Carlos Roncal, MS

Publications

• Fructose and sugar: a major mediator of nonalcoholic fatty liver disease Authors Thomas Jensen, Manal F Abdelmalek, Shelby Sullivan, Kristen J Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, Masanari Kuwabara, Yuka Sato, Duk-Hee Kang, Dean R Tolan, Laura G Sanchez-Lozada, Hugo R Rosen, Miguel A Lanaspa, Anna Mae Diehl, Richard J Johnson. Journal of hepatology
• Exposome and metabolome analysis of sugarcane workers reveals predictors of kidney injury. Arthur D Stem, Stephen Brindley, Keegan L Rogers, Adil Salih, Carlos A Roncal-Jimenez, Richard J Johnson, Lee S Newman, Jaime Butler-Dawson, Lyndsay Krisher, Jared M Brown. Kidney International Reports
• Intranasal administration of sugarcane ash causes chronic kidney disease in rats.Carlos A Roncal-Jimenez, Keegan L Rogers, Arthur Stem, Julia Wijkstrom, Annika Wernerson, Jacob Fox, Ramon Garcia Trabanino, Stephen Brindley, Gabriela Garcia, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Fumihiko Sasai, Manuel Urra, Gabriel Cara-Fuentes, L Gabriela Sánchez-Lozada, Bernardo Rodriguez-Iturbe, Jaime Butler Dawson, Magdalena Madero, Jared M Brown, Richard J Johnson. American Journal of Physiology-Renal Physiology
• Silica nanoparticles and Mesoamerican nephropathy: a case series.Keegan L Rogers, Carlos A Roncal-Jimenez, Ricardo Leiva, Arthur Stem, Julia Wijkstrom, Lissbeth Serpas, Marvin A González-Quiroz, Fumihiko Sasai, Annika Wernerson, Joshua Schaeffer, Jacob Fox, Matthew Ray, Anip Bansal, Manuel Urra, Jaime Butler-Dawson, Scott Lucia, Lee S Newman, Jason Glaser, Richard J Johnson, Jared M Brown
• Health burden of sugarcane burning on agricultural workers and nearby communities. Arthur D Stem, Matthew Gibb, Carlos A Roncal-Jimenez, Richard J Johnson, Jared M Brow.Inhalation Toxicology
• Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in GN. Luan D. Truong, Jessica Trostel, Carlos Roncal ,Gabriel Cara-Fuentes, Makoto Miyazaki ,Shinobu Miyazaki-Anzai, Ana Andres-Hernando, Fumihiko Sasai , Miguel Lanaspa , Richard J. Johnson ,and Gabriela E. Garcia
• [HTML] from sciencedirect.com Full-Text at CU Anschutz Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells
• 66 Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Mitochondrial Function and Metabolic Activity in Human Proximal Tubular Kidney Cells
• Climate change and nephrology
• Silica Nanoparticles and Mesoamerican Nephropathy: A Case Series
• Inhaled silica nanoparticles cause chronic kidney disease in rats. Fumihiko Sasai, Keegan L Rogers, David J Orlicky, Arthur Stem, Joshua Schaeffer, Gabriela Garcia, Jacob Fox, Matthew S Ray, Jaime Butler-Dawson, Marvin Gonzalez-Quiroz, Ricardo Leiva, Gangadhar Taduri, Sirirat Anutrakululchai, Vidhya Venugopal, Magdalena Madero, Jason Glaser, Julia Wijkstrom, Annika Wernerson, Jared M Brown, Richard J Johnson, Carlos A Roncal-Jimenez
• Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study Authors Isabella Melena, Federica Piani, Kalie L Tommerdahl, Cameron Severn, Linh T Chung, Alexis MacDonald, Carissa Vinovskis, David Cherney, Laura Pyle, Carlos A Roncal-Jimenez, Miguel A Lanaspa, Arleta Rewers, Daniël H van Raalte, Gabriel Cara-Fuentes, Chirag R Parikh, Robert G Nelson, Meda E Pavkov, Kristen J Nadeau, Richard J Johnson, Petter Bjornstad
• Minimal change disease is associated with endothelial glycocalyx degradation and endothelial activation Authors Colin Bauer, Federica Piani, Mindy Banks, Flor A Ordoñez, Carmen de Lucas-Collantes, Kaori Oshima, Eric P Schmidt, Igor Zakharevich, Alfons Segarra, Cristina Martinez, Carlos Roncal-Jimenez, Simon C Satchell, Petter Bjornstad, Marshall Scott Lucia, Judith Blaine, Joshua M Thurman, Richard J Johnson, Gabriel Cara-Fuentes
• Uric Acid: A Friend in the Past, a Foe in the Present Authors Abutaleb Ahsan Ejaz, Jo Ann Antenor, Vijay Kumar, Carlos Roncal, Gabriela E Garcia, Ana Andres-Hernando, Miguel A Lanaspa, Richard J Johnson
• Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study. Federica Piani, Isabella Melena, Cameron Severn, Linh T Chung, Carissa Vinovskis, David Cherney, Laura Pyle, Carlos A Roncal-Jimenez, Miguel A Lanaspa, Arleta Rewers, Daniël H van Raalte, Wassim Obeid, Chirag Parikh, Robert G Nelson, Meda E Pavkov, Kristen J Nadeau, Richard J Johnson, Petter Bjornstad
