Marileila Garcia, PhD

Clinical Professor, Medicine-Medical Oncology

FacultyPhoto

Publications

  • Sunpaweravong P, Sunpaweravong S, Puttawibul P, Mitranun W, Zeng C, Baron A, Franklin WA, Said S, Varella-Garcia M. Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 131(2):111-9, 2005
  • Sunpaweravong P, Sunpaweravong S, Puttawibul P, Mitranun W, Zeng C, Baron A, Franklin WA, Said S, Varella-Garcia M. Epidermal growth factor receptor and cyclin D1 are independently amplified and overexpressed in esophageal squamous cell carcinoma. Journal of Cancer Research and Clinical Oncology, 131(2):111-9, 2005
  • Reichenberger KJ, Coletta RD, Schult AP, Varella-Garcia M, Ford HL Gene amplification is a mechanism of Six1 overexpression in breast cancer. Cancer Res, 65(7):2668-75, 2005.
  • Cappuzzo F, Hirsch FR, Rossi E., Bartolini B., Ceresoli GL Bemis L, Haney J, Witta S, Danenberg K, Domenichini I., Ludovini L., Lombardo L, Gregorc V., Doglioni C, Sidoni A, Tonato M, Franklin WA, Crino L., Bunn Jr PA, Varella-Garcia M. Epidermal growth factor receptor gene copy number, gene mutations and protein level predict outcome to gefitinib therapy in advanced non-small cell lung cancer. J Natl Cancer Inst; 97: 643-655, 2005.
  • Biggs JR, Zhang Y, Peterson LF, Garcia M, Zhang DE, Kraft AS. Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association. Mol Cancer Res. 3(7):391-401, 2005.
  • Hirsch FR*, Varella-Garcia M* , McCoy J, West H, Xavier AC, Crowely J, Gummerlock P,. Bunn Jr PA., Franklin WA, Gandara DJ Increased EGFR gene copy number detected by FISH associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes. J Clin Oncol 23 (28):6838-45, 2005
  • Cappuzzo F*, Varella-Garcia M*, Domenichini I, Bartolini I, Ceresoli GL Rossi E, Ludovini V, Gregorc V, Toschi L, Franklin WA, Crino L, Bunn Jr PA, Hirsch FR Increased HER2 gene copy number enhances response to gefitinib therapy in EGFR positive non-small cell lung cancer patients. J Clin Oncol, 23(22):5007-18, 2005.
  • Piazza RG, Magistroni V, Andreoni F, Franceschino A, Tornaghi L, Varella-Garcia M, Bungaro S, Colnaghi F, Corneo G, Pogliani EM, Gambacorti-Passerini C Imatinib dose increase up to 1200 mg daily can induce new durable complete cytogenetic remissions in relapsed Ph+ chronic myeloid leukemia patients. Leukemia. 19(11):1985-7, 2005
  • Cappuzzo F, Toschi L, Domenichini I, Bartolini S, Ceresoli GL, Rossi E, Ludovini V, Cancellieri A, Magrini E, Bemis L, Franklin WA, Crino L, Bunn Jr PA, Hirsch FR, Marileila VArella-Garcia. HER3 genomic gain and sensitivity to gefitinib in advanced non-small cell lung cancer patients. British Journal Cancer, 93(12):1334-40, 2005.
  • Ford HL, Patrick AN, Varella-Garcia M. SIX1 (sine oculis homeobox homolog 1) (mammalian). Atlas Genet Cytogenet Oncol Haematol. November 2005. URL : http://www.infobiogen.fr/services/chromcancer/Genes/SIX1ID42302ch14q23.html
  • Cappuzzo F, Toschi L, Tallini G, Ceresoli GL, Domenichini I, Bartolini S, Finocchiaro G, Cancellieri A, Trisolini R, Magrini E, Crino L, Bunn Jr. PA, Santoro A, Franklin WA, Varella-Garcia M, Hirsch FR. Insulin-like growth factor receptor 1 (IGFR-1) and PTEN as determinants for intrinsic resistance to gefitinib therapy in non-small cell lung cancer (NSCLC) patients. Annals of Oncology, 17(7):1120-7, 2006
  • Vulcani-Freitas TM, Gil-da-Silva-Lopes VL, Varella-Garcia M, Maciel-Guerra AT Infertility and marker chromosomes: Application of molecular cytogenetic techniques in a case of inv dup(15). Journal of Applied Genetics 47(1): 89  91, 2006.
  • Gomez GG, Varella-Garcia M, Kruse CA. Isolation of immunoresistant human glioma cell clones after selection with alloreactive cytotoxic T lymphocytes: Cytogenetic and molecular cytogenetic characterization. Cancer Genetics and Cytogenetics, 165 (2):121-134, 2006
  • Bunn PA Jr, Dziadziuszko R, Varella-Garcia M, Franklin WA, Witta SE, Kelly K, Hirsch FR. Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy. Clin Cancer Res.;12(12):3652-3656, 2006.
  • Cappuzzo F, Bemis L, Varella-Garcia M. HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med.;354(24):2619-21, 2006
  • Dziadziuszko R, Witta SE, Cappuzzo F, Park S, Tanaka K, Danenberg PV, Barsn AE, Crino L, Franklin WA, Bunn, Jr. PA, Varella-Garcia M, Danenberg KD, Hirsch FR. Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in nonsmall cell lung cancer . Clinical Cancer Res;12(10):3078-84, 2006.
  • Dziadziuszko R, Hirsch FR, Varella-Garcia M, Bunn PA Jr. Selecting lung cancer patients for treatment with epidermal growth factor receptor tyrosine kinase inhibitors by immunohistochemistry and fluorescence in situ hybridization--Why, When, and How? Clin Cancer Res;12(14):4409s-15s, 2006
  • Rothschild BL Shim AH , Ammer AG, Kelly LC, Irby KB,. Head JA, Chen L, Varella-Garcia M, Sacks PG, Frederick B, Raben D, Weed SA. Cortactin overexpression regulates Arp2/3 complex activity, motility and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res, 66: 8017-8025, 2006.
  • Jacobsen BM, Harell JC, Jedlicka P, Borges VF, Varella-Garcia M, Horwitz KB. Spontaneous fusion with, and transformation of mouse stroma by, malignant human breast cancer epithelium. Cancer Res, 66: 8274-8279, 2006
  • Varella-Garcia M, Chen L, Zheng X, Yu L, Darlene Dixon. Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction. Cancer Genetics and Cytogenetics, 170(1):71-5, 2006
  • Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burley BR, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJC, Hirsch FR. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol, 24: 4170-4176, 2006.
  • Varella-Garcia M. Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay. Diagnostic Pathology, 1: 19, 2006
  • Hirsch Fr, Varella-Garcia M, Bunn Jr Pa, Franklin Wa, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira Jr, Ciuleanu T, Von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums D, Botwood N, Holloway B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced Non-Small-Cell Lung Cancer. J Clin Oncol, 24:5034-42, 2006
  • Helfrich BA, Raben D, Varella-Garcia M, Gustafson D, Chan DC, Bemis L, Coldren C, Baron A, Zeng C, Franklin WA, Hirsch FR, Gazdar A, Minna J, Bunn PA Jr. Antitumor Activity of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Gefitinib (ZD1839, Iressa) in Non-Small Cell Lung Cancer Cell Lines Correlates with Gene Copy Number and EGFR Mutations but not EGFR Protein Levels. Clin Cancer Res, 12(23):7117-7125, 2006
  • Dziadziuszko R, Holm B, Skov BG, Osterlind K, Sellers MV, Franklin WA, Bunn PA Jr, Varella-Garcia M, Hirsch FR. Epidermal growth factor receptor gene copy number and protein level are not associated with outcome of non-small-cell lung cancer patients treated with chemotherapy. Ann Oncol. 2006 Nov 2; [Epub ahead of print]
  • Dziadziuszko R, Siemiatkoswska A, Limon J, Rzyman W, Jassem J, Bunn PA Jr, Varella-Garcia M, Hirsch FR. Unusual chemosensitivity of advanced bronchioalveolar carcinoma after gefitinib response and progression: a case report. J. Thor Oncology, 2:92-92, 2007
  • Hirsch FR, Varella-Garcia M, Cappuzzo F, McCoy J, Bemis L, Xavier AC, Dziadziuszko R, Gumerlock P, Witta SE, West H, Crowley J, Gazdar AF, Crino L, Gandara D, Franklin WA, Bunn Jr. PA. Combination of EGFR gene copy number and protein expression predicts outcome for advanced non-small-cell lung cancer patients treated with gefitinib. Ann. Oncology, 18(4):752-60, 2007.
