Christopher Hoyte, MD

Publications

• A Characterization of Spice Exposures Reported to the National Poison Data System in 2010; Annals of Emergency Medicine, Oct 2012. 60(4):435-8
• The Use of Energy Drinks, Dietary Supplements, and Prescription Medications by United States College Students to Enhance Athletic Performance; Journal of Community Health; epub February 2013
• The Use of Energy Drinks, Dietary Supplements, and Prescription Medications by United States College Students to Enhance Athletic Performance; Journal of Community Health
• Borderline and Long QT Interval in Adolescent Athletes; American College of Medical Toxicology 2013
• Medications that Prolong QT Interval in Adolescent Athletes; American College of Sports Medicine 2013
• Medications and the Risk of Long QT in Adolescent Athletes; American Society of Sports Medicine
• Aurora Fire Educational Video on Toxic Exposures
• The Use of Energy Drinks, Dietary Supplements, and Prescription Medications by United States College Students to Enhance Athletic Performance
• Medications that Prolong QT Interval in Adolescent Athletes; American College of Sports Medicine 2013
• Monte AA, Bronstein AC, Cao DJ, Heard KJ, Hoppe JA, Hoyte CO, Iwanicki JL, Lavonas EJ. An outbreak of exposure to a novel synthetic cannabinoid. N Engl J Med. 2014 Jan 23;370(4):389-90. PubMed PMID: 24450915
• An outbreak of exposure to a novel synthetic cannabinoid. Monte AA, Bronstein AC, Cao DJ, Heard KJ, Hoppe JA, Hoyte CO, Iwanicki JL, Lavonas EJ The New England journal of medicine. 370(4): 389-90
• Chua-Tuan, J, Cao, D, Iwanicki, J, Hoyte, C. Cardiac Sodium Channel Blockade after an Intentional Ingestion of Lacosamide, Cyclobenzaprine and Levetiracetam: Case Report. Clin Tox. 2015 May 8:1-4.
• Srisuma S, Bronstein AC, Hoyte CO. NBOMe and 2C substituted phenylethylamine exposures reported to the National Poison Data System. Clin Toxicol (Phila). 2015 Jun 11:1-5.
• Srisuma S, Winai A, Hoyte CO. Serotonin Syndrome Precipitated by Sertraline and Discontinuation of Clozapine: a Case Report and Literature Review. Clin Toxicol (Phila). 2015
• Lavonas EJ, Drennan IR, Gabrielli A, Heffner AC, Hoyte CO, Orkin AM, Sawyer KN, Donnino MW. Part 10: Special Circumstances of Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015 Nov 3;132(18 Suppl 2):S501-18.
• 25i and 2C Substituted Phenylethylamine Exposures Reported to a Regional Poison Center, American College of Medical Toxicology (2015)
• Unintentional Occupational Irritant and Asphyxiant Gas Exposures, American College of Medical Toxicology (2015)
• Characterization of Medical Marijuana Product Exposures Reported to the National Poison Data System, American College of Medical Toxicology (2015)
• Characterization of Edible Marijuana Product Exposures Reported, American College of Medical Toxicology (2015)
• Do Good Samaritan Laws and Laws Expanding Naloxone Access Decrease Opioid Death Rates?, American College of Medical Toxicology (2015)
• "Caustics". Rosen. 2015
• "Carbon Monoxide". Critical Care Toxicology. 2015
• Heard K, Marlin M, Nappe T. Hoyte C. Marijuana Experience in Colorado. Nov 2016. American Journal of Health-System accepted for publication
• Heard K, Marlin M, Nappe T. Hoyte C. Common marijuana-related cases encountered in the emergency department. Nov 15. 2017. American Journal of Health-System 16:7.
• Nappe, TN, Hoyte CO. Pediatric Death Due to Myocarditis After Exposure to Cannabis. Clinical Practice and Cases in Emergency Medicine, 1(3) Mar 16, 2017.
