Vijaya Karoor, PhD

Publications

• Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol. 2006 Mar;100(3):996-1002.
• Karoor V, Walchak SJ, Miller YE, Dempsey EC. Role of rho in the increased migration of pulmonary artery smooth muscle cells observed in the neprilysin knockout mouse. Chest. 2005 Dec;128(6 Suppl):582S-583S.
• Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. AJRCCM vol 2 A 704 2005
• Noriyuki Homma , Vijaya Karoor, Tetsutaro Nagaoka, Masatoshi Imamura, Ivan F. McMurtry and Masahiko Oka DHEA Prevents and Reverses Monocroataline-induced severe Pulmonary Hypertension and Pulmonary Neointima Formation in Pnemonectomized rats. Circulation supp vol 112 II-98 A554 2005
• Vijaya karoor, Mysan Le, Cindy Avram Carol Wehling , Dempsey EC and Miller YE. Alveolar Hypoxia and Carcinogenesis Keystone Symposia Hypoxia and Development, Physiology and Disease Breckenridge 2006
• Noriyuki Homma ,Tetsutaro Nagaoka, Yoshiteru Morio, Sarah A. Gebb Vijaya Karoor, Ivan F. McMurtry and Masahiko Oka Endothelin-1 and Sertonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic rat pulmonary circulation Keystone Symposia Hypoxia and Development, Physiology and Disease Breckenridge 2006
• Vijaya karoor, Mysan Le, Cindy Avram Carol Wehling , Dempsey EC and Miller YE. Alveolar Hypoxia and Carcinogenesis Keystone Symposia Hypoxia and Development, Physiology and Disease Breckenridge 2006
• Dehydrepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension. Cardiovasc Res 2007 Masahiko Oka, Vijaya Karoor, Noriyuki Homma, Tetsutaro Nagaoka, Eiko Sako, Scott M> Gombleski, Jennifer Limbird, Mastoshi Imamura. Sarah A gebb, Karen Fagan and Ivan F. McMurtrty.
• Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, Walchak SJ, Laudi S, Le M, Oka M, Majka S, Cool CD, Fagan KA, Klemm DJ, Hersh LB, Gerard NP, Gerard C, Miller YE. Am J Pathol. 2009 Mar;174(3):782-96.
• Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M. Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L71-8. Epub 2008 May 9.
• Sustained hypoxia promotes the development of a pulmonary artery-specific chronic inflammatory microenvironment. Burke DL, Frid MG, Kunrath CL, Karoor V, Anwar A, Wagner BD, Strassheim D, Stenmark KR. Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L238-50. Epub 2009 May 22.
• Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression. Keith RL, Karoor V, Mozer AB, Hudish TM, Le M, Miller YE. Lung Cancer. 2010 Jan 27. [Epub ahead of print]
• VEGFR-2 Targeted Chemoprevention of Murine Lung Tumors Vijaya Karoor1,4, Mysan Le3, Daniel Merrick2,3,4, Edward C. Dempsey1,3,4 and York E. Miller1,3,4 Departments of Medicine1 and Pathology2, University of Colorado Denver and Department of Veterans Affairs Medical Center3, University of Colorado Cancer Center4, Denver, CO. Cancer prevention Research
• Neprilysin Regulates PASMC Phenotype and PDGFR Signaling in Mice. Short title: Neprilysin regulates PDGFR signaling in PA SMC Vijaya Karoor PhD*, Masahiko Oka MD PhD#, Sandra J. Walchak*, Hersh LB, York E. Miller MD Edward C. Dempsey MD*
• Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors. Cancer Prev Res (Phila). 2010 Sep;3(9):1141-7.
• Neprilysin Regulates PASMC Phenotype And PDGFR Signaling In Mice V.Am J Respir Crit Care Med 181;2010:A1171
• Neprilysin Regulates Cytoskeletal Protein Expression And Phenotype Of Murine Pulmonary Artery Smooth Muscle Cells Am J Respir Crit Care Med 189;2014:A3289
• Am J Respir Crit Care Med. 2013 Feb 1;187(3):330-1 Sleep-disordered breathing, hypoxemia, and cancer mortality. Miller YE, Karoor V, Dempsey EC, Fagan KA.
• Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism. Karoor V, Oka M, Walchak SJ, Hersh LB, Miller YE, Dempsey EC. Hypertension. 2013 Apr;61(4):921-30. doi: 10.1161/HYPERTENSIONAHA.111.199588. Epub 2013 Feb 4.
• Vascular Bed Specific Functions Of Neprilysin In Smooth Muscle Cells Vijaya Karoor , Ph.D 1 , , 2 , David Irwin , PhD 1 , Timothy M. Sullivan , BS 1 , Zoe Loomis , Ms 1 , Louis B. Hersh , Ph.D. 3 , Edward C. Dempsey , MD 1 , Ajrccm conference.2015.191.1_MeetingAbstracts.A1935
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017 Feb 2;12(2):e0171219. PubMed PMID: 28152051
• Lapel M, Weston P, Strassheim D, Karoor V, Burns N, Lyubchenko T, Paucek P, Stenmark KR, Gerasimovskaya EV. Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C56-C70. PubMed PMID: 27856430
• Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC. Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):154-163. PubMed PMID: 29191928
