Tanabe K, Lanaspa M, Kitagawa W, Rivard C, Miyazaki M, Klawitter J, Schreiner G, Saleem M, Mathieson P, Makino H, Johnson R, and Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS deficient mouse. Am J of Physiol – Renal Physiol 2011 (in press).
Christians U, Klepacki J, Shokati T, Klawitter J, Klawitter J. Mass spectrometry-based multiplexing for the analysis of biomarkers in drug development and clinical diagnostics- how much is too much? Microchem J 2011 (in press).
Sirota J, Klawitter J and Edelstein CL. Biomarkers of Acute Kidney injury. Journal of Toxicology 2011 (in press).
Klepacki J, Klawitter J, Bendrick-Peart J, Schniedewind B, Heischmann S, Shokati T, Christians U, Klawitter J. A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 (in press).
Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U. Bezielle (BZL101)-Induced Oxidative Stress Damage Followed by Redistribution of Metabolic Fluxes in Breast Cancer Cells: A Combined Proteomic and Metabolomic Study. Int J Cancer 2011 (in press).
Klawitter J, Haschke M, Shokati T, Klawitter J, Christians U. Quantification of 15-F(2t)-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared. Rapid Commun Mass Spectrom 2011, 25: 463-8.
Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel H, Christians U, Structural Identification of SAR-943 Metabolites Generated by Human Liver Microsomes In Vitro Using Mass Spectrometry in Combination with Analysis of Fragmentation Patterns. Journal of Mass Spectrometry 2011, 46:615-24.
Christians U, Klawitter J, Klawitter J, Brunner N, Schmitz V. Biomarkers of Immunosuppressant Organ Toxicity after Transplantation - Status, Concepts and Misconceptions, Expert Opin Drug Metab Toxicol 2011, 7:175-200.
Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014 Jan 3;9(1):e86202. PubMed PMID: 24497939
Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2013 Dec 16. [Epub ahead of print] PubMed PMID: 24343898
Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christians U, Thurman JM. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol. 2013 Nov;24(11):1849-62. PubMed PMID: 24092930
Klawitter J, Zafar I, Klawitter J, Pennington AT, Klepacki J, Gitomer BY, Schrier RW, Christians U, Edelstein CL. Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD Rat model of polycystic kidney disease. BMC Nephrol. 2013 Jul 31;14(1):165. [Epub ahead of print] PubMed PMID: 23902712
Shimizu T, Macey TA, Quillinan N, Klawitter J, Perraud AL, Traystman RJ, Herson PS. Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab. 2013 Oct;33(10):1549-55. PubMed PMID: 23801245
Fernandez-Bustamante A, Klawitter J, Wilson P, Elkins ND, Agazio A, Shibata T, Uchida K, Christians U, Repine JE. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation. 2013 Oct;36(5):1030-40. PubMed PMID: 23616184
Klepacki J, Brunner N, Schmitz V, Klawitter J, Christians U, Klawitter J. Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma. Clin Chim Acta. 2013 Jun 5;421:91-7. PubMed PMID: 23499573
Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis?. Transpl Int. 2013 Mar;26(3):225-41. PubMed PMID: 23350848
Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc Res. 2013 Jan 1;97(1):66-76. PubMed PMID: 23015639
Christians U, Schmitz V, Klawitter J, Klawitter J. Proteo-metabolomic strategies in the future of drug development. In: The Applicability of Analytical Techniques to Clinical Studies. Caroli S, Záray G (eds.) John Wiley and Sons, Inc. New York (in press).
Christians U, McCrery S, Klawitter J, Klawitter J. The role of proteomics in the study of kidney diseases and in the development of diagnostic tools. In: Biomarkers of Kidney Disease. Edelstein C (ed.) Elsevier, San Diego.
Klawitter J, Reed-Gitomer BY, McFann K, Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M, Christians U, Schrier RW. Endothelial dysfunction and oxidative stress in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1198-206. PubMed PMID: 25234311
Christians U, Albuisson J, Klawitter J, Klawitter J. The role of metabolomics in the study of kidney diseases and in the development of diagnostic tools. In: Biomarkers of Kidney Disease. Edelstein C (ed.) Elsevier, San Diego.
Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boernsen KO. Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct;406(25):6399-408. PubMed PMID: 25116600
Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC. Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1( ) leukemia. Am J Hematol. 2014 Sep;89(9):896-903. PubMed PMID: 24891015
Klawitter J, Klawitter J, Christians U, Edelstein C. Effects of lovastatin treatment on the metabolic distributions in the ADPKD rat kidney. J Am Soc Nephrol 2011; 22: TH-PO416.
Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep;121(3):469-81. PubMed PMID: 24809976
Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014;9(1):e86202. PubMed PMID: 24497939
Klawitter J, Klawitter J, Corby K, Schrier RW, Christians U, Reed-Gitomer B, Conchol M. Oxidative stress and methylation cycle intermediates in ADPKD. J Am Soc Nephrol 2011; 22: TH-PO812.
Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol. 2014 Mar;25(3):547-63. PubMed PMID: 24262796
Klawitter J, Klawitter J, Corby K, Schrier RW, Christians U, Reed-Gitomer B, Conchol M. Biomarkers of endothelial dysfunction and vascular inflammation in ADPKD. J Am Soc Nephrol 2011; 22: TH-PO8111.
Kitagawa W, Tanabe K, Tamura Y, Klawitter J, Rivard CJ, Johnson RJ, Nakagawa T. ACE inhibition attenuates renal injury in mice lacking endothelial nitric oxide synthase. J Am Soc Nephrol 2011; 22: TH-PO733.
Crunk A, Klawitter J, Rivard C, Schniedewind B, Christians U. HSP70 is a potential kidney dysfunction marker for the toxicodynamic therapeutic drug monitoring of calcineurin inhibitors. Ther Drug Monit 2011; 33: 533-534.
Alexander JW, Linda W. Moore LW, Christians U, Klawitter J, Gaber O, Woodle SE. Biomarkers for prevention of complications following renal transplantation. Transplantomics and Biomarkers, San Diego, CA, March 8-10.
Crader K, Repine JDJ, Klawitter J, Fernandez-Bustamante A, Beehler C, Christians U, Repine JE. Metabolomic Analysis Distinguishes Long-Lived Tolerant rat Strain that Resists Acute Lung Injury. American Thoracic Society, San Francisco, CA, May 18-23, 2012.
Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec 1;125(12):4666-80. PubMed PMID: 26551682
U C, Klawitter J, Klawitter J. Biomarkers in Transplantation- Proteomics and Metabolomics. Ther Drug Monit. 2015 Aug 28. [Epub ahead of print] PubMed PMID: 26418702
Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1534-41. PubMed PMID: 26224879
Moore L, Haykal N, Klawitter J, Christians U, Alexander J, Gaber A. Correlation of Omega-3 Index with Dietary Intake in Kidney Transplant Recipients. 36th National Nutrient Database Conference, Houston, TX, March 26-28, 2012.
Klawitter J, Nashan B, Christians U. Everolimus and sirolimus in transplantation-related but different. Expert Opin Drug Saf. 2015 Jul;14(7):1055-70. PubMed PMID: 25912929
Jablonski KL, Klawitter J, Chonchol M, Bassett CJ, Racine ML, Seals DR. Effect of dietary sodium restriction on human urinary metabolomic profiles. Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1227-34. PubMed PMID: 25901092
Niederlechner S, Klawitter J, Christians U, Wishmeyer P. Fibronectin-Integrin Interaction: Role in L-Glutamine’s Intracellular Transport and in Its’ Molecular Cytoprotective Mechanisms in Heat Stressed Intestinal Epithelial-6 Cells. 41st Critical Care Congress, Houston, TX, February 4-8, 2012 (won GI/Nutrition Specialty Award).
Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15;446:43-53. PubMed PMID: 25871999
Strand T-E, Khiabani HZ, Boico A, Radiloff D, Irwin D, Hamilton K, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Schroeder T. Safety of combined bambuterol and theophylline as a potential treatment of high altitude-induced fatigue in humans. Journal of Cardiovascular Pharmacology 2016 (in press).
Niederlechner S, Klawitter J, Christians U, Wishmeyer P. Role of EGFR Tyrosine Kinase Activity in the Cytoprotective Mechanism and Intracellular Transport of L-Glutamine in Heat Stressed Intestinal Epithelial-6 Cells. Clinical Nutrition Week, Orlando, FL, January 21-24, 2012.