• Farrugia LA, Rhyee SH, Calello DP, Campleman SL, Riederer AM, Hoyte C, Malashock HR, Pizon A, Wiegand T, Wax PM, Brent J; Toxicology Investigators Consortium Study Group. The Toxicology Investigators Consortium Case Registry-the 2016 Experience. J Med Toxicol. 2017 Aug 1. [Epub ahead of print]
• Glatstein M, Carbell G, Scolnik D, Rimon A, Hoyte C.Treatment of pediatric black widow spider envenomation: A national poison center's experience. Am J Emerg Med. 2017 Nov 6. [Epub ahead of print]
• Hoyte C. The Abuse and Misuse of Gabapentin Reported to US Poison Control Centers, European Association of Poison Control Centers (2017)
• Glatstein M, Hoyte C. Evaluation of antivenom therpay for Vipera Palaestinae bites in children: experience of two large, tertiary care pediatric hospitals. Accepted Nov 2016. Clinical Toxicology.
• Hoyte C. The Abuse and Misuse of Levetiracetam Reported to US Poison Control Centers, European Association of Poison Control Centers
• Hoyte C. The Abuse and Misuse of Pregabalin Reported to US Poison Control Centers, European Association of Poison Control Centers
• Hoyte C, Banerji S. Acetylcysteine Discontinuation Criteria for Repeated Supratherapeutic Acetaminophen Ingestions, European Association of Poison Control Centers
• Hoyte C, Dart RC. A Survey of Medical Toxicologists Regarding Sentiment of Acetylcysteine Regimens for the Treatment of Acetaminophen Overdose, North American Congress of Clinical Toxicology
• Hoyte C. Wilson J. Opioid Prescription Practices for Pediatric Musculoskeletal Injuries, North American Congress of Clinical Toxicology
• Seidel LS, Hoyte C. Prevalence of Acute Liver Injury Associated with Exposure to Acetaminophen-Opioid Combination Products Reported to the National Poison Data System Pre- and Post-Reformulation, North American Congress of Clinical Toxicology
• Marlin M, Hoyte C. Illicit Drug Sale on the Darknet, North American Congress of Clinical Toxicology
• -Farrugia LA, Rhyee SH, Campleman SL, Ruha AM, Hoyte C, Weigand T, Wax PM, Brent J; Toxicology Investigators Consortium. The Toxicology Investigators Consortium Case Registry- the 2015 Experience. J Med Toxicol. 2016 Sep;12(3):224-47. doi: 10.1007/s13181-016-0580-6.
• Baker KA, Hoyte C. Multiple Seizures in a Pediatric Patient Following Marijuana Ingestion, North American Congress of Clinical Toxicology
• Christopher Hoyte, Caustics, Rosen's Emergency Medicine, 9th Edition
• Christopher Hoyte, Carbon Monoxide Poisoning, Critical Care Toxicology 2nd Edition
• Deaths from Unintentional Occupational Irritant and Asphyxiant Gas Exposures, European Association of Poison Control Centers (2016)
• A Characterization of Illicit and Prescription Drugs Available on the Darknet, North American Congress of Clinical Toxicology
• Brandehoff NP, Hoyte C. Beta-blockers and Hypoglycemia: Myth or Reality?, North American Congress of Clinical Toxicology
• Brandehoff NP, Hoyte C. Pediatric Ingestion of Cariprazine Causing Recurrent Central Nervous System Depression and Thrombocytopenia: A Case Report, North American Congress of Clinical Toxicology
• A Characterization of Fentanyl Exposures Reported to the National Poison Data System, North American Congress of Clinical Toxicology
• Pediatric Death Associated with Cannabis Exposure, North American Congress of Clinical Toxicology
• Illicit Drug Abuse Exposures Reported to the National Poison Data System after Legalization of Recreational Marijuana in Colorado, North American Congress of Clinical Toxicology
• -Brandehoff NP, Baker KA, Bonney CF, Ng PC, Schimmel J, Hoyte CO. Articles You May Have Missed. J Med Toxicol. 2018 Jun;14(2):156-159.
