Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-?B-dependent pathway.
Shimada M, Ishimoto T, Lee PY, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Wymer DT, Yamabe H, Mathieson PW, Saleem MA, Garin EH, Johnson RJ.Nephrol Dial Transplant. 2012 Jan;27(1):81-9. Epub 2011 May 26.
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.
Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.Proc Natl Acad Sci U S A. 2012 Feb 27. [Epub ahead of print]
Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake.
Roncal-Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Jalal D, Andres-Hernando A, Tanabe K, Madero M, Li N, Cicerchi C, Mc Fann K, Sautin YY, Johnson RJ.Metabolism. 2011 Sep;60(9):1259-70. Epub 2011 Apr 12.
“Synergistic effect of uricase blockade plus physiologic amounts of fructose - glucose on glomerular hypertension and oxidative stress in rats”.Tapia E, Cristobal M, Garcia-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jimenez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sanchez-Lozada LG
Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2013 Dec 11. [Epub ahead of print] PubMed PMID: 24336030
Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver.Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ.
J Biol Chem. 2012 Nov 23;287(48):40732-44. doi: 10.1074/jbc.M112.399899. Epub 2012 Oct 3.
Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872
Tapia E, Cristóbal M, García-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jiménez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sánchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F727-36. PubMed PMID: 23303409
Effects of excessive fructose intake on health.
Johnson RJ, Lanaspa MA, Roncal-Jimenez C, Sanchez-Lozada LG.
Ann Intern Med. 2012 Jun 19;156(12):905; author reply 905-6. doi: 10.7326/0003-4819-156-12-201206190-00024
Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan;63(1):150-60. PubMed PMID: 24269076
Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver.
Lanaspa MA, Cicerchi C, Garcia G, Li N, Roncal-Jimenez CA, Rivard CJ, Hunter B, Andrés-Hernando A, Ishimoto T, Sánchez-Lozada LG, Thomas J, Hodges RS, Mant CT, Johnson RJ.
PLoS One. 2012;7(11):e48801. doi: 10.1371/journal.pone.0048801. Epub 2012 Nov 9.
Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver.
Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ.
PLoS One. 2012;7(10):e47948. doi: 10.1371/journal.pone.0047948. Epub 2012 Oct 24.
Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014 Nov;25(11):2526-38. PubMed PMID: 24876114
Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, Lanaspa MA, Ishimoto T, Nakagawa T, Correa-Rotter R, Wesseling C, Bankir L, Sanchez-Lozada LG. Hyperosmolarity drives hypertension and CKD--water and salt revisited. Nat Rev Nephrol. 2014 Jul;10(7):415-20. PubMed PMID: 24802066
Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. FASEB J. 2014 Aug;28(8):3339-50. PubMed PMID: 24755741
Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2014 Aug;86(2):294-302. PubMed PMID: 24336030
Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan;63(1):150-60. PubMed PMID: 24269076
Kidney function in sugarcane cutters in Nicaragua – A longitudinal study of workers at risk of Mesoamerican nephropathy.
May 2016 · Environmental Research
"Hyperfiltration and uricosuria in adolescents with type 1 diabetes".
Dec 2015 · Pediatric Nephrology
"Uric acid in metabolic syndrome: From an innocent bystander to a central player".
Dec 2015 · European Journal of Internal Medicine
"Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy".
Oct 2015 · American Journal of Kidney Diseases
"Heat stress, dehydration, and kidney function in sugarcane cutters in EI Salvador - A cross-shift study of workers at risk of Mesoamerican nephropathy".
Jul 2015 · Environmental Research
"Mechanisms by Which Dehydration May Lead to Chronic Kidney Disease".
Jun 2015 · Annals of Nutrition and Metabolism.
"Opposing Activity Changes in AMP Deaminase and AMP-Activated Protein Kinase in the Hibernating Ground Squirrel"
Apr 2015 · PLoS ONE.
