Jason Gien, MD

Recognitions

• F. Joseph Butterfield Award-Outstanding Fellow in Neonatal–Perinatal Medicine, F. Joseph Butterfield Foundation (2007)
  
• Fellows Travel Award, Pediatric Academic Societies (2007)
  
• Fellow Research Award for Outstanding Research Best, Children's Hospital Colorado (2006)
• Dyson Award for Pediatric Advocacy, Dyson Award for Pediatric Advocacy (2004)
  

Publications

• Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res. 2012 Nov 30. [Epub ahead of print] PubMed PMID: 23202724
• Pediatr Res. 2012 Nov 30. [Epub ahead of print]
• Mandell E, Seedorf GJ, Gien J, Abman SH. Vitamin D Improves Infant Lung Injury and Structure After Intra-Amniotic Endotoxin Exposure in Rats: Potential Role for Prevention of Bronchopulmonary Dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Jan 10. [Epub ahead of print] PubMed PMID: 24414254
• Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Peroxisome proliferator activated receptor-?-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L299-308. PubMed PMID: 24375792
• Wolf D, Tseng N, Seedorf GJ, Roe GB, Abman SH, Gien J. Endothelin-1 decreases Endothelial PPAR gamma Signaling and Impairs Angiogenesis After Chronic Intrauterine Pulmonary Hypertension. Am J Physiol Lung Cell Mol Physiol. 2013 Dec 13. [Epub ahead of print] PubMed PMID: 24337925
• Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Partrick DA, Gien J. Pulmonary artery endothelial cell dysfunction and decreased populations of highly proliferative endothelial cells in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L943-52. PubMed PMID: 24124189
• Delaney C, Gien J, Roe G, Isenberg N, Kailey J, Abman SH. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15;304(12):L894-901. PubMed PMID: 23605003
• Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res. 2013 Mar;73(3):252-62. PubMed PMID: 23202724
• Gien J, Campbell D, Mitchell M, Twite MD, Ing RJ, Kinsella JP. Surgical management of iatrogenic airway perforation in three preterm infants. Journal of Pediatric Surgery. 12/16/13
• Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered Pulmonary Artery Endothelial-Smooth Muscle Cell Interactions in Experimental Congenital Diaphragmatic Hernia. Pediatr Res. 2015 Jan 12. [Epub ahead of print] PubMed PMID: 25580737
• Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan;166(1):178-83. PubMed PMID: 25306189
• Gien J, Abman SH, Baker CD. Interdisciplinary care for ventilator-dependent infants with chronic lung disease. J Pediatr. 2014 Dec;165(6):1274-5. PubMed PMID: 25258147
• Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015 Jan;70(1):84-5. PubMed PMID: 25052575
• Acker SN, Kinsella JP, Abman SH, Gien J. Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia. J Pediatr. 2014 Jul;165(1):53-58.e1. PubMed PMID: 24840762
• Gien J, Ing RJ, Twite MD, Campbell D, Mitchell M, Kinsella JP. Successful Surgical Management of Airway Perforation in Preterm Infants. J Pediatr Surg Case Rep. 2014 Feb 1;2(2):47-51. PubMed PMID: 24791225
• Mandell E, Seedorf G, Gien J, Abman SH. Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 1;306(5):L420-8. PubMed PMID: 24414254
• Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Peroxisome proliferator activated receptor-?-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb;306(3):L299-308. PubMed PMID: 24375792
• Wolf D, Tseng N, Seedorf G, Roe G, Abman SH, Gien J. Endothelin-1 decreases endothelial PPAR? signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15;306(4):L361-71. PubMed PMID: 24337925
• Gien J, Kinsella JP. Differences in preductal and postductal arterial blood gas measurements in infants with severe congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2015 Oct 29. [Epub ahead of print] PubMed PMID: 26514398
• Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L1018-26. PubMed PMID: 26342089
• Grover TR, Murthy K, Brozanski B, Gien J, Rintoul N, Keene S, Najaf T, Chicoine L, Porta N, Zaniletti I, Pallotto EK. Short-term outcomes and medical and surgical interventions in infants with congenital diaphragmatic hernia. Am J Perinatol. 2015 Sep;32(11):1038-44. PubMed PMID: 25825963
• Guaman MC, Gien J, Baker CD, Zhang H, Austin ED, Collaco JM. Point Prevalence, Clinical Characteristics, and Treatment Variation for Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2015 Aug;32(10):960-7. PubMed PMID: 25738785
• Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered pulmonary artery endothelial-smooth muscle cell interactions in experimental congenital diaphragmatic hernia. Pediatr Res. 2015 Apr;77(4):511-9. PubMed PMID: 25580737
• Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan;166(1):178-83. PubMed PMID: 25306189
• Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015 Jan;70(1):84-5. PubMed PMID: 25052575
• Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2016 Nov 28. [Epub ahead of print] PubMed PMID: 27908648
• Gien J, Tseng N, Seedorf G, Kuhn K, Abman SH. Endothelin-1-Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1090-L1100. PubMed PMID: 27760762
• Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH, Baker CD. Retrospective Analysis of an Interdisciplinary Ventilator Care Program Intervention on Survival of Infants with Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Perinatol. 2017 Jan;34(2):155-163. PubMed PMID: 27355979
• Baker CD, Martin S, Thrasher J, Moore HM, Baker J, Abman SH, Gien J. A Standardized Discharge Process Decreases Length of Stay for Ventilator-Dependent Children. Pediatrics. 2016 Apr;137(4). PubMed PMID: 26966133
• Deeney S, Howley LW, Hodges M, Liechty KW, Marwan AI, Gien J, Kinsella JP, Crombleholme TM. Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair. J Pediatr. 2017 Oct 26. [Epub ahead of print] PubMed PMID: 29106923
• Gien J, Murthy K, Pallotto EK, Brozanski B, Chicoine L, Zaniletti I, Seabrook R, Keene S, Alapati D, Porta N, Rintoul N, Grover TR. Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH). Early Hum Dev. 2017 Mar - Apr;106-107:7-12. PubMed PMID: 28178582
• Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 Feb;181:12-28.e1. PubMed PMID: 27908648
• Gien J, Kinsella JP. Differences in preductal and postductal arterial blood gas measurements in infants with severe congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2016 Jul;101(4):F314-8. PubMed PMID: 26514398
• Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH, Baker CD. Retrospective Analysis of an Interdisciplinary Ventilator Care Program Intervention on Survival of Infants with Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Perinatol. 2017 Jan;34(2):155-163. PubMed PMID: 27355979
• Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2018 Oct 12. [Epub ahead of print] PubMed PMID: 30315405
• Murthy K, Pallotto EK, Gien J, Brozanski BS, Porta NF, Zaniletti I, Keene S, Chicoine LG, Rintoul NE, Dykes FD, Asselin JM, Short BL, Padula MA, Durand DJ, Reber KM, Evans JR, Grover TR. Predicting death or extended length of stay in infants with congenital diaphragmatic hernia. J Perinatol. 2016 Aug;36(8):654-9. PubMed PMID: 26963428
• Murthy K, Porta NFM, Pallotto EK, Rintoul N, Keene S, Chicoine L, Gien J, Brozanski BS, Johnson YR, Haberman B, DiGeronimo R, Zaniletti I, Grover TR. Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 Dec;203:101-107.e2. PubMed PMID: 30217691
• Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2019 Jan;34(1):169-176. PubMed PMID: 30155763
• Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L348-L359. PubMed PMID: 29722560
