Ulli Bayer, PhD

Publications

• Buard I, Coultrap SJ, Freund RK, Lee YS, Dell'Acqua ML, Silva AJ, Bayer KU CaMKII "autonomy" is required for initiating but not for maintaining neuronal long-term information storage. J Neurosci 30:8214-8220 (2010)
• Vest RS, O'Leary H, Coultrap SJ, Kindy MS, Bayer KU Effective post-insult neuroprotection by a novel Ca(2+)/ calmodulin-dependent protein kinase II (CaMKII) inhibitor. J Biol Chem 285:20675-20682 (2010)
• Coultrap SJ, Buard I, Kulbe JR, Dell'Acqua ML, Bayer KU CaMKII autonomy is substrate-dependent and further stimulated by Ca2+/calmodulin. J Biol Chem 285:17930-17933 (2010)
• Cipolletta E, Monaco S, Maione SA, Vitiello L, Campiglia P, Pastore L, Franchini G, Novellina E, Bayer KU, Means AR, Rossi G, Trimarco B, Iaccarino G, Illario M CaMKII mediates vascular smooth muscle cell proliferation and is potentiated by Erk. Endocrinology (In Press) (2010)
• * Loweth, J. A., Li, D., Cortright, J. J., Wilke, G., Jeyifous, O., Neve, R.L., Bayer, K. U., Vezina P. (2013) Persistent reversal of enhanced amphetamine intake by transient CaMKII inhibition. J. Neurosci. 33:1411-1416.
• Vest RS, Coultrap SJ, Kindy MS, O'Leary H, Bayer KU Effective post insult neuroprotection by a novel CaMKII inhibitor. J Biol Chem (In Press) (2010)
• Yang, Y., Tao-Chen, J.-H., Bayer, K. U., Reese, T. S., and Dosemeci, A. (2013) CaMKII-mediated phosphorylation regulates distribution of SynGAP-a1 and –a2 at the postsynaptic density. PLoS ONE 8(8): e71795.
• Tao-Cheng, J.-H., Yang, Y., Bayer, K. U., Reese, T. S., and Dosemeci, A. (2013) Effects of the CaMKII inhibitor tatCN21 on activity-dependent redistribution of CaMKII in hippocampal neurons. Neurosci. 244:188-196.
• * Barcomb, K., Coultrap, S. J., and Bayer, K. U. (2013) Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B. Mol. Pharmacol. 84:834-843.
• Thein S, Tao-Cheng JH, Li Y, Bayer KU, Reese TS, Dosemeci A. CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density. PLoS One. 2014;9(3):e91312. PubMed PMID: 24614225
• Barcomb K, Goodell DJ, Arnold DB, Bayer KU. Live imaging of endogenous Ca²?/calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity. J Neurochem. 2015 Nov;135(4):666-73. PubMed PMID: 26212614
• Goodell DJ, Benke TA, Bayer KU. Developmental restoration of LTP deficits in heterozygous CaMKIIa KO mice. J Neurophysiol. 2016 Nov 1;116(5):2140-2151. PubMed PMID: 27535377
• Dosemeci A, Toy D, Burch A, Bayer KU, Tao-Cheng JH. CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core. FEBS Lett. 2016 Sep;590(17):2934-9. PubMed PMID: 27477489
• Khan S, Conte I, Carter T, Bayer KU, Molloy JE. Multiple CaMKII Binding Modes to the Actin Cytoskeleton Revealed by Single-Molecule Imaging. Biophys J. 2016 Jul 26;111(2):395-408. PubMed PMID: 27463141
• Barcomb K, Hell JW, Benke TA, Bayer KU. The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength. J Biol Chem. 2016 Jul 29;291(31):16082-9. PubMed PMID: 27246855
• Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. PubMed PMID: 26799652
• Deng, G., Orfila, J. E., Dietz, R. M., Moreno-Garcia, M., Coultrap, S. J., Quilinan, N., Traystman, R. J., Bayer, K. U., and Herson, P. S. (2017) Autonomous CaMKII activity as a drug target for histological and functional neuroprotection after resuscitation from cardiac arrest. Cell Reports in press
• Kulbe JR, Mulcahy Levy JM, Coultrap SJ, Thorburn A, Bayer KU. Excitotoxic glutamate insults block autophagic flux in hippocampal neurons. Brain Res. 2014 Jan 13;1542:12-9. PubMed PMID: 24505621
• Goodell DJ, Eliseeva TA, Coultrap SJ, Bayer KU. CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents. PLoS One. 2014;9(5):e96522. PubMed PMID: 24796865