"Hispanic Americans living in the United States and their risk for obesity, diabetes and kidney disease: Genetic and environmental considerations"
Mar 2015 · Postgraduate Medicine
Climate change and the emergent epidemic of CKD from heat stress in rural communities: The case for heat stress nephropathy
J Glaser, J Lemery, B Rajagopalan, HF Diaz, R García-Trabanino, ...
Clinical Journal of the American Society of Nephrology 11 (8), 1472-1483
Role of Fructose and Fructokinase in Acute Dehydration Induced Vasopressin Gene Expression and Secretion in Mice
Z Song, CA Roncal-Jimenez, MA Lanaspa-Garcia, SA Oppelt, ...
Journal of Neurophysiology, jn. 00781.2016
Asymptomatic hyperuricemia without comorbidities predicts cardiometabolic diseases: five-year japanese cohort study.
Hypertension
Increased serum sodium and serum osmolarity are independent risk factors for developing chronic kidney disease; 5 Year Cohort Study.
PloS one.
"Elevated serum uric acid level predicts rapid decline in kidney function".
American journal of nephrology
"Effects of exogenous desmopressin on a model of heat stress nephropathy in mice".
American Journal of Physiology-Renal Physiology
"Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice".
Nature Communications.
"Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese cohort study".
Hypertension
"Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge’s disease)".
Respiratory physiology & neurobiology
“Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study.
Obesity
"Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic DiseasesNovelty and Significance: Five-Year Japanese Cohort Study".
Hypertension
General Internal Medicine Predictors of abdominal adipose tissue compartments: 18
PM Mannucci, M Kanbay, T Jensen, Y Solak, M Le, C Roncal-Jimenez, ...
The effects of exogenous desmopressin on a model of heat stress nephropathy in mice
CA Roncal-Jimenez, T Milagres, A Andres-Hernando, M Kuwabara, ...
American Journal of Physiology-Renal Physiology, ajprenal. 00495.2016
Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study
M Kuwabara, I Hisatome, CA Roncal-Jimenez, K Niwa, ...
PLOS ONE 12 (1), e0169137
Kidney function in sugarcane cutters in Nicaragua–A longitudinal study of workers at risk of Mesoamerican nephropathy
C Wesseling, A Aragón, M González, I Weiss, J Glaser, NA Bobadilla, ...
Environmental research 147, 125-132
"Fructose and Sugar: A Major Mediator of Nonalcoholic Fatty Liver Disease".
Journal of hepatology
Rehydration with soft drink-like beverages exacerbates dehydration and worsens dehydration-associated renal injury
FE García-Arroyo, M Cristóbal, AS Arellano-Buendía, H Osorio, E Tapia, ...
American Journal of Physiology-Regulatory, Integrative and Comparative ...
P4556Obesity and serum uric acid as a risk factor for hypertension and diabetes mellitus: 5-year Japanese cohort study.
European Heart Journal
Chronic Dehydration Induced Changes in Mouse Supraoptic Nucleus (SON): Contribution to Chronic Kidney Diseases (CKD)?
The FASEB Journa
Hyperfiltration and uricosuria in adolescents with type 1 diabetes
P Bjornstad, C Roncal, T Milagres, L Pyle, MA Lanaspa, FK Bishop, ...
Pediatric Nephrology 31 (5), 787-793
Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats.
International journal of biological sciences
MP063
AGING-ASSOCIATED RENAL DISEASE IN MICE IS DEPENDENT ON FRUCTOKINASE.
Nephrology Dialysis Transplantation, Volume 32
Mesoamerican Nephropathy or Global Warming Nephropathy?