Fæste CK, Moen A, Schniedewind B, Anonsen JH, Klawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish. Journal of Chromatography A 2016 (in press).
Niederlechner S, Klawitter J, Baird C, Kallweit, Christians U, Wishmeyer P. Fibronectin stabilization and Fibronectin-Integrin signaling via MAPK are required in L-Glutamine-meadiated protection against gut injury. Experimental Biology, San Diego, CA, April 21-25, 2012.
Christians U, Klepacki J, Shokati T, Klawitter J, Klawitter J. Mass spectrometry-based multiplexing for the analysis of biomarkers in drug development and clinical diagnostics- how much is too much? Microchem J 2012;105: 32–38.
Tanabe K, Lanaspa M, Kitagawa W, Rivard C, Miyazaki M, Klawitter J, Schreiner G, Saleem M, Mathieson P, Makino H, Johnson R, and Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS deficient mouse. Am J of Physiol – Renal Physiol 2012; 302: 1151-1160.
Niederlechner S, Klawitter J, Baird C, Kallweit A, Christians U, Wishmeyer P. Fibronectin-Integrin Signaling Is Required for L-Glutamine's Protection against Gut Injury. PLOS One 2012; 7: 50185.
Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN. Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med. 2016 Dec;121:59-66. PubMed PMID: 27888993
Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and Metabolomics in Renal Transplantation- Quo Vadis? Transpl Int 2012
Bohra R*, Schöning W*, Klawitter J*, Brunner N, Schmitz V, Shokati T, Lawrence R, Zapata MF, Schniedewind B, Christians U, Klawitter J. Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PLOS One 2012;7:e48063(*authors contributed equally).
Klawitter J*, Klawitter J*, Schmitz V*, Brunner N, Crunk A, Corby C, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. A Low-Salt Diet and Cyclosporine Nephrotoxicity: Changes in Kidney Cell Metabolism. J Proteome Res. 2012;11: 5135-5144.
Davidson JA, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer PE, Klawitter J. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. PLoS One. 2016 Jul 6;11(7):e0158981. PubMed PMID: 27384524
Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U. Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?. Clin Biochem. 2016 Sep;49(13-14):955-61. PubMed PMID: 27288551
Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 2016;51(6):366-73. PubMed PMID: 26950528
Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish. J Chromatogr A. 2016 Feb 5;1432:58-72. PubMed PMID: 26787163
Christians U, Klawitter J, Klawitter J. Biomarkers in Transplantation--Proteomics and Metabolomics. Ther Drug Monit. 2016 Apr;38 Suppl 1:S70-4. PubMed PMID: 26418702
Christians U, Klawitter J, Klepacki J, Klawitter J. The role of metabolomics in the study of kidney diseases and in the development of diagnostic tools.
In: Biomarkers of Kidney Disease. Edelstein C (ed.) Elsevier, San Diego (2016), 2nd edition
Klepacki J, Brunner N, Schmitz V, Klawitter J, Christians U, Klawitter J. LC-MS/MS Assay for the Quantification of Trans-Methylation Pathway Intermediates S-Adenosylmethionine and S-Adenosylhomocysteine in Human Plasma. Clin Chim Acta 2013 (in press).
Christians U, Klawitter J, Klepacki J, Klawitter J. The role of proteomics in the study of kidney diseases and in the development of diagnostic tools. In:
Biomarkers of Kidney Disease. Edelstein C (ed.) Elsevier, San Diego (2016), 2nd edition
Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT and ASK1/p38 Mediated Cell Signaling with Ischemic Cardiomyopathy. Cardiovascular Research 2013;97: 66-76.
