Laurent Gapin, PhD, MS

Publications

• Laurent Gapin (2010) iNKT cell autoreactivity: what is “self” and how is it recognized? Nature Reviews Immunology. Vol 10, p 272-277. (PMID: 20224567).
• Matsuda H, Takeda K, Koya T, Okamoto M, Shiraishi Y, Miyahara N, Dakhama A, Matsuda JL, Gapin L, Gelfand EW. (2010) Plasticity of invariant NKT cell regulation of allergic airway disease is dependent on IFN? production. J. Immunol. Vol. 185, p253-262. (PMID: 20525882).
• Thierry Mallevaey, Andrew J. Clarke, James P. Scott-Browne, Mary H. Young, Daniel G. Pellicci, Onisha Patel, Jennifer L. Matsuda, James McCluskey, Dale I. Godfrey, Philippa Marrack, Jamie Rossjohn and Laurent Gapin (2011) The molecular basis of NKT cell autoreactivity and recognition of self-CD1d. Immunity. Vol. 34, p. 327-339.
• Kwok S. Wun, Garth Cameron, Onisha Patel, Siew Siew Pang, Daniel G. Pellicci, Lucy C. Sullivan, Santosh Keshipeddy, Mary H. Young, Adam P. Uldrich, Meena Thakur, Stewart K. Richardson, Amy R. Howell, Petr A. Illarionov, Andrew G. Brooks, Gurdyal S. Besra, James McCluskey, Laurent Gapin, Steven A. Porcelli, Dale I. Godfrey, Jamie Rossjohn. (2011) A molecular basis for the exquisite CD1d-restricted Ag-specificity and functional responses of NKT cells. Immunity. Vol. 34, p 253-262.
• Mary H. Young and Laurent Gapin. (2011) Group 1 CD1-restricted T cells take center stage. European Journal of Immunology. Vol. 41, p 592-594.
• James P. Scott-Browne, Frances Crawford, Mary H. Young, John W. Kappler, Philippa Marrack* and Laurent Gapin* (2011) Evolutionarily conserved features of aß TCR specificity. Immunity. Vol. 35, p. 526-535. (PMID: 21962492) * denotes equal contribution.
• Daniel G. Pellicci, Andrew J. Clarke, Onisha Patel, Thierry Mallevaey, Travis Beddoe, Adam P. Uldrich, James McCluskey, Gurdyal S. Besra, Steven A. Porcelli, Laurent Gapin, Jamie Rossjohn and Dale I. Godfrey (2011) Natural Killer T cell receptor mediated recognition of ß-linked self-glycolipids. Nature Immunology. Vol. 12, p. 827-833. (PMID:21804559).
• Onisha Patel, Daniel G. Pellicci, Adam P. Uldrich, Lucy C. Sullivan, Melissa McKnight, Stewart K. Richardson, Amy R. Howell, Thierry Mallevaey, Jingjing Zhang, Romain Bedel, Gurdyal S. Besra, Andrew G. Brooks, Lars-Kjer-Nielsen, James McCluskey, Steven A. Porcelli, Laurent Gapin, Dale I. Godfrey and Jamie Rossjohn (2011) Vß2 Natural Killer T cell receptor mediated recognition of CD1d-glycolipid antigen. Proceedings of the National Academy of Science USA. In press (PMID: 22065767).
• Young MH, Gapin L. Mucosal associated invariant T cells: don't forget your vitamins. Cell Res. 2013 Apr;23(4):460-2. PubMed PMID: 23208418
• Maki Nakayama, Todd Castoe, Tomasz Sosinowski, XiangLing He, Kelly Johnson, Kathryn Haskins, Dario A.A. Vignali, Laurent Gapin, David Pollock, & George S. Eisenbarth. Germline TRAV5D-4 T Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice. Diabetes. In press.
• Patel O, Pellicci DG, Gras S, Sandoval-Romero ML, Uldrich AP, Mallevaey T, Clarke AJ, Le Nours J, Theodossis A, Cardell SL, Gapin L, Godfrey DI, Rossjohn J. (2012) Type-II Natural Killer T cell antigen receptor mediated recognition of CD1d-sulfatide. Nature Immunology. Vol. 13, p. 857-863. (PMID: 22820603).
• Ryan L. Bjordahl, Laurent Gapin, Philippa Marrack, and Yosef Refaeli. (2012) iNKT cells suppress the CD8+ T cell response to a murine Burkitt’s-like B cell lymphoma. PloS One. Vol. 7, e42635. (PMID: 22880059)
• K. Christopher Garcia, Laurent Gapin, Jarrett Adams, Michael Birnbaum, James Scott-Browne, John Kappler, Philippa Marrack (2012) A closer look at TCR germline recognition. Immunity. Vol 36, p 887-888. (PMID: 22705103).