• Glatstein M, Carbell G, Scolnik D, Rimon A, Banerji S, Hoyte C. Pyridoxine for the treatment of isoniazid-induced seizures in intentional ingestions: The experience of a national poison center. Am J Emerg Med. 2018 Jan 31.
• Wang GS and Hoyte C. Substances of Abuse. Pediatrics in Review. March 2018.
• Wang GS, Hoyte C, Roosevelt G, Heard K. The Continued Impact of Marijuana Legalization on Unintentional Pediatric Exposures in Colorado. Clin Pediatr (Phila). 2019 Jan;58(1):114-116
• Illicit Drug Abuse Trends among Persons Living with HIV, North American Congress of Clinical Toxicology
• Wang GS, Yip L, Hoyte C. Review of Biguanide (Metformin) Toxicity. Journal of Intensive Care Medicine. Aug 1, 2018
• Hoyte C and Dart RC. Transition to Two-Bag Intravenous Acetylcysteine for Acetaminophen Overdose: A Poison Center’s Experience. Clin Tox. Aug 2, 2018
• -Schimmel J, Camarena-Michel A, Hoyte C. Pediatric Cases Involving Chemical Burns to Garlic Used to Treat Warts. Dermatitis. 2019 Jan/Feb;30(1):80-82.
• Hoyte C, Dart RC. Transition to two-bag intravenous acetylcysteine for acetaminophen overdose: a poison center's experience. Clin Toxicol (Phila). 2019 Mar;57(3):217-218
• Glatstein M, Carbell G, Koplowitz J, Hoyte C. Publication outcomes of abstracts presented at an international toxicology conference. Clin Toxicol (Phila). 2019 Apr 7:1-3.
• Glatstein M, Lerman L, Friedman S, Carbell G, Munchak I, Valla U, Scolnik D, Hoyte C. Severe disseminated intravascular coagulation in a child envenomated by echis coloratus and succesful treatment with monovalent equine immunoglobulin g antivenom. Toxicon. 2019 May 28
• Spyres MB, Farrugia LA, Kang AM, Calello DP, Campleman SL, Pizon A, Hoyte C, Wiegand T, Kao L, Riley BD, Li S, Wax PM, Brent J. Toxicology Investigators Consortium (ToxIC) Study Group. J Med Toxicol. 2019 Oct;15(4):228-254.
• Rachel E. Bridwell, Keith A. Baker, Christopher O. Hoyte, Patrick C. Ng. Digoxin Toxicity in a Patient with Pacemaker: A Case Report. Cureus. 2019 Nov 2;11(11). November 02, 2019.
• Prolonged Toxicity Following Self-Administration of a Kambô Cleansing Ritual, European Association of Poison Centres and Clinical Toxicologists, Napoli, Italy (2019)
• Toxicology on the Steppe: Evaluating the Burden of Toxicologic Disease in Mongolia, North American Congress of Clinical Toxicology (2019)
• Nakhaee S, Brent J, Hoyte C, Farrokhfall K, Shirazi FM, Askari M, Mehrpour O. The effect of tramadol on blood glucose concentrations: a systematic review. Expert Rev Clin Pharmacol. 2020 May 12:1-13.
• Farkhondeh T, Khan H, Aschner M, Samini F, Pourbagher-Shahri AM, Aramjoo H, Roshanravan B,Hoyte C, Mehrpour O, Samarghandian S. Impact of Cannabis-Based Medicine on Alzheimer's disease by Focusing on the Amyloid ß- Modifications: A Systematic Study. CNS Neurol Disord Drug Targets. 2020 Jul 8.
• Mehrpour O, Hoyte C, Amirabadizadeh A, Brent J; Toxicology Investigators Consortium (ToxIC). Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017. BMC Pharmacol Toxicol. 2020 Jul 22;21(1):53.