  • Fett-Conte A, Estrela RV, Vendrame-Goloni CB, Carvalho-Sales AB, Ricci Jr O, Varella-Garcia M. Atypical chromosome abnormalities in acute myeloid leukemia type M4. Gen Mol Biol, 30:6-9, 2007.
  • Cappuzzo F, Ligorio C, Toschi L, Rossi E, Trisolini R, Paioli D, Magrini E, Finocchiaro G, Bartolini S, Cancellieri A, Hirsch FR, Crino L, Varella-Garcia M. EGFR and HER2 gene copy number and response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). J. Thor Oncol, 2(5):423-9, 2007
  • Stearman RS, Grady M, Nana-Sinkam P, Varella-Garcia M, Geraci MW. Genetic and Epigenetic Regulation of the Human Prostacyclin Synthase Promoter in Lung Cancer Cell Lines. Molecular Cancer Res, 5 (3):295-308, 2007
  • Bemis LT, Robinson WA, McFarlane R, Byers E, Kelly K, Varella-Garcia M, Mitchell JD, Franklin WA. EGFR-mutant lung adenocarcinoma in a patient with Li-Fraumeni syndrome. Lancet Oncology, 8(6):559-60, 2007
  • Massarelli E, Varella-Garcia M, Tang X, Xavier AC, Ozburn NC, Liu DD, B. Nebiyou Bekele BN, Herbst RS, Wistuba II KRAS Mutation is an Important Predictor of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Cancer. Clin Cancer Res, 13(10):2890-2896, 2007
  • Cappuzzo F, Ligorio C, J?nne PA, Toschi L, Rossi E, Trisolini R, Paioli D, Holmes AJ, Magrini E, Finocchiaro G, Bartolini S, Cancellieri A, Ciardiello F, Patelli M, Crino L, Varella-Garcia M. Prospective study of gefitinib in EGFRFISH positive/p-AKT positive or never smoker patients with advanced non-small cell lung cancer (NSCLC): results of the ONCOBELL trial. J Clin Oncol., 25(16):2248-55, 2007.
  • Varella-Garcia M, Chen L, Powell R, Hirsch FR, Kennedy TC, Keith R, Miller YE, Mitchell JD, Franklin WA. Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer. Am J Respir Crit Care Med, 176: 505-512, 2007
  • Cappuzzo F, Finocchiaro G, Rossi E, Jänne PA, Carnaghi C, Calandri C, Bencardino K, Ligorio C, Ciardiello F, Pressiani T, Destro A, Roncalli M, Crino L, Franklin WA, Santoro A, Varella-Garcia M. EGFR FISH assay predicts for response to cetuximab in chemotherapy refractory colorectal cancer patients. Ann Oncol, 2007 online on Oct 31 2007
  • Jonsson S, Varella-Garcia M, Miller YE, Wolf HJ, Byers T, Braudrick S, Kiatsimkul P, Lewis M, Kennedy TC, Keith RL, Bjornsson J, McWilliams A, Lam S, Hirsch FR, Franklin WA Chromosomal Aneusomy in Bronchial High Grade Lesions is Associated with Invasive Lung Cancer. Am J Respir Crit Care Med,177(3):342-7, 2008
  • Weiss GJ, Bemis LT, Nakajima E, Sugita M, Birks DK, Robinson WA, Varella-Garcia V, Bunn, Jr PA, Haney Helfrich BH, Kato K, Hirsch FR, Franklin WA. EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Annals of Oncology, online on Feb 25, 2008.
  • Greer RO Jr, Said S, Shroyer KR, Varella-Garcia M, Weed SA. Overexpression of cyclin D1 and cortactin is primarily independent of gene amplification in salivary gland adenoid cystic carcinoma. Oral Oncol, 43(8):735-41, 2007.
  • Zhong CH, Prima V, Liang X, Frye C, McGavran L, Meltesen L, Wei Q, Boomer T, Varella-Garcia M, Gump J, Hunger SP. E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia. Leukemia. 22(4):723-9, 2008
  • Coletta RD, Christensen KL, Micalizzi DS, Jedlicka P, Varella-Garcia M, Ford, H. Six1 overexpression in mammary epithelial cells induces genomic instability and is sufficient for malignant transformation. Cancer Res 68 (7):2204-13, 2008.
  • Martin J, Helm K, Ruegg P, Varella-Garcia M, Burham E and Majka S. Adult lung side population cells have mesenchymal stem cell potential. Cytotherapy, 10 (2): 140-151, 2008.
  • Jimeno A, Tan AC, Coffa J, Rajeshkumar NV, Kulesza P, Rubio-Viqueira B, Wheelhouse J, Diosdado B, Messersmith WA, Iacobuzio-Donahue C, Maitra A, Varella-Garcia M, Hirsch FR, Meijer GA, Hidalgo M. Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer. Cancer Res.;68(8):2841-9, 2008
  • Vendrame-Goloni CB, Carvalho-Salles AB, Ruiz MA, Ricci Júnior O, Varella-Garcia M, Fett-Conte AC. Clinical outcome in chronic myeloid leukemia after allogeneic hematopoietic stem cell transplantation: the experience of the Bone Marrow Transplantation Unit of FUNFARME/BRAZIL using FISH. Genet Mol Res;7(2):417-23, 2008.
  • Hirsch FR, Dziadziuszko R, Varella-Garcia M, Franklin WA, Gandara DR, Bunn PA Jr. First-generation epidermal growth factor receptor inhibitors in non-small cell lung cancer: clinical impact of the epidermal growth factor receptor fluorescence in situ hybridization assay. J Thorac Oncol;3(6 Suppl 2):S138-42, 2008.
  • Rosa RFM, Pilla CB, Flores JAM, Golendziner E, Koshiyama DB, Herts MT, Ricachinevsky CP, Roman T, Varella-Garcia M, Paskulin, GA. 22q11.2 deletion syndrome in patients admitted to a cardiac pediatric intensive care unit in Brazil. American Journal of Medical Genetics, 146A(13):1655-61, 2008
  • Tang X, Varella-Garcia M,. Xavier AC, Massarelli E, Ozburn N, Moran C,. Wistuba II. Epidermal Growth Factor Receptor Abnormalities in the Pathogenesis and Progression of Lung Adenocarcinomas. Cancer Prevention Research 1: 192-200, 2008.
  • Zucali PA, Ruiz MG, Giovannetti E, Destro A, Varella-Garcia M, Floor K, Ceresoli GL, Rodriguez JA, Garassino I, Comoglio P, Roncalli M, Santoro A, Giaccone G. Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors. Ann Oncol. 19(9):1605-12, 2008.
  • Hirsch FR, Herbst RS, Olsen CC, Chansky K, Crowley J, Kelly K, Franklin WA, Bunn PA, Varella-Garcia M, Gandara DR Increased EGFR gene copy number detected by FISH predicts outcome in non-small cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol;26(20):3351-7, 2008
  • Guo W, Lasky JL, Chang CJ, Mosessian S, Lewis X, Xiao Y, Yeh JE, Chen JY, Iruela-Arispe ML, Varella-Garcia M, Wu H. Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature 453(7194):529-33, 2008
  • Cappuzzo F, Varella-Garcia M, Finocchiaro G, Skokan M, Gajapathy S, Carnaghi C, Rimassa L, Rossi E, Ligorio C, Di Tommaso L, Holmes AJ, Toschi L, Tallini G, Destro A, Roncalli M, Santoro A, Jänne PA. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer; 99(1):83-9, 2008
  • Hirsch FR, Dziadziuszko R, Varella-Garcia M, Franklin WA, Gandara DR, Bunn PA Jr. First-generation epidermal growth factor receptor inhibitors in non-small cell lung cancer: clinical impact of the epidermal growth factor receptor fluorescence in situ hybridization assay. J Thorac Oncol.(6 Suppl 2):S138-42, 2008.
