, Merlo M, Carniel E, Fain P, Aragona P, Di Lenarda A, Taylor MRG, Whole Exome Sequencing Identifies a Troponin T Mutation Hot Spot in Familial Dilated Cardiomyopathy. American College of Cardiology 62nd Annual Scientific Session, San Francisco, CA, March 11, 2013
  • Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR. Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy. J Cell Physiol. 2014 Mar 13. [Epub ahead of print] PubMed PMID: 24623017
  • Mestroni L, Nguyen DT. Inhibition of Proto-Oncogene c-Src Tyrosine Kinase: Toward a New Antiarrhythmic Strategy?. J Am Coll Cardiol. 2014 Mar 11;63(9):935-7. PubMed PMID: 24412447
  • Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA, American Heart Association Council on Functional Genomics and Translational Biology, American Heart Association Council on Epidemiology and Prevention, American Heart Association Council on Basic Cardiovascular Sciences, American Heart Association Council on Cardiovascular Disease in the Young, American Heart Association Council on Cardiovascular and Stroke Nursing, American Heart Association Stroke Council. Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. Circulation. 2013 Dec 24;128(25):2813-51. PubMed PMID: 24297835
  • Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA, American Heart Association Council on Functional Genomics and Translational Biology, American Heart Association Council on Epidemiology and Prevention, American Heart Association Council on Basic Cardiovascular Sciences, American Heart Association Council on Cardiovascular Disease in the Young, American Heart Association Council on Cardiovascular and Stroke Nursing, American Heart Association Stroke Council. Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association. Circulation. 2013 Dec 24;128(25):2813-51. PubMed PMID: 24297835
  • Campbell N, Sinagra G, Jones KL, Slavov D, Gowan K, Merlo M, Carniel E, Fain PR, Aragona P, Di Lenarda A, Mestroni L, Taylor MR. Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy. PLoS One. 2013;8(10):e78104. PubMed PMID: 24205113
  • Merlo M, Sinagra G, Carniel E, Slavov D, Zhu X, Barbati G, Spezzacatene A, Ramani F, Salcedo E, Di Lenarda A, Mestroni L, Taylor MR, Familial Cardiomyopathy Registry. Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy. Clin Transl Sci. 2013 Dec;6(6):424-8. PubMed PMID: 24119082
  • Martinelli V, Cellot G, Fabbro A, Bosi S, Mestroni L, Ballerini L. Improving cardiac myocytes performance by carbon nanotubes platforms. Front Physiol. 2013;4:239. PubMed PMID: 24027533
  • Fabris E, Brun F, Porto AG, Losurdo P, Vitali Serdoz L, Zecchin M, Severini GM, Mestroni L, Di Chiara A, Sinagra G. Cardiac hypertrophy, accessory pathway, and conduction system disease in an adolescent: the PRKAG2 cardiac syndrome. J Am Coll Cardiol. 2013 Aug 27;62(9):e17. PubMed PMID: 23810891
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes instruct physiological growth and functionally mature syncytia: nongenetic engineering of cardiac myocytes. ACS Nano. 2013 Jul 23;7(7):5746-56. PubMed PMID: 23734857
  • Codan B, Martinelli V, Mestroni L, Sbaizero O. Atomic force microscopy of 3T3 and SW-13 cell lines: an investigation of cell elasticity changes due to fixation. Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3303-8. PubMed PMID: 23706214
  • Mestroni L, Taylor MR. Genetics and genetic testing of dilated cardiomyopathy: a new perspective. Discov Med. 2013 Jan;15(80):43-9. PubMed PMID: 23375013
  • Mestroni L, Begay R, Graw SL, Taylor MR. Pharmacogenetics of Heart Failure. Curr Opin Cardiol 2014 (in press)
  • Mestroni L, Brun F, Spezzacatene A, Sinagra G, Taylor MR. Chapter 19. Arrhythmogenic right ventricular cardiomyopathy (ARVC). In Right ventricule in Health and Disease, Voelkel NF & Schranz D eds. Springer Science
  • Brun F, Mestroni L, Sinagra G. [Molecular genetic testing according to the latest European guidelines on hypertrophic cardiomyopathy]. G Ital Cardiol (Rome). 2015 Mar;16(3):138-42. PubMed PMID: 25837456
  • Sbaizero O, DelFavero G, Martinelli V, Long CS, Mestroni L. Analysis of long- and short-range contribution to adhesion work in cardiac fibroblasts: an atomic force microscopy study. Mater Sci Eng C Mater Biol Appl. 2015 Apr;49:217-24. PubMed PMID: 25686942
  • Mestroni L, Brun F, Spezzacatene A, Sinagra G, Taylor MR. GENETIC CAUSES OF DILATED CARDIOMYOPATHY. Prog Pediatr Cardiol. 2014 Dec;37(1-2):13-18. PubMed PMID: 25584016
  • Ho CY, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy AM, Cirino AL, Abraham TP, Taylor M, Mestroni L, Bluemke DA, Jarolim P, Shi L, Sleeper LA, Seidman CE, Orav EJ. The Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers: Findings From the HCMNet Study. JAMA Cardiol. 2017 Feb 22. [Epub ahead of print] PubMed PMID: 28241245
  • Te Riele AS, Agullo-Pascual E, James CA, Leo-Macias A, Cerrone M, Zhang M, Lin X, Lin B, Sobreira NL, Amat-Alarcon N, Marsman RF, Murray B, Tichnell C, van der Heijden JF, Dooijes D, van Veen TA, Tandri H, Fowler SJ, Hauer RN, Tomaselli G, van den Berg MP, Taylor MR, Brun F, Sinagra G, Wilde AA, Mestroni L, Bezzina CR, Calkins H, Peter van Tintelen J, Bu L, Delmar M, Judge DP. Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis. Cardiovasc Res. 2017 Jan;113(1):102-111. PubMed PMID: 28069705
  • Pinamonti B, Brun F, Mestroni L, Sinagra G. Arrhythmogenic right ventricular cardiomyopathy: From genetics to diagnostic and therapeutic challenges. World J Cardiol. 2014 Dec 26;6(12):1234-44. PubMed PMID: 25548613
  • Begay RL, Tharp CA, Martin A, Graw SL, Sinagra G, Miani D, Sweet ME, Slavov DB, Stafford N, Zeller MJ, Alnefaie R, Rowland TJ, Brun F, Jones KL, Gowan K, Mestroni L, Garrity DM, Taylor MR. FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy. JACC Basic Transl Sci. 2016 Aug;1(5):344-359. PubMed PMID: 28008423
  • Rowland TJ, Graw SL, Sweet ME, Gigli M, Taylor MR, Mestroni L. Obscurin Variants in Patients With Left Ventricular Noncompaction. J Am Coll Cardiol. 2016 Nov 15;68(20):2237-2238. PubMed PMID: 27855815
  • D'souza RS, Levandowski C, Slavov D, Graw SL, Allen LA, Adler E, Mestroni L, Taylor MR. Danon disease: clinical features, evaluation, and management. Circ Heart Fail. 2014 Sep;7(5):843-9. PubMed PMID: 25228319
  • Brun F, Groeneweg JA, Gear K, Sinagra G, van der Heijden J, Mestroni L, Hauer RN, Borgstrom M, Marcus FI, Hughes T. Risk Stratification in Arrhythmic Right Ventricular Cardiomyopathy Without Implantable Cardioverter-Defibrillators. JACC Clin Electrophysiol. 2016 Oct;2(5):558-564. PubMed PMID: 27790640
  • Seriani S, Del Favero G, Mahaffey J, Marko D, Gallina P, Long CS, Mestroni L, Sbaizero O. The cell-stretcher: A novel device for the mechanical stimulation of cell populations. Rev Sci Instrum. 2016 Aug;87(8):084301. PubMed PMID: 27587132
  • Brun F, Barnes CV, Sinagra G, Slavov D, Barbati G, Zhu X, Graw SL, Spezzacatene A, Pinamonti B, Merlo M, Salcedo EE, Sauer WH, Taylor MR, Mestroni L, Familial Cardiomyopathy Registry. Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2014 Oct;51(10):669-76. PubMed PMID: 25157032
  • Gigli M, Begay RL, Morea G, Graw SL, Sinagra G, Taylor MR, Granzier H, Mestroni L. A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies. Front Cardiovasc Med. 2016 Jul 21;3:21. PubMed PMID: 27493940
