Min Li, PhD

Publications

• Plecitá-Hlavatá L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, Ježek P, Stenmark KR. Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Dec 23. [Epub ahead of print] PubMed PMID: 26699943
• Aerobic Glycolysis Activates C-Terminal Binding Protein-1 (CtBP1) and Leads to a Pro-Inflammatory and Hyper-Proliferative Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension
• Circulation. 2016 Oct 11;134(15):1105-1121. Epub 2016 Aug 25.
• Am J Respir Cell Mol Biol. 2016 Jul;55(1):47-57. doi: 10.1165/rcmb.2015-0142OC.
• ATS 2016 4-Methylthio-2-Oxobutyric Acid (MTOB), a Novel Small Molecule and Inhibitor of CtBP1, Inhibits the Proliferative and Pro-inflammatory Phenotype of Adventitial Fibroblast in Pulmonary Hypertension
• ATS 2016 Metabolic Reprogramming in Pulmonary Hypertension as Gleaned Through Mass Spectrometry-Based Metabolomics
• Plecitá-Hlavatá L, D'alessandro A, El Kasmi K, Li M, Zhang H, Ježek P, Stenmark KR. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension. Adv Exp Med Biol. 2017;967:241-260. PubMed PMID: 29047090
• Zhang H, Wang D, Li M, Plecitá-Hlavatá L, D'Alessandro A, Tauber J, Riddle S, Kumar S, Flockton A, McKeon BA, Frid MG, Reisz JA, Caruso P, El Kasmi KC, Ježek P, Morrell NW, Hu CJ, Stenmark KR. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017 Dec 19;136(25):2468-2485. PubMed PMID: 28972001
• Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30;8:15494. PubMed PMID: 28555642
• Pharmacologic Inhibition of CtBP1 has multiple beneficial effects in the treatment of Pulmonary Hypertension.
• ROS Production and DNA Instability of Adventitial Fibroblasts are Regulated by CtBP1 in Pulmonary Hypertension.
• Hu CJ, Poth JM, Zhang H, Flockton A, Laux A, Kumar S, McKeon B, Mouradian G, Li M, Riddle S, Pugliese SC, Brown RD, Wallace EM, Graham BB, Frid MG, Stenmark KR. Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension. Eur Respir J. 2019 Dec;54(6). PubMed PMID: 31515405
• New Insights on Macrophage Function in Pulmonary Hypertension Gained from Comparative Transcriptomics and Metabolomics American Journal of Respiratory and Critical Care Medicine 2019;199:A4207
• Fibroblast Generated Extracellular Vesicles Induces Metabolic Reprogramming in Bone Marrow Derived Macrophages American Journal of Respiratory and Critical Care Medicine 2019;199:A4201
• Li M, Riddle S, Kumar S, Poczobutt J, McKeon BA, Frid MG, Ostaff M, Reisz JA, Nemkov T, Fini MA, Laux A, Hu CJ, El Kasmi KC, D'Alessandro A, Brown RD, Zhang H, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol. 2021;12:640718. PubMed PMID: 33868271
• Kumar S, Frid MG, Zhang H, Li M, Riddle S, Brown RD, Yadav SC, Roy MK, Dzieciatkowska ME, D'Alessandro A, Hansen KC, Stenmark KR. Complement-containing small extracellular vesicles from adventitial fibroblasts induce proinflammatory and metabolic reprogramming in macrophages. JCI Insight. 2021 Nov 8;6(21). PubMed PMID: 34499621
• Applegate TJ, Krafsur GM, Boon JA, Zhang H, Li M, Holt TN, Ambler SK, Abrams BA, Gustafson DL, Bartels K, Garry FB, Stenmark KR, Brown RD. Brief Report: Case Comparison of Therapy With the Histone Deacetylase Inhibitor Vorinostat in a Neonatal Calf Model of Pulmonary Hypertension. Front Physiol. 2021;12:712583. PubMed PMID: 34552503
• SIRT3 Regulates Mitochondrial Function of Adventitial Fibroblasts in Pulmonary Hypertension
• Mitochondrial Function of Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through Sirt3 Deacetylase Activity
• Zhang H, D'Alessandro A, Li M, Reisz JA, Riddle S, Muralidhar A, Bull T, Zhao L, Gerasimovskaya E, Stenmark KR. Histone deacetylase inhibitors synergize with sildenafil to suppress purine metabolism and proliferation in pulmonary hypertension. Vascul Pharmacol. 2023 Apr;149:107157. PubMed PMID: 36849042
• Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 Jul;69(1):73-86. PubMed PMID: 36944195
• Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 Jun 1;324(6):H804-H820. PubMed PMID: 36961489
• Zhang H, Gerasimovskaya E, McCarthy MK, May NA, Prasad RR, Riddle S, McKeon BA, Kumar S, Li M, Hu CJ, Frid MG, Morrison TE, Stenmark KR. Local Complement Contributes to Pathogenic Activation of Lung Endothelial Cells in SARS-CoV-2 Infection. Am J Respir Cell Mol Biol. 2023 Aug;69(2):210-219. PubMed PMID: 37071849
• Li M, Plecitá-Hlavatá L, Dobrinskikh E, McKeon BA, Gandjeva A, Riddle S, Laux A, Prasad RR, Kumar S, Tuder RM, Zhang H, Hu CJ, Stenmark KR. SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 Nov;69(5):570-583. PubMed PMID: 37343939
• Plecitá-Hlavatá L, Brázdová A, Krivonosková M, Hu CJ, Phang T, Tauber J, Li M, Zhang H, Hoetzenecker K, Crnkovic S, Kwapiszewska G, Stenmark KR. Microenvironmental regulation of T-cells in pulmonary hypertension. Front Immunol. 2023;14:1223122. PubMed PMID: 37497214