CA Roncal-Jimenez, R García-Trabanino, C Wesseling, RJ Johnson
Blood purification 41 (1-3), 135-138
Fasting blood glucose is predictive of hypertension in a general Japanese population
Masanari Kuwabara, Yaswanth Chintaluru, Mehmet Kanbay, Koichiro Niwa, Ichiro Hisatome, Ana Andres-Hernando, Carlos Roncal-Jimenez, Minoru Ohno, Richard J Johnson, Miguel A Lanaspa
Journal of hypertension 37 (1), 167-174
Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress
Authors
Richard J Johnson, Santos E Perez-Pozo, Julian Lopez Lillo, Felix Grases, Jesse D Schold, Masanari Kuwabara, Yuka Sato, Ana Andres Hernando, Gabriela Garcia, Thomas Jensen, Christopher Rivard, Laura G Sanchez-Lozada, Carlos Roncal, Miguel A Lanaspa.
BMC nephrology
"Rehydration with fructose worsens dehydration-induced renal damage"
Authors
Tamara Milagres, Fernando E García-Arroyo, Miguel A Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G Sánchez-Lozada, Richard J Johnson, Carlos Roncal-Jimenez. BMC nephrology
"Effects of fructose-containing sweeteners on fructose intestinal, hepatic, and oral bioavailability in dual-catheterized rats"
Authors
Leah R Villegas, Christopher J Rivard, Brandi Hunter, Zhiying You, Carlos Roncal, Melanie S Joy, MyPhuong T Le.
Plos One
"High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism" (vol 115, pg 3138, 2018)
Authors
Miguel A Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J Orlicky, Carlos A Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S MacLean, Richard J Johnson.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
"Increased Serum Uric Acid over five years is a Risk Factor for Developing Fatty Liver"
Authors
Thomas Jensen, Koichiro Niwa, Ichiro Hisatome, Mehmet Kanbay, Ana Andres-Hernando, Carlos A Roncal-Jimenez, Yuka Sato, Gabriela Garcia, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson, Masanari Kuwabara.
Scientific reports- Nature Publishing Group
"Different risk for hypertension, diabetes, dyslipidemia, and hyperuricemia according to level of body mass index in japanese and american subjects"
Authors
Masanari Kuwabara, Remi Kuwabara, Koichiro Niwa, Ichiro Hisatome, Gerard Smits, Carlos Roncal-Jimenez, Paul MacLean, Joseph Yracheta, Minoru Ohno, Miguel Lanaspa, Richard Johnson, Diana Jalal.
Nutrients
Correction: Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study
Authors
Masanari Kuwabara, Ichiro Hisatome, Carlos A Roncal-Jimenez, Koichiro Niwa, Ana Andres-Hernando, Thomas Jensen, Petter Bjornstad, Tamara Milagres, Christina Cicerchi, Zhilin Song, Gabriela Garcia, Laura G Sánchez-Lozada, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson.
PloS one
Metabolic and kidney diseases in the setting of climate change, water shortage, and survival factors
RJ Johnson, P Stenvinkel, T Jensen, MA Lanaspa, C Roncal, Z Song, ...
Journal of the American Society of Nephrology 27 (8), 2247-2256
Serum Uromodulin (SUMOD) Inversely Correlates with Aortic Stiffness in Type 1 Diabetes (T1D) Youth
Authors
PATTARA WIROMRAT, PETTER BJORNSTAD, CARLOS ALBERTO RONCAL-JIMENEZ, MICHAL SCHÄFER, AMY BAUMGARTNER, LAURA PYLE, MELANIE CREE-GREEN, YESENIA GARCIA REYES, LORNA BROWNE, RICHARD JOHNSON, KRISTEN J NADEAU. Source Diabetes-American Diabetes Association
High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism
Authors
Miguel A Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nancy Li, Christina Cicerchi, Thomas Jensen, David J Orlicky, Carlos A Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S MacLean, Richard J Johnson.
National Academy of Sciences
Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes
Authors
Petter Bjornstad, David M Maahs, Carlos A Roncal, Janet K Snell-Bergeon, Viral N Shah, Tamara Milagres, Samuel L Ellis, Matthew Hatch, Linh T Chung, Marian J Rewers, Satish Garg, David Z Cherney, Laura Pyle, Kristen J Nadeau, Richard J Johnson.