• Gien J, Kinsella JP. Management of pulmonary hypertension in infants with congenital diaphragmatic hernia. J Perinatol. 2016 Jun;36 Suppl 2:S28-31. PubMed PMID: 27225962
• Gien J, Meyers ML, Kinsella JP. Assessment of Carina Position Antenatally and Postnatally in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 Jan;192:93-98.e1. PubMed PMID: 29246364
• Keene S, Murthy K, Pallotto E, Brozanski B, Gien J, Zaniletti I, Hulbert C, Seabrook R, Rintoul N, Chicoine L, Porta N, Grover TR. Acquired Infection and Antimicrobial Utilization During Initial NICU Hospitalization in Infants With Congenital Diaphragmatic Hernia. Pediatr Infect Dis J. 2018 May;37(5):469-474. PubMed PMID: 29189614
• Aschner JL, Gien J, Ambalavanan N, Kinsella JP, Konduri GG, Lakshminrusimha S, Saugstad OD, Steinhorn RH. Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate. J Perinatol. 2016 Jun;36 Suppl 2:S32-6. PubMed PMID: 27225964
• Deeney S, Howley LW, Hodges M, Liechty KW, Marwan AI, Gien J, Kinsella JP, Crombleholme TM. Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair. J Pediatr. 2018 Jan;192:99-104.e4. PubMed PMID: 29106923
• Selewski DT, Akcan-Arikan A, Bonachea EM, Gist KM, Goldstein SL, Hanna M, Joseph C, Mahan JD, Nada A, Nathan AT, Reidy K, Staples A, Wintermark P, Boohaker LJ, Griffin R, Askenazi DJ, Guillet R. The impact of fluid balance on outcomes in critically ill near-term/term neonates: a report from the AWAKEN study group. Pediatr Res. 2018 Sep 20. [Epub ahead of print] PubMed PMID: 30237572
• Kraut EJ, Boohaker LJ, Askenazi DJ, Fletcher J, Kent AL. Incidence of neonatal hypertension from a large multicenter study [Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates-AWAKEN]. Pediatr Res. 2018 Aug;84(2):279-289. PubMed PMID: 29795211
• Harer MW, Askenazi DJ, Boohaker LJ, Carmody JB, Griffin RL, Guillet R, Selewski DT, Swanson JR, Charlton JR. Association Between Early Caffeine Citrate Administration and Risk of Acute Kidney Injury in Preterm Neonates: Results From the AWAKEN Study. JAMA Pediatr. 2018 Jun 4;172(6):e180322. PubMed PMID: 29610830
• Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 1;309(9):L1018-26. PubMed PMID: 26342089
• Jetton JG, Guillet R, Askenazi DJ, Dill L, Jacobs J, Kent AL, Selewski DT, Abitbol CL, Kaskel FJ, Mhanna MJ, Ambalavanan N, Charlton JR. Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates: Design of a Retrospective Cohort Study. Front Pediatr. 2016 Jul 19;4:68. PubMed PMID: 27486571
• Charlton JR, Boohaker L, Askenazi D, Brophy PD, D'Angio C, Fuloria M, Gien J, Griffin R, Hingorani S, Ingraham S, Mian A, Ohls RK, Rastogi S, Rhee CJ, Revenis M, Sarkar S, Smith A, Starr M, Kent AL. Incidence and Risk Factors of Early Onset Neonatal AKI. Clin J Am Soc Nephrol. 2019 Feb 7;14(2):184-195. PubMed PMID: 31738181
• Leopold DK, Phillips RC, Shahi N, Gien J, Marwan AI, Kinsella JP, Mulligan J, Liechty KW, Moulton SL. Low Postnatal CRI Values Are Associated with the Need for ECMO in Newborns with CDH. J Pediatr Surg. 2019 Oct 25. [Epub ahead of print] PubMed PMID: 31679772
• Phillips RC, Shahi N, Leopold D, Levek C, Shirek G, Hilton S, Hyslop R, Gien J, Kinsella JP, Buckvold S, Liechty KW, Kim JS, Marwan AI. Thromboelastography-guided management of coagulopathy in neonates with congenital diaphragmatic hernia supported by extracorporeal membrane oxygenation. Pediatr Surg Int. 2020 Sep;36(9):1027-1033. PubMed PMID: 32607833
• Nada A, Askenazi D, Boohaker LJ, Li L, Mahan JD, Charlton J, Griffin RL. Low hemoglobin levels are independently associated with neonatal acute kidney injury: a report from the AWAKEN Study Group. Pediatr Res. 2020 Jun 11. [Epub ahead of print] PubMed PMID: 32526767