  • Crino L, Cappuzzo F, Zatloukal P, Reck M, Pesek M, Thompson JC, Ford HE, Hirsch FR, Varella-Garcia M, Ghiorghiu S, Duffield EL, Armour AA, Speake G, Cullen M Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase ii study. J Clin Oncol.;26(26):4253-60, 2008
  • Hirsch FR, Varella-Garcia M, Dziadziuszko R, Xiao Y, Gajapathy S, Skokan M, Lin M, O'Neill V, Bunn PA Jr. Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer. Clin Cancer Res, 14(19):6317-23, 2008
  • Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension: Am J Physiol Lung Cell Mol Physiol, 295(6):L1028-39,2008
  • Kubo T, Yamamoto H, Lockwood WW, Valencia I, Soh J, Peyton M, Jida M, Otani H, Fujii T, Ouchida M, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Varella-Garcia M, Lam WL, Gazdar AF, Toyooka S. MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors. Int J Cancer. Apr 15;124(8):1778-84, 2009
  • Fred R. Hirsch, Roy S. Herbst, Christine Olsen, Kari Chansky, John Crowley, Karen Kelly, Wilbur A. Franklin, Paul A. Bunn, Jr, Marileila Varella-Garcia, David R. Gandara Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non–Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy In Reply. J Clin Oncol 27(3): 465-467, 2009
  • Cappuzzo F, Janne PA, Skokan M, Finocchiaro G, Rossi E, Ligorio C, Zucali PA, Terracciano L, Toschi L, Roncalli M, Destro A, Incarbone M, Alloisio M, Santoro A, Varella-Garcia M. MET increased gene copy number and primary resistance to gefitinib therapy in non-small cell lung cancer patients. Ann Oncol, 2008 Oct 3. [Epub ahead of print].
  • Cappuzzo F, Marchetti A, Skokan M, Rossi E, Gajapathy S, Felicioni L, Grammastro M, Sciarrotta MG, Buttitta F, Incarbone M, Toschi L, Finocchiaro G, Destro A, Terracciano L, Roncalli M, Alloisio M, Santoro A, Varella-Garcia M. Increased MET gene copy number negatively affects survival of surgically resected non-small cell lung cancer patients (NSCLC). J Clin Oncol, in press.
  • Witta SE, Dziadziuszko R, Yoshida K, Hedman K, Varella-Garcia M, Bunn PA Jr, Hirsch FR. ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC). Ann Oncol. 2009 Jan 15. [Epub ahead of print]
  • Cappuzzo F, Varella-Garcia M, Rossi E, Gajapathy S, Valente M, Drabkin H, Gemmill RMYC and EIF3H. Coamplification Significantly Improve Response and Survival of Non-small Cell Lung Cancer Patients (NSCLC) Treated with Gefitinib. J Thorac Oncol. 2009 Feb 6. [Epub ahead of print]
  • Flaig TW, Su LJ, McCoach C, Li Y, Raben D, Varella-Garcia M, Bemis LT.Dual epidermal growth factor receptor and vascular endothelial growth factor receptor inhibition with vandetanib sensitizes bladder cancer cells to cisplatin in a dose- and sequence-dependent manner. BJU Int. 2009 Feb 10. [Epub ahead of print]
  • Varella-Garcia M. Genomic Alterations in Lung Cancer. Lung Cancer: Principles and Practice, Fourth Edition, edited by Harvey I. Pass, M.D., David P. Carbone, M.D., Ph.D., David H. Johnson, M.D., John D. Minna, M.D., Andrew T. Turrisi, III, M.D., and Giorgio V. Scagliotti, M.D; in press.
  • Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF. Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS ONE ; 4(2):e4576. Epub 2009.
  • Stewart JS, Cohen EE, Licitra L, Van Herpen CM, Khorprasert C, Soulieres D, Vodvarka P, Rischin D, Garin AM, Hirsch FR, Varella-Garcia M, Ghiorghiu S, Hargreaves L, Armour A, Speake G, Swaisland A, Vokes EE. Phase III study of gefitinib 250 compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck. J Clin Oncol ;27(11):1864-71, 2009
  • Goss G, Ferry D, Wierzbicki R, Laurie SA, Thompson J, Biesma B, Hirsch FR, Varella-Garcia M, Duffield E, Ataman OU, Zarenda M, Armour AA. Randomized Phase II Study of Gefitinib Compared With Placebo in Chemotherapy-Naive Patients With Advanced Non-Small-Cell Lung Cancer and Poor Performance Status. J Clin Oncol. 27(13):2253-60, 2009.
  • Varella-Garcia M, Mitsudomi T, Yatabe Y, Kosaka T, Nakajima E, Xavier AC, Skokan M, Zeng C, Franklin WA, Bunn PA Jr, Hirsch FR. EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort. J Thorac Oncol; 4(3):318-25, 2009.
  • Massion P, Zou Y, Uner H, Kiatsimkul P, Wolf H, Baron AE, Byers, Jonsson S, Lam S, Hirsch FR, Miller YE, Franklin WA, Varella-Garcia M. Recurrent genomic gains in preinvasive lesions as a biomarker of risk for lung cancer. PLoS One;4(6):e5611, 2009.
  • Hirsch FR, Varella-Garcia M, Cappuzzo F. Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer. Oncogene., 28 Suppl 1:S32-7, 2009
  • Sun M, Behrens C, Feng L, Ozburn N, Tang X, Yin G, Komaki R, Varella-Garcia M, Hong WK, Aldape KD, Wistuba II HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors. Clin Cancer Res.,15(15):4829-37, 2009.
  • Varella-Garcia M, Diebold J, Eberhard DA, Geenen K, Hirschmann A, Kockx M, Nagelmeier I, Rischoff J, Schmitt M, Arbogast S, Cappuzzo F. EGFR fluorescence in situ hybridisation assay: guidelines for application to non?small-cell lung cancer. Journal of Clinical Pathology, 62:970-977, 2009.
  • Leidner RS, Clifford B, Hamdan A, Jin C, Eisenberg R, Fu P, Boggon TJ, Skokan M, Cappuzzo C, Hirsch FR, Varella-Garcia M, Halmos B. Genetic Abnormalities of the EGFR pathway in African American Patients with Non-Small Cell Lung Cancer. J Clin Oncol, 27(33):5620-6, 2009
  • Soh J, Okumura N, Lockwood W, Yamamoto H, Shigematsu H, Zhang Z, Chari R, Shames D, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba II, Lam S, Brekken R, Toyooka S, Minna JD, Lam W, Gazdar AF. Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One. Oct 14;4(10):e7464, 2009.
  • Rosa RF, Zen PR, Ricachinevsky CP, Pilla CB, Pereira VL, Roman T, Varella-Garcia M, Paskulin GA. 22q11.2 duplication and congenital heart defects. Arq Bras Cardiol. 93(4):e67-9, e55-7, 2009.
  • Solomon B, Varella-Garcia M, Camidge R. ALK gene rearrangements: A new therapeutic target in a molecularly- defined subset of non-small cell lung cancer. J Thorac Oncol, 4(12): 1450-1454, 2009.
  • Cappuzzo F, Tallini G, Finocchiaro G, Wilson RS, Ligorio C, Giordano L, Toschi L, Incarbone M, Cavina R, Terracciano L, Roncalli M, Alloisio M, Varella-Garcia M, Franklin WA, Santoro A. Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small cell lung cancer patients (NSCLC), Ann Oncol, 21(3):562-7, 2010.
  • Dziadziuszko D, Merrick DT, Witta SE, Mendoza AM, Szostakiewicz B, Szymanowska A, Rzyman W, Jaskiewicz K, Jassem J, Bunn Jr PA, Varella-Garcia M, Hirsch FR. The Insulin-like Growth Factor Receptor 1 protein expression, mRNA expression, and gene copy number in operable non-small cell lung cancer. J Clin Oncol, in press
  • Xu XZ, Varella-Garcia M, Li TY, Khor LY, Gajapathy RS, Spittle C, Weed S, Lessin SR, Wu H Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression. Mod. Pathol, in press.
  • Sastre J, Aranda E, Grávalos C, Massutí B, Varella-Garcia M, Rivera F, Soler G, Carrato A, Manzano JL, Díaz-Rubio E, Hidalgo M. First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD). Crit Rev Oncol Hematol, in press
  • Bellini MF, Silva AE, Varella-Garcia M Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques. Genetics and Molecular Biology, in press. Review.
  • Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin X, Hirsch FR, Kennedy TC, Keith RL, Barón AE, Belinsky SB, Miller YE, Byers T, Franklin WA. Chromosomal aneusomy in sputum, as detected by Fluorescence in Situ Hybridization (FISH) predicts lung cancer incidence. Cancer Prevention Research, in press
  • Varella-Garcia, M. Chromosomal and Genomic Changes in Lung Cancer. Cell Adhesion and Migration, 2010 Jan 7;4(1), 2010. Review
  • Bellini MF, Manzato AJ, Silva AE, Varella-Garcia M. Chromosomal imbalances are uncommon in Chagasic megaesophagus. BMC Gastroenterology, Feb 17;10(1):20, 2010.