Diabetes, Obesity and Metabolism
Fructose and sugar: a major mediator of nonalcoholic fatty liver disease
Authors
Thomas Jensen, Manal F Abdelmalek, Shelby Sullivan, Kristen J Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, Masanari Kuwabara, Yuka Sato, Duk-Hee Kang, Dean R Tolan, Laura G Sanchez-Lozada, Hugo R Rosen, Miguel A Lanaspa, Anna Mae Diehl, Richard J Johnson.
Journal of hepatology
Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate
Authors
Laura-Gabriela Sánchez-Lozada, Fernando E García-Arroyo, Guillermo Gonzaga, Octaviano Silverio, Mónica G Blas-Marron, Itzel Muñoz-Jimenez, Edilia Tapia, Horacio Osorio-Alonso, Magdalena Madero, Carlos A Roncal-Jiménez, Ilana Weiss, Jason Glaser, Richard J Johnson.
American journal of nephrology
Different Effects of Global Osteopontin and Macrophage Osteopontin in Glomerular Injury
Authors
Jessica Trostel, Luan D Truong, Carlos A Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Masanari Kuwabara, Rachel H McMahan, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Miguel A Lanaspa, Richard J Johnson, Gabriela E Garcia.
American Journal of Physiology-Renal Physiology
Aging-associated renal disease in mice is fructokinase dependent
CA Roncal-Jimenez, T Ishimoto, MA Lanaspa, T Milagres, AA Hernando, ...
American Journal of Physiology-Renal Physiology 311 (4), F722-F730
Uric acid in metabolic syndrome: from an innocent bystander to a central player
M Kanbay, T Jensen, Y Solak, M Le, C Roncal-Jimenez, C Rivard, ...
European journal of internal medicine 29, 3-8
Heat stress nephropathy from exercise-induced uric acid crystalluria: a perspective on Mesoamerican nephropathy
C Roncal-Jimenez, R García-Trabanino, L Barregard, MA Lanaspa, ...
American journal of kidney diseases 67 (1), 20-30
Experimental Heat Stress Nephropathy and Liver Injury are Improved by Allopurinol
Authors
Carlos A Roncal-Jimenez, Yuka Sato, Tamara Milagres, Ana Andres-Hernando, Gabriela E Garcia, Petter Bjornstad, Jaime Butler-Dawson, Cecilia Sorensen, Lee Newman, Lyndsay Krisher, Magdalena Madero, Jason Glaser, Ramon Garcia-Trabannino, Emmanuel Jarquin-Romero, Zhilin Song, Thomas Jensen, Masanari Kuwabara, Bernardo Rodriguez-Iturbe, Laura-Gabriela Sanchez-Lozada, Miguel A Lanaspa, Richard J Johnson.
American Journal of Physiology-Renal Physiology
Uric acid is a strong risk marker for developing hypertension from prehypertension: a 5-year Japanese cohort study
Authors
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson.