  • Puggia I, Merlo M, Barbati G, Rowland TJ, Stolfo D, Gigli M, Ramani F, Di Lenarda A, Mestroni L, Sinagra G. Natural History of Dilated Cardiomyopathy in Children. J Am Heart Assoc. 2016 Jun 30;5(7). PubMed PMID: 27364989
  • Cortez D, Graw S, Mestroni L. In Hypertrophic Cardiomyopathy, the Spatial Peaks QRS-T Angle Identifies Those With Sustained Ventricular Arrhythmias. Clin Cardiol. 2016 Aug;39(8):459-63. PubMed PMID: 27175825
  • Nguyen DT, Barham W, Zheng L, Shillinglaw B, Tzou WS, Neltner B, Mestroni L, Bosi S, Ballerini L, Prato M, Sauer WH. Carbon nanotube facilitation of myocardial ablation with radiofrequency energy. J Cardiovasc Electrophysiol. 2014 Dec;25(12):1385-90. PubMed PMID: 25091811
  • Rowland TJ, Sweet ME, Mestroni L, Taylor MR. Danon disease - dysregulation of autophagy in a multisystem disorder with cardiomyopathy. J Cell Sci. 2016 Jun 1;129(11):2135-43. PubMed PMID: 27165304
  • Peña B, Martinelli V, Jeong M, Bosi S, Lapasin R, Taylor MR, Long CS, Shandas R, Park D, Mestroni L. Biomimetic Polymers for Cardiac Tissue Engineering. Biomacromolecules. 2016 May 9;17(5):1593-601. PubMed PMID: 27073119
  • Mohanraj J, Puzzi L, Capria E, Corvaglia S, Casalis L, Mestroni L, Sbaizero O, Fraleoni-Morgera A. Easy fabrication of aligned PLLA nanofibers-based 2D scaffolds suitable for cell contact guidance studies. Mater Sci Eng C Mater Biol Appl. 2016 May;62:301-6. PubMed PMID: 26952427
  • Marcus F, Mestroni L. Family members of patients with ARVC: who is at risk? At what age? When and how often should we evaluate to determine risk?. J Am Coll Cardiol. 2014 Jul 22;64(3):302-3. PubMed PMID: 25034068
  • Codan B, Del Favero G, Martinelli V, Long CS, Mestroni L, Sbaizero O. Exploring the elasticity and adhesion behavior of cardiac fibroblasts by atomic force microscopy indentation. Mater Sci Eng C Mater Biol Appl. 2014 Jul 1;40:427-34. PubMed PMID: 24857511
  • Disertori M, Gulizia MM, Casolo G, Delise P, Di Lenarda A, Di Tano G, Lunati M, Mestroni L, Salerno-Uriarte J, Tavazzi L. Improving the appropriateness of sudden arrhythmic death primary prevention by implantable cardioverter-defibrillator therapy in patients with low left ventricular ejection fraction. Point of view. J Cardiovasc Med (Hagerstown). 2016 Apr;17(4):245-55. PubMed PMID: 26895401
  • Mestroni L, Sweet ME, Taylor MR. Pediatric Cardiomyopathy: New Insight Into Potential Disease Mechanisms. J Am Coll Cardiol. 2016 Feb 9;67(5):526-8. PubMed PMID: 26846951
  • Porto AG, Brun F, Severini GM, Losurdo P, Fabris E, Taylor MR, Mestroni L, Sinagra G. Clinical Spectrum of PRKAG2 Syndrome. Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003121. PubMed PMID: 26729852
  • Mestroni L, Begay RL, Graw SL, Taylor MR. Pharmacogenetics of heart failure. Curr Opin Cardiol. 2014 May;29(3):227-34. PubMed PMID: 24717669
  • Feldman AM, Begay RL, Knezevic T, Myers VD, Slavov DB, Zhu W, Gowan K, Graw SL, Jones KL, Tilley DG, Coleman RC, Walinsky P, Cheung JY, Mestroni L, Khalili K, Taylor MR. Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy. J Cell Physiol. 2014 Nov;229(11):1697-702. PubMed PMID: 24623017
  • Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S. Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. Cardiovasc Res. 2018 Feb 8. [Epub ahead of print] PubMed PMID: 29432544
  • Puzzi L, Borin D, Martinelli V, Mestroni L, Kelsell DP, Sbaizero O. Cellular biomechanics impairment in keratinocytes is associated with a C-terminal truncated desmoplakin: An atomic force microscopy investigation. Micron. 2018 Mar;106:27-33. PubMed PMID: 29291530
  • Mestroni L, Nguyen DT. Inhibition of proto-oncogene c-Src tyrosine kinase: toward a new antiarrhythmic strategy?. J Am Coll Cardiol. 2014 Mar 11;63(9):935-7. PubMed PMID: 24412447
  • Ho JE, Shi L, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy A, Taylor M, Mestroni L, Cirino AL, Sleeper LA, Jarolim P, Lopez B, Gonzalez A, Diez J, Orav EJ, Ho CY. Biomarkers of cardiovascular stress and fibrosis in preclinical hypertrophic cardiomyopathy. Open Heart. 2017;4(2):e000615. PubMed PMID: 29177058
  • Chen SN, Taylor MRG, Mestroni L. Unraveling Missing Genes and Missing Inheritance in Arrhythmogenic Cardiomyopathy. Circ Arrhythm Electrophysiol. 2017 Oct;10(10). PubMed PMID: 29038109
  • Cortez D, Svensson A, Carlson J, Graw S, Sharma N, Brun F, Spezzacatene A, Mestroni L, Platonov PG. Right precordial-directed electrocardiographical markers identify arrhythmogenic right ventricular cardiomyopathy in the absence of conventional depolarization or repolarization abnormalities. BMC Cardiovasc Disord. 2017 Oct 13;17(1):261. PubMed PMID: 29029613
  • McNally EM, Mestroni L. Dilated Cardiomyopathy: Genetic Determinants and Mechanisms. Circ Res. 2017 Sep 15;121(7):731-748. PubMed PMID: 28912180
  • Peña B, Bosi S, Aguado BA, Borin D, Farnsworth NL, Dobrinskikh E, Rowland TJ, Martinelli V, Jeong M, Taylor MRG, Long CS, Shandas R, Sbaizero O, Prato M, Anseth KS, Park D, Mestroni L. Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation. ACS Appl Mater Interfaces. 2017 Sep 20;9(37):31645-31656. PubMed PMID: 28895403
  • D'souza RS, Mestroni L, Taylor MRG. Danon disease for the cardiologist: case report and review of the literature. J Community Hosp Intern Med Perspect. 2017 Mar;7(2):107-114. PubMed PMID: 28638575
  • Dal Ferro M, Stolfo D, Altinier A, Gigli M, Perrieri M, Ramani F, Barbati G, Pivetta A, Brun F, Monserrat L, Giacca M, Mestroni L, Merlo M, Sinagra G. Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy. Heart. 2017 Nov;103(21):1704-1710. PubMed PMID: 28416588
  • Gigli M, Sinagra G, Mestroni L. [Gene therapy in heart failure: the unexpected results from the CUPID 2 trial]. G Ital Cardiol (Rome). 2017 Feb;18(2):101-105. PubMed PMID: 28398363
  • Te Riele AS, Agullo-Pascual E, James CA, Leo-Macias A, Cerrone M, Zhang M, Lin X, Lin B, Sobreira NL, Amat-Alarcon N, Marsman RF, Murray B, Tichnell C, van der Heijden JF, Dooijes D, van Veen TA, Tandri H, Fowler SJ, Hauer RN, Tomaselli G, van den Berg MP, Taylor MR, Brun F, Sinagra G, Wilde AA, Mestroni L, Bezzina CR, Calkins H, Peter van Tintelen J, Bu L, Delmar M, Judge DP. Multilevel analyses of SCN5A mutations in arrhythmogenic right ventricular dysplasia/cardiomyopathy suggest non-canonical mechanisms for disease pathogenesis. Cardiovasc Res. 2017 Jan;113(1):102-111. PubMed PMID: 28069705
  • Ho CY, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy AM, Cirino AL, Abraham TP, Taylor M, Mestroni L, Bluemke DA, Jarolim P, Shi L, Sleeper LA, Seidman CE, Orav EJ. The Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers: Findings From the HCMNet Study. JAMA Cardiol. 2017 Apr 1;2(4):419-428. PubMed PMID: 28241245
  • Parikh VN, Caleshu C, Reuter C, Lazzeroni LC, Ingles J, Garcia J, McCaleb K, Adesiyun T, Sedaghat-Hamedani F, Kumar S, Graw S, Gigli M, Stolfo D, Dal Ferro M, Ing AY, Nussbaum R, Funke B, Wheeler MT, Hershberger RE, Cook S, Steinmetz LM, Lakdawala NK, Taylor MRG, Mestroni L, Merlo M, Sinagra G, Semsarian C, Meder B, Judge DP, Ashley E. Regional Variation in RBM20 Causes a Highly Penetrant Arrhythmogenic Cardiomyopathy. Circ Heart Fail. 2019 Mar;12(3):e005371. PubMed PMID: 30871351