  • Cappuzzo F, Camidge DR, Varella-Garcia M. Is FISH floating or still swimming in the lung cancer ocean? Annals of Oncology 22: 493–499, 2011.
  • Camidge DR, Hirsch FR, Varella-Garcia M, Franklin WA. Finding ALK-Positive Lung Cancer What Are We Really Looking for? J Thor Oncol, 6(3): 411-413, 2011.
  • Guo W, Schubbert S, Chen JY, Valamehr B, Mosessian S, Shi H, Dang NH, Garcia C, Theodoro MF, Varella-Garcia M, Wu H. Suppression of leukemia development caused by PTEN loss. Proc Natl Acad Sci USA; 108(4):1409-14, 2011.
  • Camidge RC, Kono SA, Flacco A, Tan AC, Doebele, RC, Zhou Q, Crino L, Franklin WA, Varella-Garcia M Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment . Clin Cancer Res, 16(2): 581?90, 2010.
  • Kwak EL, Bang, YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SHI., Dezube BJ, J?nne PA, Costa DB, Varella-Garcia M, Kim WH, Lynch TJ, Fidias P,Stubbs H, Engelman JA, Sequist LV, Tan WW, Gandhi L, Mino-Kenudson M, Wei GC, Shreeve SM, Ratain MJ, Settleman J. Christensen JG, Haber DA, Wilner K, Salgia R, Shapiro GI, Clark JW, and A. John Iafrate JA. Anaplastic Lymphoma Kinase Inhibition in Non?Small-Cell Lung Cancer. N Engl J Med; 363:1693-1703, 2010.
  • Bunn PA Jr, Hirsch FR, Doebele RC, Camidge DR, Varella-Garcia M, Franklin W. Biomarkers are here to stay for clinical research and standard care. Thorac Oncol. Aug;5(8):1113-5, 2010.
  • Majka SM, Fox KE, Psilas JC, Helm KM, Childs CR, Acosta AS, Janssen RC, Friedman JE, Woessner BT, Shade TR, Varella-Garcia M, Klemm DJ. De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific. Proc Natl Acad Sci U S A. 107(33):14781-6, 2010.
  • Arcaroli JJ, Touban BM, Tan AC, Varella-Garcia M, Powell RW, Eckhardt SG, Elvin P, Gao D, Messersmith WA. Gene array and fluorescence in situ hybridization biomarkers of activity of Saracatinib (AZD0530), a SRC inhibitor, in a preclinical model of colorectal cancer. Clin Cancer Res; 16(16); 4165-77, 2010
  • Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite PA, Tuder RM, Erzurum SC, Geraci MW, Coldren CD. Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension. Am J Respir Crit Care Med. 182(9):1153-60, 2010.
  • Pitts TM, Tan AC, Kulikowski GN, Tentler JJ, Brown AM, Flanigan SA, Leong S, Coldren CD, Hirsch FR, Varella-Garcia M, Korch C, Eckhardt SG. Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development. Clin Cancer Res.;16(12):3193-204, 2010.
  • Dziadziuszko D, Merrick DT, Witta SE, Mendoza AM, Szostakiewicz B, Szymanowska A, Rzyman W, Jaskiewicz K, Jassem J, Bunn Jr PA, Varella-Garcia M, Hirsch FR. The Insulin-like Growth Factor Receptor 1 protein expression, mRNA expression, and gene copy number in operable non-small cell lung cancer. J Clin Oncol, 28(13):2174-80, 2010.
  • Varella-Garcia, M. Chromosomal and Genomic Changes in Lung Cancer. Cell Adh Migr;4(1):100-6, 2010.
  • Varella-Garcia M, Schulte AP, Wolf HJ, Feser WJ, Zeng C, Braudrick S, Yin X, Hirsch FR, Kennedy TC, Keith RL, Baron AE, Belinsky SB, Miller YE, Byers T, Franklin WA. Chromosomal aneusomy in sputum, as detected by Fluorescence in Situ Hybridization (FISH) predicts lung cancer incidence. Cancer Prevention Research, 3(4):447-53, 2010.
  • Xu XZ, Varella-Garcia M, Li TY, Khor LY, Gajapathy RS, Spittle C, Weed S, Lessin SR, Wu H. Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression. Mod. Pathol, 23(2):187-96, 2010.
  • Cappuzzo F, Tallini G, Finocchiaro G, Wilson RS, Ligorio C, Giordano L, Toschi L, Incarbone M, Cavina R, Terracciano L, Roncalli M, Alloisio M, Varella-Garcia M, Franklin WA, Santoro A. Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small cell lung cancer patients (NSCLC), Ann Oncol, 21(3):562-7, 2010.
  • Bellini MF, Manzato AJ, Silva AE, Varella-Garcia M. Chromosomal imbalances are uncommon in Chagasic megaesophagus. BMC Gastroenterology, Feb 17,10:20, 2010.
  • Sastre J, Aranda E, Grávalos C, Massutí B, Varella-Garcia M, Rivera F, Soler G, Carrato A, Manzano JL, Díaz-Rubio E, Hidalgo M. First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD). Crit Rev Oncol Hematol. 77(1):78-84, 2010
  • Varella-Garcia M. Genomic Alterations in Lung Cancer. Lung Cancer: Principles and Practice, Fourth Edition, edited by Harvey I. Pass, M.D., David P. Carbone, M.D., Ph.D., David H. Johnson, M.D., John D. Minna, M.D., Andrew T. Turrisi, III, M.D., and Giorgio V. Scagliotti, M.D, 2010.
  • Bellini MF, Silva AE, Varella-Garcia M Genomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniques. Genetics and Molecular Biology, 33, 2, 205-213. 2011, Review.
  • Tang X, Kadara H, Behrens C, Liu D, Xiao Y, Rice DC, Gazdar AF, Fujimoto J, Moran C, Varella-Garcia M, Lee JJ, Hong WK, Wistuba II. Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: Implications in lung cancer pathogenesis and prognosis. Clin Cancer Res 17(8):2434-43, 2011
  • Camidge DR, Kono SA, Lu X, Okuyama S, Barón AE, Oton AB, Davies AM, Varella-Garcia M, Franklin W, Doebele RC Anaplastic Lymphoma Kinase Gene Rearrangements in Non-small Cell Lung Cancer are Associated with Prolonged Progression-Free Survival on Pemetrexed. J Thorac Oncol. 6(4):774-80, 2011.
  • Yang F, Tang X, Riquelme E, Behrens C, Nilsson MB, Giri U, Varella-Garcia M, Byers LA, Lin HY, Wang J, Raso MG, Girard L, Coombes K, Lee JJ, Herbst RS, Minna JD, Heymach JV, Washtub II. Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small cell lung carcinoma who receive adjuvant chemotherapy. Cancer Res. 71(16):5512-21, 2011.
  • Flaig TW, Wilson S, van Bokhoven A, Varella-Garcia M, Wolfe P, Maroni P, Genova EE, Morales D, Lucia MS. Detection of circulating tumor cells in metastatic and clinically localized urothelial carcinoma. Urology, 78(4):863-7, 2011.
  • Hirsch FR, Kabbinavar F, Eisen T, Martins R, Schnell FM, Dziadziuszko R, Richardson K, Richardson F, Wacker B, Sternberg DW, Rusk J, Franklin WA, Varella-Garcia M, Bunn PA Jr, Camidge R . A Randomized, Phase II, Biomarker-Selected Study Comparing Erlotinib to Erlotinib Intercalated With Chemotherapy in First-Line Therapy for Advanced Non-Small-Cell Lung Cancer. J Clin Oncol.; 29(26):3567-73, 2011.
  • Cota-Gomez A, Flores AC, Ling X, Varella-Garcia M, Flores SC. HIV-1 Tat increases oxidant burden in the lungs of transgenic mice. Free Radic Biol Med; 51(9):1697-707, 2011.
  • Rosa RF, Rosa RC, Krumenauer RC, Varella-Garcia M, Paskulin GA. Anterior laryngeal membrane and 22q11 deletion syndrome. Braz J Otorhinolaryngol; 77(4):540, 2011.
  • Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, Ercan D, Rogers A, Roncalli M, Takeda M, Fujisaka Y, Philips J, Shimizu T, Maenishi O, Cho Y, Sun J, Destro A, Taira K, Takeda K, Okabe T, Swanson J, Itoh H, Takada M, Lifshits E, Okuno K, Engelman JA, Shivdasani RA, Nishio K, Fukuoka M, Varella-Garcia M, Nakagawa K, Jänne PA. Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab. Sci Transl Med. Sep 7;3(99):99ra86, 2011.
  • Shaw AT, Yeap BY, Solomon BJ, Riely GJ, Gainor J, Engelman JA, Shapiro GI, Costa DB, Ou SH, Butaney M, Salgia R, Maki RG, Varella-Garcia M, Doebele RC, Bang YJ, Kulig K, Selaru P, Tang Y, Wilner KD, Kwak EL, Clark JW, Iafrate AJ, Camidge DR. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol. 12(11):1004-12, 2011.
  • Weickhardt A; Doebele R; Oton, A; Lettieri J; Maxson D; Reynolds M; Brown A; Jackson MK; Dy G; Adjei A; Fetterly G; Lu X; Franklin W; Varella-Garcia M; Hirsch FR; Wynes MW; Youssoufian, H; Adjei, A; Camidge, DR. A Phase I/II study of erlotinib in combination with the anti-insulin-like growth factor-1 receptor monoclonal antibody IMC-A12 (Cixutumumab) in patients with Advanced non-small cell lung cancer. J Thorac Oncol, (2):419-26, 2012.
  • Sartore-Bianchi A, Fieuws S, Veronese S, Moroni M, Personeni N, Frattini M, Torri V, Cappuzzo F, Vander Borght S, Martin V, Skokan M, Santoro A, Gambacorta M, Tejpar S, Varella-Garcia M, Siena S. Standardization of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study. J Clin Pathol.;65(3):218-23, 2012
  • Cappuzzo F, Cho YG, Sacconi A, Alì G, Siclari O, Incarbone M, Destro A, Terracciano L, Fontanini G, Marchetti A, Roncalli M, Varella-Garcia M. p95HER2 Truncated Form in Resected Non-small Cell Lung Cancer. J Thorac Oncol 7(3):520-527, 2012.
  • Doebele RC, Pilling AB, Aisner D, Kutateladze TG, Le AT, Weickhardt AJ, Kondo KL, Linderman DJ, Heasley LE, Franklin WA, Varella-Garcia M, Camidge DR. Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non-Small Cell Lung Cancer. Clin Cancer Res. 2012 Jan 10.
  • Doebele RC, Lu X, Sumey C, Maxson DA, Weickhardt AJ, Oton AB, Bunn PA Jr, Barón AE, Franklin WA, Aisner DL, Varella-Garcia M, Camidge DR. Oncogene status predicts patterns of metastatic spread in treatment-naive nonsmall cell lung cancer. Cancer. 2012 Jan 26. doi: 10.1002/cncr.27409.
  • Camidge DR, Theodoro M, Maxson DA, Skokan M, O'Brien T, Lu X, Doebele RC, Barón AE, Varella-Garcia M. Correlations between the percentage of tumor cells showing an ALK (anaplastic lymphoma kinase) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall cell lung cancer. Cancer. 2012 Jan 26. doi: 10.1002/cncr.27411.
  • Franklin WA, Aisner DL, Varella-Garcia M. Prognostic Patterns in the Histopathology of Pulmonary Adenocarcinoma. J Clin Oncol 2012
  • Arcaroli J, Quackenbush K, Powell R, Pitts T, Spreafico S, Varella-Garcia M, Bemis L, Tan AC, Reinemann J, Touban B, Dasari A, Eckhardt SG, Messersmith W. Common PIK3CA mutants and a novel 3'UTR mutation are associated with increased sensitivity to saracatinib. Clin Cancer Res;18(9):2704-14, 2012.
  • Witta SE, Jotte RM, Konduri K, Neubauer MA, Spira AI, Ruxer RL, Varella-Garcia M, Bunn PA Jr, Hirsch FR. Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non-Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy. J Clin Oncol; 30(18):2248-55, 2012.
  • Fett-Conte AC, Carvalho-Salles AB, Vendrame CB, Pedrassa P, Freitas PC, Varella-Garcia M. New complex chromosome abnormalities in multiple myeloma associated with a poor prognosis: A case report. Leuk Res. 36 (7):140–142, 2012.
  • Bellini MF, Silistino-Souza R, Varella-Garcia M, de Azeredo-Oliveira MT, Silva AE. Biologic and genetics aspects of Chagas disease at endemic areas. J Trop Med. 2012:357948, 2012.
  • Arcaroli JJ, Powell RW, Varella-Garcia M, McManus M, Tan ACa, Quackenbus KSa,Pitts TMa, Gao Dc, Spreafico Aa, Arvind Dasari Aa, Touban BMa, Messersmith WA. ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a gamma-secretase inhibitor and irinotecan in colorectal cancer. Molecular Oncology, 6 (3): 370?381, 2012.
  • Minuti G, Cappuzzo F, Duchnowska R, Jassem J, Fabi A, O'Brien T, Mendoza AD, Landi L, Biernat W, Czartoryska-Arlukowicz B, Jankowski T, Zuziak D, Zok J, Szostakiewicz B, Foszczynska-Kloda M, Tempinska-Szalach A, Rossi E, Varella-Garcia M. Increased MET and HGF gene copy numbers are associated with trastuzumab failure in HER2-positive metastatic breast cancer. Br J Cancer, 21;107(5):793-9, 2012.
  • Davies KD, Le AT, Theodoro MF, Skokan MC, Aisner DL, Berge EM, Terracciano LM, Cappuzzo F, Incarbone M, Roncalli M, Alloisio M, Santoro A, Camidge DR, Varella-Garcia M*, Doebele RC*. Identifying and Targeting ROS1 Gene Fusions in Non-Small Cell Lung Cancer. Clin Cancer Res. 18(17):4570-9, 2012.
  • Rudin CM, Durinck S, Stawiski EW, Poirier JT, Modrusan Z, Shames DS, Bergbower EA, Guan Y, Shin J, Guillory J, Rivers CS, Foo CK, Bhatt D, Stinson J, Gnad F, Haverty PM, Gentleman R, Chaudhuri S, Janakiraman V, Jaiswal BS, Parikh C, Yuan W, Zhang Z, Koeppen H, Wu TD, Stern HM, Yauch RL, Huffman KE, Paskulin DD, Illei PB, Varella-Garcia M, Gazdar AF, de Sauvage FJ, Bourgon R, Minna JD, Brock MV, Seshagiri S. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet, 44(10):1111-6, 2012.
  • Peled N, Palmer G, Hirsch FR, Wynes MW, Ilouze M, Varella-Garcia M, Soussan-Gutman L, Otto GA, Stephens PJ, Ross JS, Cronin MT, Lipson D, Miller VA. Next-Generation Sequencing Identifies and Immunohistochemistry Confirms a Novel Crizotinib-Sensitive ALK Rearrangement in a Patient with Metastatic Non-Small-Cell Lung Cancer. J Thorac Oncol, 7(9):e14-6, 2012
  • Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, Riely GJ, Solomon B, Ou SH, Kim DW, Salgia R, Fidias P, Engelman JA, Gandhi L, J?nne PA, Costa DB, Shapiro GI, Lorusso P, Ruffner K, Stephenson P, Tang Y, Wilner K, Clark JW, Shaw AT. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol, 13(10):1011-9, 2012.
  • Le AT, Varella-Garcia M, Doebele RC Oncogenic fusions involving exon 19 of ALK. J Thorac Oncol. Dec;7(12):e44; author reply e44, 2012
  • Rosa RC, Rosa RF, Flores JA, Golendziner E, Oliveira CA, Varella-Garcia M, Paskulin GA, Zen PR Malformations detected by abdominal ultrasound in children with congenital heart disease. Arq Bras Cardiol;99(6):1092-1099, 2012.
  • Yang X, Su LJ, Thorburn A, Frankel AE, Li Y, La Rosa FG, Kessler E, Shen J, Li CY, Varella-Garcia M, Glod? LM, Flaig TW Diphtheria Toxin-Epidermal Growth Factor Fusion Protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res, 19(1):148-57, 2013.
  • Diamond JR, Eckhardt SG, Tan AC, Newton TP, Selby HM, Brunkow KL, Kachaeva MI, Varella-Garcia M, Pitts TM, Bray MR, Fletcher GC, Tentler JJ. Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models. Clin Cancer Res, 19(1):291-303, 2013.
