David Orlicky, PhD

Chong BM, Reigan P, Mayle-Combs KD, Orlicky DJ, McManaman JL Determinants of adipophilin function in milk lipid formation and secretion. Trends Endocrinol Metab. 2011 May 16. [Epub ahead of print] PMID:21592818

Russell TT, Schaack J, Orlicky DJ, Palmer C, Chang BH, Chan L, McManaman JL. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands. J Cell Sci. 2011 Aug 30. [Epub ahead of print]. PMID: 21878492

Gentile CL, Nivala AM, Gonzales JC, Pfaffenbach KT, Wang D, Wei Y, Jiang H, Orlicky DJ, Petersen DR, Pagliassotti MJ, Maclean KN. Experimental evidence for therapeutic potential of taurine in the treatment of non-alcoholic fatty liver disease. Am J Physiol Regul Integr Comp Physiol. 2011 Sep 28. [Epub ahead of print]. PMID: 21957160

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease. Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR. J Toxicol. 2012;2012:207594. Epub 2012 Jul 5 PMID:22829816

Kidney proteome changes provide evidence for a dynamic metabolism and regional redistribution of plasma proteins during torpor-arousal cycles of hibernation. (* Co-first authors) Jani A*, Orlicky DJ*, Karimpour-Fard A, Epperson LE, Russell RL, Hunter LE, Martin SL. Physiol Genomics. 2012 Jul 18;44(14):717-27. Epub 2012 May 29. PMID:22643061

Increased susceptibility of natural killer t cell deficient mice to acetaminophen-induced liver injury. Martin-Murphy BV, Kominsky DJ, Orlicky DJ, Donohue TM Jr, Ju C. Hepatology. 2012 Nov 13. doi: 10.1002/hep.26134. [Epub ahead of print] PMID:23150232

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in an early mouse model of ethanol-mediated steatosis. Colin T. Shearn, Rebecca L Smathers, Ph.D.; Hua Jiang, Ph.D; David J Orlicky, Ph.D.; Kenneth N Maclean, Ph.D; Dennis R Petersen, Ph.D.. Journal of Nutritional Biochemistry, Manuscript (JNB-12-281R2). Accepted for publication 12/06/2012.

Susceptibility of L-FABP-/- Mice to Oxidative Stress in Early-Stage Alcoholic Liver. Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR. J Lipid Res. 2013 Jan 28. [Epub ahead of print] PMID: 23359610

Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease. McManaman JL, Bales ES, Orlicky DJ, Jackman M, Maclean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS.J Lipid Res. 2013 Feb 12. [Epub ahead of print] PMID: 23402988

Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Exp Toxicol Pathol. 2014 Mar;66(2-3):129-38. PubMed PMID: 24373750

Shrotriya S, Tyagi A, Deep G, Orlicky DJ, Wisell J, Wang XJ, Sclafani RA, Agarwal R, Agarwal C. Grape seed extract and resveratrol prevent 4-nitroquinoline 1-oxide induced oral tumorigenesis in mice by modulating AMPK activation and associated biological responses. Mol Carcinog. 2013 Nov 14. [Epub ahead of print] PubMed PMID: 24243690

Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321

Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL. Dynamic regulation of hepatic lipid droplet properties by diet. PLoS One. 2013;8(7):e67631. PubMed PMID: 23874434

Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR. Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis. Free Radic Biol Med. 2013 Dec;65:680-92. PubMed PMID: 23872024

Orlicky DJ, Monks J, Stefanski AL, McManaman JL. Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion. PLoS One. 2013;8(6):e66837. PubMed PMID: 23825572

Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, Maclean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov;58(5):1632-43. PubMed PMID: 23813872

Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR. Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem. 2013 Aug;24(8):1436-45. PubMed PMID: 23465594

McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May;54(5):1346-59. PubMed PMID: 23402988

Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR. Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. J Lipid Res. 2013 May;54(5):1335-45. PubMed PMID: 23359610

Martin-Murphy BV, Kominsky DJ, Orlicky DJ, Donohue TM Jr, Ju C. Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury. Hepatology. 2013 Apr;57(4):1575-84. PubMed PMID: 23150232

Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. Exp Toxicol Pathol. 2014 Mar;66(2-3):129-38. doi: 10.1016/j.etp.2013.11.005. Epub 2013 Dec 25. PMID: 24373750

