Brian Freed, PhD, MA, MS
Professor, Medicine-Allergy/Clinical Immunology

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Medical School:
  • PhD, Albany Medical College (1990)
Graduate Schools :
  • MA, State University Of New York, College At Plattsburgh (1978)
  • MS, Albany Medical College (1990)
Undergraduate School:
  • BS, State University of New York at Plattsburgh (1976)
Languages: English, Portuguese
Department: Medicine-Allergy/Clinical Immunology

Professional Titles

  • Executive Director, ClinImmune Cell and Gene Therapy

Recognition & Awards

  • Ph.D. Research and Teaching Award, CU Department of Medicine (2007)

Research Interests

HLA gene editing in the treatment of autoimmunity


  • Professor (1997)
    School of Medicine, Immunology
    HLA and peptide binding in its association with autoimmunity, HLA gene editing as a treatment for autoimmunity


  • Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Mar 25;12(1):5207. doi: 10.1038/s41598-022-09133-9.
  • Roark CL, Ho BE, Aubrey MT, Anobile C, Israeli S, Phang TL, Braxton D, Ho AP, Freed BM. HLA homozygosity is associated with non-Hodgkin lymphoma. Human Immunol 83:730, 2022
  • Solomon SR, Aubrey MT, Zhang X, Jackson KC, Roark CL, Freed BM, Morris LE, Holland HK, Bashey A, Solh MM. Lineage-specific relapse prediction following haploidentical transplant with posttransplant cyclophosphamide based on recipient HLA-B-leader genotype and HLA-C-Group KIR ligand. Transplantation Cellular Therapy 2022
  • Lang J, Leal AD, Jiménez JAM, Hartman SJ, Shulman J, Navarro N, Lewis M, Capasso A, Bagby S, Yacob BW, MacBeth M, Freed BM, Eckhardt SG, Jordan K, Blatchford PJ, Pelanda R, Lieu C, Messersmith WA, Pitts TM. Cabozantinib sensitizes microsatellite stable colorectal cancer to immune checkpoint blockade by immune modulation in human immune system mouse models. Frontiers Oncology 2022
  • Alves da Costa T, Peterson JN, Lang J, Shulman J, Liang X, Freed BM, Boackle SA, Lauzurica P, Torres RM, Pelanda R. Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice. Proc Natl Acad Sci U S A. 2021 Apr 20;118(16). PubMed PMID: 33850015
  • Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan;146:110394. PubMed PMID: 33239231
  • Marín-Jiménez JA, Capasso A, Lewis MS, Bagby SM, Hartman SJ, Shulman J, Navarro NM, Yu H, Rivard CJ, Wang X, Barkow JC, Geng D, Kar A, Yingst A, Tufa DM, Dolan JT, Blatchford PJ, Freed BM, Torres RM, Davila E, Slansky JE, Pelanda R, Eckhardt SG, Messersmith WA, Diamond JR, Lieu CH, Verneris MR, Wang JH, Kiseljak-Vassiliades K, Pitts TM, Lang J. Testing Cancer Immunotherapy in a Human Immune System Mouse Model: Correlating Treatment Responses to Human Chimerism, Therapeutic Variables and Immune Cell Phenotypes. Front Immunol. 2021;12:607282. PubMed PMID: 33854497
  • Zhang Y, Anderson KM, Freed BM, Dai S, Pacheco KA. HLA-DR53 (DRB4*01) associates with nickel sensitization. Ann Allergy Asthma Immunol. 2020 Nov;125(5):614-616. PubMed PMID: 32693207
  • Lang J, Capasso A, Jordan KR, French JD, Kar A, Bagby SM, Barbee J, Yacob BW, Head LS, Tompkins KD, Freed BM, Somerset H, Clark TJ, Pitts TM, Messersmith WA, Eckhardt SG, Wierman ME, Leong S, Kiseljak-Vassiliades K. Development of an Adrenocortical Cancer Humanized Mouse Model to Characterize Anti-PD1 Effects on Tumor Microenvironment. J Clin Endocrinol Metab. 2020 Jan 1;105(1). PubMed PMID: 31513709
  • Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM. Complement fragments are biomarkers of antibody-mediated endothelial injury. Mol Immunol. 2020 Feb;118:142-152. PubMed PMID: 31884386
  • Schade H, Sen S, Neff CP, Freed BM, Gao D, Gutman JA, Palmer BE. Programmed Death 1 Expression on CD4( ) T Cells Predicts Mortality after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 Dec;22(12):2172-2179. PubMed PMID: 27519280
  • Roark CL, Anderson KM, Aubrey MT, Rosloniec EF, Freed BM. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J Autoimmun. 2016 Aug;72:25-32. PubMed PMID: 27143337
  • Anderson KM, Stastny TH, Freed BM. Reply. Arthritis Rheumatol. 2016 Aug;68(8):2051-2. PubMed PMID: 27110851
  • Anderson KM, Roark CL, Portas M, Aubrey MT, Rosloniec EF, Freed BM. A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles. Arthritis Rheumatol. 2016 Jul;68(7):1627-36. PubMed PMID: 26866513
  • Lang J, Ota T, Kelly M, Strauch P, Freed BM, Torres RM, Nemazee D, Pelanda R. Receptor editing and genetic variability in human autoreactive B cells. J Exp Med. 2016 Jan 11;213(1):93-108. PubMed PMID: 26694971
  • Adebiyi OO, Gralla J, Klem P, Freed B, Davis S, Wiseman A, Cooper JE. Clinical Significance of Pre-Transplant Donor Specific Antibodies in the Setting of Negative Cell-Based Flow Cytometry Crossmatching in Kidney Transplant Recipients. Am J Transplant. 2016 May 3. [Epub ahead of print] PubMed PMID: 27140940
  • Brady C, Armitage S, Freed B, Duffy M, Gass A, Spellman S, Kurtzberg J, Regan D. How transplant centers deal with the dextran shortage: recommendations for comparing alternatives. Transfusion. 2016 Sep 5. [Epub ahead of print] PubMed PMID: 27596242
  • Mack CL, Anderson KM, Aubrey MT, Rosenthal P, Sokol RJ, Freed BM. Lack of HLA predominance and HLA shared epitopes in biliary Atresia. Springerplus. 2013 Dec;2(1):42. PubMed PMID: 23505615
  • Lang J, Kelly M, Freed BM, McCarter MD, Kedl RM, Torres RM, Pelanda R. Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol. 2013 Mar 1;190(5):2090-101. PubMed PMID: 23335750
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Professional Memberships

  • American Society for Histocompatibility and Immunogenetics, Member
  • American Society of Transplantation, Member
  • American Association of Immunologists, Member
  • American Society for Blood and Marrow Transplantation, Member
  • The Donor Alliance Medical Advisory Council, Member

Practice Locations

Hospital Affiliation
  • University of Colorado Hospital
  • Presbyterian/St. Luke's Medical Center
  • Children's Hospital Colorado

Specialty Information

  • Allergy and Immunology
  • Fellow American College of Histocompatibility and Immunogenetics, Board Certification (2021)
  • Histocompatibility and Immunogenetics, Board Certification (0001)
Clinical Interests
HLA gene editing to treat rheumatoid arthritis, cell and gene therapy.

General Information

Medical Schools:
  • PhD, Albany Medical College (1990)
Graduate Schools:
  • MA, State University Of New York, College At Plattsburgh (1978)
  • MS, Albany Medical College (1990)
Undergraduate Schools:
  • BS, State University of New York at Plattsburgh (1976)
Download CV
Languages: English, Portuguese
Department: Medicine-Allergy/Clinical Immunology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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