• McKinney RL, Keszler M, Truog WE, Norberg M, Sindelar R, Wallström L, Schulman B, Gien J, Abman SH. Multicenter Experience with Neurally Adjusted Ventilatory Assist in Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2020 Mar 24. [Epub ahead of print] PubMed PMID: 32208500
• Gien J, Nuxoll C, Kinsella JP. Inhaled Nitric Oxide in Emergency Medical Transport of the Newborn. Neoreviews. 2020 Mar;21(3):e157-e164. PubMed PMID: 32123120
• Dewberry L, Hilton S, Gien J, Liechty KW, Marwan AI. Flap repair in congenital diaphragmatic hernia leads to lower rates of recurrence. J Pediatr Surg. 2019 Aug 30. [Epub ahead of print] PubMed PMID: 31515112
• Gien J, Soranno D. Identifying the Patient at Risk for Acute Kidney Injury: Pediatric Sepsis Biomarker Risk Model Study. Am J Respir Crit Care Med. 2020 Apr 1;201(7):764-766. PubMed PMID: 32032496
• Keene S, Grover TR, Murthy K, Pallotto EK, Brozanski B, Gien J, Zaniletti I, Johnson YR, Seabrook RB, Porta NFM, Haberman B, DiGeronimo R, Rintoul N. Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia. J Perinatol. 2019 Oct;39(10):1384-1391. PubMed PMID: 31383944
• Wehrmann M, Patel SS, Haxel C, Cassidy C, Howley L, Cuneo B, Gien J, Kinsella JP. Implications of Atrial-Level Shunting by Echocardiography in Newborns with Congenital Diaphragmatic Hernia. J Pediatr. 2020 Apr;219:43-47. PubMed PMID: 32014282
• Gorga SM, Sahay RD, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT. Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy: a multicenter retrospective cohort study. Pediatr Nephrol. 2020 May;35(5):871-882. PubMed PMID: 31953749
• Starr MC, Boohaker L, Eldredge LC, Menon S, Griffin R, Mayock DE, Li L, Askenazi D, Hingorani S. Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation. Am J Perinatol. 2020 Feb;37(3):341-348. PubMed PMID: 31777046
• Chatterjee D, Ing RJ, Gien J. Update on Congenital Diaphragmatic Hernia. Anesth Analg. 2019 Jul 17. [Epub ahead of print] PubMed PMID: 31335403
• Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2019 Feb;34(2):363. PubMed PMID: 30315405
• Starr MC, Boohaker L, Eldredge LC, Menon S, Griffin R, Mayock D, Askenazi D, Hingorani S. Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born =32 Weeks of Gestational Age. Am J Perinatol. 2020 Jan;37(2):231-240. PubMed PMID: 31739364
• Charlton JR, Boohaker L, Askenazi D, Brophy PD, Fuloria M, Gien J, Griffin R, Hingorani S, Ingraham S, Mian A, Ohls RK, Rastogi S, Rhee CJ, Revenis M, Sarkar S, Starr M, Kent AL. Late onset neonatal acute kidney injury: results from the AWAKEN Study. Pediatr Res. 2019 Feb;85(3):339-348. PubMed PMID: 30546043
• Leopold DK, Phillips RC, Shahi N, Gien J, Marwan AI, Kinsella JP, Mulligan J, Liechty KW, Moulton SL. Low postnatal CRI values are associated with the need for ECMO in newborns with CDH. J Pediatr Surg. 2020 Jan;55(1):39-44. PubMed PMID: 31679772
• Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2019 Jan;34(1):169-176. PubMed PMID: 30155763
• Chatterjee D, Ing RJ, Gien J. Update on Congenital Diaphragmatic Hernia. Anesth Analg. 2020 Sep;131(3):808-821. PubMed PMID: 31335403
• Selewski DT, Gist KM, Nathan AT, Goldstein SL, Boohaker LJ, Akcan-Arikan A, Bonachea EM, Hanna M, Joseph C, Mahan JD, Mammen C, Nada A, Reidy K, Staples A, Wintermark P, Griffin R, Askenazi DJ, Guillet R. The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group. Pediatr Res. 2020 Feb;87(3):550-557. PubMed PMID: 31537009
• Starr MC, Boohaker L, Eldredge LC, Menon S, Griffin R, Mayock D, Askenazi D, Hingorani S. Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born =32 Weeks of Gestational Age. Am J Perinatol. 2019 Nov 18. [Epub ahead of print] PubMed PMID: 31739364
• Askenazi D, Abitbol C, Boohaker L, Griffin R, Raina R, Dower J, Davis TK, Ray PE, Perazzo S, DeFreitas M, Milner L, Ambalavanan N, Cole FS, Rademacher E, Zappitelli M, Mhanna M. Optimizing the AKI definition during first postnatal week using Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) cohort. Pediatr Res. 2019 Feb;85(3):329-338. PubMed PMID: 30643188
