Inhaled silica nanoparticles cause chronic kidney disease in rats.
Fumihiko Sasai, Keegan L Rogers, David J Orlicky, Arthur Stem, Joshua Schaeffer, Gabriela Garcia, Jacob Fox, Matthew S Ray, Jaime Butler-Dawson, Marvin Gonzalez-Quiroz, Ricardo Leiva, Gangadhar Taduri, Sirirat Anutrakululchai, Vidhya Venugopal, Magdalena Madero, Jason Glaser, Julia Wijkstrom, Annika Wernerson, Jared M Brown, Richard J Johnson, Carlos A Roncal-Jimenez
Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study
Authors
Isabella Melena, Federica Piani, Kalie L Tommerdahl, Cameron Severn, Linh T Chung, Alexis MacDonald, Carissa Vinovskis, David Cherney, Laura Pyle, Carlos A Roncal-Jimenez, Miguel A Lanaspa, Arleta Rewers, Daniël H van Raalte, Gabriel Cara-Fuentes, Chirag R Parikh, Robert G Nelson, Meda E Pavkov, Kristen J Nadeau, Richard J Johnson, Petter Bjornstad
Minimal change disease is associated with endothelial glycocalyx degradation and endothelial activation
Authors
Colin Bauer, Federica Piani, Mindy Banks, Flor A Ordoñez, Carmen de Lucas-Collantes, Kaori Oshima, Eric P Schmidt, Igor Zakharevich, Alfons Segarra, Cristina Martinez, Carlos Roncal-Jimenez, Simon C Satchell, Petter Bjornstad, Marshall Scott Lucia, Judith Blaine, Joshua M Thurman, Richard J Johnson, Gabriel Cara-Fuentes
Uric Acid: A Friend in the Past, a Foe in the Present
Authors
Abutaleb Ahsan Ejaz, Jo Ann Antenor, Vijay Kumar, Carlos Roncal, Gabriela E Garcia, Ana Andres-Hernando, Miguel A Lanaspa, Richard J Johnson
Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study.
Federica Piani, Isabella Melena, Cameron Severn, Linh T Chung, Carissa Vinovskis, David Cherney, Laura Pyle, Carlos A Roncal-Jimenez, Miguel A Lanaspa, Arleta Rewers, Daniël H van Raalte, Wassim Obeid, Chirag Parikh, Robert G Nelson, Meda E Pavkov, Kristen J Nadeau, Richard J Johnson, Petter Bjornstad
Climate change and nephrology
F Sasai, C Roncal-Jimenez, K Rogers, Y Sato, JM Brown, J Glaser, ...
Nephrology Dialysis Transplantation
A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats
GE Garcia, YJ Lu, LD Truong, CA Roncal-Jiménez, M Miyazaki, ...
Cells 10 (8), 2113
Hiperuricemia e doença renal crônica: tratar ou não tratar
Authors
Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Hyperuricemia and chronic kidney disease: to treat or not to treat
Authors
Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2020 Mar;287(3):252-262. PubMed PMID: 31621967
Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor
A Andres-Hernando, TJ Jensen, M Kuwabara, DJ Orlicky, C Cicerchi, N Li, ...
JCI insight
Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report
Authors
Gautam Phadke, Amit Kaushal, Dean R Tolan, Kai Hahn, Thomas Jensen, Petter Bjornstad, Carlos Roncal-Jimenez, Ana Andres Hernando, Miguel A Lanaspa, Mariam Priya Alexander, Aleksandra Kukla, Richard J Johnson
Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan
Authors
Masanari Kuwabara, Mehmet Kanbay, Koichiro Niwa, Ryusuke Ae, Ana Andres-Hernando, Carlos A Roncal-Jimenez, Gabriela Garcia, Laura Gabriela Sánchez-Lozada, Bernardo Rodriguez-Iturbe, Ichiro Hisatome, Miguel A Lanaspa, Richard J Johnson
Fructose Production and Metabolism in the Kidney
Authors
Takahiko Nakagawa, Richard J Johnson, Ana Andres-Hernando, Carlos Roncal-Jimenez, Laura G Sanchez-Lozada, Dean R Tolan, Miguel A Lanaspa
The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study
Authors
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Petter Bjornstad, Carlos A Roncal-Jimenez, Ana Andres-Hernando, Mehmet Kanbay, Richard J Johnson, Miguel A Lanaspa
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts
RJ Johnson, P Stenvinkel, P Andrews, LG Sánchez-Lozada, T Nakagawa, ...
Journal of Internal Medicine 287 (3), 252-262
García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2019 Dec 5. [Epub ahead of print] PubMed PMID: 31813623
García-Arroyo FE, Muñoz-Jiménez I, Gonzaga G, Tapia E, Osorio-Alonso H, Roncal-Jiménez CA, Iroz A, Vecchio M, Reyes-García JG, Johnson RJ, Sánchez-Lozada LG. A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose. Int J Mol Sci. 2019 Nov 16;20(22). PubMed PMID: 31744099
Ko J, Kang HJ, Kim DA, Kim MJ, Ryu ES, Lee S, Ryu JH, Roncal C, Johnson RJ, Kang DH. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019 Dec;33(12):13334-13345. PubMed PMID: 31553887
Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP. Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes. Pediatr Diabetes. 2019 Dec;20(8):1110-1117. PubMed PMID: 31433534
Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ. Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F941-F948. PubMed PMID: 31411075
Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ. Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1111-F1121. PubMed PMID: 31390229
Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. J Diabetes Complications. 2019 Sep;33(9):648-650. PubMed PMID: 31253490
García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages. Free Radic Biol Med. 2019 Sep;141:182-191. PubMed PMID: 31212064
Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA. Climate Change and the Kidney. Ann Nutr Metab. 2019;74 Suppl 3:38-44. PubMed PMID: 31203298
Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
Sánchez-Lozada LG, Roncal-Jimenez CA, García-Arroyo FE, Jensen T, Lanaspa MA, Johnson RJ. The perils of rehydrating with soft drinks following heat and exercise. Am J Physiol Regul Integr Comp Physiol. 2019 Mar 1;316(3):R187-R188. PubMed PMID: 30673300
Sanchez-Lozada LG, Andres-Hernando A, Garcia-Arroyo FE, Cicerchi C, Li N, Kuwabara M, Roncal-Jimenez CA, Johnson RJ, Lanaspa MA. Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. PubMed PMID: 30651350
Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan;63(1):150-60. PubMed PMID: 24269076
Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2526-38. PubMed PMID: 24876114
Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, Lanaspa MA, Ishimoto T, Nakagawa T, Correa-Rotter R, Wesseling C, Bankir L, Sanchez-Lozada LG. Hyperosmolarity drives hypertension and CKD--water and salt revisited. Nat Rev Nephrol. 2014 Jul;10(7):415-20. PubMed PMID: 24802066
Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. FASEB J. 2014 Aug;28(8):3339-50. PubMed PMID: 24755741
Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2014 Aug;86(2):294-302. PubMed PMID: 24336030
Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan;63(1):150-60. PubMed PMID: 24269076
Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24336030
Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872
Tapia E, Cristóbal M, García-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jiménez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sánchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F727-36. PubMed PMID: 23303409