Simona Zarini, PhD

Professional Titles

• Sr. Instructor

Publications

• Broussard JL, Garfield A, Zarini S, Brozinick JT, Perreault L, Newsom SA, Kahn D, Kerege A, Berry KZ, Bui HH, Bergman BC. Combined diet and exercise training decreases serum lipids associated with insulin resistance. Obesity (Silver Spring). 2024 Dec;32(12):2334-2344. PubMed PMID: 39587896
• Bergman BC, Zemski Berry K, Garfield A, Keller A, Zarini S, Bowen S, McKenna C, Kahn D, Pavelka J, Macias E, Uhlson C, Johnson C, Russ HA, Viesi CH, Seldin M, Liu C, Doliba N, Schoen J, Rothchild K, Hazel K, Naji A. Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription. J Clin Endocrinol Metab. 2024 Nov 1. [Epub ahead of print] PubMed PMID: 39484843
• Zemski Berry KA, Garfield A, Jambal P, Zarini S, Perreault L, Bergman BC. Oxidised phosphatidylcholine induces sarcolemmal ceramide accumulation and insulin resistance in skeletal muscle. Diabetologia. 2024 Dec;67(12):2819-2832. PubMed PMID: 39347985
• McKenna CF, Stierwalt HD, Zemski Berry KA, Ehrlicher SE, Robinson MM, Zarini S, Kahn DE, Snell-Bergeon JK, Perreault L, Bergman BC, Newsom SA. Intramuscular diacylglycerol accumulates with acute hyperinsulinemia in insulin-resistant phenotypes. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E183-E193. PubMed PMID: 38895980
• Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris JC, Don AS, Garfield A, Zarini S, Zemski Berry KA, Ryan AP, Bergman BC, Brozinick JT, James DE, Burchfield JG. Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle. Elife. 2023 Dec 27;12. PubMed PMID: 38149844
• Zarini S, Zemski Berry KA, Kahn DE, Garfield A, Perreault L, Kerege A, Bergman BC. Deoxysphingolipids: Atypical Skeletal Muscle Lipids Related to Insulin Resistance in Humans That Decrease Insulin Sensitivity In Vitro. Diabetes. 2023 Jul 1;72(7):884-897. PubMed PMID: 37186949
• Bodkin SG, Smith AC, Bergman BC, Huo D, Weber KA, Zarini S, Kahn D, Garfield A, Macias E, Harris-Love MO. Utilization of Mid-Thigh Magnetic Resonance Imaging to Predict Lean Body Mass and Knee Extensor Strength in Obese Adults. Front Rehabil Sci. 2022;3. PubMed PMID: 35419566
• Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, Gerszten R, Schoen J, Cree-Green M, Bergman BC. Quantifying the inflammatory secretome of human intermuscular adipose tissue. Physiol Rep. 2022 Aug;10(16):e15424. PubMed PMID: 35980018
• Zarini S, Brozinick JT, Zemski Berry KA, Garfield A, Perreault L, Kerege A, Bui HH, Sanders P, Siddall P, Kuo MS, Bergman BC. Serum dihydroceramides correlate with insulin sensitivity in humans and decrease insulin sensitivity in vitro. J Lipid Res. 2022 Oct;63(10):100270. PubMed PMID: 36030929
• Kahn D, Macias E, Zarini S, Garfield A, Zemski Berry K, MacLean P, Gerszten RE, Libby A, Solt C, Schoen J, Bergman BC. Exploring Visceral and Subcutaneous Adipose Tissue Secretomes in Human Obesity: Implications for Metabolic Disease. Endocrinology. 2022 Oct 11;163(11). PubMed PMID: 36036084
• Fridman V, Zarini S, Sillau S, Harrison K, Bergman BC, Feldman EL, Reusch JEB, Callaghan BC. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021 Apr;35(4):107852. PubMed PMID: 33485750
• Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan;64(1):168-180. PubMed PMID: 33128577
• Fridman V, Zarini S, Sillau S, Harrison K, Bergman BC, Feldman EL, Reusch JEB, Callaghan BC. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021 Jan 9;:107852. [Epub ahead of print] PubMed PMID: 33485750
• Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan;64(1):168-180. PubMed PMID: 33128577
• Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann S, Bergman BC. Intermuscular adipose tissue (IMAT) directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 Jan 8. [Epub ahead of print] PubMed PMID: 30620635
• Bapputty R, Talahalli R, Zarini S, Samuels I, Murphy R, Gubitosi-Klug R. Montelukast Prevents Early Diabetic Retinopathy in Mice. Diabetes. 2019 Oct;68(10):2004-2015. PubMed PMID: 31350303
• Zarini S, Barkley RM, Gijón MA, Murphy RC. Overview of Lipid Mass Spectrometry and Lipidomics. Methods Mol Biol. 2019;1978:81-105. PubMed PMID: 31119658
• Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann SM, Bergman BC. Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E866-E879. PubMed PMID: 30620635
• Okuno T, Gijón MA, Zarini S, Martin SA, Barkley RM, Johnson CA, Ohba M, Yokomizo T, Murphy RC. Altered eicosanoid production and phospholipid remodeling during cell culture. J Lipid Res. 2018 Mar;59(3):542-549. PubMed PMID: 29353239
• Turcotte C, Zarini S, Jean S, Martin C, Murphy RC, Zarini S, Laviolette M, Blanchet MR, and Flamand N. The endocannabinoid metabolite prostaglandin E2-glycerol inhibits human neutrophil functions: involvement of its hydrolysis inti PGE2 and EP receptors. J. Immunol. 198: 3255-63 (2017).
• Sorgi CA, Zarini S, Martin SA, Sanchez RL, Scandiuzzi RF, Gijón MA, Guijas C, Flamand N, Murphy RC, and Faccioli LH. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. Sci Rep. 7: 10981 (2017).
• Talahalli R, Bapputty R, Zarini S, Murphy R, Gubitosi-Klug R. Montelukast Prevents Early Diabetic Retinopathy in Mice. Submitted for publication to JCI
• Turcotte C, Zarini S, Jean S, Martin C, Murphy RC,Laviolette M, Blanchet M, Flamand N. The endocannabinoid metabolite prostaglandin E2-glycerol inhibits human neutrophil functions: involvement of its hydrolysis into PGE2 and EP receptors. Submitted for publication to The Journal of Immunology.

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties

• Psychology