• Selewski DT, Gist KM, Nathan AT, Goldstein SL, Boohaker LJ, Akcan-Arikan A, Bonachea EM, Hanna M, Joseph C, Mahan JD, Mammen C, Nada A, Reidy K, Staples A, Wintermark P, Griffin R, Askenazi DJ, Guillet R. The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group. Pediatr Res. 2019 Sep 19. [Epub ahead of print] PubMed PMID: 31537009
• Mahmood B, Murthy K, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Seabrook R, Ali N, Chapman R, Daniel J, Harrison A, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Grover TR. Predicting treatment of pulmonary hypertension at discharge in infants with congenital diaphragmatic hernia. J Perinatol. 2021 Oct 28. [Epub ahead of print] PubMed PMID: 34711937
• Phillips R, Meier M, Shahi N, Niemiec S, Ogle S, Reppucci ML, Acker S, Gien J, Liechty KW, Meyers ML, Marwan A. Correction to: The novel fetal MRI O/E CLV versus O/E LHR in predicting prognosis in congenital diaphragmatic hernias: can we teach an old dog new tricks?. Pediatr Surg Int. 2021 Oct 15. [Epub ahead of print] PubMed PMID: 34652511
• Gist KM, Misfeldt A, Sahay RD, Gorga SM, Askenazi DJ, Bridges BC, Paden ML, Zappitelli M, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT, Cooper DS. Acute Kidney Injury and Fluid Overload in Pediatric Extracorporeal Cardio-Pulmonary Resuscitation: A Multicenter Retrospective Cohort Study. ASAIO J. 2021 Oct 12. [Epub ahead of print] PubMed PMID: 34643574
• Gorga SM, Lima L, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Jetton JG, Murphy HJ, Fleming GM, Selewski DT, Basu RK. Fluid Balance Management Informs Renal Replacement Therapy Use During Pediatric Extracorporeal Membrane Oxygenation: A Survey Report From the Kidney Intervention During Extracorporeal Membrane Oxygenation Group. ASAIO J. 2021 May 10. [Epub ahead of print] PubMed PMID: 34570725
• Phillips R, Shahi N, Meier M, Niemiec S, Ogle S, Acker S, Gien J, Liechty KW, Meyers ML, Marwan A. The novel fetal MRI O/E CLV versus O/E LHR in predicting prognosis in congenital diaphragmatic hernias: can we teach an old dog new tricks?. Pediatr Surg Int. 2021 Nov;37(11):1499-1504. PubMed PMID: 34505169
• Liberio BM, Brinton JT, Gist KM, Soranno DE, Kirkley MJ, Gien J. Risk factors for acute kidney injury in neonates with congenital diaphragmatic hernia. J Perinatol. 2021 Aug;41(8):1901-1909. PubMed PMID: 34120147
• Weems MF, Grover TR, Seabrook R, DiGeronimo R, Gien J, Keene S, Rintoul N, Daniel JM, Johnson Y, Guner Y, Zaniletti I, Murthy K. Analgesia, Sedation, and Neuromuscular Blockade in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2021 May 27. [Epub ahead of print] PubMed PMID: 34044457
• Fleming H, Dempsey AG, Palmer C, Dempsey J, Friedman S, Galan HL, Gien J. Primary contributors to gastrostomy tube placement in infants with Congenital Diaphragmatic Hernia. J Pediatr Surg. 2021 Nov;56(11):1949-1956. PubMed PMID: 33773801
• Seabrook RB, Grover TR, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Ali N, Chapman R, Daniel J, Harrison HA, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Murthy K. Treatment of pulmonary hypertension during initial hospitalization in a multicenter cohort of infants with congenital diaphragmatic hernia (CDH). J Perinatol. 2021 Apr;41(4):803-813. PubMed PMID: 33649432
• Murphy HJ, Gien J, Sahay R, King E, Selewski DT, Bridges BC, Cooper DS, Fleming GM, Paden ML, Zappitelli M, Gist KM, Basu RK, Jetton JG, Askenazi D. Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately. Blood Purif. 2021;50(6):808-817. PubMed PMID: 33461205