• Amirabadizadeh A, Nakhaee S, Jahani F, Soorgi S, Hoyte CO, Mehrpour O. Prognostic indicators in critically ill poisoned patients: development of a risk-prediction nomogram. Drug Metab Pers Ther. 2020 Sep 28.
• Miguel Glatstein, Amanda Katz, Nicole Taylor, Julieta Werthein, Efrat Zandberg, Christopher Hoyte. Publication outcomes of abstracts presented at 2013 North American Congress of Clinical Toxicology (NACCT) conference. Clin Toxicol (Phila). 2020 Feb 18;1-4.
• Applications of Machine Learning Within Clinical Toxicology: A Review, American College of Medical Toxicology, Annual Spring Meeting (2020)
• Serial Bicarbonate Monitoring in Toxic Alcohol Management, North American Congress of Clinical Toxicology (2020)
• Managing Methemoglobinemia in the Resource-Limited Setting: A Case Report from Nepal, North American Congress of Clinical Toxicology (2019)
• Regional Poison Center (RPC) Post-Marketing Surveillance Pilot Study: Safety and Effectiveness of Antivenom for the Treatment of Crotalid Envenomation, North American Congress of Clinical Toxicology (2020)
• Adolescent Marijuana Exposures Reported to the Rocky Mountain Poison Center, North American Congress of Clinical Toxicology (2020)
• Unintentional Pediatric Marijuana Exposures Reported to the Rocky Mountain Poison Center, North American Congress of Clinical Toxicology (2020)
• Does time to treatment after Crotaline envenomation predict amount of antivenom used to achieve initial control?, North American Congress of Clinical Toxicology (2020)
• Rosen's Emergency Medicine: Concepts and Clinical Practice; Volumes 1 &2, 10th Edition. Caustics
• Marijuana Legalization: The Experience of a Regional Poison Center, Emergency Medicine Society of South Africa, Capetown, South Africa (2019)
• Opioid Use Disorder Adjunctive Therapies: Exposures Reported to US Poison Centers. Emergency Medicine Society of South Africa, Capetown, South Africa (2019)
• Amirabadizadeh A, Nakhaee S, Jahani F, Soorgi S, Hoyte CO, Mehrpour O. Prognostic indicators in critically ill poisoned patients: development of a risk-prediction nomogram. Drug Metab Pers Ther. 2020 Sep 28.
• Glatstein M, Lerman L, Gatt D, Scolnik D, Rimon A, Hoyte C, Iazar I. Echis coloratus envenomation in children: a retrospective case series. Clin Toxicol. 2021 Jul 28;1-5.
• Spyres MB, Aldy K, Farrugia LA, Kang AM, Love JS, Hoyte C, Campleman SL, Li S, Amaducci A, Schwarz E, Wax PM, Brent J. The Toxicology Investigators Consortium 2020 Annual Report; Toxicology Investigators Consortium Study Group.J Med Toxicol. 2021 Oct;17(4):333-362.
• Mehrpour O, Saeedi F, Hoyte C. Decision tree outcome prediction of acute acetaminophen exposure in the United States: a study of 30,000 cases from the National Poison Data System. Basic Clin Pharmacol Toxicol. 2021 Oct 14.
• Hoyte C, Schimmel J, Hadianfar A, Banerji S, Nakhaee S, Mehrpour O. Toxic alcohol poisoning characteristics and treatments from 2000 to 2017 at a United States regional poison center. Daru. 2021 Oct 28.
• Mehrpour O, Saeedi F, Hadianfar A, Mégarbane B, Hoyte C. Prognostic factors of acetaminophen exposure in the United States: An analysis of 39,000 patients. Hum Exp Toxicol. 2021 Nov 12.