Cutaneous Injury-Related Structural Changes and Their Progression following Topical Nitrogen Mustard Exposure in Hairless and Haired Mice. Tewari-Singh N, Jain AK, Orlicky DJ, White CW, Agarwal R. PLoS One. 2014 Jan 8;9(1):e85402. doi: 10.1371/journal.pone.0085402. PMID: 24416404

Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. Toxicology. 2014 Jun 5;320:25-33. doi: 10.1016/j.tox.2014.02.013. Epub 2014 Mar 12. PMID: 24631667

Identification of 5' AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol. Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR. J Biol Chem. 2014 May 30;289(22):15449-15462. Epub 2014 Apr 10. PMID: 24722988

Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, Agarwal R, Day BJ. Free Radic Biol Med. 2014 Jul;72:285-95. doi: 10.1016/j.freeradbiomed.2014.04.022. Epub 2014 May 9. PMID: 24815113

Short Term Feeding of a High Fat Diet Exerts an Additive Effect on Hepatocellular Damage and Steatosis in Liver-Specific PTEN Knockout Mice. Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR. PLoS One. 2014 May 12;9(5):e96553. doi: 10.1371/journal.pone.0096553. eCollection 2014. PMID: 24818992

Increased methylation demand exacerbates ethanol-induced liver injury. Kharbanda KK, Todero SL, Thomes PG, Orlicky DJ, Osna NA, French SW, Tuma DJ. Exp Mol Pathol. 2014 May 16;97(1):49-56. doi: 10.1016/j.yexmp.2014.05.006. [Epub ahead of print] PMID: 24842317

Maternal Obesity Reduces Milk Lipid Production in Lactating Mice by Inhibiting Acetyl-CoA Carboxylase and Impairing Fatty Acid Synthesis. Saben JL, Bales ES, Jackman MR, Orlicky D, MacLean PS, McManaman JL. PLoS One. 2014 May 21;9(5):e98066. doi: 10.1371/journal.pone.0098066. eCollection 2014. PMID: 24849657

Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy. Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. J Am Soc Nephrol. 2014 May 29. pii: ASN.2013080901. [Epub ahead of print]. PMID: 24876114 [PubMed - as supplied by publisher

Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas. Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD. Front Immunol. 2014 Nov 25;5:587. doi: 10.3389/fimmu.2014.00587. eCollection 2014. PMID: 25505466

Goswami DG, Kumar D, Tewari-Singh N, Orlicky DJ, Jain AK, Kant R, Rancourt RC, Dhar D, Inturi S, Agarwal C, White CW, Agarwal R. Topical nitrogen mustard exposure causes systemic toxic effects in mice. Exp Toxicol Pathol. 2014 Dec 3. pii: S0940-2993(14)00176-6. doi: 10.1016/j.etp.2014.11.006. [Epub ahead of print] PMID: 25481215

INCREASED 4-HYDROXYNONENAL PROTEIN ADDUCTS IN MALE GSTA4-4/PPARa DOUBLE KNOCKOUT MICE ENHANCE INJURY DURING EARLY STAGES OF ALCOHOLIC LIVER DISEASE. Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 11:ajpgi.00154.2014. doi: 10.1152/ajpgi.00154.2014. [Epub ahead of print]. PMID: 25501545

Topical nitrogen mustard exposure causes systemic toxic effects in mice. Goswami DG, Kumar D, Tewari-Singh N, Orlicky DJ, Jain AK, Kant R, Rancourt RC, Dhar D, Inturi S, Agarwal C, White CW, Agarwal R.. Exp Toxicol Pathol. 2015 Feb;67(2):161-70. doi: 10.1016/j.etp.2014.11.006. Epub 2014 Dec 4. PMID: 25481215

Increased 4-hydroxylnoneanal protein adducts in male GSTA4-4/PPARa double knockout mice enhance injury during early stages of alcoholic liver disease. Ronis MJ, Mercer KE, Gannon B, Engi B, Zimniak P, Shearn CT, Orlicky DJ, Albano E, Badger TM, Petersen DR. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G403-15. doi: 10.1152/ajpgi.00154.2014. Epub 2014 Dec 11. PMID: 25501545

Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma. Singh S, Arcaroli JJ, Orlicky DJ, Chen Y, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Thompson DC, Vasiliou V. Pancreas. 2015 Nov 12. [Epub ahead of print] PMID: 26566217

Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Jain AK, Tewari-Singh N, Inturi S, Kumar D, Orlicky DJ, Agarwal C, White CW, Agarwal R. Toxicol Appl Pharmacol. 2015 Mar 16. pii: S0041-008X(15)00091-5. doi: 10.1016/j.taap.2015.03.009. [Epub ahead of print] PMID: 25791923

ALDH1B1 links Alcohol Consumption and Diabetes. Singh S, Chen Y, Matsumoto A, Orlicky DJ, Dong H, Thompson DC, Vasiliou V. Biochem Biophys Res Commun. 2015 Jun 15. pii: S0006-291X(15)30064-4. doi: 10.1016/j.bbrc.2015.06.011. [Epub ahead of print] PMID: 26086111

Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine. Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL. PLoS One. 2015 Jul 6;10(7):e0131944. doi: 10.1371/journal.pone.0131944. eCollection 2015. PMID: 26147095

Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney. Harris PS, Roy SR, Coughlan C, Orlicky DJ, Liang Y, Shearn CT, Roede JR, Fritz KS. Redox Biol. 2015 Jul 6;6:33-40. doi: 10.1016/j.redox.2015.06.021. [Epub ahead of print] PMID: 26177469

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap. Jiang H, Hurt KJ, Breen K, Stabler SP, Allen RH, Orlicky DJ, Maclean KN. Biol Open. 2015 Aug 14. pii: bio.013433. doi: 10.1242/bio.013433. [Epub ahead of print] PMID: 26276101

Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis. Shearn CT, Orlicky DJ, Saba LM, Shearn AH, Petersen DR. Free Radic Biol Med. 2015 Oct 27. pii: S0891-5849(15)01089-8. doi: 10.1016/j.freeradbiomed.2015.10.420. [Epub ahead of print] PMID: 26518673

Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Redox Biol. 2015 Nov 27;7:68-77. doi: 10.1016/j.redox.2015.11.013. [Epub ahead of print] PMID: 26654979

Shearn CT, Fritz KS, Shearn AH, Saba LM, Mercer KE, Engi B, Galligan JJ, Zimniak P, Orlicky DJ, Ronis MJ, Petersen DR. Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol. 2016 Apr;7:68-77. PubMed PMID: 26654979

Koppaka V, Chen Y, Mehta G, Orlicky DJ, Thompson DC, Jester JV, Vasiliou V. ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis. PLoS One. 2016 Jan 11;11(1):e0146433. PubMed PMID: 26751691

Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M. FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2017 Oct 31. [Epub ahead of print] PubMed PMID: 29089371

Shearn CT, Saba LM, Roede JR, Orlicky DJ, Shearn AH, Petersen DR. Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. Free Radic Biol Med. 2017 Dec;113:280-290. PubMed PMID: 28988798

Wang D, Luo Y, Myakala K, Orlicky DJ, Dobrinskikh E, Wang X, Levi M. Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats. Sci Rep. 2017 Aug 29;7(1):9793. PubMed PMID: 28851937

Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS. Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714. PubMed PMID: 28804911

Iwanaga R, Orlicky DJ, Arnett J, Guess MK, Hurt KJ, Connell KA. Comparative histology of mouse, rat, and human pelvic ligaments. Int Urogynecol J. 2016 Nov;27(11):1697-1704. PubMed PMID: 27091643

Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016 Apr 20;11(4):e0152877. PubMed PMID: 27097220

Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ. Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver. PLoS One. 2016 May 4;11(5):e0155282. PubMed PMID: 27145222

Prigge JR, Coppo L, Martin SS, Ogata F, Miller CG, Bruschwein MD, Orlicky DJ, Shearn CT, Kundert JA, Lytchier J, Herr AE, Mattsson Å, Taylor MP, Gustafsson TN, Arnér ESJ, Holmgren A, Schmidt EE. Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Rep. 2017 Jun 27;19(13):2771-2781. PubMed PMID: 28658624

Jacobs RL, Jiang H, Kennelly JP, Orlicky DJ, Allen RH, Stabler SP, Maclean KN. Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria. Mol Genet Metab. 2017 Apr;120(4):325-336. PubMed PMID: 28291718

