Neil Box, PhD

Publications

• Valentin-Vega YA, Box NF, Terzian T, Lozano G (2008) Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation 77(5):442-449.
• Aalborg J., Morelli JG., Mokrohisky ST., Asdigian N., Byers TE., Dellavalle RP., Box NF., Crane LA. (2009) Tanning increases nevus development in light-skinned children without red hair. Archives of Dermatology 145(9):1-8.
• Chen D., Lin Q., Box N., Roop D., Ishii S., Matsuzaki K., Fang T., Hornyak T., Reed J., Stavnezer E., Timchenko N., Medrano E. (2009) SKI deficiency inhibits human melanoma tumor growth in vivo. Pigment Cell and Melanoma Research Accepted PCMR 08-0178.
• Terzian T., Robinsons S., Stiegmann R., Lozano G., Robinson W., Roop D., Box N.F. “The role of p53 in melanoma tumor suppression” Oral Presentation 4, Research in Cutaneous Surgery Symposium, Society for Investigative Dermatology 69th Annual Meeting, Montreal, Canada, May 6 – 9, 2009.
• Terzian T., Stiegmann R., Crane L., Lozano G., Roop D., Box N.F. ?A role for keratinocyte p53 in formation of pigmented lesions? Oral Presentation 3, Pigmentation and Melanoma Concurrent Mini-Symposium, Society for Investigative Dermatology 69th Annual Meeting, Montreal, Canada, May 6 ? 9, 2009.
• Terzian, T., Stiegmann, R., Lozano, G., Roop, D., Box, N. p53 and pigmentation in mice: coordinating melanocyte and keratinocyte roles during the sunburn response, Oral Presentation, XVth PanAmerican Society for Pigment Cell Research, Memphis, TN, Sept 4 – 7, 2009
• Terzian T., Stiegmann, R., Gonzalez, V., Zhang, Q., Dumble, M., Justice, M.J., Roop, D.R. Lozano, G. and Box, N.F. Rpl27a participates with Mdm2 and Mdm4 in the negative regulation of p53 in vivo. Mdm2 Workshop V, August 23 - 26, 2009, Ghent, Belgium.
• 3. Terzian, T, Torchia E, Dai D, Robinson SE, Murao K, Gonzalez V, Stiegmann RA, Boyle GM, Pollock PM, Powell MB, Lozano G, Robinson WA, Roop DR, and Box NF (2010) p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res. 23(6): 781-794. PMID 20849464.
• Terzian T, Dumble M, Arbab F, Thaller C, Donehower LA, Lozano G, Justice MJ, Roop DR, and Box NF (2011) Rpl27a mutation in the Sooty Foot Ataxia mouse phenocopies high p53 mouse models. Accepted J. Pathol. (10-652).
• Box NF, Torchia EC and Roop DR (2010) Are stem cell niches shared for skin cancers? Pigment Cell Melanoma Res. 23(4):517-20. PMID 20546533.
• Walker GJ, Soyer HP, Handoko HY, Ferguson B, Kunisada T, Khosrotehrani K, Box NF, and Muller HK (2011) Superficial Spreading-Like Melanoma in Arf(-/-)::Tyr-Nras(Q61K)::K14-Kitl Mice: Keratinocyte Kit Ligand Expression Sufficient to "Translocate" Melanomas from Dermis to Epidermis. J Invest Dermatol. PMID 21307875.
• Torchia E.C., Caulin C., Acin S., Terzian T., Kubick B.J., Box N.F., Roop D.R. (2011) Unraveling the pathways mediating the gain of function properties of mutant p53R172H in a mouse model of skin cancer. Cancer Research CAN-11-1068. Under Review.
• Gamble R.G., Asdigian N.L., Aalborg J., Gonzalez V., Mokrohisky S., Morelli J.G., Baron A., Box N.F., Crane L.A., Dellavalle R.P. (2011) Sun damage in ultraviolet photographs correlates with phenotypic melanoma risk factors in 12-year-old children. Journal of the American Academy of Dermatology JAAD-D-11-00542. Under Review.
• Xing Q., Brauweiler A., Wang M., Shellman Y.G., Chen X., Lambert K., Ji H., Box N.F., Gu B., Terzian T., Wang L., Martini M., Wei Z., Janssen K.P., Yu L., Horvath A., Xuan J., Stratakis C.A., Feng G., Fain P., Gao R., Spritz R., Qin S., He L., and Pacheco T. Mutations of the SASH1 Gene are Associated with a Lentiginous Pigmentation Phenotype in Three Families. Science (MS# 1208655) Submitted.
• Walker G.J., Soyer H.P., and Box N. F. Engineering mice to model melanoma histopathological and molecular subtypes. Pigment Cell and Melanoma Research. In Submission.