• Romain Bedel, Jennifer Matsuda, Manfred Brigl, Janice White, John Kappler, Philippa Marrack and Laurent Gapin (2012) Lower TCR repertoire diversity in Traj18-deficient mice. Nature Immunology. Vol 13, p. 705-706. (PMID: 22814339).
• Jamie Rossjohn, Daniel G. Pellicci, Onisha Patel, Laurent Gapin and Dale Godfrey (2012) Natural Killer T cell antigen receptor recognition of CD1d-restricted antigens. Nature Review Immunology. Vol 12, p845-857. (PMID:23154222)
• Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P (2012) T cells and theirs eons-old obsession with MHC. Immunol. Rev. Vol. 250, p49-60. (PMID:23046122)
• Mary H. Young, Lance U’Ren, Shouxiong Huang, Thierry Mallevaey, James Scott-Browne, Frances Crawford, Olivier Lantz, Ted H. Hansen, John Kappler, Philippa Marrack and Laurent Gapin (2013) MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One. Vol. 8, e53789. (PMID:23342002)
• Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. (2013) CD8a+ dendritic cell trans presentation of IL-15 to naïve CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. Journal of Immunology, In press.
• Laurent Gapin, Dale I. Godfrey, Jamie Rossjohn (2013) Natural Killer T cells obsession with self-antigens. Current Opinion in Immunology. In press.
• Mary H. Young and Laurent Gapin (2012) Mucosal Associated Invariant T cells: Don’t forget your vitamins. Cell Research. In press.
• Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L. MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One. 2013;8(1):e53789. PubMed PMID: 23342002
• Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a dendritic cell trans presentation of IL-15 to naive CD8 T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 1;190(5):1936-47. PubMed PMID: 23355737
• Gapin L, Godfrey DI, Rossjohn J. Natural Killer T cell obsession with self-antigens. Curr Opin Immunol. 2013 Apr;25(2):168-73. PubMed PMID: 23384972
• Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
• Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
• Gapin L. Check MAIT. J Immunol. 2014 May 15;192(10):4475-80. PubMed PMID: 24795465
• Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. PubMed PMID: 25267651
• Krovi SH, Gapin L. It is time to beelieve the CD1a hype!. Eur J Immunol. 2016 Jan;46(1):56-9. PubMed PMID: 26617406
• Krovi SH, Gapin L. It is time to beelieve the CD1a hype!. Eur J Immunol. 2016 Jan;46(1):56-9. PubMed PMID: 26617406
• Gapin L. Development of invariant natural killer T cells. Curr Opin Immunol. 2016 Apr;39:68-74. PubMed PMID: 26802287
• Krovi SH, Gapin L. Revealing the TCR bias for MHC molecules. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2809-11. PubMed PMID: 26933216
• Zhang J, Bedel R, Krovi SH, Tuttle KD, Zhang B, Gross J, Gapin L, Matsuda JL. Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. Sci Rep. 2016 Jun 3;6:27375. PubMed PMID: 27256918
• Krovi SH, Gapin L. Structure and function of the non-classical major histocompatibility complex molecule MR1. Immunogenetics. 2016 Aug;68(8):549-59. PubMed PMID: 27448212
• Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW. Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5608-17. PubMed PMID: 27588903
• Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J. T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun. 2016 Oct 27;7:13257. PubMed PMID: 27807341
• Krovi SH, Gapin L. iNKT cells need UTX-tra demethylation. Nat Immunol. 2017 Jan 19;18(2):148-150. PubMed PMID: 28102220
• Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 Nov;462:65-73. PubMed PMID: 30165064
• Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, Gapin L. TCR signal strength controls thymic differentiation of iNKT cell subsets. Nat Commun. 2018 Jul 9;9(1):2650. PubMed PMID: 29985393
• Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB. CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails. Eur J Immunol. 2017 Sep;47(9):1525-1534. PubMed PMID: 28665555
• Krovi SH, Gapin L. Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates. Front Immunol. 2018;9:1393. PubMed PMID: 29973936
• Tuttle KD, Gapin L. Characterization of Thymic Development of Natural Killer T Cell Subsets by Multiparameter Flow Cytometry. Methods Mol Biol. 2018;1799:121-133. PubMed PMID: 29956149
• Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. PubMed PMID: 29351991
• Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J. The somatically generated portion of T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor. Elife. 2017 Nov 17;6. PubMed PMID: 29148973
• Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 Jan 19. [Epub ahead of print] PubMed PMID: 29351991