  • Marreddy Cheedipudi S, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet ME, Taylor M, Mestroni L, Cleveland JC, Willerson JT, Gurha P, Marian AJ. Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes is Associated with Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy. Circ Res. 2019 Feb 11. [Epub ahead of print] PubMed PMID: 30739589
  • Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJ. DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 Mar 15;124(6):856-873. PubMed PMID: 30696354
  • Cortez D, Svensson A, Carlson J, Graw S, Sharma N, Brun F, Spezzacatene A, Mestroni L, Platonov PG. The S-wave angle identifies arrhythmogenic right ventricular cardiomyopathy in patients with electrocardiographically concealed disease phenotype. J Electrocardiol. 2018 Nov - Dec;51(6):1003-1008. PubMed PMID: 30497719
  • Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018 Nov 12;19(1):812. PubMed PMID: 30419824
  • Paldino A, De Angelis G, Merlo M, Gigli M, Dal Ferro M, Severini GM, Mestroni L, Sinagra G. Genetics of Dilated Cardiomyopathy: Clinical Implications. Curr Cardiol Rep. 2018 Aug 13;20(10):83. PubMed PMID: 30105555
  • Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
  • Peña B, Laughter M, Jett S, Rowland TJ, Taylor MRG, Mestroni L, Park D. Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci. 2018 Jun;18(6):e1800079. PubMed PMID: 29733514
  • Mestroni L, Sbaizero O. Arrhythmogenic Cardiomyopathy: Mechanotransduction Going Wrong. Circulation. 2018 Apr 10;137(15):1611-1613. PubMed PMID: 29632153
  • Chen SN, Taylor MRG, Mestroni L. Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Genom Precis Med. 2018 Mar;11(3):e002088. PubMed PMID: 29545481
  • Sweet ME, Mestroni L, Taylor MRG. Genetic Infiltrative Cardiomyopathies. Heart Fail Clin. 2018 Apr;14(2):215-224. PubMed PMID: 29525649
  • Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S. Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. Cardiovasc Res. 2018 May 1;114(6):846-857. PubMed PMID: 29432544
  • Puzzi L, Borin D, Martinelli V, Mestroni L, Kelsell DP, Sbaizero O. Cellular biomechanics impairment in keratinocytes is associated with a C-terminal truncated desmoplakin: An atomic force microscopy investigation. Micron. 2018 Mar;106:27-33. PubMed PMID: 29291530
  • Chen SN, Mestroni L, Taylor MRG. Genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2021 May 1;36(3):288-294. PubMed PMID: 33769382
  • Eldemire R, Taylor MRG, Mestroni L. Precision medicine in laminopathies: insights from the REDLAMINA registry. Rev Esp Cardiol (Engl Ed). 2021 Mar;74(3):208-209. PubMed PMID: 33162390
  • Eldemire R, Taylor MRG, Mestroni L. Understanding the role of titin in dilated cardiomyopathy. Int J Cardiol. 2020 Oct 1;316:186-187. PubMed PMID: 32634495
  • Merlo M, Cannatà A, Pio Loco C, Stolfo D, Barbati G, Artico J, Gentile P, De Paris V, Ramani F, Zecchin M, Gigli M, Pinamonti B, Korcova R, Di Lenarda A, Giacca M, Mestroni L, Camici PG, Sinagra G. Contemporary survival trends and aetiological characterization in non-ischaemic dilated cardiomyopathy. Eur J Heart Fail. 2020 Jul;22(7):1111-1121. PubMed PMID: 32452075
  • Finocchiaro G, Merlo M, Sheikh N, De Angelis G, Papadakis M, Olivotto I, Rapezzi C, Carr-White G, Sharma S, Mestroni L, Sinagra G. The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy. Eur J Heart Fail. 2020 Jul;22(7):1097-1107. PubMed PMID: 32243666
  • Borin D, Peña B, Chen SN, Long CS, Taylor MRG, Mestroni L, Sbaizero O. Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C. Heliyon. 2020 Jan;6(1):e03175. PubMed PMID: 32021920
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • Merlo M, Cappelletto C, De Angelis G, Porcari A, Caiffa T, Lardieri G, Pagnan L, Severini GM, Dal Ferro M, Stolfo D, Vitrella G, De Luca A, Korkova R, Massa L, Tavc?ar I, Aleksova A, Barbati G, Zanchi C, Ramani F, Di Lenarda A, Perkan A, Mestroni L, Zecchin M, Pinamonti B, Bussani R, Sinagra G. [Diagnostic work-up and clinical management of cardiomyopathies: the operative protocol from the Cardiothoracovascular Department of Trieste, Italy]. G Ital Cardiol (Rome). 2020 Dec;21(12):935-953. PubMed PMID: 33231213
  • Bui QM, Hong KN, Kraushaar M, Ma GS, Brambatti M, Kahn AM, Bougault C, Boynton K, Mestroni L, Taylor MRG, Adler E. Apical Sparing Strain Pattern in Danon Disease: Insights From a Global Registry. JACC Cardiovasc Imaging. 2020 Dec;13(12):2689-2691. PubMed PMID: 32739374
  • Corrado D, van Tintelen PJ, McKenna WJ, Hauer RNW, Anastastakis A, Asimaki A, Basso C, Bauce B, Brunckhorst C, Bucciarelli-Ducci C, Duru F, Elliott P, Hamilton RM, Haugaa KH, James CA, Judge D, Link MS, Marchlinski FE, Mazzanti A, Mestroni L, Pantazis A, Pelliccia A, Marra MP, Pilichou K, Platonov PGA, Protonotarios A, Rampazzo A, Saffitz JE, Saguner AM, Schmied C, Sharma S, Tandri H, Te Riele ASJM, Thiene G, Tsatsopoulou A, Zareba W, Zorzi A, Wichter T, Marcus FI, Calkins H. Arrhythmogenic right ventricular cardiomyopathy: evaluation of the current diagnostic criteria and differential diagnosis. Eur Heart J. 2020 Apr 7;41(14):1414-1429. PubMed PMID: 31637441
  • Camors EM, Purevjav E, Jefferies JL, Saffitz JE, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JA. Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 Apr;13(2):e002800. PubMed PMID: 32164419
  • Brun F, Gigli M, Graw SL, Judge DP, Merlo M, Murray B, Calkins H, Sinagra G, Taylor MR, Mestroni L, James CA. FLNC truncations cause arrhythmogenic right ventricular cardiomyopathy. J Med Genet. 2020 Apr;57(4):254-257. PubMed PMID: 31924696
  • Borin D, Peña B, Taylor MRG, Mestroni L, Lapasin R, Sbaizero O. Viscoelastic behavior of cardiomyocytes carrying LMNA mutations. Biorheology. 2020;57(1):1-14. PubMed PMID: 32083564
  • Gigli M, Merlo M, Graw SL, Barbati G, Rowland TJ, Slavov DB, Stolfo D, Haywood ME, Dal Ferro M, Altinier A, Ramani F, Brun F, Cocciolo A, Puggia I, Morea G, McKenna WJ, La Rosa FG, Taylor MRG, Sinagra G, Mestroni L. Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 2019 Sep 17;74(11):1480-1490. PubMed PMID: 31514951
  • Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 Nov;16(11):e373-e407. PubMed PMID: 31676023
  • Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM 3rd, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 Nov;16(11):e301-e372. PubMed PMID: 31078652
  • Peña B, Maldonado M, Bonham AJ, Aguado BA, Dominguez-Alfaro A, Laughter M, Rowland TJ, Bardill J, Farnsworth NL, Alegret Ramon N, Taylor MRG, Anseth KS, Prato M, Shandas R, McKinsey TA, Park D, Mestroni L. Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications. ACS Appl Mater Interfaces. 2019 May 22;11(20):18671-18680. PubMed PMID: 31021594
  • Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ. Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy. J Clin Invest. 2019 Jul 2;129(8):3171-3184. PubMed PMID: 31264976
  • Addison J, Taylor MRG, Mestroni L. Genotype-phenotype correlations in ARVC: Toward a precision medicine approach. Int J Cardiol. 2019 Jul 1;286:115-116. PubMed PMID: 30898427
  • Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY. Baseline Characteristics of the VANISH Cohort. Circ Heart Fail. 2019 Dec;12(12):e006231. PubMed PMID: 31813281
