Liyen Loh, Salomé Carcy, Harsha S. Krovi, Joanne Domenico, Andrea Spengler, Yong Lin, Joshua Torres, William Palmer, Paul J. Norman, Matthew Stone, Tonya Brunetti, Hannah V. Meyer, Laurent Gapin. Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models. bioRxiv 2023.12.07.570707; doi: https://doi.org/10.1101/2023.12.07.570707
Katsnelson EN, Spengler A, Domenico J, Couts KL, Loh L, Gapin L, McCarter MD, Tobin RP. Dysfunctional States of Unconventional T cell Subsets in Cancer. J Leukoc Biol. 2023 Oct 14. [Epub ahead of print] PubMed PMID: 37837379
Loh L, Orlicky D, Spengler A, Levens C, Celli S, Domenico J, Klarquist J, Onyiah J, Matsuda J, Kuhn K, Gapin L. MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitis. bioRxiv. 2023 Dec 1. PubMed PMID: 38076996
Krovi SH, Loh L, Spengler A, Brunetti T, Gapin L. Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data. Semin Immunol. 2022 Sep 28;60:101658. [Epub ahead of print] PubMed PMID: 36182863
Vorwald VM, Davis DM, Van Gulick RJ, Torphy RJ, Borgers JS, Klarquist J, Couts KL, Amato CM, Cogswell DT, Fujita M, Castleman MJ, Davis T, Lozupone C, Medina TM, Robinson WA, Gapin L, McCarter MD, Tobin RP. Circulating CD8( ) mucosal-associated invariant T cells correlate with improved treatment responses and overall survival in anti-PD-1-treated melanoma patients. Clin Transl Immunology. 2022;11(1):e1367. PubMed PMID: 35028137
Krovi SH, Loh L, Spengler A, Brunetti T, Gapin L. Current insights in mouse iNKT and MAIT cell development using single cell transcriptomics data. Semin Immunol. 2022 Mar;60:101658. PubMed PMID: 36182863
Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
Brown IK, Dyjack N, Miller MM, Krovi H, Rios C, Woolaver R, Harmacek L, Tu TH, O'Connor BP, Danhorn T, Vestal B, Gapin L, Pinilla C, Seibold MA, Scott-Browne J, Santos RG, Reinhardt RL. Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4 T cell repertoire. PLoS Pathog. 2021 Jun;17(6):e1009602. PubMed PMID: 34106992
Gapin L. CD1a autoreactivity: When size does matter. J Exp Med. 2021 Jul 5;218(7). PubMed PMID: 34014254
Cogswell DT, Gapin L, Tobin HM, McCarter MD, Tobin RP. MAIT Cells: Partners or Enemies in Cancer Immunotherapy?. Cancers (Basel). 2021 Mar 25;13(7). PubMed PMID: 33805904
Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
Brown IK, Dyjack N, Miller MM, Krovi H, Rios C, Woolaver R, Harmacek L, Tu TH, O'Connor BP, Danhorn T, Vestal B, Gapin L, Pinilla C, Seibold MA, Scott-Browne J, Santos RG, Reinhardt RL. Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4 T cell repertoire. PLoS Pathog. 2021 Jun;17(6):e1009602. PubMed PMID: 34106992
Gapin L. CD1a autoreactivity: When size does matter. J Exp Med. 2021 Jul 5;218(7). PubMed PMID: 34014254
Cogswell DT, Gapin L, Tobin HM, McCarter MD, Tobin RP. MAIT Cells: Partners or Enemies in Cancer Immunotherapy?. Cancers (Basel). 2021 Mar 25;13(7). PubMed PMID: 33805904
Gray JI, Al-Khabouri S, Morton F, Clambey ET, Gapin L, Matsuda JL, Kappler JW, Marrack P, Garside P, Otto TD, MacLeod MKL. Tolerance induction in memory CD4 T cells is partial and reversible. Immunology. 2021 Jan;162(1):68-83. PubMed PMID: 32931017
Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020;11:610010. PubMed PMID: 33312179
Harsha Krovi S, Zhang J, Michaels-Foster MJ, Brunetti T, Loh L, Scott-Browne J, Gapin L. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020 Dec 7;11(1):6238. PubMed PMID: 33288744
Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 2020 Oct;50(10):1454-1467. PubMed PMID: 32460359
Genardi S, Visvabharathy L, Cao L, Morgun E, Cui Y, Qi C, Chen YH, Gapin L, Berdyshev E, Wang CR. Type II Natural Killer T Cells Contribute to Protection Against Systemic Methicillin-Resistant Staphylococcus aureus Infection. Front Immunol. 2020;11:610010. PubMed PMID: 33312179
Harsha Krovi S, Zhang J, Michaels-Foster MJ, Brunetti T, Loh L, Scott-Browne J, Gapin L. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Nat Commun. 2020 Dec 7;11(1):6238. PubMed PMID: 33288744
Perroteau J, Navet B, Devilder MC, Hesnard L, Scotet E, Gapin L, Saulquin X, Gautreau-Rolland L. Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. Eur J Immunol. 2020 Oct;50(10):1454-1467. PubMed PMID: 32460359