• Bernard PB, Castano AM, Bayer KU, Benke TA. Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures. Neuropharmacology. 2014 Sep;84:1-12. PubMed PMID: 24780380
• Liu X, Liu Y, Zhong P, Wilkinson B, Qi J, Olsen CM, Bayer KU, Liu QS. CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. Neuropsychopharmacology. 2014 Mar;39(4):989-99. PubMed PMID: 24154664
• Barcomb K, Buard I, Coultrap SJ, Kulbe JR, O'Leary H, Benke TA, Bayer KU. Autonomous CaMKII requires further stimulation by Ca2 /calmodulin for enhancing synaptic strength. FASEB J. 2014 Aug;28(8):3810-9. PubMed PMID: 24843070
• Coultrap SJ, Zaegel V, Bayer KU. CaMKII isoforms differ in their specific requirements for regulation by nitric oxide. FEBS Lett. 2014 Dec 20;588(24):4672-6. PubMed PMID: 25447522
• Deng G, Orfila JE, Dietz RM, Moreno-Garcia M, Rodgers KM, Coultrap SJ, Quillinan N, Traystman RJ, Bayer KU, Herson PS. Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep. 2017 Jan 31;18(5):1109-1117. PubMed PMID: 28147268
• Myers JB, Zaegel V, Coultrap SJ, Miller AP, Bayer KU, Reichow SL. The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun. 2017 Jun 7;8:15742. PubMed PMID: 28589927
• Goodell DJ, Zaegel V, Coultrap SJ, Hell JW, Bayer KU. DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific. Cell Rep. 2017 Jun 13;19(11):2231-2243. PubMed PMID: 28614711
• Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the de-palmitoylation and synaptic removal of AKAP79/150 to mediate structural LTD. J Biol Chem. 2017 Dec 1. [Epub ahead of print] PubMed PMID: 29196604
• Opazo P, Viana da Silva S, Carta M, Breillat C, Coultrap SJ, Grillo-Bosch D, Sainlos M, Coussen F, Bayer KU, Mulle C, Choquet D. CaMKII Metaplasticity Drives Aß Oligomer-Mediated Synaptotoxicity. Cell Rep. 2018 Jun 12;23(11):3137-3145. PubMed PMID: 29898386
• Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ß splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 Apr 3;8(1):5448. PubMed PMID: 29615706
• Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018 Feb 2;293(5):1551-1567. PubMed PMID: 29196604
• Chalmers NE, Yonchek J, Steklac KE, Ramsey M, Bayer KU, Herson PS, Quillinan N. Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice. Mol Neurobiol. 2019 Sep 13. [Epub ahead of print] PubMed PMID: 31520314
• Bayer KU, Schulman H. CaM Kinase: Still Inspiring at 40. Neuron. 2019 Aug 7;103(3):380-394. PubMed PMID: 31394063
• Cook SG, Goodell DJ, Restrepo S, Arnold DB, Bayer KU. Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer's-Related Plasticity Impairment. Cell Rep. 2019 Apr 16;27(3):658-665.e4. PubMed PMID: 30995464
• Opazo P, Viana da Silva S, Carta M, Breillat C, Coultrap SJ, Grillo-Bosch D, Sainlos M, Coussen F, Bayer KU, Mulle C, Choquet D. CaMKII Metaplasticity Drives Aß Oligomer-Mediated Synaptotoxicity. Cell Rep. 2018 Jun 12;23(11):3137-3145. PubMed PMID: 29898386
• Myers JB, Zaegel V, Coultrap SJ, Miller AP, Bayer KU, Reichow SL. Publisher Correction: The CaMKII holoenzyme structure in activation-competent conformations. Nat Commun. 2018 May 25;9:16180. PubMed PMID: 29799013
• Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ß splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 Apr 3;8(1):5448. PubMed PMID: 29615706
• Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018 Feb 2;293(5):1551-1567. PubMed PMID: 29196604
• Tullis JE, Rumian NL, Brown CN, Bayer KU. The CaMKII K42M and K42R mutations are equivalent in suppressing kinase activity and targeting. PLoS One. 2020;15(7):e0236478. PubMed PMID: 32716967
• Buonarati OR, Cook SG, Goodell DJ, Chalmers NE, Rumian NL, Tullis JE, Restrepo S, Coultrap SJ, Quillinan N, Herson PS, Bayer KU. CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest. Cell Rep. 2020 Jan 7;30(1):1-8.e4. PubMed PMID: 31914378