  • Ludovini V, Flacco A, Bianconi F, Ragusa M, Vannucci J, Bellezza G, Chiari R, Minotti V, Pistola L,. Tofanetti FR, Siggillino A, Baldelli E, Sidoni A, Daddi N, Puma F, Varella-Garcia M, Crino L. Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients. Cancer Chemother Pharmacol, 71(3):671-80, 2013.
  • Weickhardt AJ, Aisner DL, Franklin WA, Varella-Garcia M, Doebele RC, Camidge DR Diagnostic assays for identification of anaplastic lymphoma kinase-positive non-small cell lung cancer. Cancer, in press
  • Franklin WA, Aisner DL, Post M, Bunn PA, Varella Garcia M. Chapter: Pathology, Biomarkers and Molecular Diagnostics. In Clinical Oncology, Editor: Abeloff M et al., in press.
  • Aisner DL, Doebele RC, Varella-Garcia M, Franklin WA, chapter Molecular Pathology of Lung Cancer in Molecular Pathology in Clinical Practice, 2nd edition, Editor: Debra Leonard DGB, in press.
  • Davies KD, Mahale S, Astling DP, Aisner DL, Le AT, Hinz TK, Vaishnavi A, Bunn PA Jr, Heasley LE, Tan AC, Camidge DR, Varella-Garcia M, Doebele RC. Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-Small Cell Lung Cancer. PLoS One. 2013;8(12):e82236. PubMed PMID: 24349229
  • Vaishnavi A, Capelletti M, Le AT, Kako S, Butaney M, Ercan D, Mahale S, Davies KD, Aisner DL, Pilling AB, Berge EM, Kim J, Sasaki H, Park SI, Kryukov G, Garraway LA, Hammerman PS, Haas J, Andrews SW, Lipson D, Stephens PJ, Miller VA, Varella-Garcia M, Jänne PA, Doebele RC. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nat Med. 2013 Nov;19(11):1469-72. PubMed PMID: 24162815
  • Camidge DR, Skokan M, Kiatsimkul P, Helfrich B, Lu X, Barón AE, Schulte N, Maxson D, Aisner DL, Franklin WA, Doebele RC, Varella-Garcia M. Native and rearranged ALK copy number and rearranged cell count in non-small cell lung cancer: Implications for ALK inhibitor therapy. Cancer. 2013 Sep 10. [Epub ahead of print] PubMed PMID: 24022839
  • Jones M, Varella-Garcia M, Skokan M, Bryce S, Schowinsky J, Peters R, Vang B, Brecheisen M, Startz T, Frank N, Nankervis B. Genetic stability of bone marrow-derived human mesenchymal stromal cells in the Quantum System. Cytotherapy. 2013 Nov;15(11):1323-39. PubMed PMID: 23992670
  • de Mattos VF, Sulczinski LP, Milner OG, da Silva FA, de Moraes SA, Trevisan P, Fiegenbaum M, Varella-Garcia M, Zen PR, Rosa RF. Role of hypocalcemia in identification of 22q11 deletion syndrome among patients with congenital heart defects. Int J Cardiol. 2014 Nov 15;177(1):6-7. PubMed PMID: 25499322
  • Berge EM, Lu X, Maxson D, Barón AE, Gadgeel SM, Solomon BJ, Doebele RC, Varella-Garcia M, Camidge DR. Clinical benefit from pemetrexed before and after crizotinib exposure and from crizotinib before and after pemetrexed exposure in patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer. Clin Lung Cancer. 2013 Nov;14(6):636-43. PubMed PMID: 23931899
  • Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner KD, Clark JW, Iafrate AJ. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2014 Nov 20;371(21):1963-71. PubMed PMID: 25264305
  • Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Varella-Garcia M, Franklin WA, Aronson SL, Su PF, Shyr Y, Camidge DR, Sequist LV, Glisson BS, Khuri FR, Garon EB, Pao W, Rudin C, Schiller J, Haura EB, Socinski M, Shirai K, Chen H, Giaccone G, Ladanyi M, Kugler K, Minna JD, Bunn PA. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014 May 21;311(19):1998-2006. PubMed PMID: 24846037
  • Figg WD, Chau CH, Price DK, Till C, Goodman PJ, Cho Y, Varella-Garcia M, Reichardt JK, Tangen CM, Leach RJ, van Bokhoven A, Thompson IM, Lucia MS. Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: results From the Prostate Cancer Prevention Trial. Urology. 2014 Jul;84(1):127-31. PubMed PMID: 24824408
  • Anderson RT, Keysar SB, Bowles DW, Glogowska MJ, Astling DP, Morton JJ, Le P, Umpierrez A, Eagles-Soukup J, Gan GN, Vogler BW, Sehrt D, Takimoto SM, Aisner DL, Wilhelm F, Frederick BA, Varella-Garcia M, Tan AC, Jimeno A. The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. Mol Cancer Ther. 2013 Oct;12(10):1994-2005. PubMed PMID: 23873848
  • Diamond JR, Salgia R, Varella-Garcia M, Kanteti R, LoRusso PM, Clark JW, Xu LG, Wilner K, Eckhardt SG, Ching KA, Lira ME, Schoenmakers EF, Christensen JG, Camidge DR. Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma. J Clin Oncol. 2013 Jun 1;31(16):e254-8. PubMed PMID: 23610116
  • Toschi L, Finocchiaro G, Nguyen TT, Skokan MC, Giordano L, Gianoncelli L, Perrino M, Siracusano L, Di Tommaso L, Infante M, Alloisio M, Roncalli M, Scorsetti M, Jänne PA, Santoro A, Varella-Garcia M. Increased SOX2 gene copy number is associated with FGFR1 and PIK3CA gene gain in non-small cell lung cancer and predicts improved survival in early stage disease. PLoS One. 2014;9(4):e95303. PubMed PMID: 24736592
  • Rosa RF, Rosa RC, Trevisan P, Graziadio C, Varella-Garcia M, Paskulin GA, Zen PR. Screening for 22q11 deletion syndrome among patients with congenital heart defects. Sao Paulo Med J. 2014;132(2):125-6. PubMed PMID: 24714995
  • Keysar SB, Astling DP, Anderson RT, Vogler BW, Bowles DW, Morton JJ, Paylor JJ, Glogowska MJ, Le PN, Eagles-Soukup JR, Kako SL, Takimoto SM, Sehrt DB, Umpierrez A, Pittman MA, Macfadden SM, Helber RM, Peterson S, Hausman DF, Said S, Leem TH, Goddard JA, Arcaroli JJ, Messersmith WA, Robinson WA, Hirsch FR, Varella-Garcia M, Raben D, Wang XJ, Song JI, Tan AC, Jimeno A. A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins. Mol Oncol. 2013 Aug;7(4):776-90. PubMed PMID: 23607916
  • Ren S, Hirsch FR, Varella-Garcia M, Aisner DL, Boyle T, Zhou C, Camidge DR. Atypical negative ALK break-apart FISH harboring a crizotinib-responsive ALK rearrangement in non-small-cell lung cancer. J Thorac Oncol. 2014 Mar;9(3):e21-3. PubMed PMID: 24518095
  • Pitts TM, Kulikowski GN, Tan AC, Murray BW, Arcaroli JJ, Tentler JJ, Spreafico A, Selby HM, Kachaeva MI, McPhillips KL, Britt BC, Bradshaw-Pierce EL, Messersmith WA, Varella-Garcia M, Eckhardt SG. Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. Front Pharmacol. 2013;4:35. PubMed PMID: 23543898
  • Ludovini V, Flacco A, Bianconi F, Ragusa M, Vannucci J, Bellezza G, Chiari R, Minotti V, Pistola L, Tofanetti FR, Siggillino A, Baldelli E, Sidoni A, Daddi N, Puma F, Varella-Garcia M, Crinò L. Concomitant high gene copy number and protein overexpression of IGF1R and EGFR negatively affect disease-free survival of surgically resected non-small-cell-lung cancer patients. Cancer Chemother Pharmacol. 2013 Mar;71(3):671-80. PubMed PMID: 23314677