  • Tharp CA, Haywood ME, Sbaizero O, Taylor MRG, Mestroni L. The Giant Protein Titin's Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease. Front Physiol. 2019;10:1436. PubMed PMID: 31849696
  • Losurdo P, Stolfo D, Merlo M, Barbati G, Gobbo M, Gigli M, Ramani F, Pinamonti B, Zecchin M, Finocchiaro G, Mestroni L, Sinagra G. Early Arrhythmic Events in Idiopathic Dilated Cardiomyopathy. JACC Clin Electrophysiol. 2016 Oct;2(5):535-543. PubMed PMID: 29759572
  • Disertori M, Gulizia MM, Casolo G, Delise P, Di Lenarda A, Di Tano G, Lunati M, Mestroni L, Salerno-Uriarte JA, Tavazzi L. [Remarks on polyparametric assessment of sudden death risk for primary prevention ICD implantation in patients with left ventricular dysfunction of ischemic and non ischemic etiology. Italian Association of Hospital Cardiologists (ANMCO) Experts Position Paper]. G Ital Cardiol (Rome). 2015 Nov;16(11):651-66. PubMed PMID: 26571481
  • Lanzicher T, Martinelli V, Long CS, Del Favero G, Puzzi L, Borelli M, Mestroni L, Taylor MR, Sbaizero O. AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus. 2015;6(5):394-407. PubMed PMID: 26309016
  • Sweet M, Taylor MR, Mestroni L. Diagnosis, prevalence, and screening of familial dilated cardiomyopathy. Expert Opin Orphan Drugs. 2015;3(8):869-876. PubMed PMID: 27547593
  • Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE. Truncations of titin causing dilated cardiomyopathy. N Engl J Med. 2012 Feb 16;366(7):619-28. PubMed PMID: 22335739
  • Miani D, Taylor M, Mestroni L, D'Aurizio F, Finato N, Fanin M, Brigido S, Proclemer A. Sudden death associated with danon disease in women. Am J Cardiol. 2012 Feb 1;109(3):406-11. PubMed PMID: 22074992
  • Steckman DA, Schneider PM, Schuller JL, Aleong RG, Nguyen DT, Sinagra G, Vitrella G, Brun F, Cova MA, Pagnan L, Mestroni L, Varosy PD, Sauer WH. Utility of cardiac magnetic resonance imaging to differentiate cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy. Am J Cardiol. 2012 Aug 15;110(4):575-9. PubMed PMID: 22595349
  • Martinelli V, Cellot G, Toma FM, Long CS, Caldwell JH, Zentilin L, Giacca M, Turco A, Prato M, Ballerini L, Mestroni L. Carbon nanotubes promote growth and spontaneous electrical activity in cultured cardiac myocytes. Nano Lett. 2012 Apr 11;12(4):1831-8. PubMed PMID: 22432413
  • Bortot B, Athanasakis E, Brun F, Rizzotti D, Mestroni L, Sinagra G, Severini GM. High-throughput genotyping robot-assisted method for mutation detection in patients with hypertrophic cardiomyopathy. Diagn Mol Pathol. 2011 Sep;20(3):175-9. PubMed PMID: 21817903
  • McNair WP, Sinagra G, Taylor MR, Di Lenarda A, Ferguson DA, Salcedo EE, Slavov D, Zhu X, Caldwell JH, Mestroni L. SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism. J Am Coll Cardiol. 2011 May 24;57(21):2160-8. PubMed PMID: 21596231
  • Pinamonti B, Dragos AM, Pyxaras SA, Merlo M, Pivetta A, Barbati G, Di Lenarda A, Morgera T, Mestroni L, Sinagra G. Prognostic predictors in arrhythmogenic right ventricular cardiomyopathy: results from a 10-year registry. Eur Heart J. 2011 May;32(9):1105-13. PubMed PMID: 21362707
  • Mestroni L, Taylor MR. Hearing the noise the challenges of human genome variation in genetic testing. J Am Coll Cardiol. 2011 Jun 7;57(23):2328-9. PubMed PMID: 21636033
  • Mestroni L, Taylor MR. Pharmacogenomics, personalized medicine, and heart failure. Discov Med. 2011 Jun;11(61):551-61. PubMed PMID: 21712021
  • Mestroni L, Merlo M, Taylor MR, Camerini F, Sinagra G. Heart failure and personalized medicine. J Cardiovasc Med (Hagerstown). 2011 Jan;12(1):6-12. PubMed PMID: 20814312
  • Taylor M, Graw S, Sinagra G, Barnes C, Slavov D, Brun F, Pinamonti B, Salcedo EE, Sauer W, Pyxaras S, Anderson B, Simon B, Bogomolovas J, Labeit S, Granzier H, Mestroni L. Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation. 2011 Aug 23;124(8):876-85. PubMed PMID: 21810661
  • MacRae CA, Taylor MRG, Mestroni L, Moses J, Ashley EA, Wheeler MT, Lakdawala NK, Hershberger RE, Sandor V, Saunders ME, Oliver C, Lee PA, Judge DP. Efficacy and Safety of ARRY-371797 in LMNA-Related Dilated Cardiomyopathy: A Phase 2 Study. Circ Genom Precis Med. 2023 Feb;16(1):e003730. PubMed PMID: 36515663
  • Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larrañaga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodríguez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogollón-Jiménez MV, Lopez J, Peña-Peña ML, Garcia-Alvarez A, López-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P. Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 2022 Sep 20;80(12):1115-1126. PubMed PMID: 36109106
  • Chadalawada S, Rassi A Jr, Samara O, Monzon A, Gudapati D, Vargas Barahona L, Hyson P, Sillau S, Mestroni L, Taylor M, da Consolação Vieira Moreira M, DeSanto K, Agudelo Higuita NI, Franco-Paredes C, Henao-Martínez AF. Mortality risk in chronic Chagas cardiomyopathy: a systematic review and meta-analysis. ESC Heart Fail. 2021 Dec;8(6):5466-5481. PubMed PMID: 34716744
  • Castrichini M, Eldemire R, Groves DW, Taylor MR, Miyamoto S, Mestroni L. Clinical and genetic features of arrhythmogenic cardiomyopathy: diagnosis, management and the heart failure perspective. Prog Pediatr Cardiol. 2021 Dec;63. PubMed PMID: 34970070
  • Bui QM, Hong KN, Kraushaar M, Ma GS, Brambatti M, Kahn AM, Battiha CE, Boynton K, Storm G, Mestroni L, Taylor MRG, DeMaria AN, Adler EA. Myocardial Strain and Association With Clinical Outcomes in Danon Disease: A Model for Monitoring Progression of Genetic Cardiomyopathies. J Am Heart Assoc. 2021 Dec 7;10(23):e022544. PubMed PMID: 34845930
  • Cappelletto C, Gregorio C, Barbati G, Romani S, De Luca A, Merlo M, Mestroni L, Stolfo D, Sinagra G. Antiarrhythmic therapy and risk of cumulative ventricular arrhythmias in arrhythmogenic right ventricle cardiomyopathy. Int J Cardiol. 2021 Jul 1;334:58-64. PubMed PMID: 33961942
  • Mueller AC, Piper M, Goodspeed A, Bhuvane S, Williams JS, Bhatia S, Phan AV, Van Court B, Zolman KL, Peña B, Oweida AJ, Zakem S, Meguid C, Knitz MW, Darragh L, Bickett TE, Gadwa J, Mestroni L, Taylor MRG, Jordan KR, Dempsey P, Lucia MS, McCarter MD, Del Chiaro M, Messersmith WA, Schulick RD, Goodman KA, Gough MJ, Greene CS, Costello JC, Neto AG, Lagares D, Hansen KC, Van Bokhoven A, Karam SD. Induction of ADAM10 by Radiation Therapy Drives Fibrosis, Resistance, and Epithelial-to-Mesenchyal Transition in Pancreatic Cancer. Cancer Res. 2021 Jun 15;81(12):3255-3269. PubMed PMID: 33526513
  • Travers JG, Wennersten SA, Peña B, Bagchi RA, Smith HE, Hirsch RA, Vanderlinden LA, Lin YH, Dobrinskikh E, Demos-Davies KM, Cavasin MA, Mestroni L, Steinkühler C, Lin CY, Houser SR, Woulfe KC, Lam MPY, McKinsey TA. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 May 11;143(19):1874-1890. PubMed PMID: 33682427
  • Manca P, Cannatà A, Nuzzi V, Bromage DI, Varrà GG, Rossi M, Dal Ferro M, Paldino A, Gigli M, Barbati G, Ramani F, Pinamonti B, Stolfo D, Porcu M, Mestroni L, Merlo M, Sinagra G. Prevalence and Evolution of Right Ventricular Dysfunction Among Different Genetic Backgrounds in Dilated Cardiomyopathy. Can J Cardiol. 2021 Nov;37(11):1743-1750. PubMed PMID: 34273475