• Climate change and nephrology F Sasai, C Roncal-Jimenez, K Rogers, Y Sato, JM Brown, J Glaser, ... Nephrology Dialysis Transplantation
• A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats GE Garcia, YJ Lu, LD Truong, CA Roncal-Jiménez, M Miyazaki, ... Cells 10 (8), 2113
• Hiperuricemia e doença renal crônica: tratar ou não tratar Authors Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
• Hyperuricemia and chronic kidney disease: to treat or not to treat Authors Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
• Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2020 Mar;287(3):252-262. PubMed PMID: 31621967
• Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor A Andres-Hernando, TJ Jensen, M Kuwabara, DJ Orlicky, C Cicerchi, N Li, ... JCI insight
• Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report Authors Gautam Phadke, Amit Kaushal, Dean R Tolan, Kai Hahn, Thomas Jensen, Petter Bjornstad, Carlos Roncal-Jimenez, Ana Andres Hernando, Miguel A Lanaspa, Mariam Priya Alexander, Aleksandra Kukla, Richard J Johnson
• Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan Authors Masanari Kuwabara, Mehmet Kanbay, Koichiro Niwa, Ryusuke Ae, Ana Andres-Hernando, Carlos A Roncal-Jimenez, Gabriela Garcia, Laura Gabriela Sánchez-Lozada, Bernardo Rodriguez-Iturbe, Ichiro Hisatome, Miguel A Lanaspa, Richard J Johnson
• Fructose Production and Metabolism in the Kidney Authors Takahiko Nakagawa, Richard J Johnson, Ana Andres-Hernando, Carlos Roncal-Jimenez, Laura G Sanchez-Lozada, Dean R Tolan, Miguel A Lanaspa
• The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study Authors Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Petter Bjornstad, Carlos A Roncal-Jimenez, Ana Andres-Hernando, Mehmet Kanbay, Richard J Johnson, Miguel A Lanaspa
• Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts RJ Johnson, P Stenvinkel, P Andrews, LG Sánchez-Lozada, T Nakagawa, ... Journal of Internal Medicine 287 (3), 252-262
• Ko J, Kang HJ, Kim DA, Kim MJ, Ryu ES, Lee S, Ryu JH, Roncal C, Johnson RJ, Kang DH. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019 Dec;33(12):13334-13345. PubMed PMID: 31553887
• Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP. Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes. Pediatr Diabetes. 2019 Dec;20(8):1110-1117. PubMed PMID: 31433534
• Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ. Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F941-F948. PubMed PMID: 31411075
• Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ. Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1111-F1121. PubMed PMID: 31390229
• Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. J Diabetes Complications. 2019 Sep;33(9):648-650. PubMed PMID: 31253490
• García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages. Free Radic Biol Med. 2019 Sep;141:182-191. PubMed PMID: 31212064
• Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA. Climate Change and the Kidney. Ann Nutr Metab. 2019;74 Suppl 3:38-44. PubMed PMID: 31203298
• Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
• Sánchez-Lozada LG, Roncal-Jimenez CA, García-Arroyo FE, Jensen T, Lanaspa MA, Johnson RJ. The perils of rehydrating with soft drinks following heat and exercise. Am J Physiol Regul Integr Comp Physiol. 2019 Mar 1;316(3):R187-R188. PubMed PMID: 30673300
• Sanchez-Lozada LG, Andres-Hernando A, Garcia-Arroyo FE, Cicerchi C, Li N, Kuwabara M, Roncal-Jimenez CA, Johnson RJ, Lanaspa MA. Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. PubMed PMID: 30651350
• García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2019 Dec 5. [Epub ahead of print] PubMed PMID: 31813623
• García-Arroyo FE, Muñoz-Jiménez I, Gonzaga G, Tapia E, Osorio-Alonso H, Roncal-Jiménez CA, Iroz A, Vecchio M, Reyes-García JG, Johnson RJ, Sánchez-Lozada LG. A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose. Int J Mol Sci. 2019 Nov 16;20(22). PubMed PMID: 31744099
• Fasting blood glucose is predictive of hypertension in a general Japanese population Masanari Kuwabara, Yaswanth Chintaluru, Mehmet Kanbay, Koichiro Niwa, Ichiro Hisatome, Ana Andres-Hernando, Carlos Roncal-Jimenez, Minoru Ohno, Richard J Johnson, Miguel A Lanaspa Journal of hypertension 37 (1), 167-174
• Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress Authors Richard J Johnson, Santos E Perez-Pozo, Julian Lopez Lillo, Felix Grases, Jesse D Schold, Masanari Kuwabara, Yuka Sato, Ana Andres Hernando, Gabriela Garcia, Thomas Jensen, Christopher Rivard, Laura G Sanchez-Lozada, Carlos Roncal, Miguel A Lanaspa. BMC nephrology