Klawitter J, Hildreth KL, Christians U, Kohrt WM, Moreau KL. A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition. Physiol Rep. 2017 Sep;5(17). PubMed PMID: 28904082
Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 Sep 5;7(1):10540. PubMed PMID: 28874678
Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2017 Aug 31. [Epub ahead of print] PubMed PMID: 28857147
Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct;39(5):556-564. PubMed PMID: 28640062
Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 Sep;95(9):1009-1018. PubMed PMID: 28467859
Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB. Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data. J Proteome Res. 2017 Apr 7;16(4):1515-1525. PubMed PMID: 28314371
Tavera-Mendoza LE, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, Cameron LA, Ficarro SB, Marto JA, Klawitter J, Brown M. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2186-E2194. PubMed PMID: 28242709
Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017 Sep;118(9):2933-2940. PubMed PMID: 28230282
Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN. Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med. 2016 Dec;121:59-66. PubMed PMID: 27888993
Davidson JA, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer PE, Klawitter J. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. PLoS One. 2016;11(7):e0158981. PubMed PMID: 27384524
Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U. Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?. Clin Biochem. 2016 Sep;49(13-14):955-61. PubMed PMID: 27288551
Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 2016;51(6):366-73. PubMed PMID: 26950528
Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish. J Chromatogr A. 2016 Feb 5;1432:58-72. PubMed PMID: 26787163
Christians U, Klawitter J, Klawitter J. Biomarkers in Transplantation--Proteomics and Metabolomics. Ther Drug Monit. 2016 Apr;38 Suppl 1:S70-4. PubMed PMID: 26418702
Schoening W, Schmitz V, Klawitter J, Christians U, Klawitter J. Metabolic markers for differentiation between renal allograft
rejection and immunosuppressant toxicity in rat urine. Metabolomics 2017; 13(9): 102.
Alloway RR, Vinks, AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle SE, Tremblay S, Klawitter J, Klawitter J,
Christians U. Bioequivalence between brand and generic tacrolimus in liver and kidney transplant recipients: a randomized clinical trial. PLOS Medicine
Nowak KL, Wang W, Farmer-Bailey H, Gitomer B, Malaczewski M, Klawitter J, Jovanovich A, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1493-1501. PubMed PMID: 30228110
Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jul 13;7(14). PubMed PMID: 30006493
Sundaram SS, Halbower AC, Klawitter J, Pan Z, Robbins K, Capocelli KE, Sokol RJ. Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2018 Jul;198:67-75.e1. PubMed PMID: 29752170
Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2018 May;103(5):888-898. PubMed PMID: 28857147
Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res. 2018 Feb;59(2):380-390. PubMed PMID: 29229740
Persson JN, Baird CH, Tong S, Urban TT, Klawitter J, Wischmeyer PE, Davidson JA. Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. Pediatr Res. 2018 Apr;83(4):858-865. PubMed PMID: 29278640
Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 May;48(5):791-802. PubMed PMID: 29389016
Shokati T, Hartmann M, Davari B, Klawitter J, Klawitter J, Christians U. Temsirolimus metabolic pathways revisited. Xenobiotica. 2019 Oct 23;:1-14. [Epub ahead of print] PubMed PMID: 31596164
Weinberg A, Huo Y, Kacanek D, Patel K, Watts DH, Wara D, Hoffman RM, Klawitter J, Christians U. Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D. J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):181-187. PubMed PMID: 31513074
Klawitter J, Klawitter J, Pennington A, Kirkpatrick B, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683-F694. PubMed PMID: 31188033
Golomb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawitter J, Klawitter J, Smith D, Repine JE. Depressed prostaglandins and leukotrienes in veterans with Gulf War illness. J Environ Sci Health B. 2019;54(8):623-639. PubMed PMID: 31033394