Charkoftaki G, Chen Y, Han M, Sandoval M, Yu X, Zhao H, Orlicky DJ, Thompson DC, Vasiliou V. Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function. Chem Biol Interact. 2017 Oct 1;276:15-22. PubMed PMID: 28254523

Tewari-Singh N, Goswami DG, Kant R, Croutch CR, Casillas RP, Orlicky DJ, Agarwal R. Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity. Toxicol Appl Pharmacol. 2017 Feb 15;317:25-32. PubMed PMID: 28087322

Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V. Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med. 2017 Feb;103:48-56. PubMed PMID: 27939935

Rigby CM, Roy S, Deep G, Guillermo-Lagae R, Jain AK, Dhar D, Orlicky DJ, Agarwal C, Agarwal R. Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis. Carcinogenesis. 2017 Jan;38(1):40-50. PubMed PMID: 27729375

Shearn CT, Orlicky DJ, Petersen DR. Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease. Exp Mol Pathol. 2017 Nov 24. [Epub ahead of print] PubMed PMID: 29180269

Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016 Apr 28;11(4):e0154152. PubMed PMID: 27124661

Monks J, Dzieciatkowska M, Bales ES, Orlicky DJ, Wright RM, McManaman JL. Xanthine oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion. J Physiol. 2016 Oct 15;594(20):5899-5921. PubMed PMID: 27357166

Ranjit S, Dobrinskikh E, Montford J, Dvornikov A, Lehman A, Orlicky DJ, Nemenoff R, Gratton E, Levi M, Furgeson S. Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis. Kidney Int. 2016 Nov;90(5):1123-1128. PubMed PMID: 27555119

McGettigan BM, McMahan RH, Luo Y, Wang XX, Orlicky DJ, Porsche C, Levi M, Rosen HR. Sevelamer Improves Steatohepatitis, Inhibits Liver and Intestinal Farnesoid X Receptor (FXR), and Reverses Innate Immune Dysregulation in a Mouse Model of Non-alcoholic Fatty Liver Disease. J Biol Chem. 2016 Oct 28;291(44):23058-23067. PubMed PMID: 27605663

Osna NA, Feng D, Ganesan M, Maillacheruvu PF, Orlicky DJ, French SW, Tuma DJ, Kharbanda KK. Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury. World J Gastroenterol. 2016 Oct 14;22(38):8497-8508. PubMed PMID: 27784962

Libby AE, Bales E, Orlicky DJ, McManaman JL. Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. J Biol Chem. 2016 Nov 11;291(46):24231-24246. PubMed PMID: 27679530

PQQ prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. . Jacob E. Friedman, PhD,† Evgenia Dobrinskikh,¶ Alba Alfonso-Garcia, PhD,‡ Alexander Fast, ‡ Aimee L. Anderson†, Julie A. Reisz, PhD?, Angelo D’Alessandro, PhD?, Daniel Frank, PhD#, Becky A. de la Houssaye†, Linda K. Johnson, DVM**, Xiaoxin X. Wang, PhD,¶ David J. Orlicky, PhD**, Moshe Levi, MD¶, Eric O. Potma, PhD, ‡ Karim C. El Kasmi, MD, PhD† and Karen R. Jonscher, PhD 12/05/2017 Accepted for publication in Hepatology Communications

Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V. Catalase deletion promotes prediabetic phenotype in mice. Free Radic Biol Med. 2016 Dec 8;103:48-56. [Epub ahead of print] PubMed PMID: 27939935

Jones-Carson J, Husain M, Liu L, Orlicky DJ, Vázquez-Torres A. Cytochrome bd-Dependent Bioenergetics and Antinitrosative Defenses in Salmonella Pathogenesis. MBio. 2016 Dec 20;7(6). PubMed PMID: 27999164

Rigby CM, Roy S, Deep G, Guillermo-Lagae R, Jain AK, Dhar D, Orlicky DJ, Agarwal C, Agarwal R. Role of p53 in silibinin-mediated inhibition of ultraviolet B radiation-induced DNA damage, inflammation and skin carcinogenesis. Carcinogenesis. 2016 Oct 11. [Epub ahead of print] PubMed PMID: 27729375

Shearn CT, Orlicky DJ, Petersen DR. Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease. Exp Mol Pathol. 2018 Feb;104(1):1-8. PubMed PMID: 29180269

Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M. FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 Jan;29(1):118-137. PubMed PMID: 29089371

Wang D, Luo Y, Wang X, Orlicky DJ, Myakala K, Yang P, Levi M. The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Renal and Liver Disease in Western Diet Induced Obesity Mice. Int J Mol Sci. 2018 Jan 3;19(1). PubMed PMID: 29301371

Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018 Mar;2(3):313-328. PubMed PMID: 29507905

Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ. High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. PubMed PMID: 29507217

Monks J, Orlicky DJ, Stefanski AL, Libby AE, Bales ES, Rudolph MC, Johnson GC, Sherk VD, Jackman MR, Williamson K, Carlson NE, MacLean PS, McManaman JL. Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction. Nutr Diabetes. 2018 Apr 25;8(1):18. PubMed PMID: 29695710

Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB. Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes. 2018 Jul;67(7):1369-1379. PubMed PMID: 29643061

Bednarek J, Traxinger B, Brigham D, Roach J, Orlicky D, Wang D, Pelanda R, Mack CL. Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia. Hepatology. 2018 Nov;68(5):1890-1904. PubMed PMID: 29679373

Shearn CT, Pulliam CF, Pedersen K, Meredith K, Mercer KE, Saba LM, Orlicky DJ, Ronis MJ, Petersen DR. Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet. Alcohol Clin Exp Res. 2018 Jul;42(7):1192-1205. PubMed PMID: 29708596

Petersen DR, Orlicky DJ, Roede JR, Shearn CT. Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease. Exp Mol Pathol. 2018 Aug;105(1):32-36. PubMed PMID: 29852184

Merrick DT, Edwards MG, Franklin WA, Sugita M, Keith RL, Miller YE, Friedman MB, Dwyer-Nield LD, Tennis MA, O'Keefe MC, Donald EJ, Malloy JM, van Bokhoven A, Wilson S, Koch PJ, O'Shea C, Coldren C, Orlicky DJ, Lu X, Baron AE, Hickey G, Kennedy TC, Powell R, Heasley L, Bunn PA, Geraci M, Nemenoff RA. Altered Cell-Cycle Control, Inflammation, and Adhesion in High-Risk Persistent Bronchial Dysplasia. Cancer Res. 2018 Sep 1;78(17):4971-4983. PubMed PMID: 29997230

Libby AE, Bales ES, Monks J, Orlicky DJ, McManaman JL. Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature. J Lipid Res. 2018 Aug;59(8):1482-1500. PubMed PMID: 29866659

Davenport BJ, Martin CG, Beverley SM, Orlicky DJ, Vazquez-Torres A, Morrison TE. SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice. PLoS Negl Trop Dis. 2018 Oct;12(10):e0006921. PubMed PMID: 30372439

Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018 Jun 1;128(6):2226-2238. PubMed PMID: 29533924

Petersen DR, Saba LM, Sayin VI, Papagiannakopoulos T, Schmidt EE, Merrill GF, Orlicky DJ, Shearn CT. Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice. PLoS One. 2018;13(5):e0198139. PubMed PMID: 29799837

Orlicky DJ, Libby AE, Bales ES, McMahan RH, Monks J, La Rosa FG, McManaman JL. Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. J Physiol. 2018 Dec 8. [Epub ahead of print] PubMed PMID: 30536914

McGettigan B, McMahan R, Orlicky D, Burchill M, Danhorn T, Francis P, Cheng LL, Golden-Mason L, Jakubzick CV, Rosen HR. Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages. Hepatology. 2019 Jul;70(1):67-83. PubMed PMID: 30516830

Shearn CT, Fennimore B, Orlicky DJ, Gao YR, Saba LM, Battista KD, Aivazidis S, Assiri M, Harris PS, Michel C, Merrill GF, Schmidt EE, Colgan SP, Petersen DR. Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response. Free Radic Biol Med. 2019 Nov 1;143:101-114. PubMed PMID: 31377417

Guerra DD, Bok R, Vyas V, Orlicky DJ, Lorca RA, Hurt KJ. Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17541-17546. PubMed PMID: 31405982

Andres-Hernando A, Lanaspa MA, Kuwabara M, Orlicky DJ, Cicerchi C, Bales E, Garcia GE, Roncal-Jimenez CA, Sato Y, Johnson RJ. Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F941-F948. PubMed PMID: 31411075