• "Rehydration with fructose worsens dehydration-induced renal damage" Authors Tamara Milagres, Fernando E García-Arroyo, Miguel A Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G Sánchez-Lozada, Richard J Johnson, Carlos Roncal-Jimenez. BMC nephrology
• "Effects of fructose-containing sweeteners on fructose intestinal, hepatic, and oral bioavailability in dual-catheterized rats" Authors Leah R Villegas, Christopher J Rivard, Brandi Hunter, Zhiying You, Carlos Roncal, Melanie S Joy, MyPhuong T Le. Plos One
• "High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism" (vol 115, pg 3138, 2018) Authors Miguel A Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J Orlicky, Carlos A Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S MacLean, Richard J Johnson. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• "Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver" Authors Thomas Jensen, Koichiro Niwa, Ichiro Hisatome, Mehmet Kanbay, Ana Andres-Hernando, Carlos A Roncal-Jimenez, Yuka Sato, Gabriela Garcia, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson, Masanari Kuwabara. Scientific reports- Nature Publishing Group
• "Different risk for hypertension, diabetes, dyslipidemia, and hyperuricemia according to level of body mass index in japanese and american subjects" Authors Masanari Kuwabara, Remi Kuwabara, Koichiro Niwa, Ichiro Hisatome, Gerard Smits, Carlos Roncal-Jimenez, Paul MacLean, Joseph Yracheta, Minoru Ohno, Miguel Lanaspa, Richard Johnson, Diana Jalal. Nutrients
• Correction: Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study Authors Masanari Kuwabara, Ichiro Hisatome, Carlos A Roncal-Jimenez, Koichiro Niwa, Ana Andres-Hernando, Thomas Jensen, Petter Bjornstad, Tamara Milagres, Christina Cicerchi, Zhilin Song, Gabriela Garcia, Laura G Sánchez-Lozada, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson. PloS one
• Serum Uromodulin (SUMOD) Inversely Correlates with Aortic Stiffness in Type 1 Diabetes (T1D) Youth Authors PATTARA WIROMRAT, PETTER BJORNSTAD, CARLOS ALBERTO RONCAL-JIMENEZ, MICHAL SCHÄFER, AMY BAUMGARTNER, LAURA PYLE, MELANIE CREE-GREEN, YESENIA GARCIA REYES, LORNA BROWNE, RICHARD JOHNSON, KRISTEN J NADEAU. Source Diabetes-American Diabetes Association
• High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism Authors Miguel A Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nancy Li, Christina Cicerchi, Thomas Jensen, David J Orlicky, Carlos A Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S MacLean, Richard J Johnson. National Academy of Sciences
• Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes Authors Petter Bjornstad, David M Maahs, Carlos A Roncal, Janet K Snell-Bergeon, Viral N Shah, Tamara Milagres, Samuel L Ellis, Matthew Hatch, Linh T Chung, Marian J Rewers, Satish Garg, David Z Cherney, Laura Pyle, Kristen J Nadeau, Richard J Johnson. Diabetes, Obesity and Metabolism
• Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate Authors Laura-Gabriela Sánchez-Lozada, Fernando E García-Arroyo, Guillermo Gonzaga, Octaviano Silverio, Mónica G Blas-Marron, Itzel Muñoz-Jimenez, Edilia Tapia, Horacio Osorio-Alonso, Magdalena Madero, Carlos A Roncal-Jiménez, Ilana Weiss, Jason Glaser, Richard J Johnson. American journal of nephrology
• Different Effects of Global Osteopontin and Macrophage Osteopontin in Glomerular Injury Authors Jessica Trostel, Luan D Truong, Carlos A Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Masanari Kuwabara, Rachel H McMahan, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Miguel A Lanaspa, Richard J Johnson, Gabriela E Garcia. American Journal of Physiology-Renal Physiology
• Experimental Heat Stress Nephropathy and Liver Injury are Improved by Allopurinol Authors Carlos A Roncal-Jimenez, Yuka Sato, Tamara Milagres, Ana Andres-Hernando, Gabriela E Garcia, Petter Bjornstad, Jaime Butler-Dawson, Cecilia Sorensen, Lee Newman, Lyndsay Krisher, Magdalena Madero, Jason Glaser, Ramon Garcia-Trabannino, Emmanuel Jarquin-Romero, Zhilin Song, Thomas Jensen, Masanari Kuwabara, Bernardo Rodriguez-Iturbe, Laura-Gabriela Sanchez-Lozada, Miguel A Lanaspa, Richard J Johnson. American Journal of Physiology-Renal Physiology
• Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese cohort study Authors Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson. Journal: Hypertension
• "Fructose and Sugar: A Major Mediator of Nonalcoholic Fatty Liver Disease". Journal of hepatology
• P4556Obesity and serum uric acid as a risk factor for hypertension and diabetes mellitus: 5-year Japanese cohort study. European Heart Journal
• Chronic Dehydration Induced Changes in Mouse Supraoptic Nucleus (SON): Contribution to Chronic Kidney Diseases (CKD)? The FASEB Journa
• Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats. International journal of biological sciences
• MP063 AGING-ASSOCIATED RENAL DISEASE IN MICE IS DEPENDENT ON FRUCTOKINASE. Nephrology Dialysis Transplantation, Volume 32
• Asymptomatic hyperuricemia without comorbidities predicts cardiometabolic diseases: five-year japanese cohort study. Hypertension
• Increased serum sodium and serum osmolarity are independent risk factors for developing chronic kidney disease; 5 Year Cohort Study. PloS one.
• "Elevated serum uric acid level predicts rapid decline in kidney function". American journal of nephrology
• "Effects of exogenous desmopressin on a model of heat stress nephropathy in mice". American Journal of Physiology-Renal Physiology
• "Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice". Nature Communications.
• "Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese cohort study". Hypertension
• "Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge’s disease)". Respiratory physiology & neurobiology
• “Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Obesity
• "Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic DiseasesNovelty and Significance: Five-Year Japanese Cohort Study". Hypertension
• Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study M Kuwabara, I Hisatome, CA Roncal-Jimenez, K Niwa, ... PLOS ONE 12 (1), e0169137
• Kidney function in sugarcane cutters in Nicaragua–A longitudinal study of workers at risk of Mesoamerican nephropathy C Wesseling, A Aragón, M González, I Weiss, J Glaser, NA Bobadilla, ... Environmental research 147, 125-132
• Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury FE García-Arroyo, M Cristóbal, AS Arellano-Buendía, H Osorio, E Tapia, ... American Journal of Physiology-Regulatory, Integrative and Comparative ...
• Hyperfiltration and uricosuria in adolescents with type 1 diabetes P Bjornstad, C Roncal, T Milagres, L Pyle, MA Lanaspa, FK Bishop, ... Pediatric Nephrology 31 (5), 787-793
• Mesoamerican Nephropathy or Global Warming Nephropathy? CA Roncal-Jimenez, R García-Trabanino, C Wesseling, RJ Johnson Blood purification 41 (1-3), 135-138
• Metabolic and kidney diseases in the setting of climate change, water shortage, and survival factors RJ Johnson, P Stenvinkel, T Jensen, MA Lanaspa, C Roncal, Z Song, ... Journal of the American Society of Nephrology 27 (8), 2247-2256
• Aging-associated renal disease in mice is fructokinase dependent CA Roncal-Jimenez, T Ishimoto, MA Lanaspa, T Milagres, AA Hernando, ... American Journal of Physiology-Renal Physiology 311 (4), F722-F730
• Uric acid in metabolic syndrome: from an innocent bystander to a central player M Kanbay, T Jensen, Y Solak, M Le, C Roncal-Jimenez, C Rivard, ... European journal of internal medicine 29, 3-8
• Heat stress nephropathy from exercise-induced uric acid crystalluria: a perspective on Mesoamerican nephropathy C Roncal-Jimenez, R García-Trabanino, L Barregard, MA Lanaspa, ... American journal of kidney diseases 67 (1), 20-30
• Kidney function in sugarcane cutters in Nicaragua – A longitudinal study of workers at risk of Mesoamerican nephropathy. May 2016 · Environmental Research
• Climate change and the emergent epidemic of CKD from heat stress in rural communities: The case for heat stress nephropathy J Glaser, J Lemery, B Rajagopalan, HF Diaz, R García-Trabanino, ... Clinical Journal of the American Society of Nephrology 11 (8), 1472-1483
• Role of Fructose and Fructokinase in Acute Dehydration Induced Vasopressin Gene Expression and Secretion in Mice Z Song, CA Roncal-Jimenez, MA Lanaspa-Garcia, SA Oppelt, ... Journal of Neurophysiology, jn. 00781.2016
• General Internal Medicine Predictors of abdominal adipose tissue compartments: 18 PM Mannucci, M Kanbay, T Jensen, Y Solak, M Le, C Roncal-Jimenez, ...