• Terzian T., Dumble M., Arbab F., Thaller C., Donehower L.A., Justice M.J., Roop D.R., Box N.F. (2011) Rpl27a mutation in the Sooty Foot Ataxia mouse phenocopies high p53 mouse models. Journal of Pathology, 224(4):540-552.
• Walker G.J., Soyer H.P., Terzian T., and Box N.F. (2011) Modeling melanoma subtypes in mice. Pigment Cell and Melanoma Research. 24(6):1158-1176.
• Torchia E.C., Caulin C., Acin S., Terzian T., Kubick B.J., Box N.F., Roop D.R. (2011) Unraveling the pathways mediating the gain of function properties of mutant p53R172H in a mouse model of skin cancer. Oncogene. Epub ahead of print, October 3.
• Gamble R.G., Asdigian N.L., Aalborg J., Gonzalez V., Mokrohisky S., Morelli J.G., Baron A., Box N.F., Crane L.A., Dellavalle R.P. (2012) Sun damage in ultraviolet photographs correlates with phenotypic melanoma risk factors in 12-year-old children. Journal of the American Academy of Dermatology JAAD-D-11-00542. Accepted.
• Tran A.D., Asdigian N.A., Aalborg J., Morelli J.G., Mokrohisky S., Box N.F., Dellavalle R., Berwick M., Crane L.A. (2012) Skin Cancer Perceptions, Sun Protection Behaviors, and Physical Activity. Preventing Chronic Diseases. Accepted (PCD-11-0345).
• Handoko H., Box N.F. and Walker G.J. (2012) Modeling epidermal melanoma in mice: moving into new realms but with unexpected complexities. Journal of Investigative Dermatology - Favorably reviewed and resubmitted April 15, 2012.
• Gamble R.G., Asdigian N.L., Aalborg J., Gonzalez V., Box N.F., Huff L.S., Baron A.E., Morelli J.G., Mokrohisky S., Baron A., Crane L.A., Dellavalle R.P. (2012) Sun damage in ultraviolet photographs correlates with phenotypic melanoma risk factors in 12-year-old children. Journal of the American Academy of Dermatology Oct;67(4):587-597
• Handoko H., Box N.F. and Walker G.J. (2012) Modeling epidermal melanoma in mice: moving into new realms but with unexpected complexities. Journal of Investigative Dermatology Sept;132(9):2299-2302.
• Tran A.D., Asdigian N.A., Aalborg J., Morelli J.G., Mokrohisky S., Box N.F., Dellavalle R., Berwick M., Crane L.A. (2012) Skin Cancer Perceptions, Sun Protection Behaviors, and Physical Activity. Preventing Chronic Diseases. Aug;9:E143
• Terzian T. and Box N.F. (2013) Genetics of ribosomal proteins: "Curiouser and curiouser". PLOS Genetics, online Jan;9(1):e1003300.
• Wallace MD, Box NF, Bond GL. SNPing away at human skin color. Pigment Cell Melanoma Res. 2014 Feb 12. [Epub ahead of print] PubMed PMID: 24517848
• Zeron-Medina J, Wang X, Repapi E, Campbell MR, Su D, Castro-Giner F, Davies B, Peterse EF, Sacilotto N, Walker GJ, Terzian T, Tomlinson IP, Box NF, Meinshausen N, De Val S, Bell DA, Bond GL. A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell. 2013 Oct 10;155(2):410-22. PubMed PMID: 24120139
• Box NF, Vukmer TO, Terzian T. Targeting p53 in melanoma. Pigment Cell Melanoma Res. 2014 Jan;27(1):8-10. PubMed PMID: 24118922
• Terzian T, Box N. Genetics of ribosomal proteins: "curiouser and curiouser". PLoS Genet. 2013;9(1):e1003300. PubMed PMID: 23382707
• Asdigian N.L., Baron A., Gonzalez V., Aalborg J., Terzian T., Stiegmann R.A., Torchia E., Dellavalle R.P., Mokrohisky S.T., Morelli J.G., Crane L.A. and Box N.F. Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. American Journal of Human Genetics, submitted.
• Barón AE, Asdigian NL, Gonzalez V, Aalborg J, Terzian T, Stiegmann RA, Torchia EC, Berwick M, Dellavalle RP, Morelli JG, Mokrohisky ST, Crane LA, Box NF. Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2829-39. PubMed PMID: 25410285
• Wallace MD, Box NF, Bond GL. SNPing away at human skin color. Pigment Cell Melanoma Res. 2014 May;27(3):322-3. PubMed PMID: 24517848
• Box NF, Vukmer TO, Terzian T. Targeting p53 in melanoma. Pigment Cell Melanoma Res. 2014 Jan;27(1):8-10. PubMed PMID: 24118922
• Shellman YG, Lambert KA, Brauweiler A, Fain P, Spritz RA, Martini M, Janssen KP, Box NF, Terzian T, Rewers M, Horvath A, Stratakis CA, Robinson WA, Robinson SE, Norris DA, Artinger KB, Pacheco TR. SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype. J Invest Dermatol. 2015 Dec;135(12):3192-4. PubMed PMID: 26203640
• Hintzsche J., Kim J., Yadav V., Amato C.., Robinson S.E.., Seelenfreund E., Shellman Y., Wisell J., Applegate A.J., McCarter M., Box N.F., Tentler J.J., De S., Robinson W.A., Tan A.C. (2015) IMPACT: Whole-Exome Sequencing Analysis Pipeline of Integrating Molecular Profiles with Actionable Therapeutics in Clinical Samples. Journal of the Academy of Medical Infomatics Association. Accepted.