Journal: Hypertension
García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Corrigendum to "Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages" [Free Radic. Biol. Med. 141 (2019) 182-191]. Free Radic Biol Med. 2019 Dec 5. [Epub ahead of print] PubMed PMID: 31813623
García-Arroyo FE, Muñoz-Jiménez I, Gonzaga G, Tapia E, Osorio-Alonso H, Roncal-Jiménez CA, Iroz A, Vecchio M, Reyes-García JG, Johnson RJ, Sánchez-Lozada LG. A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose. Int J Mol Sci. 2019 Nov 16;20(22). PubMed PMID: 31744099
Johnson RJ, Stenvinkel P, Andrews P, Sánchez-Lozada LG, Nakagawa T, Gaucher E, Andres-Hernando A, Rodriguez-Iturbe B, Jimenez CR, Garcia G, Kang DH, Tolan DR, Lanaspa MA. Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts. J Intern Med. 2020 Mar;287(3):252-262. PubMed PMID: 31621967
Ko J, Kang HJ, Kim DA, Kim MJ, Ryu ES, Lee S, Ryu JH, Roncal C, Johnson RJ, Kang DH. Uric acid induced the phenotype transition of vascular endothelial cells via induction of oxidative stress and glycocalyx shedding. FASEB J. 2019 Dec;33(12):13334-13345. PubMed PMID: 31553887
Wiromrat P, Bjornstad P, Vinovskis C, Chung LT, Roncal C, Pyle L, Lanaspa MA, Johnson RJ, Cherney DZ, Reznick-Lipina TK, Bishop F, Maahs DM, Wadwa RP. Elevated copeptin, arterial stiffness, and elevated albumin excretion in adolescents with type 1 diabetes. Pediatr Diabetes. 2019 Dec;20(8):1110-1117. PubMed PMID: 31433534
Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ. Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F941-F948. PubMed PMID: 31411075
Sato Y, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Tolan DR, Sanchez-Lozada LG, Newman LS, Butler-Dawson J, Sorensen C, Glaser J, Miyazaki M, Diaz HF, Ishimoto T, Kosugi T, Maruyama S, Garcia GE, Lanaspa MA, Johnson RJ. Increase of core temperature affected the progression of kidney injury by repeated heat stress exposure. Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1111-F1121. PubMed PMID: 31390229
Wiromrat P, Bjornstad P, Roncal C, Pyle L, Johnson RJ, Cherney DZ, Lipina T, Bishop F, Maahs DM, Wadwa RP. Serum uromodulin is associated with urinary albumin excretion in adolescents with type 1 diabetes. J Diabetes Complications. 2019 Sep;33(9):648-650. PubMed PMID: 31253490
García-Arroyo FE, Gonzaga G, Muñoz-Jiménez I, Osorio-Alonso H, Iroz A, Vecchio M, Tapia E, Roncal-Jiménez CA, Johnson RJ, Sánchez-Lozada LG. Antioxidant supplements as a novel mean for blocking recurrent heat stress-induced kidney damage following rehydration with fructose-containing beverages. Free Radic Biol Med. 2019 Sep;141:182-191. PubMed PMID: 31212064
Johnson RJ, Sánchez-Lozada LG, Newman LS, Lanaspa MA, Diaz HF, Lemery J, Rodriguez-Iturbe B, Tolan DR, Butler-Dawson J, Sato Y, Garcia G, Hernando AA, Roncal-Jimenez CA. Climate Change and the Kidney. Ann Nutr Metab. 2019;74 Suppl 3:38-44. PubMed PMID: 31203298
Wiromrat P, Bjornstad P, Roncal C, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Truong U, Pyle L, Johnson RJ, Nadeau KJ. Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study. J Diabetes Complications. 2019 Jun;33(6):434-436. PubMed PMID: 31003921
Sánchez-Lozada LG, Roncal-Jimenez CA, García-Arroyo FE, Jensen T, Lanaspa MA, Johnson RJ. The perils of rehydrating with soft drinks following heat and exercise. Am J Physiol Regul Integr Comp Physiol. 2019 Mar 1;316(3):R187-R188. PubMed PMID: 30673300
Sanchez-Lozada LG, Andres-Hernando A, Garcia-Arroyo FE, Cicerchi C, Li N, Kuwabara M, Roncal-Jimenez CA, Johnson RJ, Lanaspa MA. Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. PubMed PMID: 30651350
Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor
A Andres-Hernando, TJ Jensen, M Kuwabara, DJ Orlicky, C Cicerchi, N Li, ...