• McKinney RL, Keszler M, Truog WE, Norberg M, Sindelar R, Wallström L, Schulman B, Gien J, Abman SH. Multicenter Experience with Neurally Adjusted Ventilatory Assist in Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2021 Aug;38(S 01):e162-e166. PubMed PMID: 32208500
• Guillet R, Selewski DT, Griffin R, Rastogi S, Askenazi DJ, D'Angio CT. Relationship of patent ductus arteriosus management with neonatal AKI. J Perinatol. 2021 Jun;41(6):1441-1447. PubMed PMID: 33875795
• Stephen Niemiec; Amanda E. Louiselle; Ryan Phillips; Sarah A. Hilton; Sarkis C. Derderian; Michael V. Zaretsky; Henry L. Galan; Nicholas Behrendt; John P. Kinsella; Kenneth W. Liechty; Jason Gien. Reduction in Blood Product Transfusion Requirements with Early On-ECMO Repair of Congenital Diaphragmatic Hernia. Annals of Pediatric Surgery
• Gien J, Liechty K, Kinsella J, Early Abnormalities in Gas Exchange in Infants with Congenital Diaphragmatic Hernia. Journal of Pediatrics
• Hypoxic Respiratory Failure in the Newborn: From Origins to Clinical Management
• Fetal and Neonatal Physiology, 2-Volume Set, 6th Edition Editors : Richard A. Polin & Steven H. Abman & David Rowitch & William E. Benitz Pathophysiology of Meconium Aspiration Syndrome
• Maia PD, Gien J, Kinsella JP, Zablah J, Morgan G, Ivy DD, Abman SH, Frank BS. Hemodynamic Characterization of Neonates with Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension by Cardiac Catheterization. J Pediatr. 2022 Dec 1. [Epub ahead of print] PubMed PMID: 36463937
• Eskander A, Zanchetta C, Coburn N, Enepekides D, Gien LT, Menalo R, Austria G, Linton O, Su-Myat S, Yermakhanova O, Irish J. Cancer surgery cancellation: incidence, outcomes and recovery in a universal health care system. Can J Surg. 2022 Nov-Dec;65(6):E782-E791. PubMed PMID: 36384689
• Niemiec SM, Louiselle AE, Phillips R, Gien J, Zaretsky MV, Derderian SC, Liechty KW, Meyers ML. Third-trimester percentage predicted lung volume and percentage liver herniation as prognostic indicators in congenital diaphragmatic hernia. Pediatr Radiol. 2022 Oct 27. [Epub ahead of print] PubMed PMID: 36289070
• Pettit KA, Selewski DT, Askenazi DJ, Basu RK, Bridges BC, Cooper DS, Fleming GM, Gien J, Gorga SM, Jetton JG, King EC, Steflik HJ, Paden ML, Sahay RD, Zappitelli M, Gist KM. Synergistic association of fluid overload and acute kidney injury on outcomes in pediatric cardiac ECMO: a retrospective analysis of the KIDMO database. Pediatr Nephrol. 2022 Aug 9. [Epub ahead of print] PubMed PMID: 35943578
• Enzer KG, Wine TM, Gien J, Somme S, Prager JD, Baker CD. Posterior tracheopexy for preterm infants with severe bronchopulmonary dysplasia and severe tracheobronchomalacia: A case series. Pediatr Pulmonol. 2022 Sep;57(9):2279-2281. PubMed PMID: 35666077
• Gien J, Kinsella JP, Behrendt NJ, Zaretsky MV, Galan HL, Liechty KW. Improved survival for infants with severe congenital diaphragmatic hernia. J Perinatol. 2022 Sep;42(9):1189-1194. PubMed PMID: 35461332
• Chuah S, Lee J, Song Y, Kim HD, Wasser M, Kaya NA, Bang K, Lee YJ, Jeon SH, Suthen S, A'Azman S, Gien G, Lim CJ, Chua C, Hazirah SN, Lee HK, Lim JQ, Lim TKH, Yeong J, Chen J, Shin EC, Albani S, Zhai W, Yoo C, Liu H, Choo SP, Tai D, Chew V. Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma. J Hepatol. 2022 Sep;77(3):683-694. PubMed PMID: 35430299
• Gien J, Palmer C, Liechty K, Kinsella JP. Early Abnormalities in Gas Exchange in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2022 Apr;243:188-192. PubMed PMID: 34929245
• Kosa SD, Ferguson SE, Panzarella T, Lau S, Abitbol J, Samouëlian V, Giede C, Steed H, Renkosinski B, Gien LT, Bernardini MQ. A prospective comparison of costs between robotics, laparoscopy, and laparotomy in endometrial cancer among women with Class III obesity or higher. J Surg Oncol. 2022 Mar;125(4):747-753. PubMed PMID: 34904716