Golomb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawitter J, Klawitter J, Smith D, Repine JE. Depressed prostaglandins and leukotrienes in veterans with Gulf War illness. J Environ Sci Health B. 2019;54(8):623-639. PubMed PMID: 31033394
Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 Jun 1;126(6):1533-1540. PubMed PMID: 30896357
Nowak KL, Gitomer B, Farmer-Bailey H, Wang W, Malaczewski M, Klawitter J, You Z, George D, Patel N, Jovanovich A, Chonchol M. Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial. Am J Kidney Dis. 2019 Aug;74(2):213-223. PubMed PMID: 30803706
Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr;120(4):768-778. PubMed PMID: 29576117
Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J Am Heart Assoc. 2018 Dec 18;7(24):e010711. PubMed PMID: 30561257
Quillinan N, Dingman AL, Deng G, Tatum S, Orfila JE, Clevenger AC, Klawitter J, Traystman RJ, Herson PS. Single dose of 17ß-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation. Neurochem Int. 2019 Jul;127:80-86. PubMed PMID: 30471325
Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB. A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction. Eur J Nutr. 2018 Nov 7. [Epub ahead of print] PubMed PMID: 30406389
Nowak KL, Wang W, Farmer-Bailey H, Gitomer B, Malaczewski M, Klawitter J, Jovanovich A, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1493-1501. PubMed PMID: 30228110
Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jul 13;7(14). PubMed PMID: 30006493
Sundaram SS, Halbower AC, Klawitter J, Pan Z, Robbins K, Capocelli KE, Sokol RJ. Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia Improves the Severity of Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2018 Jul;198:67-75.e1. PubMed PMID: 29752170
Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr;120(4):768-778. PubMed PMID: 29576117
Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 May;48(5):791-802. PubMed PMID: 29389016
Persson JN, Baird CH, Tong S, Urban TT, Klawitter J, Wischmeyer PE, Davidson JA. Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. Pediatr Res. 2018 Apr;83(4):858-865. PubMed PMID: 29278640
Montford JR, Lehman AMB, Bauer CD, Klawitter J, Klawitter J, Poczobutt JM, Scobey M, Weiser-Evans M, Nemenoff RA, Furgeson SB. Bone marrow-derived cPLA2a contributes to renal fibrosis progression. J Lipid Res. 2018 Feb;59(2):380-390. PubMed PMID: 29229740
Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2018 May;103(5):888-898. PubMed PMID: 28857147
Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2020 Oct 9. [Epub ahead of print] PubMed PMID: 33045409
Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2020 Oct 2. [Epub ahead of print] PubMed PMID: 33002141
Frymoyer A, Van Meurs KP, Drover DR, Klawitter J, Christians U, Chock VY. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2020 Dec;88(6):871-877. PubMed PMID: 32919393
Sabapathy D, Klawitter J, Silveira L, Khailova L, Mitchell MB, Morgan GJ, DiMaria MV, Twite M, Frank BS, Davidson JA. Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics. 2020 Sep 5;16(9):93. PubMed PMID: 32889608
Cooney SJ, Klawitter J, Khailova L, Robison J, Jaggers J, Ing RJ, Lawson S, Frank BS, Lujan SO, Davidson JA. Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest. Metabolomics. 2021 Sep 22;17(10):89. PubMed PMID: 34553313
Pagano E, Frank B, Jaggers J, Twite M, Urban TT, Klawitter J, Davidson J. Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease. Congenit Heart Dis. 2020 Sep 7;15(4):251-265. PubMed PMID: 34413893
Moreau KL, Hildreth KL, Klawitter J, Blatchford P, Kohrt WM. Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress. Geroscience. 2020 Aug 8. [Epub ahead of print] PubMed PMID: 32770384
Brosnahan GM, Wang W, Gitomer B, Struemph T, George D, You Z, Nowak KL, Klawitter J, Chonchol M. Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study. Am J Kidney Dis. 2021 Aug 12. [Epub ahead of print] PubMed PMID: 34391872
Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 Oct;36(10):3259-3269. PubMed PMID: 33954809
Klawitter J, Klawitter J, Pennington A, Kirkpatrick B, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683-F694. PubMed PMID: 31188033