• Chalmers NE, Yonchek J, Steklac KE, Ramsey M, Bayer KU, Herson PS, Quillinan N. Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice. Mol Neurobiol. 2020 Jan;57(1):150-158. PubMed PMID: 31520314
• Ramirez-Gordillo D, Bayer KU, Restrepo D. Hippocampal-prefrontal theta coupling develops as mice become proficient in associative odorant discrimination learning. eNeuro. 2022 Sep 20;9(5). [Epub ahead of print] PubMed PMID: 36127136
• Cook SG, Rumian NL, Bayer KU. CaMKII T286 phosphorylation has distinct essential functions in three forms of long-term plasticity. J Biol Chem. 2022 Sep;298(9):102299. PubMed PMID: 35872016
• Brown CN, Rumian NL, Tullis JE, Coultrap SJ, Bayer KU. Aß-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events. iScience. 2022 Jun 17;25(6):104368. PubMed PMID: 35620430
• Tullis JE, Buonarati OR, Coultrap SJ, Bourke AM, Tiemeier EL, Kennedy MJ, Herson PS, Bayer KU. GluN2B S1303 phosphorylation by CaMKII or DAPK1: no indication for involvement in ischemia or LTP. iScience. 2021 Oct 22;24(10):103214. PubMed PMID: 34704002
• Rumian NL, Chalmers NE, Tullis JE, Herson PS, Bayer KU. CaMKIIa knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest. Brain Res. 2021 Dec 15;1773:147699. PubMed PMID: 34687697
• Tullis JE, Larsen ME, Rumian NL, Freund RK, Boxer EE, Brown CN, Coultrap SJ, Schulman H, Aoto J, Dell'Acqua ML, Bayer KU. LTP induction by structural rather than enzymatic functions of CaMKII. Nature. 2023 Sep;621(7977):146-153. PubMed PMID: 37648853
• Rumian NL, Freund RK, Dell'Acqua ML, Coultrap SJ, Bayer KU. Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice. Sci Signal. 2023 Jul 25;16(795):eade5892. PubMed PMID: 37490545
• Tullis JE, Bayer KU. Distinct synaptic pools of DAPK1 differentially regulate activity-dependent synaptic CaMKII accumulation. iScience. 2023 May 19;26(5):106723. PubMed PMID: 37216104
• Larsen ME, Buonarati OR, Qian H, Hell JW, Bayer KU. Stimulating ß-adrenergic receptors promotes synaptic potentiation by switching CaMKII movement from LTD to LTP mode. J Biol Chem. 2023 Jun;299(6):104706. PubMed PMID: 37061000
• Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs. J Biol Chem. 2023 May;299(5):104693. PubMed PMID: 37037305
• Ramirez-Gordillo D, Bayer KU, Restrepo D. Hippocampal-prefrontal theta coupling develops as mice become proficient in associative odorant discrimination learning. eNeuro. 2022 Sep 20;9(5). [Epub ahead of print] PubMed PMID: 36127136
• Cook SG, Rumian NL, Bayer KU. CaMKII T286 phosphorylation has distinct essential functions in three forms of long-term plasticity. J Biol Chem. 2022 Sep;298(9):102299. PubMed PMID: 35872016
• Brown CN, Rumian NL, Tullis JE, Coultrap SJ, Bayer KU. Aß-induced synaptic impairments require CaMKII activity that is stimulated by indirect signaling events. iScience. 2022 Jun 17;25(6):104368. PubMed PMID: 35620430
• Brown CN, Cook SG, Allen HF, Crosby KC, Singh T, Coultrap SJ, Bayer KU. Characterization of six CaMKIIa variants found in patients with schizophrenia. iScience. 2021 Oct 22;24(10):103184. PubMed PMID: 34667946
• Goodell DJ, Tullis JE, Bayer KU. Young DAPK1 knockout mice have altered presynaptic function. J Neurophysiol. 2021 May 1;125(5):1973-1981. PubMed PMID: 33881939
• Cook SG, Buonarati OR, Coultrap SJ, Bayer KU. CaMKII holoenzyme mechanisms that govern the LTP versus LTD decision. Sci Adv. 2021 Apr;7(16). PubMed PMID: 33853773
• Buonarati, O. R., Miller, A. P., Coultrap, S. J., Bayer, K. U. and Reichow, S. L. (2021) Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly. In press