• Swift BE, Philp L, Atenafu EG, Malkani N, Gien LT, Bernardini MQ. Lymphadenectomy for high-grade endometrial cancer: Does it impact lymph node recurrence?. Eur J Surg Oncol. 2022 May;48(5):1181-1187. PubMed PMID: 34782183
• Mahmood B, Murthy K, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Seabrook R, Ali N, Chapman R, Daniel J, Harrison A, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Grover TR. Predicting treatment of pulmonary hypertension at discharge in infants with congenital diaphragmatic hernia. J Perinatol. 2022 Jan;42(1):45-52. PubMed PMID: 34711937
• Phillips R, Meier M, Shahi N, Niemiec S, Ogle S, Reppucci ML, Acker S, Gien J, Liechty KW, Meyers ML, Marwan A. Correction to: The novel fetal MRI O/E CLV versus O/E LHR in predicting prognosis in congenital diaphragmatic hernias: can we teach an old dog new tricks?. Pediatr Surg Int. 2022 Feb;38(2):357. PubMed PMID: 34652511
• Gist KM, Misfeldt A, Sahay RD, Gorga SM, Askenazi DJ, Bridges BC, Paden ML, Zappitelli M, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT, Cooper DS. Acute Kidney Injury and Fluid Overload in Pediatric Extracorporeal Cardio-Pulmonary Resuscitation: A Multicenter Retrospective Cohort Study. ASAIO J. 2022 Jul 1;68(7):956-963. PubMed PMID: 34643574
• Gorga SM, Lima L, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Jetton JG, Murphy HJ, Fleming GM, Selewski DT, Basu RK. Fluid Balance Management Informs Renal Replacement Therapy Use During Pediatric Extracorporeal Membrane Oxygenation: A Survey Report From the Kidney Intervention During Extracorporeal Membrane Oxygenation Group. ASAIO J. 2022 Mar 1;68(3):407-412. PubMed PMID: 34570725
• Gallagher LT, Lyttle BD, Meyers ML, Gien J, Zaretsky MV, Galan HL, Behrendt N, Liechty KW, Derderian SC. Fetal lung volumes measured by MRI predict pulmonary morbidity among infants with giant omphaloceles. Prenat Diagn. 2023 Nov;43(12):1514-1519. PubMed PMID: 37807606
• Le LS, Kinsella JP, Gien J, Frank BS. Failure to Normalize Biventricular Function Is Associated with Extracorporeal Membrane Oxygenation Use in Neonates with Congenital Diaphragmatic Hernia. J Pediatr. 2023 Sep;260:113490. PubMed PMID: 37201678
• Liberio BM, Seedorf G, Soranno DE, Montford JR, Faubel SG, Hernandez A, Abman SH, Gien J. Acute kidney injury decreases pulmonary vascular growth and alveolarization in neonatal rat pups. Pediatr Res. 2023 Oct;94(4):1308-1316. PubMed PMID: 37138027
• Dias Maia P, Rodrigues KK, Gien J, Turner MJ. Neonatal acute kidney injury during indomethacin therapy: does it predict ductal closure?. J Nephrol. 2023 Jul;36(6):1591-1597. PubMed PMID: 37097555
• Gien J. Timing of umbilical cord clamping in infants with congenital diaphragmatic hernia. Semin Perinatol. 2023 Jun;47(4):151746. PubMed PMID: 36997450
• Maia PD, Gien J, Kinsella JP, Zablah J, Morgan G, Ivy DD, Abman SH, Frank BS. Hemodynamic Characterization of Neonates With Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension by Cardiac Catheterization. J Pediatr. 2023 Apr;255:230-235.e2. PubMed PMID: 36463937
• Niemiec SM, Louiselle AE, Phillips R, Gien J, Zaretsky MV, Derderian SC, Liechty KW, Meyers ML. Third-trimester percentage predicted lung volume and percentage liver herniation as prognostic indicators in congenital diaphragmatic hernia. Pediatr Radiol. 2023 Mar;53(3):479-486. PubMed PMID: 36289070
• Enzer KG, Wine TM, Gien J, Somme S, Prager JD, Baker CD. Posterior tracheopexy for preterm infants with severe bronchopulmonary dysplasia and severe tracheobronchomalacia: A case series. Pediatr Pulmonol. 2022 Sep;57(9):2279-2281. PubMed PMID: 35666077
• Gien J, Kinsella JP, Behrendt NJ, Zaretsky MV, Galan HL, Liechty KW. Improved survival for infants with severe congenital diaphragmatic hernia. J Perinatol. 2022 Sep;42(9):1189-1194. PubMed PMID: 35461332