• Fomepizole as an Adjunct to Acetylcysteine for Acetaminophen Poisoning, American College of Medical Toxicology, Annual Spring Meeting (2021)
• Impact on Non-Allergic Anaphylactoid Reactions after Implementation of 2-bag Intravenous N-acetylcysteine Regimen for Pediatric Acetaminophen Toxicity, Pediatric Academic Societies (2021)
• Mehrpour O, Hoyte C, Delva-Clark H, Al Masud A, Biswas A, Schimmel J, Nakhaee S, Goss F. Classification of acute poisoning exposures with machine learning models derived from the National Poison Data System. Basic Clin Pharmacol Toxicol. 2022 Dec;131(6):566-574. PubMed PMID: 36181236
• Wang GS, Leonard J, Cornell A, Hoyte C. Adolescent US Poison Center Exposure Calls During the COVID-19 Pandemic. J Adolesc Health. 2022 Dec;71(6):764-767. PubMed PMID: 36088226
• Mehrpour O, Saeedi F, Hoyte C, Goss F, Shirazi FM. Correction: Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System. BMC Pharmacol Toxicol. 2022 Sep 9;23(1):68. PubMed PMID: 36085086
• Mehrpour O, Saeedi F, Hoyte C, Goss F, Shirazi FM. Utility of support vector machine and decision tree to identify the prognosis of metformin poisoning in the United States: analysis of National Poisoning Data System. BMC Pharmacol Toxicol. 2022 Jul 13;23(1):49. PubMed PMID: 35831909
• Mehrpour O, Hoyte C, Goss F, Shirazi FM, Nakhaee S. Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases. Drug Chem Toxicol. 2022 Jun 7;:1-7. [Epub ahead of print] PubMed PMID: 35670081
• Sudanagunta S, Camarena-Michel A, Pennington S, Leonard J, Hoyte C, Wang GS. Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity. Ann Pharmacother. 2023 Jan;57(1):36-43. PubMed PMID: 35587124
• Mehrpour O, Saeedi F, Hoyte C, Hadianfar A, Nakhaee S, Brent J. Distinguishing characteristics of exposure to biguanide and sulfonylurea anti-diabetic medications in the United States. Am J Emerg Med. 2022 Jun;56:171-177. PubMed PMID: 35398707
• Cohen N, Mathew M, Davis A, Brent J, Wax P, Schuh S, Freedman SB, Froberg B, Schwarz E, Canning J, Tortora L, Hoyte C, Koons AL, Burns MM, McFalls J, Wiegand TJ, Hendrickson RG, Judge B, Quang LS, Hodgman M, Chenoweth JA, Algren DA, Carey J, Caravati EM, Akpunonu P, Geib AJ, Seifert SA, Kazzi Z, Othong R, Greene SC, Holstege C, Tweet MS, Vearrier D, Pizon AF, Campleman SL, Li S, Aldy K, Finkelstein Y. Predictors of severe outcome following opioid intoxication in children. Clin Toxicol (Phila). 2022 Jun;60(6):702-707. PubMed PMID: 35333145
• Spyres MB, Padilla GK, Gerkin RD, Hoyte CO, Wolk BJ, Ruha AM. Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry. Clin Toxicol (Phila). 2022 Jul;60(7):838-842. PubMed PMID: 35261320
• Mehrpour O, Saeedi F, Hoyte C. Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System. Basic Clin Pharmacol Toxicol. 2022 Jan;130(1):191-199. PubMed PMID: 34649297
• Glatstein M, Lerman L, Gatt D, Scolnik D, Rimon A, Hoyte C, Iazar I. Echis coloratus envenomation in children: a retrospective case series. Clin Toxicol (Phila). 2022 Mar;60(3):293-297. PubMed PMID: 34319210
• Sudanagunta S, Camarena-Michel A, Pennington S, Leonard J, Hoyte C, Wang GS. Comparison of Two-Bag Versus Three-Bag N-Acetylcysteine Regimens for Pediatric Acetaminophen Toxicity. Ann Pharmacother. 2023 Jan;57(1):36-43. PubMed PMID: 35587124
