Richard Hughes, MD

Professional Titles

• Neurohospitalist
• Consultative Neurology
• Vascular Neurology

Research Interests

I have participated in multiple clinical trials on acute stroke resuscitation, secondary prevention of stroke and the detection of intracranial aneurysms. Current trials include treatment of intracerebral hemorrhage with activated Factor VII, the use of warfarin and aspirin in heart failure, and treatment of insulin resistance to reduce stroke.

Publications

• Stroke. 2010 Apr;41(4):732-8
• Level of systolic blood pressure within the normal range and risk of recurrent stroke.Ovbiagele B, Diener HC, Yusuf S, Martin RH, Cotton D, Vinisko R, Donnan GA, Bath PM; PROFESS Investigators.JAMA. 2011 Nov 16;306(19):2137-44.
• Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS, Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G. for the ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group Investigators. The Lancet 375:1695 - 1703, 15 May 2010 Collaborators (752)
• Reversible Cerebral Vasoconstriction Syndrome 3 Months after Blood Transfusion. Braun CN, Hughes RL, Bosque PJ. J Stroke Cerebrovasc Dis. 2012 Feb 15. [Epub ahead of print]
• Case D, Seinfeld J, Folzenlogen Z,Simpson J, Hughes R. Acute posterior Multifocal Placoid Pigment Epitheliopathy associated with Stroke: A Case Report and review. Journal of Stroke and Cerebrovascular Diseases 2015 24:e295-302.
• Final results of NIH Multicenter IRIS trial. Published Feb 17th simultaneous with the ISC presentation in Los Angelos.
• Keenan, WN et al. Insulin Resistance Intervention in Stroke Trial. N Engl J Med 2016. DOI:10:1056/NEJMoa156930
• Hughes RL, Nagel M. Herpes Simplex Virus Infection in the Acute Presentation of Fibromuscular Dysplasia. World Stroke Organization Conference, Hyderabad India. Oct 2016.
• Keenan, WN et al. Insulin Resistance Intervention in Stroke Trial. N Engl J Med 2016. ISC Feb 2016
• Hughes RL, Nagel M: Is HSV-1 the cause of most Cervical Fibromuscular Dysplasia? ESOC Gotherberg, Sweden May 2018
• Viscoli CM, Inzucchi SE, Young LH, Insogna KL, Conwit R, Furie KL, Gorman M, Kelly MA, Lovejoy AM, Kernan WN, IRIS Trial Investigators: Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial. J Clin Endocrinol Metab. 2017 Mar 1;102(3):914-922. doi: 10.1210/jc.2016-3237. PMID: 27935736; PubMed Central PMCID: PMC5460686
• Young LH, Viscoli CM, Curtis JP, Inzucchi SE, Schwartz GG, Lovejoy AM, Furie KL, Gorman MJ, Conwit R, Abbott JD, Jacoby DL, Kolansky DM, Pfau SE, Ling FS, Kernan WN, IRIS Investigators: Cardiac Outcomes After Ischemic Stroke or Transient Ischemic Attack: Effects of Pioglitazone in Patients With Insulin Resistance Without Diabetes Mellitus. Circulation. 2017 May 16;135(20):1882-1893. doi: 10.1161/CIRCULATIONAHA.116.024863
• Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS, Tirschwell DL; RESPECT Investigators: Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke. N Engl J Med. 2017 Sep 14;377(11):1022-1032. doi: 10.1056/NEJMoa1610057
• Furie KL, Viscoli CM, Gorman M, Ford GA, Young LH, Inzucchi SE, Guarino PD, Lovejoy AM, Conwit R, Tanne D, Kernan WN; IRIS Trial Investigators: Effects of pioglitazone on cognitive function in patients with a recent ischaemic stroke or TIA: a report from the IRIS trial. J Neurol Neurosurg Psychiatry. 2017 Sep 22. pii: jnnp-2017-316361. doi: 10.1136/jnnp-2017-316361
• Yaghi S, Furie KL, Viscoli CM, Kamel H, Gorman M, Dearborn J, Young LH, Inzucchi SE, Lovejoy AM, Kasner SE, Conwit R, Kernan WN, IRIS Trial Investigators: Pioglitazone Prevents Stroke in Patients with a Recent TIA or Ischemic Stroke: A Planned Secondary Analysis of the IRIS Trial. Circulation. 2017 Oct 30. pii: CIRCULATIONAHA.117.030458. doi: 10.1161/CIRCULATIONAHA.117.030458
• Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD, Dixit A, Furie KL, Kernan WN; IRIS Trial Investigators: Smoking Cessation and Outcome After Ischemic Stroke or TIA. Neurology 2017 Oct 17;89(16):1723-1729. doi: 10.1212/WNL.0000000000004524. Epub 2017 Sep 8. PubMed PMID: 28887378; PubMed Central PMCID: PMC5644463
• Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Stuart A, Young LH, IRIS Trial Investigators: Insulin Resistance Intervention After Stroke: Targeting Pioglitazone Hydrochloride Therapy After Stroke or Transient Ischemic Attack According to Pretreatment Risk for Stroke or Myocardial Infarction. JAMA Neurol. 2017 Nov 1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.2136
• Kernan WN, Viscoli CM, Dearborn JL, Kent DM, Conwit R, Fayad P, Furie KL, Gorman M, Guarino PD, Inzucchi SE, Stuart A, Young LH, IRIS Trial Investigators: Insulin Resistance Intervention After Stroke. JAMA Neurol. 2017 Nov 1;74(11):1319-1327. doi: 10.1001/jamaneurol.2017.213
• Grotta JC, Yamal JM, Parker SA, Rajan SS, Gonzales NR, Jones WJ, Alexandrov AW, Navi BB, Nour M, Spokoyny I, Mackey J, Persse D, Jacob AP, Wang M, Singh N, Alexandrov AV, Fink ME, Saver JL, English J, Barazangi N, Bratina PL, Gonzalez M, Schimpf BD, Ackerson K, Sherman C, Lerario M, Mir S, Im J, Willey JZ, Chiu D, Eisshofer M, Miller J, Ornelas D, Rhudy JP, Brown KM, Villareal BM, Gausche-Hill M, Bosson N, Gilbert G, Collins SQ, Silnes K, Volpi J, Misra V, McCarthy J, Flanagan T, Rao CPV, Kass JS, Griffin L, Rangel-Gutierrez N, Lechuga E, Stephenson J, Phan K, Sanders Y, Noser EA, Bowry R. Prospective, Multicenter, Controlled Trial of Mobile Stroke Units. N Engl J Med. 2021 Sep 9;385(11):971-981. PubMed PMID: 34496173

Professional Memberships

• American Medical Association, Member
• American Academy of Neurology, Member
• American Heart Association (AHA), Member
• North American Neuro-Ophthalmology Society, Member
• Colorado Society of Clinical Neurologists, Member

Practice Locations

UCHealth Stroke and Brain Aneurysm Center - Anschutz Medical Campus
12401 E 17th Ave
Leprino Building, 3rd floor
Aurora, CO 80045
720-848-2080

UCHealth Neurosciences Center - Anschutz Medical Campus
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Anschutz Inpatient Pavilion 2 - Anschutz Medical Campus
12505 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Neurology, Board Certification (1988)
• Vascular Neurology, Board Certification (2005, 2015)

Conditions & Treatments

• Brain and Nervous System
• Brain and Nervous System - Stroke