• Gien J, Palmer C, Liechty K, Kinsella JP. Early Abnormalities in Gas Exchange in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2022 Apr;243:188-192. PubMed PMID: 34929245
• Mahmood B, Murthy K, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Seabrook R, Ali N, Chapman R, Daniel J, Harrison A, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Grover TR. Predicting treatment of pulmonary hypertension at discharge in infants with congenital diaphragmatic hernia. J Perinatol. 2022 Jan;42(1):45-52. PubMed PMID: 34711937
• Phillips R, Meier M, Shahi N, Niemiec S, Ogle S, Reppucci ML, Acker S, Gien J, Liechty KW, Meyers ML, Marwan A. Correction to: The novel fetal MRI O/E CLV versus O/E LHR in predicting prognosis in congenital diaphragmatic hernias: can we teach an old dog new tricks?. Pediatr Surg Int. 2022 Feb;38(2):357. PubMed PMID: 34652511
• Gist KM, Misfeldt A, Sahay RD, Gorga SM, Askenazi DJ, Bridges BC, Paden ML, Zappitelli M, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT, Cooper DS. Acute Kidney Injury and Fluid Overload in Pediatric Extracorporeal Cardio-Pulmonary Resuscitation: A Multicenter Retrospective Cohort Study. ASAIO J. 2022 Jul 1;68(7):956-963. PubMed PMID: 34643574
• Gorga SM, Lima L, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Jetton JG, Murphy HJ, Fleming GM, Selewski DT, Basu RK. Fluid Balance Management Informs Renal Replacement Therapy Use During Pediatric Extracorporeal Membrane Oxygenation: A Survey Report From the Kidney Intervention During Extracorporeal Membrane Oxygenation Group. ASAIO J. 2022 Mar 1;68(3):407-412. PubMed PMID: 34570725
• Weems MF, Grover TR, Seabrook R, DiGeronimo R, Gien J, Keene S, Rintoul N, Daniel JM, Johnson Y, Guner Y, Zaniletti I, Murthy K. Analgesia, Sedation, and Neuromuscular Blockade in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2023 Mar;40(4):415-423. PubMed PMID: 34044457
• Pettit KA, Selewski DT, Askenazi DJ, Basu RK, Bridges BC, Cooper DS, Fleming GM, Gien J, Gorga SM, Jetton JG, King EC, Steflik HJ, Paden ML, Sahay RD, Zappitelli M, Gist KM. Synergistic association of fluid overload and acute kidney injury on outcomes in pediatric cardiac ECMO: a retrospective analysis of the KIDMO database. Pediatr Nephrol. 2023 Apr;38(4):1343-1353. PubMed PMID: 35943578
• Steflik HJ, Charlton JR, Briley M, Selewski DT, Gist KM, Hanna MH, Askenazi D, Griffin R. Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study. J Perinatol. 2023 Aug;43(8):1029-1037. PubMed PMID: 37100984
• Haynes N, Bell J, Griffin R, Askenazi DJ, Jetton J, Kent AL. Receipt of high-frequency ventilation is associated with acute kidney injury in very preterm neonates. Pediatr Nephrol. 2023 Aug 18. [Epub ahead of print] PubMed PMID: 37594576

Professional Memberships

• American Medical Association , Member
• American Academy of Pediatrics (AAP), Member

Practice Locations

UCHealth - Neonatal Intensive Care Unit - Anschutz
12605 E. 16th Avenue
Aurora, CO 80045
720-848-5224

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Children's Hospital Colorado - Colorado Fetal Care Center
13123 E 16th Ave, B735
Aurora, CO 80045
720-777-4463

Hospital Affiliation

• Children's Hospital Colorado
• University of Colorado Hospital

Center Affiliations

• Colorado Fetal Care Center

Specialty Information

Specialties

• Neonatal-Perinatal Medicine, Board Certification (2007)
• Pediatrics

Conditions & Treatments

• Child and Teen Health - Infant and Toddler Health
• Lungs and Breathing - Pulmonary Hypertension
• Pregnancy and Reproduction - Neonatal Intensive Care
• Pregnancy and Reproduction - Maternal and Fetal Health
• Child and Teen Health
• Lungs and Breathing
• Pregnancy and Reproduction