• Krovi SH, Kappler JW, Marrack P, Gapin L. Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22252-22261. PubMed PMID: 31570608
• Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 Apr 5;4(34). PubMed PMID: 30952805
• Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020;11:610010. PubMed PMID: 33312179
• Harsha Krovi S, Zhang J, Michaels-Foster MJ, Brunetti T, Loh L, Scott-Browne J, Gapin L. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020 Dec 7;11(1):6238. PubMed PMID: 33288744
• Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
• Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 2020 Oct;50(10):1454-1467. PubMed PMID: 32460359
• Brown IK, Dyjack N, Miller MM, Krovi H, Rios C, Woolaver R, Harmacek L, Tu TH, O'Connor BP, Danhorn T, Vestal B, Gapin L, Pinilla C, Seibold MA, Scott-Browne J, Santos RG, Reinhardt RL. Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4 T cell repertoire. PLoS Pathog. 2021 Jun;17(6):e1009602. PubMed PMID: 34106992
• Gapin L. CD1a autoreactivity: When size does matter. J Exp Med. 2021 Jul 5;218(7). PubMed PMID: 34014254
• Cogswell DT, Gapin L, Tobin HM, McCarter MD, Tobin RP. MAIT Cells: Partners or Enemies in Cancer Immunotherapy?. Cancers (Basel). 2021 Mar 25;13(7). PubMed PMID: 33805904
• Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020;11:610010. PubMed PMID: 33312179
• Harsha Krovi S, Zhang J, Michaels-Foster MJ, Brunetti T, Loh L, Scott-Browne J, Gapin L. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020 Dec 7;11(1):6238. PubMed PMID: 33288744
• Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
• Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 2020 Oct;50(10):1454-1467. PubMed PMID: 32460359
• Krovi SH, Loh L, Spengler A, Brunetti T, Gapin L. Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data. Semin Immunol. 2022 Sep 28;60:101658. [Epub ahead of print] PubMed PMID: 36182863
• Vorwald VM, Davis DM, Van Gulick RJ, Torphy RJ, Borgers JS, Klarquist J, Couts KL, Amato CM, Cogswell DT, Fujita M, Castleman MJ, Davis T, Lozupone C, Medina TM, Robinson WA, Gapin L, McCarter MD, Tobin RP. Circulating CD8( ) mucosal-associated invariant T cells correlate with improved treatment responses and overall survival in anti-PD-1-treated melanoma patients. Clin Transl Immunology. 2022;11(1):e1367. PubMed PMID: 35028137
• Brown IK, Dyjack N, Miller MM, Krovi H, Rios C, Woolaver R, Harmacek L, Tu TH, O'Connor BP, Danhorn T, Vestal B, Gapin L, Pinilla C, Seibold MA, Scott-Browne J, Santos RG, Reinhardt RL. Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4 T cell repertoire. PLoS Pathog. 2021 Jun;17(6):e1009602. PubMed PMID: 34106992
• Gapin L. CD1a autoreactivity: When size does matter. J Exp Med. 2021 Jul 5;218(7). PubMed PMID: 34014254
• Cogswell DT, Gapin L, Tobin HM, McCarter MD, Tobin RP. MAIT Cells: Partners or Enemies in Cancer Immunotherapy?. Cancers (Basel). 2021 Mar 25;13(7). PubMed PMID: 33805904
• Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
• Krovi SH, Loh L, Spengler A, Brunetti T, Gapin L. Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data. Semin Immunol. 2022 Mar;60:101658. PubMed PMID: 36182863
• Katsnelson EN, Spengler A, Domenico J, Couts KL, Loh L, Gapin L, McCarter MD, Tobin RP. Dysfunctional States of Unconventional T cell Subsets in Cancer. J Leukoc Biol. 2023 Oct 14. [Epub ahead of print] PubMed PMID: 37837379
• Loh L, Orlicky D, Spengler A, Levens C, Celli S, Domenico J, Klarquist J, Onyiah J, Matsuda J, Kuhn K, Gapin L. MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitis. bioRxiv. 2023 Dec 1. PubMed PMID: 38076996
• Liyen Loh, Salomé Carcy, Harsha S. Krovi, Joanne Domenico, Andrea Spengler, Yong Lin, Joshua Torres, William Palmer, Paul J. Norman, Matthew Stone, Tonya Brunetti, Hannah V. Meyer, Laurent Gapin. Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models. bioRxiv 2023.12.07.570707; doi: https://doi.org/10.1101/2023.12.07.570707
• Katsnelson EN, Spengler A, Domenico J, Couts KL, Loh L, Gapin L, McCarter MD, Tobin RP. Dysfunctional states of unconventional T-cell subsets in cancer. J Leukoc Biol. 2024 Jan 5;115(1):36-46. PubMed PMID: 37837379
• Loh L, Carcy S, Krovi HS, Domenico J, Spengler A, Lin Y, Torres J, Prabakar RK, Palmer W, Norman PJ, Stone M, Brunetti T, Meyer HV, Gapin L. Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models. Cell Rep. 2024 Sep 24;43(9):114705. PubMed PMID: 39264810
• Brown AJ, White J, Shaw L, Gross J, Slabodkin A, Kushner E, Greiff V, Matsuda J, Gapin L, Scott-Browne J, Kappler J, Marrack P. MHC heterozygosity limits T cell receptor variability in CD4 T cells. Sci Immunol. 2024 Jul 12;9(97):eado5295. PubMed PMID: 38996008