  • Gigli M, Stolfo D, Graw SL, Merlo M, Gregorio C, Nee Chen S, Dal Ferro M, PaldinoMD A, De Angelis G, Brun F, Jirikowic J, Salcedo EE, Turja S, Fatkin D, Johnson R, van Tintelen JP, Te Riele ASJM, Wilde AAM, Lakdawala NK, Picard K, Miani D, Muser D, Maria Severini G, Calkins H, James CA, Murray B, Tichnell C, Parikh VN, Ashley EA, Reuter C, Song J, Judge DP, McKenna WJ, Taylor MRG, Sinagra G, Mestroni L. Phenotypic Expression, Natural History, and Risk Stratification of Cardiomyopathy Caused by Filamin C Truncating Variants. Circulation. 2021 Nov 16;144(20):1600-1611. PubMed PMID: 34587765
  • Dries AM, Kirillova A, Reuter CM, Garcia J, Zouk H, Hawley M, Murray B, Tichnell C, Pilichou K, Protonotarios A, Medeiros-Domingo A, Kelly MA, Baras A, Ingles J, Semsarian C, Bauce B, Celeghin R, Basso C, Jongbloed JDH, Nussbaum RL, Funke B, Cerrone M, Mestroni L, Taylor MRG, Sinagra G, Merlo M, Saguner AM, Elliott PM, Syrris P, van Tintelen JP, James CA, Haggerty CM, Parikh VN. The genetic architecture of Plakophilin 2 cardiomyopathy. Genet Med. 2021 Oct;23(10):1961-1968. PubMed PMID: 34120153
  • Dries AM, Kirillova A, Reuter CM, Garcia J, Zouk H, Hawley M, Murray B, Tichnell C, Pilichou K, Protonotarios A, Medeiros-Domingo A, Kelly MA, Baras A, Ingles J, Semsarian C, Bauce B, Celeghin R, Basso C, Jongbloed JDH, Nussbaum RL, Funke B, Cerrone M, Mestroni L, Taylor MRG, Sinagra G, Merlo M, Saguner AM, Elliott PM, Syrris P, van Tintelen JP, James CA, Haggerty CM, Parikh VN. Correction to: The genetic architecture of Plakophilin 2 cardiomyopathy. Genet Med. 2021 Oct;23(10):2014. PubMed PMID: 34408292
  • Ho CY, Day SM, Axelsson A, Russell MW, Zahka K, Lever HM, Pereira AC, Colan SD, Margossian R, Murphy AM, Canter C, Bach RG, Wheeler MT, Rossano JW, Owens AT, Bundgaard H, Benson L, Mestroni L, Taylor MRG, Patel AR, Wilmot I, Thrush P, Vargas JD, Soslow JH, Becker JR, Seidman CE, Lakdawala NK, Cirino AL, Burns KM, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E. Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial. Nat Med. 2021 Oct;27(10):1818-1824. PubMed PMID: 34556856
  • Sidhu K, Castrini AI, Parikh V, Reza N, Owens A, Tremblay-Gravel M, Wheeler MT, Mestroni L, Taylor M, Graw S, Gigli M, Merlo M, Paldino A, Sinagra G, Judge DP, Ramos H, Mesubi O, Brown E, Turnbull S, Kumar S, Roy D, Tedrow UB, Ngo L, Haugaa K, Lakdawala NK. The response to cardiac resynchronization therapy in LMNA cardiomyopathy. Eur J Heart Fail. 2022 Apr;24(4):685-693. PubMed PMID: 35229420
  • Cannatà A, Merlo M, Dal Ferro M, Barbati G, Manca P, Paldino A, Graw S, Gigli M, Stolfo D, Johnson R, Roy D, Tharratt K, Bromage DI, Jirikowic J, Abbate A, Goodwin A, Rao K, Marawan A, Carr-White G, Robert L, Parikh V, Ashley E, McDonagh T, Lakdawala NK, Fatkin D, Taylor MRG, Mestroni L, Sinagra G. Association of Titin Variations With Late-Onset Dilated Cardiomyopathy. JAMA Cardiol. 2022 Apr 1;7(4):371-377. PubMed PMID: 35138330
  • Kuwabara JT, Hara A, Heckl JR, Peña B, Bhutada S, DeMaris R, Ivey MJ, DeAngelo LP, Liu X, Park J, Jahansooz JR, Mestroni L, McKinsey TA, Apte SS, Tallquist MD. Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation. J Mol Cell Cardiol. 2022 Aug;169:84-95. PubMed PMID: 35569524
  • Castrichini M, Porcari A, Baggio C, Gagno G, Maione D, Barbati G, Medo K, Mestroni L, Merlo M, Sinagra G. Sex differences in natural history of cardiovascular magnetic resonance- and biopsy-proven lymphocytic myocarditis. ESC Heart Fail. 2022 Dec;9(6):4010-4019. PubMed PMID: 36000547
  • Peña B, Gao S, Borin D, Del Favero G, Abdel-Hafiz M, Farahzad N, Lorenzon P, Sinagra G, Taylor MRG, Mestroni L, Sbaizero O. Cellular Biomechanic Impairment in Cardiomyocytes Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation. Langmuir. 2022 Dec 6;38(48):14928-14940. PubMed PMID: 36420863
  • Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 Feb;188(2):600-605. PubMed PMID: 34652067
  • Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25;8(8):eabk0052. PubMed PMID: 35196083
  • Merlo M, Grilli G, Cappelletto C, Masé M, Porcari A, Ferro MD, Gigli M, Stolfo D, Zecchin M, De Luca A, Mestroni L, Sinagra G. The Arrhythmic Phenotype in Cardiomyopathy. Heart Fail Clin. 2022 Jan;18(1):101-113. PubMed PMID: 34776072
  • Zanetti M, Chen SN, Conti M, Taylor MRG, Sbaizero O, Mestroni L, Lazzarino M. Microfabricated cantilevers for parallelized cell-cell adhesion measurements. Eur Biophys J. 2022 Mar;51(2):147-156. PubMed PMID: 34304293
  • Sanchez F, Weitz C, Gutierrez JM, Mestroni L, Hanneman K, Vargas D. Cardiac MR Imaging of Muscular Dystrophies. Curr Probl Diagn Radiol. 2022 Mar-Apr;51(2):225-234. PubMed PMID: 33551194
  • Judge DP, Lakdawala NK, Taylor MRG, Mestroni L, Li H, Oliver C, Angeli FS, Lee PA, MacRae CA. Long-Term Efficacy and Safety of ARRY-371797 (PF-07265803) in Patients With Lamin A/C-Related Dilated Cardiomyopathy. Am J Cardiol. 2022 Nov 15;183:93-98. PubMed PMID: 36114020
  • Paldino A, Dal Ferro M, Stolfo D, Gandin I, Medo K, Graw S, Gigli M, Gagno G, Zaffalon D, Castrichini M, Masè M, Cannatà A, Brun F, Storm G, Severini GM, Lenarduzzi S, Girotto G, Gasparini P, Bortolotti F, Giacca M, Zacchigna S, Merlo M, Taylor MRG, Mestroni L, Sinagra G. Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies. J Am Coll Cardiol. 2022 Nov 22;80(21):1981-1994. PubMed PMID: 36396199
  • Gao S, Taylor MRG, Mestroni L. Hidden Risk: Arrhythmogenic Genes in the General Population. Circ Genom Precis Med. 2022 Oct;15(5):e003869. PubMed PMID: 35980659
  • Taylor MR, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek MM, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Bristow MR, Lavori P, Mestroni L. Prevalence of desmin mutations in dilated cardiomyopathy. Circulation. 2007 Mar 13;115(10):1244-51. PubMed PMID: 17325244
  • Taylor MRG, Ku L, Slavov D, Cavanaugh J, Boucek M, Zhu X, Graw S, Carniel E, Barnes C, Quan D, Prall R, Lovell MA, Mierau G, Ruegg P, Mandava N, Bristow MR, Towbin JA, Mestroni L. Danon disease presenting with dilated cardiomyopathy and a complex phenotype. J Hum Genet. 2007;52(10):830-835. PubMed PMID: 17899313
  • Prall FR, Drack A, Taylor M, Ku L, Olson JL, Gregory D, Mestroni L, Mandava N. Ophthalmic manifestations of Danon disease. Ophthalmology. 2006 Jun;113(6):1010-3. PubMed PMID: 16751040
  • Carniel E, Taylor MR, Sinagra G, Di Lenarda A, Ku L, Fain PR, Boucek MM, Cavanaugh J, Miocic S, Slavov D, Graw SL, Feiger J, Zhu XZ, Dao D, Ferguson DA, Bristow MR, Mestroni L. Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation. 2005 Jul 5;112(1):54-9. PubMed PMID: 15998695
  • Taylor MR, Slavov D, Gajewski A, Vlcek S, Ku L, Fain PR, Carniel E, Di Lenarda A, Sinagra G, Boucek MM, Cavanaugh J, Graw SL, Ruegg P, Feiger J, Zhu X, Ferguson DA, Bristow MR, Gotzmann J, Foisner R, Mestroni L. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Hum Mutat. 2005 Dec;26(6):566-74. PubMed PMID: 16247757
  • McNair WP, Ku L, Taylor MR, Fain PR, Dao D, Wolfel E, Mestroni L. SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation. 2004 Oct 12;110(15):2163-7. PubMed PMID: 15466643
  • Taylor MR, Robinson ML, Mestroni L. Analysis of genetic variations of lamin A/C gene (LMNA) by denaturing high-performance liquid chromatography. J Biomol Screen. 2004 Oct;9(7):625-8. PubMed PMID: 15475483