Weinberg A, Huo Y, Kacanek D, Patel K, Watts DH, Wara D, Hoffman RM, Klawitter J, Christians U. Brief Report: Markers of Spontaneous Preterm Delivery in Women Living With HIV: Relationship With Protease Inhibitors and Vitamin D. J Acquir Immune Defic Syndr. 2019 Oct 1;82(2):181-187. PubMed PMID: 31513074
Baliga MM, Klawitter J, Christians U, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Klawitter J. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease. Sci Rep. 2021 Mar 23;11(1):6629. PubMed PMID: 33758231
Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids bY LC-MS-MS in Human Plasma. J Anal Toxicol. 2021 Mar 23. [Epub ahead of print] PubMed PMID: 33754154
Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis. 2021 Mar 5;12(3):248. PubMed PMID: 33674554
Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 Mar;229:24-37. PubMed PMID: 33045409
Frymoyer A, Van Meurs KP, Drover DR, Klawitter J, Christians U, Chock VY. Theophylline dosing and pharmacokinetics for renal protection in neonates with hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia. Pediatr Res. 2020 Dec;88(6):871-877. PubMed PMID: 32919393
Sabapathy D, Klawitter J, Silveira L, Khailova L, Mitchell MB, Morgan GJ, DiMaria MV, Twite M, Frank BS, Davidson JA. Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics. 2020 Sep 5;16(9):93. PubMed PMID: 32889608
Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
Moreau KL, Hildreth KL, Klawitter J, Blatchford P, Kohrt WM. Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress. Geroscience. 2020 Dec;42(6):1699-1714. PubMed PMID: 32770384
Sempio C, Lindley E, Klawitter J, Christians U, Bowler RP, Adgate JL, Allshouse W, Awdziejczyk L, Fischer S, Bainbridge J, Vandyke M, Netsanet R, Crume T, Kinney GL. Surface Detection of THC Attributable to Vaporizer Use in the Indoor Environment. Sci Rep. 2019 Dec 9;9(1):18587. PubMed PMID: 31819131
Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. PubMed PMID: 32048179
Bidwell LC, Ellingson JM, Karoly HC, YorkWilliams SL, Hitchcock LN, Tracy BL, Klawitter J, Sempio C, Bryan AD, Hutchison KE. Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment. JAMA Psychiatry. 2020 Aug 1;77(8):787-796. PubMed PMID: 32520316
Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 Feb;58(2):124-128. PubMed PMID: 31111749
Golomb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawitter J, Klawitter J, Smith D, Repine JE. Depressed prostaglandins and leukotrienes in veterans with Gulf War illness. J Environ Sci Health B. 2019;54(8):623-639. PubMed PMID: 31033394
Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 Jun 1;126(6):1533-1540. PubMed PMID: 30896357
Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol. 2022 Jul 22. [Epub ahead of print] PubMed PMID: 35867237
Nowak KL, Gitomer B, Farmer-Bailey H, Wang W, Malaczewski M, Klawitter J, You Z, George D, Patel N, Jovanovich A, Chonchol M. Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial. Am J Kidney Dis. 2019 Aug;74(2):213-223. PubMed PMID: 30803706
Iguidbashian KG, Robison J, Khailova L, Jaggers J, Ing R, Lawson S, Osorio Lujan SM, Klawitter J, Davidson JA. Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass. Pediatr Res. 2022 Jun 9. [Epub ahead of print] PubMed PMID: 35681098
Davidson JA, Robison J, Khailova L, Frank BS, Jaggers J, Ing RJ, Lawson S, Iguidbashian J, Ali E, Treece A, Soranno DE, Osorio-Lujan S, Klawitter J. Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F20-F32. PubMed PMID: 35532069
Klawitter J, Sempio C, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Christians U, Klawitter J. Endocannabinoid System in Polycystic Kidney Disease. Am J Nephrol. 2022;53(4):264-272. PubMed PMID: 35263737
Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM. Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. Cereb Cortex. 2019 Dec 17;29(11):4679-4696. PubMed PMID: 30715245
Hopp K, Kleczko EK, Gitomer BY, Chonchol M, Klawitter J, Christians U, Klawitter J. Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F258-F267. PubMed PMID: 35037466
Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai MA, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD: A Randomized Controlled Trial. Clin J Am Soc Nephrol. 2022 Feb;17(2):240-250. PubMed PMID: 34907021