Krovi SH, Kappler JW, Marrack P, Gapin L. Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules. Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22252-22261. PubMed PMID: 31570608
Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 Apr 5;4(34). PubMed PMID: 30952805
Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 Jan 19. [Epub ahead of print] PubMed PMID: 29351991
Williams T, Krovi HS, Landry LG, Crawford F, Jin N, Hohenstein A, DeNicola ME, Michels AW, Davidson HW, Kent SC, Gapin L, Kappler JW, Nakayama M. Development of T cell lines sensitive to antigen stimulation. J Immunol Methods. 2018 Nov;462:65-73. PubMed PMID: 30165064
Tuttle KD, Krovi SH, Zhang J, Bedel R, Harmacek L, Peterson LK, Dragone LL, Lefferts A, Halluszczak C, Riemondy K, Hesselberth JR, Rao A, O'Connor BP, Marrack P, Scott-Browne J, Gapin L. TCR signal strength controls thymic differentiation of iNKT cell subsets. Nat Commun. 2018 Jul 9;9(1):2650. PubMed PMID: 29985393
Krovi SH, Gapin L. Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates. Front Immunol. 2018;9:1393. PubMed PMID: 29973936
Tuttle KD, Gapin L. Characterization of Thymic Development of Natural Killer T Cell Subsets by Multiparameter Flow Cytometry. Methods Mol Biol. 2018;1799:121-133. PubMed PMID: 29956149
Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L. Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. PubMed PMID: 29351991
Krovi SH, Gapin L. iNKT cells need UTX-tra demethylation. Nat Immunol. 2017 Jan 19;18(2):148-150. PubMed PMID: 28102220
Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB. CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails. Eur J Immunol. 2017 Sep;47(9):1525-1534. PubMed PMID: 28665555
Marrack P, Krovi SH, Silberman D, White J, Kushnir E, Nakayama M, Crooks J, Danhorn T, Leach S, Anselment R, Scott-Browne J, Gapin L, Kappler J. The somatically generated portion of T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor. Elife. 2017 Nov 17;6. PubMed PMID: 29148973
Krovi SH, Gapin L. It is time to beelieve the CD1a hype!. Eur J Immunol. 2016 Jan;46(1):56-9. PubMed PMID: 26617406
Krovi SH, Gapin L. It is time to beelieve the CD1a hype!. Eur J Immunol. 2016 Jan;46(1):56-9. PubMed PMID: 26617406
Gapin L. Development of invariant natural killer T cells. Curr Opin Immunol. 2016 Apr;39:68-74. PubMed PMID: 26802287
Krovi SH, Gapin L. Revealing the TCR bias for MHC molecules. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2809-11. PubMed PMID: 26933216
Zhang J, Bedel R, Krovi SH, Tuttle KD, Zhang B, Gross J, Gapin L, Matsuda JL. Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. Sci Rep. 2016 Jun 3;6:27375. PubMed PMID: 27256918
Krovi SH, Gapin L. Structure and function of the non-classical major histocompatibility complex molecule MR1. Immunogenetics. 2016 Aug;68(8):549-59. PubMed PMID: 27448212
Silberman D, Krovi SH, Tuttle KD, Crooks J, Reisdorph R, White J, Gross J, Matsuda JL, Gapin L, Marrack P, Kappler JW. Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5608-17. PubMed PMID: 27588903
Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J. T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun. 2016 Oct 27;7:13257. PubMed PMID: 27807341
Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
Gapin L. Check MAIT. J Immunol. 2014 May 15;192(10):4475-80. PubMed PMID: 24795465
Pennock ND, Gapin L, Kedl RM. IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16472-7. PubMed PMID: 25267651
Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
Young MH, Gapin L. Mucosal associated invariant T cells: don't forget your vitamins. Cell Res. 2013 Apr;23(4):460-2. PubMed PMID: 23208418
Young MH, U'Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack P, Gapin L. MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One. 2013;8(1):e53789. PubMed PMID: 23342002
Sosinowski T, White JT, Cross EW, Haluszczak C, Marrack P, Gapin L, Kedl RM. CD8a dendritic cell trans presentation of IL-15 to naive CD8 T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. J Immunol. 2013 Mar 1;190(5):1936-47. PubMed PMID: 23355737
Gapin L, Godfrey DI, Rossjohn J. Natural Killer T cell obsession with self-antigens. Curr Opin Immunol. 2013 Apr;25(2):168-73. PubMed PMID: 23384972