  • Taylor MR, Carniel E, Mestroni L. Familial hypertrophic cardiomyopathy: clinical features, molecular genetics and molecular genetic testing. Expert Rev Mol Diagn. 2004 Jan;4(1):99-113. PubMed PMID: 14711353
  • Lindenfeld J, Miller GG, Shakar SF, Zolty R, Lowes BD, Wolfel EE, Mestroni L, Page RL 2nd, Kobashigawa J. Drug therapy in the heart transplant recipient: part II: immunosuppressive drugs. Circulation. 2004 Dec 21;110(25):3858-65. PubMed PMID: 15611389
  • Lindenfeld J, Miller GG, Shakar SF, Zolty R, Lowes BD, Wolfel EE, Mestroni L, Page RL 2nd, Kobashigawa J. Drug therapy in the heart transplant recipient: part I: cardiac rejection and immunosuppressive drugs. Circulation. 2004 Dec 14;110(24):3734-40. PubMed PMID: 15596559
  • Di Lenarda A, Pinamonti B, Mestroni L, Salvi A, Sabbadini G, Gregori D, Perkan A, Zecchin M, Carniel E, Bussani R, Silvestri F, Morgera T, Camerini F, Sinagra G. [The natural history of dilated cardiomyopathy: a review of the Heart Muscle Disease Registry of Trieste]. Ital Heart J Suppl. 2004 Apr;5(4):253-66. PubMed PMID: 15346692
  • Di Lenarda A, Pinamonti B, Mestroni L, Salvi A, Sabbadini G, Gregori D, Perkan A, Zecchin M, Carniel E, Bussani R, Silvestri F, Morgera T, Camerini F, Sinagra G. [How the natural history of dilated cardiomyopathy has changed. Review of the Registry of Myocardial Diseases of Trieste]. Ital Heart J Suppl. 2004 Apr;5(4):253-66. PubMed PMID: 15185463
  • Ku L, Feiger J, Taylor M, Mestroni L. Cardiology patient page. Familial dilated cardiomyopathy. Circulation. 2003 Oct 28;108(17):e118-21. PubMed PMID: 14581388
  • Taylor MR, Fain PR, Sinagra G, Robinson ML, Robertson AD, Carniel E, Di Lenarda A, Bohlmeyer TJ, Ferguson DA, Brodsky GL, Boucek MM, Lascor J, Moss AC, Li WL, Stetler GL, Muntoni F, Bristow MR, Mestroni L. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. J Am Coll Cardiol. 2003 Mar 5;41(5):771-80. PubMed PMID: 12628721
  • Mestroni L. Genomic medicine and atrial fibrillation. J Am Coll Cardiol. 2003 Jun 18;41(12):2193-6. PubMed PMID: 12821246
  • Muntoni F, Mestroni L. [Dilated cardiomyopathy: role of clinical and instrumental evaluation of the neuromuscular system]. Ital Heart J Suppl. 2002 Apr;3(4):399-404. PubMed PMID: 12025383
  • Startari U, Taylor MR, Sinagra G, Di Lenarda A, Mestroni L. [Dilated cardiomyopathy: etiology, clinical criteria for diagnosis and screening of the familial form]. Ital Heart J Suppl. 2002 Apr;3(4):378-85. PubMed PMID: 12025380
  • Sinagra G, Di Lenarda A, Brodsky GL, Taylor MR, Muntoni F, Pinamonti B, Carniel E, Driussi M, Bristow MR, Mestroni L. Current perspective new insights into the molecular basis of familial dilated cardiomyopathy. Ital Heart J. 2001 Apr;2(4):280-6. PubMed PMID: 11374497
  • Brodsky GL, Muntoni F, Miocic S, Sinagra G, Sewry C, Mestroni L. Lamin A/C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement. Circulation. 2000 Feb 8;101(5):473-6. PubMed PMID: 10662742
  • Sinagra G, Di Lenarda A, Pinamonti B, Bussani R, Silvestri F, Mestroni L, Camerini F. [Classification of cardiomyopathies]. G Ital Cardiol. 1999 Oct;29(10):1165-8. PubMed PMID: 10546126
  • Di Lenarda A, Sabbadini G, Salvatore L, Sinagra G, Mestroni L, Pinamonti B, Gregori D, Ciani F, Muzzi A, Klugmann S, Camerini F. Long-term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprolol. The Heart-Muscle Disease Study Group. J Am Coll Cardiol. 1999 Jun;33(7):1926-34. PubMed PMID: 10362195
  • Mestroni L, Rocco C, Gregori D, Sinagra G, Di Lenarda A, Miocic S, Vatta M, Pinamonti B, Muntoni F, Caforio AL, McKenna WJ, Falaschi A, Giacca M, Camerini. Familial dilated cardiomyopathy: evidence for genetic and phenotypic heterogeneity. Heart Muscle Disease Study Group. J Am Coll Cardiol. 1999 Jul;34(1):181-90. PubMed PMID: 10400009
  • Mestroni L, Maisch B, McKenna WJ, Schwartz K, Charron P, Rocco C, Tesson F, Richter A, Wilke A, Komajda M. Guidelines for the study of familial dilated cardiomyopathies. Collaborative Research Group of the European Human and Capital Mobility Project on Familial Dilated Cardiomyopathy. Eur Heart J. 1999 Jan;20(2):93-102. PubMed PMID: 10099905
  • Muntoni F, Ferlini A, Sewry C, Mateddu A, Marrosu G, Porcu M, Di Lenarda A, Sinagra G, Mestroni L. Dilated cardiomyopathy and muscular dystrophies: which lesson can be learned?. Cardiologia. 1999 Dec;44 Suppl 1(Pt 1):209-11. PubMed PMID: 12497909
  • Mestroni L, Rocco C, Vatta M, Miocic S, Giacca M. Advances in molecular genetics of dilated cardiomyopathy. The Heart Muscle Disease Study Group. Cardiol Clin. 1998 Nov;16(4):611-21, vii. PubMed PMID: 9891591
  • Sinagra G, Di Lenarda A, Pinamonti B, Bussani R, Silvestri F, Mestroni L, Camerini F. [The classification of cardiomyopathies]. G Ital Cardiol. 1998 Nov;28(11):1191-9. PubMed PMID: 9866795
  • Mestroni L, Giacca M. Molecular genetics of dilated cardiomyopathy. Curr Opin Cardiol. 1997 May;12(3):303-9. PubMed PMID: 9243088
  • Mestroni L. Dilated cardiomyopathy: a genetic approach. Heart. 1997 Mar;77(3):185-8. PubMed PMID: 9093029
  • Muntoni F, Di Lenarda A, Porcu M, Sinagra G, Mateddu A, Marrosu G, Ferlini A, Cau M, Milasin J, Melis MA, Marrosu MG, Cianchetti C, Sanna A, Falaschi A, Camerini F, Giacca M, Mestroni L. Dystrophin gene abnormalities in two patients with idiopathic dilated cardiomyopathy. Heart. 1997 Dec;78(6):608-12. PubMed PMID: 9470882
  • Mestroni L, Milasin J, Vatta M, Pinamonti B, Sinagra G, Rocco C, Matulic M, Falaschi A, Giacca M, Camerini F. Genetic factors in dilated cardiomyopathy. Arch Mal Coeur Vaiss. 1996 Jul;89 Spec No 2:15-20. PubMed PMID: 8881501
  • Severini GM, Krajinovic M, Pinamonti B, Sinagra G, Fioretti P, Brunazzi MC, Falaschi A, Camerini F, Giacca M, Mestroni L. A new locus for arrhythmogenic right ventricular dysplasia on the long arm of chromosome 14. Genomics. 1996 Jan 15;31(2):193-200. PubMed PMID: 8824801
  • Milasin J, Muntoni F, Severini GM, Bartoloni L, Vatta M, Krajinovic M, Mateddu A, Angelini C, Camerini F, Falaschi A, Mestroni L, Giacca M. A point mutation in the 5' splice site of the dystrophin gene first intron responsible for X-linked dilated cardiomyopathy. Hum Mol Genet. 1996 Jan;5(1):73-9. PubMed PMID: 8789442
  • Krajinovic M, Pinamonti B, Sinagra G, Vatta M, Severini GM, Milasin J, Falaschi A, Camerini F, Giacca M, Mestroni L. Linkage of familial dilated cardiomyopathy to chromosome 9. Heart Muscle Disease Study Group. Am J Hum Genet. 1995 Oct;57(4):846-52. PubMed PMID: 7573045
  • Mestroni L, Zachara E. [Genetics of dilated cardiomyopathies]. G Ital Cardiol. 1995 Nov;25(11):1469-73. PubMed PMID: 8682247
  • Mestroni L, Krajinovic M, Severini GM, Milasin J, Pinamonti B, Rocco C, Vatta M, Falaschi A, Giacca M, Camerini F. Molecular genetics of dilated cardiomyopathies. Eur Heart J. 1995 Dec;16 Suppl O:5-9. PubMed PMID: 8682101
  • Muntoni F, Wilson L, Marrosu G, Marrosu MG, Cianchetti C, Mestroni L, Ganau A, Dubowitz V, Sewry C. A mutation in the dystrophin gene selectively affecting dystrophin expression in the heart. J Clin Invest. 1995 Aug;96(2):693-9. PubMed PMID: 7635962