  • Bowles DW, Diamond JR, Lam ET, Weekes CD, Astling DP, Anderson RT, Leong S, Gore L, Varella-Garcia M, Vogler BW, Keysar SB, Freas E, Aisner DL, Ren C, Tan AC, Wilhelm F, Maniar M, Eckhardt SG, Messersmith WA, Jimeno A. Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignancies. Clin Cancer Res. 2014 Mar 15;20(6):1656-65. PubMed PMID: 24493827
  • Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MW. Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions. Cancer Prev Res (Phila). 2014 Feb;7(2):255-65. PubMed PMID: 24346345
  • Weickhardt AJ, Aisner DL, Franklin WA, Varella-Garcia M, Doebele RC, Camidge DR. Diagnostic assays for identification of anaplastic lymphoma kinase-positive non-small cell lung cancer. Cancer. 2013 Apr 15;119(8):1467-77. PubMed PMID: 23280244
  • Aisner DL, Nguyen TT, Paskulin DD, Le AT, Haney J, Schulte N, Chionh F, Hardingham J, Mariadason J, Tebbutt N, Doebele RC, Weickhardt AJ, Varella-Garcia M. ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers. Mol Cancer Res. 2014 Jan;12(1):111-8. PubMed PMID: 24296758
  • Womack JP, Varella-Garcia M, Camidge DR. Waxing and Waning of MET Amplification in EGFR-Mutated NSCLC in Response to the Presence and Absence of Erlotinib Selection Pressure. J Thorac Oncol. 2015 Dec;10(12):e115-8. PubMed PMID: 26709484
  • Yang X, Kessler E, Su LJ, Thorburn A, Frankel AE, Li Y, La Rosa FG, Shen J, Li CY, Varella-Garcia M, Glodé LM, Flaig TW. Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. Clin Cancer Res. 2013 Jan 1;19(1):148-57. PubMed PMID: 23172881
  • Trabelsi S, Mama N, Ladib M, Popov S, Burford A, Mokni M, Tlili K, Krifa H, Varella-Garcia M, Jones C, Tahar Yacoubi M, Saad A, H'mida Ben Brahim D. Adult recurrent pilocytic astrocytoma: Clinical, histopathological and molecular study. Neurochirurgie. 2015 Dec;61(6):392-7. PubMed PMID: 26597605
  • Gavin KM, Gutman JA, Kohrt WM, Wei Q, Shea KL, Miller HL, Sullivan TM, Erickson PF, Helm KM, Acosta AS, Childs CR, Musselwhite E, Varella-Garcia M, Kelly K, Majka SM, Klemm DJ. De novo generation of adipocytes from circulating progenitor cells in mouse and human adipose tissue. FASEB J. 2015 Nov 18. [Epub ahead of print] PubMed PMID: 26581599
  • Diamond JR, Eckhardt SG, Tan AC, Newton TP, Selby HM, Brunkow KL, Kachaeva MI, Varella-Garcia M, Pitts TM, Bray MR, Fletcher GC, Tentler JJ. Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models. Clin Cancer Res. 2013 Jan 1;19(1):291-303. PubMed PMID: 23136197
  • Yoshida A and Varella-Garcia M. Fluorescence in situ hybridization (FISH). pp 17-28. In IALSC Atlas of ALk Testing in Lung Cancer; Tsao, Hirsch and Yatabe (ed), 2013
  • Lantuejoul S, Varella-Garcia M, Thunnissen E, Yatabe Y. Comparison of Different Assay Platforms for ALK Testing pp 44-52; In IALSC Atlas of ALk Testing in Lung Cancer; Tsao, Hirsch and Yatabe (ed), 2013
  • Brambilla E, Thunnissen E, Varella-Garcia M, Yatabe Y. Reporting of ALK Testing pp. 58-60.In IALSC Atlas of ALk Testing in Lung Cancer; Tsao, Hirsch and Yatabe (ed), 2013
  • Franklin WA, Aisner DL, Post M, Bunn PA, Varella Garcia M. Pathology, Biomarkers and Molecular Diagnostics. In: Clinical Oncology, Editor: Abeloff M et al (ed), 2013.
  • Clinical and Laboratory Standards Institute (CLSI) Fluorescence In Situ Hybridization Methods for Clinical Laboratories; Approved Guideline - 2nd Edition. CLSI Document MM07-A2 pp: 1-60, 2013
  • Bidinotto LT, Scapulatempo-Neto C, Mackay A, de Almeida GC, Scheithauer BW, Berardinelli GN, Torrieri R, Clara CA, Feltrin LT, Viana-Pereira M, Varella-Garcia M, Jones C, Reis RM. Molecular Profiling of a Rare Rosette-Forming Glioneuronal Tumor Arising in the Spinal Cord. PLoS One. 2015;10(9):e0137690. PubMed PMID: 26371886
  • Aisner DL, Doebele RC, Varella-Garcia M, Franklin WA, Molecular Pathology of Lung Cancer. In: Molecular Pathology in Clinical Practice, 2nd Edition, Leonard DGB (ed)
  • Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM, Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat Med. 2015 Sep;21(9):1038-47. PubMed PMID: 26301689
  • Doebele RC, Davis LE, Vaishnavi A, Le AT, Estrada-Bernal A, Keysar S, Jimeno A, Varella-Garcia M, Aisner DL, Li Y, Stephens PJ, Morosini D, Tuch BB, Fernandes M, Nanda N, Low JA. An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov. 2015 Oct;5(10):1049-57. PubMed PMID: 26216294
  • Becker AP, Scapulatempo-Neto C, Carloni AC, Paulino A, Sheren J, Aisner DL, Musselwhite E, Clara C, Machado HR, Oliveira RS, Neder L, Varella-Garcia M, Reis RM. KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas. J Neuropathol Exp Neurol. 2015 Jul;74(7):743-54. PubMed PMID: 26083571
  • Zhang L, Yu H, Badzio A, Boyle TA, Schildhaus HU, Lu X, Dziadziuszko R, Jassem J, Varella-Garcia M, Heasley LE, Kowalewski AA, Ellison K, Chen G, Zhou C, Hirsch FR. Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer. J Thorac Oncol. 2015 Jul;10(7):1083-90. PubMed PMID: 26020126
  • Despierre E, Vergote I, Anderson R, Coens C, Katsaros D, Hirsch FR, Boeckx B, Varella-Garcia M, Ferrero A, Ray-Coquard I, Berns EM, Casado A, Lambrechts D, Jimeno A. Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy. Target Oncol. 2015 Dec;10(4):583-96. PubMed PMID: 26004768
  • Trevisan P, Barbosa S, Sperotto G, Costi C, de Omena Filho RL, Silva AP, Varella-Garcia M, Fiegenbaum M, Rosa RF, Zen PR. Macrothrombocytopenia as diagnosis predictor of 22q11 deletion syndrome among patients with congenital heart defects. Am J Med Genet A. 2015 Jun;167(6):1406-8. PubMed PMID: 25899105
  • Morton JJ, Bird G, Keysar SB, Astling DP, Lyons TR, Anderson RT, Glogowska MJ, Estes P, Eagles JR, Le PN, Gan G, McGettigan B, Fernandez P, Padilla-Just N, Varella-Garcia M, Song JI, Bowles DW, Schedin P, Tan AC, Roop DR, Wang XJ, Refaeli Y, Jimeno A. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene. 2015 Apr 20. [Epub ahead of print] PubMed PMID: 25893296
  • Flacco A, Ludovini V, Bianconi F, Ragusa M, Bellezza G, Tofanetti FR, Pistola L, Siggillino A, Vannucci J, Cagini L, Sidoni A, Puma F, Varella-Garcia M, Crinò L. MYC and human telomerase gene (TERC) copy number gain in early-stage non-small cell lung cancer. Am J Clin Oncol. 2015 Apr;38(2):152-8. PubMed PMID: 25806711
  • Alese OB, El-Rayes BF, Sica G, Zhang G, Alexis D, La Rosa FG, Varella-Garcia M, Chen Z, Rossi MR, Adsay NV, Khuri FR, Owonikoko TK. Anaplastic lymphoma kinase (ALK) gene alteration in signet ring cell carcinoma of the gastrointestinal tract. Ther Adv Med Oncol. 2015 Mar;7(2):56-62. PubMed PMID: 25755678
  • Sholl LM, Aisner DL, Varella-Garcia M, Berry LD, Dias-Santagata D, Wistuba II, Chen H, Fujimoto J, Kugler K, Franklin WA, Iafrate AJ, Ladanyi M, Kris MG, Johnson BE, Bunn PA, Minna JD, Kwiatkowski DJ. Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience. J Thorac Oncol. 2015 May;10(5):768-77. PubMed PMID: 25738220