Leino AD, King EC, Jiang W, Vinks AA, Klawitter J, Christians U, Woodle ES, Alloway RR, Rohan JM. Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values. Am J Transplant. 2019 May;19(5):1410-1420. PubMed PMID: 30506623
Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F105-F119. PubMed PMID: 34866403
Quillinan N, Dingman AL, Deng G, Tatum S, Orfila JE, Clevenger AC, Klawitter J, Traystman RJ, Herson PS. Single dose of 17ß-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation. Neurochem Int. 2019 Jul;127:80-86. PubMed PMID: 30471325
Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB. A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction. Eur J Nutr. 2019 Dec;58(8):3059-3068. PubMed PMID: 30406389
Cooney SJ, Klawitter J, Khailova L, Robison J, Jaggers J, Ing RJ, Lawson S, Frank BS, Lujan SO, Davidson JA. Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest. Metabolomics. 2021 Sep 22;17(10):89. PubMed PMID: 34553313
Brosnahan GM, Wang W, Gitomer B, Struemph T, George D, You Z, Nowak KL, Klawitter J, Chonchol MB. Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study. Am J Kidney Dis. 2022 Apr;79(4):518-526. PubMed PMID: 34391872
Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 Oct;36(10):3259-3269. PubMed PMID: 33954809
Sempio C, Klawitter J, Jackson M, Freni F, Shillingburg R, Hutchison K, Bidwell LC, Christians U, Klawitter J. Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. Anal Bioanal Chem. 2021 May;413(12):3381-3392. PubMed PMID: 33817753
Baliga MM, Klawitter J, Christians U, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Klawitter J. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease. Sci Rep. 2021 Mar 23;11(1):6629. PubMed PMID: 33758231
Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids by LC-MS-MS in Human Plasma. J Anal Toxicol. 2022 Apr 21;46(4):383-392. PubMed PMID: 33754154
Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis. 2021 Mar 5;12(3):248. PubMed PMID: 33674554
Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 Mar;229:24-37. PubMed PMID: 33045409
Shokati T, Drake SH, Zhao W, Klawitter J, Klawitter J, Christians U. Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns. Metabolites. 2023 Oct 19;13(10). PubMed PMID: 37887418
Ali EA, Syed A, Khailova L, Iguidbashian JP, Suarez-Pierre A, Klawitter J, Stone M, Mancuso CA, Frank BS, Davidson JA. Novel Biomarkers of Necrotizing Enterocolitis in Neonates Undergoing Congenital Heart Disease Surgery: A Pilot Cohort Study. J Am Heart Assoc. 2023 Aug;12(15):e030712. PubMed PMID: 37489765
Frank BS, Khailova L, Dekermanjian J, Mitchell MB, Morgan GJ, Twite M, Christians U, DiMaria MV, Klawitter J, Davidson JA. Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. 2023 Jan;2(1). PubMed PMID: 36875009
Soós B, Hamar A, Pusztai A, Czókolyová M, Végh E, Szamosi S, Petho Z, Gulyás K, Kerekes G, Szántó S, Szucs G, Christians U, Klawitter J, Seres T, Szekanecz Z. Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach. Front Med (Lausanne). 2022;9:1011734. PubMed PMID: 36438060
Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 Feb;130(2):154-164. PubMed PMID: 36428160
Nguyen DT, Kleczko EK, Dwivedi N, Monaghan MT, Gitomer BY, Chonchol MB, Clambey ET, Nemenoff RA, Klawitter J, Hopp K. The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression. JCI Insight. 2023 Jan 10;8(1). PubMed PMID: 36422996
Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol. 2023 Jan;36(1):83-91. PubMed PMID: 35867237
Davidson JA, Robison J, Khailova L, Frank BS, Jaggers J, Ing RJ, Lawson S, Iguidbashian J, Ali E, Treece A, Soranno DE, Osorio-Lujan S, Klawitter J. Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F20-F32. PubMed PMID: 35532069
Klawitter J, Sempio C, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Christians U, Klawitter J. Endocannabinoid System in Polycystic Kidney Disease. Am J Nephrol. 2022;53(4):264-272. PubMed PMID: 35263737
Hopp K, Kleczko EK, Gitomer BY, Chonchol M, Klawitter J, Christians U, Klawitter J. Metabolic reprogramming in a slowly developing orthologous model of polycystic kidney disease. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F258-F267. PubMed PMID: 35037466
Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai MA, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD: A Randomized Controlled Trial. Clin J Am Soc Nephrol. 2022 Feb;17(2):240-250. PubMed PMID: 34907021
Montford JR, Bauer C, Rahkola J, Reisz JA, Floyd D, Hopp K, Soranno DE, Klawitter J, Weiser-Evans MCM, Nemenoff R, Faubel S, Furgeson SB. 15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction. Am J Physiol Renal Physiol. 2022 Jan 1;322(1):F105-F119. PubMed PMID: 34866403
Brosnahan GM, Wang W, Gitomer B, Struemph T, George D, You Z, Nowak KL, Klawitter J, Chonchol MB. Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study. Am J Kidney Dis. 2022 Apr;79(4):518-526. PubMed PMID: 34391872
Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids by LC-MS-MS in Human Plasma. J Anal Toxicol. 2022 Apr 21;46(4):383-392. PubMed PMID: 33754154
Atwood D, He Z, Miyazaki M, Hailu F, Klawitter J, Edelstein CL. Early treatment with 2-deoxy-d-glucose reduces proliferative proteins in the kidney and slows cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease (PKD). Cell Signal. 2024 Nov;123:111351. PubMed PMID: 39159908
Ward AM, Shokati T, Klawitter J, Klawitter J, Nguyen V, Kozell L, Abbas AI, Jones D, Christians U. Identification and Characterization of Cannabichromene's Major Metabolite Following Incubation with Human Liver Microsomes. Metabolites. 2024 Jun 13;14(6). PubMed PMID: 38921465
Sempio C, Campos-Palomino J, Klawitter J, Harrison A, Peters EN, MacNair L, Haghdoost M, Bonn-Miller M, Babalonis S, Huestis MA, Christians U, Klawitter J. LC-MS-MS quantification of ?8-THC, ?9-THC, THCV isomers and their main metabolites in human plasma. J Anal Toxicol. 2024 Aug 21;48(7):499-506. PubMed PMID: 38836589
Frank BS, Niemiec S, Khailova L, Mancuso CA, Lehmann T, Mitchell MB, Morgan GJ, Twite M, DiMaria MV, Klawitter J, Davidson JA. Arginine-NO metabolites are associated with morbidity in single ventricle infants undergoing stage 2 palliation. Pediatr Res. 2024 Jul;96(2):347-355. PubMed PMID: 38565916
Klawitter J, Weissenborn W, Gvon I, Walz M, Klawitter J, Jackson M, Sempio C, Joksimovic SL, Shokati T, Just I, Christians U, Todorovic SM. ß-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?. Mol Pharmacol. 2024 Jan 10;105(2):75-83. PubMed PMID: 38195158
Gitomer BY, Wang W, George D, Coleman E, Nowak KL, Struemph T, Cadnapaphornchai MA, Patel NU, Jovanovich A, Klawitter J, Farmer B, Ostrow A, You Z, Chonchol M. Statin therapy in patients with early-stage autosomal dominant polycystic kidney disease: Design and baseline characteristics. Contemp Clin Trials. 2024 Feb;137:107423. PubMed PMID: 38151173
Shokati T, Drake SH, Zhao W, Klawitter J, Klawitter J, Christians U. Structural Identification of Zotarolimus (ABT-578) Metabolites Generated by Human Liver Microsomes Using Ion-Trap and High-Resolution Time-of-Flight Mass Spectrometry in Combination with the Analysis of Fragmentation Patterns. Metabolites. 2023 Oct 19;13(10). PubMed PMID: 37887418
Ali EA, Syed A, Khailova L, Iguidbashian JP, Suarez-Pierre A, Klawitter J, Stone M, Mancuso CA, Frank BS, Davidson JA. Novel Biomarkers of Necrotizing Enterocolitis in Neonates Undergoing Congenital Heart Disease Surgery: A Pilot Cohort Study. J Am Heart Assoc. 2023 Aug;12(15):e030712. PubMed PMID: 37489765
Frank BS, Khailova L, Dekermanjian J, Mitchell MB, Morgan GJ, Twite M, Christians U, DiMaria MV, Klawitter J, Davidson JA. Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. 2023 Jan;2(1). PubMed PMID: 36875009
Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. Br J Anaesth. 2023 Feb;130(2):154-164. PubMed PMID: 36428160
Nguyen DT, Kleczko EK, Dwivedi N, Monaghan MT, Gitomer BY, Chonchol MB, Clambey ET, Nemenoff RA, Klawitter J, Hopp K. The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression. JCI Insight. 2023 Jan 10;8(1). PubMed PMID: 36422996
Klawitter J, Jackson MJ, Smith PH, Hopp K, Chonchol M, Gitomer BY, Cadnapaphornchai MA, Christians U, Klawitter J. Kynurenines in polycystic kidney disease. J Nephrol. 2023 Jan;36(1):83-91. PubMed PMID: 35867237