• The effects of exogenous desmopressin on a model of heat stress nephropathy in mice CA Roncal-Jimenez, T Milagres, A Andres-Hernando, M Kuwabara, ... American Journal of Physiology-Renal Physiology, ajprenal. 00495.2016
• "Hyperfiltration and uricosuria in adolescents with type 1 diabetes". Dec 2015 · Pediatric Nephrology
• "Uric acid in metabolic syndrome: From an innocent bystander to a central player". Dec 2015 · European Journal of Internal Medicine
• "Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy". Oct 2015 · American Journal of Kidney Diseases
• "Heat stress, dehydration, and kidney function in sugarcane cutters in EI Salvador - A cross-shift study of workers at risk of Mesoamerican nephropathy". Jul 2015 · Environmental Research
• "Mechanisms by Which Dehydration May Lead to Chronic Kidney Disease". Jun 2015 · Annals of Nutrition and Metabolism.
• "Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel" Apr 2015 · PLoS ONE.
• "Hispanic Americans living in the United States and their risk for obesity, diabetes and kidney disease: Genetic and environmental considerations" Mar 2015 · Postgraduate Medicine
• Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2526-38. PubMed PMID: 24876114
• Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, Lanaspa MA, Ishimoto T, Nakagawa T, Correa-Rotter R, Wesseling C, Bankir L, Sanchez-Lozada LG. Hyperosmolarity drives hypertension and CKD--water and salt revisited. Nat Rev Nephrol. 2014 Jul;10(7):415-20. PubMed PMID: 24802066
• Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. FASEB J. 2014 Aug;28(8):3339-50. PubMed PMID: 24755741
• Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2014 Aug;86(2):294-302. PubMed PMID: 24336030
• Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan;63(1):150-60. PubMed PMID: 24269076
• Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan;63(1):150-60. PubMed PMID: 24269076
• “Synergistic effect of uricase blockade plus physiologic amounts of fructose - glucose on glomerular hypertension and oxidative stress in rats”.Tapia E, Cristobal M, Garcia-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jimenez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sanchez-Lozada LG
• Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24336030
• Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
• Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872
• Tapia E, Cristóbal M, García-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jiménez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sánchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F727-36. PubMed PMID: 23303409
• Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ. J Biol Chem. 2012 Nov 23;287(48):40732-44. doi: 10.1074/jbc.M112.399899. Epub 2012 Oct 3.
• Effects of excessive fructose intake on health. Johnson RJ, Lanaspa MA, Roncal-Jimenez C, Sanchez-Lozada LG. Ann Intern Med. 2012 Jun 19;156(12):905; author reply 905-6. doi: 10.7326/0003-4819-156-12-201206190-00024
• Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. Lanaspa MA, Cicerchi C, Garcia G, Li N, Roncal-Jimenez CA, Rivard CJ, Hunter B, Andrés-Hernando A, Ishimoto T, Sánchez-Lozada LG, Thomas J, Hodges RS, Mant CT, Johnson RJ. PLoS One. 2012;7(11):e48801. doi: 10.1371/journal.pone.0048801. Epub 2012 Nov 9.
• Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ. PLoS One. 2012;7(10):e47948. doi: 10.1371/journal.pone.0047948. Epub 2012 Oct 24.
• Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-?B-dependent pathway. Shimada M, Ishimoto T, Lee PY, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Wymer DT, Yamabe H, Mathieson PW, Saleem MA, Garin EH, Johnson RJ.Nephrol Dial Transplant. 2012 Jan;27(1):81-9. Epub 2011 May 26.
• Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.Proc Natl Acad Sci U S A. 2012 Feb 27. [Epub ahead of print]
• Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Roncal-Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Jalal D, Andres-Hernando A, Tanabe K, Madero M, Li N, Cicerchi C, Mc Fann K, Sautin YY, Johnson RJ.Metabolism. 2011 Sep;60(9):1259-70. Epub 2011 Apr 12.

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Specialty Information

Specialties

• Nephrology