  • Caforio AL, Keeling PJ, Zachara E, Mestroni L, Camerini F, Mann JM, Bottazzo GF, McKenna WJ. Evidence from family studies for autoimmunity in dilated cardiomyopathy. Lancet. 1994 Sep 17;344(8925):773-7. PubMed PMID: 7916071
  • Giacca M, Severini GM, Mestroni L, Salvi A, Lardieri G, Falaschi A, Camerini F. Low frequency of detection by nested polymerase chain reaction of enterovirus ribonucleic acid in endomyocardial tissue of patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 1994 Oct;24(4):1033-40. PubMed PMID: 7930194
  • Krajinovic M, Mestroni L, Severini GM, Pinamonti B, Camerini F, Falaschi A, Giacca M. Absence of linkage between idiopathic dilated cardiomyopathy and candidate genes involved in the immune function in a large Italian pedigree. J Med Genet. 1994 Oct;31(10):766-71. PubMed PMID: 7837253
  • Krajinovic M, Ivanovic K, Mestroni L, Diklic V, Nikolis J. Parental origin of the X chromosome in a patient with a Robertsonian translocation and Turner's syndrome. J Med Genet. 1994 Mar;31(3):255-6. PubMed PMID: 8014980
  • Mestroni L, Krajinovic M, Severini GM, Pinamonti B, Di Lenarda A, Giacca M, Falaschi A, Camerini F. Familial dilated cardiomyopathy. Br Heart J. 1994 Dec;72(6 Suppl):S35-41. PubMed PMID: 7873323
  • Mestroni L, Krajinovic M, Severini GM, Falaschi A, Giacca M, Camerini F. Molecular genetics of dilated cardiomyopathy. Herz. 1994 Apr;19(2):97-104. PubMed PMID: 8194838
  • Mestroni L, Morgera T, Miani D, Pinamonti B, Sinagra G, Tanganelli P, Silvestri F, Camerini F. Idiopathic left ventricular aneurysm: a clinical and pathological study of a new entity in the spectrum of cardiomyopathies. Postgrad Med J. 1994;70 Suppl 1:S13-20. PubMed PMID: 7971643
  • Severini GM, Mestroni L, Falaschi A, Camerini F, Giacca M. Nested polymerase chain reaction for high-sensitivity detection of enteroviral RNA in biological samples. J Clin Microbiol. 1993 May;31(5):1345-9. PubMed PMID: 8388893
  • Camerini F, Mestroni L, Perkan A, Pinamonti B, Sinagra G. [The classification of cardiomyopathies: is a revision opportune?]. G Ital Cardiol. 1993 Jul;23(7):729-33. PubMed PMID: 8405839
  • Bristow MR, Minobe W, Rasmussen R, Larrabee P, Skerl L, Klein JW, Anderson FL, Murray J, Mestroni L, Karwande SV. Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest. 1992 Mar;89(3):803-15. PubMed PMID: 1311717
  • Mestroni L, Giacca M, Severini GM, Camerini F. [The pathogenesis of dilated cardiomyopathy: current progress]. G Ital Cardiol. 1992 Jan;22(1):53-62. PubMed PMID: 1624069
  • Sinagra G, Perkan A, Di Lenarda A, Lardieri G, Pinamonti B, Mestroni L, Miani D, Camerini F. [Beta blocking agents in the treatment of dilated cardiomyopathy: review of the literature and clinical experience with 67 patients]. G Ital Cardiol. 1992 Aug;22(8):969-89. PubMed PMID: 1362167
  • Camerini F, Bussani R, Lenarda D, Lardieri G, Mestroni L, Miani D, Pinamonti B, Salvi A, Silvestri F, Sinagra G. Clinical aspects and haemodynamics in the follow-up of dilated cardiomyopathy and myocarditis. Eur Heart J. 1991 Aug;12 Suppl D:193-6. PubMed PMID: 1915452
  • Mestroni L, Miani D, Di Lenarda A, Silvestri F, Bussani R, Filippi G, Camerini F. Clinical and pathologic study of familial dilated cardiomyopathy. Am J Cardiol. 1990 Jun 15;65(22):1449-53. PubMed PMID: 2353650
  • Ciaccheri M, Castelli G, Nannini M, Santoro G, Troiani V, Di Lenarda A, Miani D, Sinagra G, Mestroni L, Risoli A. [The prognostic assessment of dilated cardiomyopathy: a follow-up of 138 patients]. G Ital Cardiol. 1990 Jul;20(7):645-50. PubMed PMID: 2245905
  • Tanganelli P, Di Lenarda A, Bianciardi G, Salvi A, Silvestri F, Mestroni L, Camerini F. Correlation between histomorphometric findings on endomyocardial biopsy and clinical findings in idiopathic dilated cardiomyopathy. Am J Cardiol. 1989 Sep 1;64(8):504-6. PubMed PMID: 2773794
  • Barbieri L, Mestroni L, Camerini F. [Calcium antagonists in congestive heart failure]. G Ital Cardiol. 1988 Nov;18(11):989-96. PubMed PMID: 3073994
  • Mestroni L, Barbieri L, Dreas L, Sinagra G, Camerini F. [Vasodilators: which, how, when]. G Ital Cardiol. 1988 Dec;18(12):1065-71. PubMed PMID: 3075570
  • Neri R, Mestroni L, Salvi A, Pandullo C, Camerini F. Ventricular arrhythmias in dilated cardiomyopathy: efficacy of amiodarone. Am Heart J. 1987 Mar;113(3):707-15. PubMed PMID: 3825860
  • Mestroni L, Miani D, Neri R, Di Lenarda A, Camerini F. [Ambulatory ECG in cardiomyopathies]. G Ital Cardiol. 1987 Dec;17(12):1139-44. PubMed PMID: 3503812
  • Pinamonti B, Dreas L, Bussani R, Mestroni L, Silvestri F, Tanganelli P, Camerini F. [Cardiac amyloidosis. Invasive and noninvasive diagnosis]. G Ital Cardiol. 1987 Dec;17(12):1016-30. PubMed PMID: 3503797
  • Neri R, Mestroni L, Salvi A, Camerini F. Arrhythmias in dilated cardiomyopathy. Postgrad Med J. 1986 Jun;62(728):593-7. PubMed PMID: 3774699
  • Mestroni L, Neri R, Camerini F. [The electrocardiogram in dilated cardiomyopathy]. G Ital Cardiol. 1986 Dec;16(12):1009-17. PubMed PMID: 3556937
  • Camerini F, Mestroni L, Neri R, Salvi A, Silvestri F. [Dilated cardiomyopathy: etiopathogenesis]. Cardiologia. 1985 Oct;30(10):865-70. PubMed PMID: 3842641
  • Binaghi G, Mancia G, Vidotto G, Mestroni L. [Protocol-guide in clinical experimentation on vasodilator agents in chronic cardiac failure]. G Ital Cardiol. 1985 Jul;15(7):700-4. PubMed PMID: 4076704
  • Camerini F, Mestroni L, Neri R, Humar F. Vasodilators in left ventricular failure. G Ital Cardiol. 1984 Sep;14(9):685-93. PubMed PMID: 6510623
  • Campello C, Dal Molin G, Gasparini V, Mestroni L, Salvi A, Camerini F, Majori L. [Retrospective study of coxsackie B virus infections and congestive cardiomyopathy]. Boll Ist Sieroter Milan. 1984 Sep;63(4):325-30. PubMed PMID: 6097290
  • Mestroni L, Fonda F, Camerini F. Ventricular arrhythmias in congestive cardiomyopathy. N Engl J Med. 1983 Aug 11;309(6):377-8. PubMed PMID: 6866073
  • Morgera T, Humar F, Mestroni L, Maras P, Camerini F. [Captopril therapy in chronic congestive heart failure]. G Ital Cardiol. 1983;13(1):39-46. PubMed PMID: 6347789
  • Sanchez F, Weitz C, Gutierrez JM, Mestroni L, Hanneman K, Vargas D. Cardiac MR Imaging of Muscular Dystrophies. Curr Probl Diagn Radiol. 2022 Mar-Apr;51(2):225-234. PubMed PMID: 33551194
  • Zanetti M, Chen SN, Conti M, Taylor MRG, Sbaizero O, Mestroni L, Lazzarino M. Microfabricated cantilevers for parallelized cell-cell adhesion measurements. Eur Biophys J. 2022 Mar;51(2):147-156. PubMed PMID: 34304293
  • Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 Feb;188(2):600-605. PubMed PMID: 34652067
  • Merlo M, Grilli G, Cappelletto C, Masé M, Porcari A, Ferro MD, Gigli M, Stolfo D, Zecchin M, De Luca A, Mestroni L, Sinagra G. The Arrhythmic Phenotype in Cardiomyopathy. Heart Fail Clin. 2022 Jan;18(1):101-113. PubMed PMID: 34776072
  • Cannatà A, Merlo M, Dal Ferro M, Barbati G, Manca P, Paldino A, Graw S, Gigli M, Stolfo D, Johnson R, Roy D, Tharratt K, Bromage DI, Jirikowic J, Abbate A, Goodwin A, Rao K, Marawan A, Carr-White G, Robert L, Parikh V, Ashley E, McDonagh T, Lakdawala NK, Fatkin D, Taylor MRG, Mestroni L, Sinagra G. Association of Titin Variations With Late-Onset Dilated Cardiomyopathy. JAMA Cardiol. 2022 Apr 1;7(4):371-377. PubMed PMID: 35138330
  • Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25;8(8):eabk0052. PubMed PMID: 35196083
  • Sidhu K, Castrini AI, Parikh V, Reza N, Owens A, Tremblay-Gravel M, Wheeler MT, Mestroni L, Taylor M, Graw S, Gigli M, Merlo M, Paldino A, Sinagra G, Judge DP, Ramos H, Mesubi O, Brown E, Turnbull S, Kumar S, Roy D, Tedrow UB, Ngo L, Haugaa K, Lakdawala NK. The response to cardiac resynchronization therapy in LMNA cardiomyopathy. Eur J Heart Fail. 2022 Apr;24(4):685-693. PubMed PMID: 35229420
  • Peña B, Adbel-Hafiz M, Cavasin M, Mestroni L, Sbaizero O. Atomic Force Microscopy (AFM) Applications in Arrhythmogenic Cardiomyopathy. Int J Mol Sci. 2022 Mar 28;23(7). PubMed PMID: 35409059
  • Kuwabara JT, Hara A, Heckl JR, Peña B, Bhutada S, DeMaris R, Ivey MJ, DeAngelo LP, Liu X, Park J, Jahansooz JR, Mestroni L, McKinsey TA, Apte SS, Tallquist MD. Regulation of extracellular matrix composition by fibroblasts during perinatal cardiac maturation. J Mol Cell Cardiol. 2022 Aug;169:84-95. PubMed PMID: 35569524
  • Gao S, Taylor MRG, Mestroni L. Hidden Risk: Arrhythmogenic Genes in the General Population. Circ Genom Precis Med. 2022 Oct;15(5):e003869. PubMed PMID: 35980659
  • Castrichini M, Porcari A, Baggio C, Gagno G, Maione D, Barbati G, Medo K, Mestroni L, Merlo M, Sinagra G. Sex differences in natural history of cardiovascular magnetic resonance- and biopsy-proven lymphocytic myocarditis. ESC Heart Fail. 2022 Dec;9(6):4010-4019. PubMed PMID: 36000547
  • Alegret N, Dominguez-Alfaro A, Mecerreyes D, Prato M, Mestroni L, Peña B. Neonatal rat ventricular myocytes interfacing conductive polymers and carbon nanotubes. Cell Biol Toxicol. 2022 Aug 27. [Epub ahead of print] PubMed PMID: 36029423
  • MacRae CA, Taylor MR, Mestroni L, Moses J, Ashley EA, Wheeler MT, Lakdawala NK, Hershberger RE, Sandor V, Saunders ME, Oliver C, Lee PA, Judge DP. Plain Language Summary of Publication of the safety and efficacy of ARRY-371797 in people with dilated cardiomyopathy and a faulty LMNA gene. Future Cardiol. 2023 Jan 31. [Epub ahead of print] PubMed PMID: 36718638
  • MacRae CA, Taylor MRG, Mestroni L, Moses J, Ashley EA, Wheeler MT, Lakdawala NK, Hershberger RE, Sandor V, Saunders ME, Oliver C, Lee PA, Judge DP. Efficacy and Safety of ARRY-371797 in LMNA-Related Dilated Cardiomyopathy: A Phase 2 Study. Circ Genom Precis Med. 2023 Feb;16(1):e003730. PubMed PMID: 36515663
  • Peña B, Gao S, Borin D, Del Favero G, Abdel-Hafiz M, Farahzad N, Lorenzon P, Sinagra G, Taylor MRG, Mestroni L, Sbaizero O. Cellular Biomechanic Impairment in Cardiomyocytes Carrying the Progeria Mutation: An Atomic Force Microscopy Investigation. Langmuir. 2022 Dec 6;38(48):14928-14940. PubMed PMID: 36420863
  • Paldino A, Dal Ferro M, Stolfo D, Gandin I, Medo K, Graw S, Gigli M, Gagno G, Zaffalon D, Castrichini M, Masè M, Cannatà A, Brun F, Storm G, Severini GM, Lenarduzzi S, Girotto G, Gasparini P, Bortolotti F, Giacca M, Zacchigna S, Merlo M, Taylor MRG, Mestroni L, Sinagra G. Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies. J Am Coll Cardiol. 2022 Nov 22;80(21):1981-1994. PubMed PMID: 36396199
  • Altman NL, Berning AA, Saxon CE, Adamek KE, Wagner JA, Slavov D, Quaife RA, Gill EA, Minobe WA, Jonas ER, Carroll IA, Huebler SP, Raines J, Messenger JC, Ambardekar AV, Mestroni L, Rosenberg RM, Rove J, Campbell TB, Bristow MR. Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination. JACC Basic Transl Sci. 2023 Feb;8(2):124-137. PubMed PMID: 36281440
  • Judge DP, Lakdawala NK, Taylor MRG, Mestroni L, Li H, Oliver C, Angeli FS, Lee PA, MacRae CA. Long-Term Efficacy and Safety of ARRY-371797 (PF-07265803) in Patients With Lamin A/C-Related Dilated Cardiomyopathy. Am J Cardiol. 2022 Nov 15;183:93-98. PubMed PMID: 36114020
  • Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, Gallego-Delgado M, Larrañaga-Moreira JM, Garcia-Pinilla JM, Basurte-Elorz MT, Rodríguez-Palomares JF, Climent V, Bermudez-Jimenez FJ, Mogollón-Jiménez MV, Lopez J, Peña-Peña ML, Garcia-Alvarez A, López-Abel B, Ripoll-Vera T, Palomino-Doza J, Bayes-Genis A, Brugada R, Idiazabal U, Mirelis JG, Dominguez F, Henkens MTHM, Krapels IPC, Brunner HG, Paldino A, Zaffalon D, Mestroni L, Sinagra G, Heymans SRB, Merlo M, Garcia-Pavia P. Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 2022 Sep 20;80(12):1115-1126. PubMed PMID: 36109106

Professional Memberships

  • American Heart Association (AHA), Fellow
  • American College of Cardiology, Fellow
  • European Society of cardiology, Fellow
  • American College of Physician, Fellow
  • American Society of Human Genetics, Member
  • European Society of Human Genetics, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

UCHealth Heart Failure Program - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation
  • University of Colorado Hospital

Center Affiliations

Specialty Information

Specialties
  • General Cardiology (1989)
  • Cardiology (1989)
  • Medical Genetics and Genomics
  • ECFMG/USMLE, License (2000)
  • National Board of Cardiology, International Certificate (1989)
Conditions & Treatments
  • Heart and Circulation
  • Heart and Circulation - Heart Failure
  • Heart and Circulation - Cardiomyopathy
  • Heart and Circulation - Heart Diseases
  • Heart and Circulation - Hypertrophic Cardiomyopathy
Clinical Interests
I am Professor of Medicine/Cardiology, Director of the International Familial Cardiomyopathy Registry and Co-Director of the Molecular Genetics Program of the Cardiovascular Institute. My clinical expertise is in inherited cardiomyopathies, including arrhythmogenic cardiomyopathies, familial cardiomyopathies (arrhythmogenic right ventricular cardiomyopathy, arrhythmogenic dilated cardiomyopathy, left ventricular noncompaction, familial restrictive cardiomyopathy), muscular dystrophies with cardiac involvement, and other genetic disease affecting the heart muscle. In my Inherited Cardiomyopathy Management Clinic, I provide comprehensive evaluation and treatment of inherited cardiomyopathies, working in close collaboration with other experienced clinicians, genetic counselors, cardiovascular nurses, and study coordinators to provide a state-of-the-art team-based approach: these include the Adult Genetics Clinic, Electrophysiology Clinic, Advanced Heart Failure Clinic, HCM Clinic, Neuromuscular Clinic, Advanced Imaging, Sarcoidosis Clinic at National Jewish Hospital, and the Colorado Children's Hospital. I offer the opportunity of enrollment in National and International research programs, including novel clinical trials, and the International Familial Cardiomyopathy Registry (NIH founded, IRB 99-177, founded in 1999) to continue identifying the genes behind inherited disease, and discover novel therapies.

Care Philosophy
I strive to provide the best care for my patients. I believe in treating the person as a whole, taking every aspect of a patient’s body and health into consideration during diagnosis and treatment.

Personal Interests
In my spare time, I enjoy skiing, hiking, reading and spending time with my family.

Volunteer Activities
I volunteer as physician in sports activities of high school students.


School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

School
General
Students