Ju Sim Kim, PhD

Publications

• Song M, Kim JS, Liu L, Husain M, Vázquez-Torres A. Antioxidant Defense by Thioredoxin Can Occur Independently of Canonical Thiol-Disulfide Oxidoreductase Enzymatic Activity. Cell Rep. 2016 Mar 29;14(12):2901-11. PubMed PMID: 26997275
• Kim JS, Liu L, Fitzsimmons LF, Wang Y, Crawford MA, Mastrogiovanni M, Trujillo M, Till JKA, Radi R, Dai S, Vázquez-Torres A. DksA-DnaJ redox interactions provide a signal for the activation of bacterial RNA polymerase. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11780-E11789. PubMed PMID: 30429329
• Tapscott T, Kim JS, Crawford MA, Fitzsimmons L, Liu L, Jones-Carson J, Vázquez-Torres A. Guanosine tetraphosphate relieves the negative regulation of Salmonella pathogenicity island-2 gene transcription exerted by the AT-rich ssrA discriminator region. Sci Rep. 2018 Jun 21;8(1):9465. PubMed PMID: 29930310
• Fitzsimmons LF, Liu L, Kim JS, Jones-Carson J, Vázquez-Torres A. Salmonella Reprograms Nucleotide Metabolism in Its Adaptation to Nitrosative Stress. MBio. 2018 Feb 27;9(1). PubMed PMID: 29487237
• Chakraborty S, Liu L, Fitzsimmons L, Porwollik S, Kim JS, Desai P, McClelland M, Vazquez-Torres A. Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ?pH. Nat Commun. 2020 Apr 14;11(1):1783. PubMed PMID: 32286292
• Pérez-Varela M, Tierney ARP, Kim JS, Vázquez-Torres A, Rather P. Characterization of RelA in Acinetobacter baumannii. J Bacteriol. 2020 May 27;202(12). PubMed PMID: 32229531
• Jones-Carson J, Yahashiri A, Kim JS, Liu L, Fitzsimmons LF, Weiss DS, Vázquez-Torres A. Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism. Sci Adv. 2020 Feb;6(9):eaaz0260. PubMed PMID: 32133408
• Fitzsimmons LF, Liu L, Kant S, Kim JS, Till JK, Jones-Carson J, Porwollik S, McClelland M, Vazquez-Torres A. SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. mBio. 2020 Feb 25;11(1). PubMed PMID: 32098823
• Kim JS, Liu L, Vázquez-Torres A. The DnaK/DnaJ Chaperone System Enables RNA Polymerase-DksA Complex Formation in Salmonella Experiencing Oxidative Stress. mBio. 2021 May 11;12(3). PubMed PMID: 33975942
• Kim JS, Liu L, Kant S, Orlicky DJ, Uppalapati S, Margolis A, Davenport BJ, Morrison TE, Matsuda J, McClelland M, Jones-Carson J, Vazquez-Torres A. Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase. Cell Host Microbe. 2024 Jan 24. [Epub ahead of print] PubMed PMID: 38307020
• Kant S, Till JKA, Liu L, Margolis A, Uppalapati S, Kim JS, Vazquez-Torres A. Gre factors help Salmonella adapt to oxidative stress by improving transcription elongation and fidelity of metabolic genes. PLoS Biol. 2023 Apr;21(4):e3002051. PubMed PMID: 37014914
• Kim JS, Born A, Till JKA, Liu L, Kant S, Henen MA, Vögeli B, Vázquez-Torres A. Promiscuity of response regulators for thioredoxin steers bacterial virulence. Nat Commun. 2022 Oct 20;13(1):6210. PubMed PMID: 36266276
• Kim JS, Liu L, Davenport B, Kant S, Morrison TE, Vazquez-Torres A. Oxidative stress activates transcription of Salmonella pathogenicity island-2 genes in macrophages. J Biol Chem. 2022 Jul;298(7):102130. PubMed PMID: 35714768
• Kitzenberg DA, Lee JS, Mills KB, Kim JS, Liu L, Vázquez-Torres A, Colgan SP, Kao DJ. Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics. mBio. 2022 Jun 28;13(3):e0048022. PubMed PMID: 35575513