• Mehrpour O, Hoyte C, Goss F, Shirazi FM, Nakhaee S. Decision tree algorithm can determine the outcome of repeated supratherapeutic ingestion (RSTI) exposure to acetaminophen: review of 4500 national poison data system cases. Drug Chem Toxicol. 2023 Nov;46(4):692-698. PubMed PMID: 35670081
• Mehrpour O, Saeedi F, Nakhaee S, Tavakkoli Khomeini F, Hadianfar A, Amirabadizadeh A, Hoyte C. Comparison of decision tree with common machine learning models for prediction of biguanide and sulfonylurea poisoning in the United States: an analysis of the National Poison Data System. BMC Med Inform Decis Mak. 2023 Apr 6;23(1):60. PubMed PMID: 37024869
• Mehrpour O, Hoyte C, Nakhaee S, Megarbane B, Goss F. Using a decision tree algorithm to distinguish between repeated supra-therapeutic and acute acetaminophen exposures. BMC Med Inform Decis Mak. 2023 Jun 1;23(1):102. PubMed PMID: 37264381
• Mehrpour O, Hoyte C, Al Masud A, Biswas A, Schimmel J, Nakhaee S, Nasr MS, Delva-Clark H, Goss F. Deep learning neural network derivation and testing to distinguish acute poisonings. Expert Opin Drug Metab Toxicol. 2023 Jan-Jun;19(6):367-380. PubMed PMID: 37395108
• Cohen N, Mathew M, Brent J, Wax P, Davis AL, Obilom C, Burns MM, Canning J, Baumgartner K, Koons AL, Wiegand TJ, Judge B, Hoyte C, Chenoweth JA, Froberg B, Farrar H, Carey JL, Hendrickson RG, Hodgman M, Caravati EM, Christian MR, Wolk BJ, Seifert SA, Bentur Y, Levine M, Farrugia LA, Vearrier D, Minns AB, Kennedy JM, Kirschner RI, Aldy K, Schuh S, Campleman S, Li S, Myran DT, Feng L, Freedman SB, Finkelstein Y. Severe outcomes following pediatric cannabis intoxication: a prospective cohort study of an international toxicology surveillance registry. Clin Toxicol (Phila). 2023 Aug;61(8):591-598. PubMed PMID: 37603042
• Simon M, Hoyte C. A Case Report of Venezuelan Suntiger Tarantula (Psalmopoeus Irminia) Envenomation and Review of Tarantula Exposures. J Emerg Med. 2023 Sep;65(3):e199-e203. PubMed PMID: 37635034
• Pepin LC, Simon MW, Banerji S, Leonard J, Hoyte CO, Wang GS. Toxic Tetrahydrocannabinol (THC) Dose in Pediatric Cannabis Edible Ingestions. Pediatrics. 2023 Sep 1;152(3). PubMed PMID: 37635689
• Lavonas EJ, Akpunonu PD, Arens AM, Babu KM, Cao D, Hoffman RS, Hoyte CO, Mazer-Amirshahi ME, Stolbach A, St-Onge M, Thompson TM, Wang GS, Hoover AV, Drennan IR. 2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2023 Oct 17;148(16):e149-e184. PubMed PMID: 37721023
• Neumann NR, du Plessis A, van Hoving DJ, Hoyte CO, Lermer A, Wittels S, Marks C. Antivenom supply and demand: An analysis of antivenom availability and utilization in South Africa. Afr J Emerg Med. 2023 Dec;13(4):245-249. PubMed PMID: 37745277
• Mehrpour O, Saeedi F, Vohra V, Hoyte C. Outcome prediction of methadone poisoning in the United States: implications of machine learning in the National Poison Data System (NPDS). Drug Chem Toxicol. 2023 Nov 9;:1-8. [Epub ahead of print] PubMed PMID: 37941394

Practice Locations

• University of Colorado Hospital

Specialty Information

• Emergency Medicine (2009)

• Emergency Care