  • Cargnelutti M, Corso S, Pergolizzi M, Mévellec L, Aisner DL, Dziadziuszko R, Varella-Garcia M, Comoglio PM, Doebele RC, Vialard J, Giordano S. Activation of RAS family members confers resistance to ROS1 targeting drugs. Oncotarget. 2015 Mar 10;6(7):5182-94. PubMed PMID: 25691052
  • da Silva JN, Trevisan P, Guimarães VB, Zen TD, da Rosa EB, Silveira DB, Varella-Garcia M, Paskulin GA, Rosa RF, Zen PR. Congenital heart disease in Southern Brazil: potential impact and prevention. Int J Cardiol. 2015 Jan 20;179:9-10. PubMed PMID: 25464392
  • Villaruz LC, Socinski MA, Abberbock S, Berry LD, Johnson BE, Kwiatkowski DJ, Iafrate AJ, Varella-Garcia M, Franklin WA, Camidge DR, Sequist LV, Haura EB, Ladanyi M, Kurland BF, Kugler K, Minna JD, Bunn PA, Kris MG. Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium. Cancer. 2015 Feb 1;121(3):448-56. PubMed PMID: 25273224
  • Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, Rix U, Le AT, Aisner DL, Varella-Garcia M, Doebele RC, Covington KR, Hampton OA, Doddapaneni HV, Jayaseelan JC, Hu J, Wheeler DA, Shay JW, Rimm DL, Gazdar A, Minna JD. Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget. 2016 Dec 29. [Epub ahead of print] PubMed PMID: 28052041
  • Turner J, Couts K, Sheren J, Saichaemchan S, Ariyawutyakorn W, Avolio I, Cabral E, Glogowska M, Amato C, Robinson S, Hintzsche J, Applegate A, Seelenfreund E, Gonzalez R, Wells K, Bagby S, Tentler J, Tan AC, Wisell J, Varella-Garcia M, Robinson W. Kinase Gene Fusions in Defined Subsets of Melanoma. Pigment Cell Melanoma Res. 2016 Nov 19. [Epub ahead of print] PubMed PMID: 27864876
  • Sufit A, Lee-Sherick AB, DeRyckere D, Rupji M, Dwivedi B, Varella-Garcia M, Pierce AM, Kowalski J, Wang X, Frye SV, Earp HS, Keating AK, Graham DK. MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. PLoS One. 2016 Oct 26;11(10):e0165107. PubMed PMID: 27783662
  • Bagby S, Messersmith WA, Pitts TM, Capasso A, Varella-Garcia M, Klauck PJ, Kim J, Tan AC, Eckhardt SG, Tentler JJ, Arcaroli J. Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies. J Vis Exp. 2016 Sep 30;(115). PubMed PMID: 27768028
  • Caparica R, Yen CT, Coudry R, Ou SI, Varella-Garcia M, Camidge DR, de Castro G Jr. Responses to Crizotinib Can Occur in High-Level MET-Amplified Non-Small Cell Lung Cancer Independent of MET Exon 14 Alterations. J Thorac Oncol. 2017 Jan;12(1):141-144. PubMed PMID: 27664533
  • Shi R, Varella-Garcia M, Li M, Ludkovski O, Danesh A, Ng C, Pham NA, Pugh T, Shepherd FA, Tsao MS. An Anaplastic Lymphoma Kinase Immunohistochemistry-Negative but Fluorescence In Situ Hybridization-Positive Lung Adenocarcinoma Is Resistant to Crizotinib. J Thorac Oncol. 2016 Dec;11(12):2248-2252. PubMed PMID: 27613526
  • Aisner DL, Rumery MD, Merrick DT, Kondo KL, Nijmeh H, Linderman DJ, Doebele RC, Thomas N, Chesnut PC, Varella-Garcia M, Franklin WA, Camidge DR. Do More With Less: Tips and Techniques for Maximizing Small Biopsy and Cytology Specimens for Molecular and Ancillary Testing: The University of Colorado Experience. Arch Pathol Lab Med. 2016 Sep 9. [Epub ahead of print] PubMed PMID: 27610643
  • Thu KL, Papari-Zareei M, Stastny V, Song K, Peyton M, Martinez VD, Zhang YA, Castro IB, Varella-Garcia M, Liang H, Xing C, Kittler R, Milchgrub S, Castrillon DH, Davidson HL, Reynolds CP, Lam WL, Lea J, Gazdar AF. A comprehensively characterized cell line panel highly representative of clinical ovarian high-grade serous carcinomas. Oncotarget. 2016 Jun 10. [Epub ahead of print] PubMed PMID: 27302921
  • Noonan SA, Berry L, Lu X, Gao D, Barón AE, Chesnut P, Sheren J, Aisner DL, Merrick D, Doebele RC, Varella-Garcia M, Camidge DR. Identifying the Appropriate FISH Criteria for Defining MET Copy Number-Driven Lung Adenocarcinoma through Oncogene Overlap Analysis. J Thorac Oncol. 2016 Aug;11(8):1293-304. PubMed PMID: 27262212
  • Paz-Ares L, Socinski MA, Shahidi J, Hozak RR, Soldatenkova V, Kurek R, Varella-Garcia M, Thatcher N, Hirsch FR. Correlation of EGFR-expression with safety and efficacy outcomes in SQUIRE: a randomized, multicenter, open-label, phase III study of gemcitabine-cisplatin plus necitumumab versus gemcitabine-cisplatin alone in the first-line treatment of patients with stage IV squamous non-small-cell lung cancer. Ann Oncol. 2016 Aug;27(8):1573-9. PubMed PMID: 27207107
  • Ariyawutyakorn W, Saichaemchan S, Varella-Garcia M. Understanding and Targeting MET Signaling in Solid Tumors - Are We There Yet?. J Cancer. 2016 Mar 20;7(6):633-49. PubMed PMID: 27076844
  • Dziadziuszko R, Le AT, Wrona A, Jassem J, Camidge DR, Varella-Garcia M, Aisner DL, Doebele RC. An Activating KIT Mutation Induces Crizotinib Resistance in ROS1-Positive Lung Cancer. J Thorac Oncol. 2016 Aug;11(8):1273-81. PubMed PMID: 27068398
  • Despierre E, Vergote I, Anderson R, Coens C, Katsaros D, Hirsch FR, Boeckx B, Varella-Garcia M, Ferrero A, Ray-Coquard I, Green JA, Steer C, Berns EM, Casado A, Lambrechts D, Jimeno A. Erratum to: Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy. Target Oncol. 2016 Jun;11(3):429. PubMed PMID: 27056749
  • Li BT, Ross DS, Aisner DL, Chaft JE, Hsu M, Kako SL, Kris MG, Varella-Garcia M, Arcila ME. HER2 Amplification and HER2 Mutation Are Distinct Molecular Targets in Lung Cancers. J Thorac Oncol. 2016 Mar;11(3):414-9. PubMed PMID: 26723242
  • Saichaemchan S, Ariyawutyakorn W, Varella-Garcia M. Fibroblast Growth Factor Receptors: From the Oncogenic Pathway to Targeted Therapy. Curr Mol Med. 2016;16(1):40-62. PubMed PMID: 26695695
  • Gavin KM, Gutman JA, Kohrt WM, Wei Q, Shea KL, Miller HL, Sullivan TM, Erickson PF, Helm KM, Acosta AS, Childs CR, Musselwhite E, Varella-Garcia M, Kelly K, Majka SM, Klemm DJ. De novo generation of adipocytes from circulating progenitor cells in mouse and human adipose tissue. FASEB J. 2016 Mar;30(3):1096-108. PubMed PMID: 26581599
  • Arcaroli JJ, Tai WM, McWilliams R, Bagby S, Blatchford PJ, Varella-Garcia M, Purkey A, Quackenbush KS, Song EK, Pitts TM, Gao D, Lieu C, McManus M, Tan AC, Zheng X, Zhang Q, Ozeck M, Olson P, Jiang ZQ, Kopetz S, Jimeno A, Keysar S, Eckhardt G, Messersmith WA. A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer. Int J Cancer. 2016 Jan 1;138(1):195-205. PubMed PMID: 26152787
  • Morton JJ, Bird G, Keysar SB, Astling DP, Lyons TR, Anderson RT, Glogowska MJ, Estes P, Eagles JR, Le PN, Gan G, McGettigan B, Fernandez P, Padilla-Just N, Varella-Garcia M, Song JI, Bowles DW, Schedin P, Tan AC, Roop DR, Wang XJ, Refaeli Y, Jimeno A. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene. 2016 Jan 21;35(3):290-300. PubMed PMID: 25893296


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