JCI insight
Osmotic Nephrosis and Acute Kidney Injury Associated With SGLT2 Inhibitor Use: A Case Report
Authors
Gautam Phadke, Amit Kaushal, Dean R Tolan, Kai Hahn, Thomas Jensen, Petter Bjornstad, Carlos Roncal-Jimenez, Ana Andres Hernando, Miguel A Lanaspa, Mariam Priya Alexander, Aleksandra Kukla, Richard J Johnson
Hyperosmolarity and Increased Serum Sodium Concentration Are Risks for Developing Hypertension Regardless of Salt Intake: A Five-Year Cohort Study in Japan
Authors
Masanari Kuwabara, Mehmet Kanbay, Koichiro Niwa, Ryusuke Ae, Ana Andres-Hernando, Carlos A Roncal-Jimenez, Gabriela Garcia, Laura Gabriela Sánchez-Lozada, Bernardo Rodriguez-Iturbe, Ichiro Hisatome, Miguel A Lanaspa, Richard J Johnson
Fructose Production and Metabolism in the Kidney
Authors
Takahiko Nakagawa, Richard J Johnson, Ana Andres-Hernando, Carlos Roncal-Jimenez, Laura G Sanchez-Lozada, Dean R Tolan, Miguel A Lanaspa
The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study
Authors
Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Petter Bjornstad, Carlos A Roncal-Jimenez, Ana Andres-Hernando, Mehmet Kanbay, Richard J Johnson, Miguel A Lanaspa
Fructose metabolism as a common evolutionary pathway of survival associated with climate change, food shortage and droughts
RJ Johnson, P Stenvinkel, P Andrews, LG Sánchez-Lozada, T Nakagawa, ...
Journal of Internal Medicine 287 (3), 252-262
Tubular injury in diabetic ketoacidosis: Results from the diabetic kidney alarm study.
Federica Piani, Isabella Melena, Cameron Severn, Linh T Chung, Carissa Vinovskis, David Cherney, Laura Pyle, Carlos A Roncal-Jimenez, Miguel A Lanaspa, Arleta Rewers, Daniël H van Raalte, Wassim Obeid, Chirag Parikh, Robert G Nelson, Meda E Pavkov, Kristen J Nadeau, Richard J Johnson, Petter Bjornstad
Climate change and nephrology
F Sasai, C Roncal-Jimenez, K Rogers, Y Sato, JM Brown, J Glaser, ...
Nephrology Dialysis Transplantation
A Novel Treatment for Glomerular Disease: Targeting the Activated Macrophage Folate Receptor with a Trojan Horse Therapy in Rats
GE Garcia, YJ Lu, LD Truong, CA Roncal-Jiménez, M Miyazaki, ...
Cells 10 (8), 2113
Hiperuricemia e doença renal crônica: tratar ou não tratar
Authors
Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Hyperuricemia and chronic kidney disease: to treat or not to treat
Authors
Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson
Inhaled silica nanoparticles cause chronic kidney disease in rats.
Fumihiko Sasai, Keegan L Rogers, David J Orlicky, Arthur Stem, Joshua Schaeffer, Gabriela Garcia, Jacob Fox, Matthew S Ray, Jaime Butler-Dawson, Marvin Gonzalez-Quiroz, Ricardo Leiva, Gangadhar Taduri, Sirirat Anutrakululchai, Vidhya Venugopal, Magdalena Madero, Jason Glaser, Julia Wijkstrom, Annika Wernerson, Jared M Brown, Richard J Johnson, Carlos A Roncal-Jimenez
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Minimal change disease is associated with endothelial glycocalyx degradation and endothelial activation
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Uric Acid: A Friend in the Past, a Foe in the Present
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Abutaleb Ahsan Ejaz, Jo Ann Antenor, Vijay Kumar, Carlos Roncal, Gabriela E Garcia, Ana Andres-Hernando, Miguel A Lanaspa, Richard J Johnson
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Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells
66 Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Mitochondrial Function and Metabolic Activity in Human Proximal Tubular Kidney Cells
Climate change and nephrology
Silica Nanoparticles and Mesoamerican Nephropathy: A Case Series