• Fini MA, Gaydos J, McNally A, Karoor V, Burnham EL. Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1047-L1057. PubMed PMID: 28839105
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark KR, Buehler PW, Irwin DC. Correction: Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017;12(3):e0173652. PubMed PMID: 28264019
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017;12(2):e0171219. PubMed PMID: 28152051
• Lapel M, Weston P, Strassheim D, Karoor V, Burns N, Lyubchenko T, Paucek P, Stenmark KR, Gerasimovskaya EV. Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells. Am J Physiol Cell Physiol. 2017 Jan 1;312(1):C56-C70. PubMed PMID: 27856430
• Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020 Feb 11;9(2). PubMed PMID: 32054096
• Dempsey E, Strassheim D, Karoor V. Impaired vascular function with age and RhoGTPase. Aging (Albany NY). 2020 Jan 6;12(1):1-2. PubMed PMID: 31905168
• Strassheim D, Dempsey EC, Gerasimovskaya E, Stenmark K, Karoor V. Role of Inflammatory Cell Subtypes in Heart Failure. J Immunol Res. 2019;2019:2164017. PubMed PMID: 31565659
• Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 Aug 8;4(15). PubMed PMID: 31391342
• Strassheim D, Gerasimovskaya E, Irwin D, Dempsey EC, Stenmark K, Karoor V. RhoGTPase in Vascular Disease. Cells. 2019 Jun 6;8(6). PubMed PMID: 31174369
• Strassheim D, Verin A, Batori R, Nijmeh H, Burns N, Kovacs-Kasa A, Umapathy NS, Kotamarthi J, Gokhale YS, Karoor V, Stenmark KR, Gerasimovskaya E. P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases. Int J Mol Sci. 2020 Sep 18;21(18). PubMed PMID: 32962005
• Verin AD, Batori R, Kovacs-Kasa A, Cherian-Shaw M, Kumar S, Czikora I, Karoor V, Strassheim D, Stenmark KR, Gerasimovskaya EV. Extracellular adenosine enhances pulmonary artery vasa vasorum endothelial cell barrier function via Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms. Am J Physiol Cell Physiol. 2020 Jul 1;319(1):C183-C193. PubMed PMID: 32432925
• Strassheim D, Karoor V, Nijmeh H, Weston P, Lapel M, Schaack J, Sullivan T, Dempsey EC, Stenmark KR, Gerasimovskaya E. c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. Cells. 2020 Feb 11;9(2). PubMed PMID: 32054096
• Dempsey E, Strassheim D, Karoor V. Impaired vascular function with age and RhoGTPase. Aging (Albany NY). 2020 Jan 6;12(1):1-2. PubMed PMID: 31905168
• Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 Nov 29;10(12). PubMed PMID: 34943862
• Karoor V, Swindle D, Pak DI, Strassheim D, Fini MA, Dempsey E, Stenmark KR, Hassell K, Nuss R, Buehler PW, Irwin DC. Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia. Pulm Circ. 2021 Oct-Dec;11(4):20458940211056806. PubMed PMID: 34777787
• Karoor V, Strassheim D, Sullivan T, Verin A, Umapathy NS, Dempsey EC, Frank DN, Stenmark KR, Gerasimovskaya E. The Short-Chain Fatty Acid Butyrate Attenuates Pulmonary Vascular Remodeling and Inflammation in Hypoxia-Induced Pulmonary Hypertension. Int J Mol Sci. 2021 Sep 14;22(18). PubMed PMID: 34576081
• Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107. PubMed PMID: 34478834
• Collins CB, Nguyen TT, Leddy RS, Alula KM, Yeckes AR, Strassheim D, Aherne CM, Luck ME, Karoor V, Jedlicka P, Pierce A, de Zoeten EF. Heat shock factor 1 drives regulatory T-cell induction to limit murine intestinal inflammation. Mucosal Immunol. 2023 Nov 7. [Epub ahead of print] PubMed PMID: 37944754
• Chakraborty A, Nathan A, Orcholski M, Agarwal S, Shamskhou EA, Auer N, Mitra A, Guardado ES, Swaminathan G, Condon DF, Yu J, McCarra M, Juul NH, Mallory A, Guzman-Hernandez RA, Yuan K, Rojas V, Crossno JT, Yung LM, Yu PB, Spencer T, Winn RA, Frump A, Karoor V, Lahm T, Hedlin H, Fineman JR, Lafyatis R, Knutsen CNF, Alvira CM, Cornfield DN, de Jesus Perez VA. Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. Eur Respir J. 2023 Jun;61(6). PubMed PMID: 37024132
• Abstract 15406: Loss of Estrogen Receptor a Inhibits Angiogenic Function in Right Ventricular Endothelial Cells (RVECs) Jiajun Li, vijaya karoor, Andrea L Frump and Tim Lahm CirculationVolume 148, Issue Suppl_17 November 2023 AbstractExport Citations
• American Journal of Respiratory and Critical Care Medicine 2023;207:A3791 17b-estradiol Prevents NLRP3 Activation and Contractile Dysfunction in Right Ventricles and Right Ventricle Cardiomyocytes From Rats With Pulmonary Hypertension R. Sobrano Fais 3, J. Li 3, E.A. Mickler 1, V.L. Karoor 3, A.L. Frump 2, L. Moreno-Vinasco 3, A. Walts 3, T.G. Cook 1, A.J. Fisher 1, T. Lahm 4,

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000