• Joselow A, Lynn D, Terzian T, Box NF. Senescence-Like Phenotypes in Human Nevi. Methods Mol Biol. 2017;1534:175-184. PubMed PMID: 27812879
• Hintzsche J, Kim J, Yadav V, Amato C, Robinson SE, Seelenfreund E, Shellman Y, Wisell J, Applegate A, McCarter M, Box N, Tentler J, De S, Robinson WA, Tan AC. IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples. J Am Med Inform Assoc. 2016 Jul;23(4):721-30. PubMed PMID: 27026619
• Hintzsche J.D., Gorden N.T. , Amato C.M. , Kim J., Robinson S.E. , Applegate A.J., Couts K.L., Wisell J.A., McCarter M.D., Box N.F., Shellman Y.G., Gonzalez R.C., Lewis K.D., Tentler J.J., Tan A.C., Robinson W.A. (2017) Whole Exome Sequencing Identifies Recurrent SF3B1 R625 Mutation and Co-Mutation of NF1 and KIT in Mucosal Melanoma, Melanoma Research, Accepted.
• Sharon, J., Box, N.F., Braunberger, T., Dellavalle R.P., (2017) Portable equipment for taking dramatic sun-damage-revealing photos at skin cancer prevention outreach events. Dermatology Online Journal Accepted.
• Skin Cancer Screening: Recommendations for Data-Driven Screening Guidelines and a Review of the USPSTF Controversy (2017) Johnson, M.M., Leachman, S.A., Aspinwall, L.G., Cranmer, L.D., Curiel-Lewandrowski, C., Sondak, V.K., Stemwedel, C.E., Swetter, S.M. Vetto, J., Bowles, T., Dellavalle, R.P., Geskin, L.J., Grossman, D., Grossmann, K.F., Hawkes, J.E., Jeter, J.M., Kim, C.C., Kirkwood, J.M., Mangold, A.R., Meyskens, F., Ming, M.E., Nelson, K.C., Piepkorn, M., Pollack, B.P., Robinson, J.K., Sober, A.J., Trotter, S., Venna, S.S., Agarwala, S., Alani, R., Averbook, B., Bar, A., Becevic, M., Box, N.F., Carson III, W.E., Cassidy, P.B., Chen, S.C., Chu, E.Y., Ellis, D.L., Ferris, L.K., Fisher, D.E., Kendra, K., Lawson, D.H., Leming, P.D., Margolin, K.A., Markovic, S., Martini, M.C., Miller, D., Sahni, D., Sharfman, W.H., Stein, J., Stratigos, A.J., Tarhini, A., Taylor, M.H., Wisco, O.J., Wong, M.K., Melanoma Management, Accepted.
• Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Kolesnikova M, Roll MV, Jowdy P, Wolff DW, Polechetti A, Yun DH, Lipchick BC, Paul LM, Wrazen B, Moparthy K, Mudambi S, Morozevich GE, Georgieva SG, Wang J, Shafirstein G, Liu S, Kandel ES, Berman AE, Box NF, Paragh G, Nikiforov MA. FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death Differ. 2018 Feb 20. [Epub ahead of print] PubMed PMID: 29463842
• Johnson MM, Leachman SA, Aspinwall LG, Cranmer LD, Curiel-Lewandrowski C, Sondak VK, Stemwedel CE, Swetter SM, Vetto J, Bowles T, Dellavalle RP, Geskin LJ, Grossman D, Grossmann KF, Hawkes JE, Jeter JM, Kim CC, Kirkwood JM, Mangold AR, Meyskens F, Ming ME, Nelson KC, Piepkorn M, Pollack BP, Robinson JK, Sober AJ, Trotter S, Venna SS, Agarwala S, Alani R, Averbook B, Bar A, Becevic M, Box N, E Carson W 3rd, Cassidy PB, Chen SC, Chu EY, Ellis DL, Ferris LK, Fisher DE, Kendra K, Lawson DH, Leming PD, Margolin KA, Markovic S, Martini MC, Miller D, Sahni D, Sharfman WH, Stein J, Stratigos AJ, Tarhini A, Taylor MH, Wisco OJ, Wong MK. Skin cancer screening: recommendations for data-driven screening guidelines and a review of the US Preventive Services Task Force controversy. Melanoma Manag. 2017 Mar;4(1):13-37. PubMed PMID: 28758010
• Mounessa JS, Box NF, Asdigian NL, Braunberger T, Dunnick CA, Crane LA, Dellavalle RR. Portable equipment for taking dramatic sun-damage revealing photos at skin cancer prevention outreach events. Dermatol Online J. 2017 May 15;23(5). PubMed PMID: 28537858
• Hintzsche JD, Gorden NT, Amato CM, Kim J, Wuensch KE, Robinson SE, Applegate AJ, Couts KL, Medina TM, Wells KR, Wisell JA, McCarter MD, Box NF, Shellman YG, Gonzalez RC, Lewis KD, Tentler JJ, Tan AC, Robinson WA. Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. Melanoma Res. 2017 Jun;27(3):189-199. PubMed PMID: 28296713
• Joselow A, Lynn D, Terzian T, Box NF. Senescence-Like Phenotypes in Human Nevi. Methods Mol Biol. 2017;1534:175-184. PubMed PMID: 27812879
• Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019 Jan 21. [Epub ahead of print] PubMed PMID: 30664687
• Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019 May;38(19):3585-3597. PubMed PMID: 30664687
• Jeter JM, Bowles TL, Curiel-Lewandrowski C, Swetter SM, Filipp FV, Abdel-Malek ZA, Geskin LJ, Brewer JD, Arbiser JL, Gershenwald JE, Chu EY, Kirkwood JM, Box NF, Funchain P, Fisher DE, Kendra KL, Marghoob AA, Chen SC, Ming ME, Albertini MR, Vetto JT, Margolin KA, Pagoto SL, Hay JL, Grossman D, Ellis DL, Kashani-Sabet M, Mangold AR, Markovic SN, Nelson KC, Powers JG, Robinson JK, Sahni D, Sekulic A, Sondak VK, Wei ML, Zager JS, Dellavalle RP, Thompson JA, Weinstock MA, Leachman SA, Cassidy PB. Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials. Cancer. 2019 Jan 1;125(1):18-44. PubMed PMID: 30281145
• Box NF, Larue L, Manga P, Montoliu L, Spritz RA, Filipp FV. The triennial International Pigment Cell Conference (IPCC). J Transl Med. 2018 Oct 3;16(1):252. PubMed PMID: 30285864
• Filipp FV, Birlea S, Bosenberg MW, Brash D, Cassidy PB, Chen S, D'Orazio JA, Fujita M, Goh BK, Herlyn M, Indra AK, Larue L, Leachman SA, Le Poole C, Liu-Smith F, Manga P, Montoliu L, Norris DA, Shellman Y, Smalley KSM, Spritz RA, Sturm RA, Swetter SM, Terzian T, Wakamatsu K, Weber JS, Box NF. Frontiers in pigment cell and melanoma research. Pigment Cell Melanoma Res. 2018 Nov;31(6):728-735. PubMed PMID: 30281213
• Jeter JM, Bowles TL, Curiel-Lewandrowski C, Swetter SM, Filipp FV, Abdel-Malek ZA, Geskin LJ, Brewer JD, Arbiser JL, Gershenwald JE, Chu EY, Kirkwood JM, Box NF, Funchain P, Fisher DE, Kendra KL, Marghoob AA, Chen SC, Ming ME, Albertini MR, Vetto JT, Margolin KA, Pagoto SL, Hay JL, Grossman D, Ellis DL, Kashani-Sabet M, Mangold AR, Markovic SN, Nelson KC, Powers JG, Robinson JK, Sahni D, Sekulic A, Sondak VK, Wei ML, Zager JS, Dellavalle RP, Thompson JA, Weinstock MA, Leachman SA, Cassidy PB. Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials. Cancer. 2019 Jan 1;125(1):18-44. PubMed PMID: 30281145
• Asdigian NL, Barón AE, Morelli JG, Mokrohisky ST, Aalborg J, Dellavalle RP, Daley MF, Berwick M, Muller KE, Box NF, Crane LA. Trajectories of Nevus Development From Age 3 to 16 Years in the Colorado Kids Sun Care Program Cohort. JAMA Dermatol. 2018 Nov 1;154(11):1272-1280. PubMed PMID: 30208471
• Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Kolesnikova M, Roll MV, Jowdy P, Wolff DW, Polechetti A, Yun DH, Lipchick BC, Paul LM, Wrazen B, Moparthy K, Mudambi S, Morozevich GE, Georgieva SG, Wang J, Shafirstein G, Liu S, Kandel ES, Berman AE, Box NF, Paragh G, Nikiforov MA. FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death Differ. 2018 Jun;25(6):1040-1049. PubMed PMID: 29463842