Ladinsky MS, Mardones GA, Orlicky DJ, Howell KE, McManaman JL. Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features. J Mammary Gland Biol Neoplasia. 2019 Dec;24(4):293-304. PubMed PMID: 31709487

Aivazidis S, Jain A, Rauniyar AK, Anderson CC, Marentette JO, Orlicky DJ, Fritz KS, Harris PS, Siegel D, Maclean KN, Roede JR. SNARE proteins rescue impaired autophagic flux in Down syndrome. PLoS One. 2019;14(11):e0223254. PubMed PMID: 31714914

Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ, Suchy FJ. Up-regulation of miR-let7a-5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis. Hepatol Commun. 2019 Dec;3(12):1674-1686. PubMed PMID: 31832574

Orlicky DJ, Libby AE, Bales ES, McMahan RH, Monks J, La Rosa FG, McManaman JL. Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. J Physiol. 2019 Mar;597(6):1565-1584. PubMed PMID: 30536914

Ali HR, Assiri MA, Harris PS, Michel CR, Yun Y, Marentette JO, Huynh FK, Orlicky DJ, Shearn CT, Saba LM, Reisdorph R, Reisdorph N, Hirschey MD, Fritz KS. Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism. J Proteome Res. 2019 Apr 5;18(4):1513-1531. PubMed PMID: 30644754

Rigby C, Deep G, Jain A, Orlicky DJ, Agarwal C, Agarwal R. Silibinin inhibits ultraviolet B radiation-induced mast cells recruitment and bone morphogenetic protein 2 expression in the skin at early stages in Ptch( /-) mouse model of basal cell carcinoma. Mol Carcinog. 2019 Jul;58(7):1260-1271. PubMed PMID: 30912211

Presby DM, Jackman MR, Rudolph MC, Sherk VD, Foright RM, Houck JA, Johnson GC, Orlicky DJ, Melanson EL, Higgins JA, MacLean PS. Compensation for cold-induced thermogenesis during weight loss maintenance and regain. Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E977-E986. PubMed PMID: 30912962

McLoughlin MR, Orlicky DJ, Prigge JR, Krishna P, Talago EA, Cavigli IR, Eriksson S, Miller CG, Kundert JA, Sayin VI, Sabol RA, Heinemann J, Brandenberger LO, Iverson SV, Bothner B, Papagiannakopoulos T, Shearn CT, Arnér ESJ, Schmidt EE. TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11408-11417. PubMed PMID: 31097586

Godri Pollitt KJ, Kim JH, Peccia J, Elimelech M, Zhang Y, Charkoftaki G, Hodges B, Zucker I, Huang H, Deziel NC, Murphy K, Ishii M, Johnson CH, Boissevain A, O'Keefe E, Anastas PT, Orlicky D, Thompson DC, Vasiliou V. 1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs. Sci Total Environ. 2019 Nov 10;690:853-866. PubMed PMID: 31302550

Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M. Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice. J Biol Chem. 2020 Apr 3;295(14):4733-4747. PubMed PMID: 32075905

Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson R, Lanaspa M. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2020 Dec 15. [Epub ahead of print] PubMed PMID: 33320834

Guerra DD, Bok R, Cari EL, Nicholas C, Orlicky DJ, Johnson J, Hurt KJ. Effect of neuronal nitric oxide synthase serine-1412 phosphorylation on hypothalamic-pituitary-ovarian function and leptin response. Biol Reprod. 2020 May 26;102(6):1281-1289. PubMed PMID: 32101284

Lorca RA, Matarazzo CJ, Bales ES, Houck JA, Orlicky DJ, Euser AG, Julian CG, Moore LG. AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies. Am J Physiol Heart Circ Physiol. 2020 Jul 1;319(1):H203-H212. PubMed PMID: 32502374

Andres-Hernando A, Orlicky DJ, Kuwabara M, Ishimoto T, Nakagawa T, Johnson RJ, Lanaspa MA. Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction. Cell Metab. 2020 Jul 7;32(1):117-127.e3. PubMed PMID: 32502381

Iwanaga R, Truong BT, Hsu JY, Lambert KA, Vyas R, Orlicky D, Shellman YG, Tan AC, Ceol C, Artinger KB. Loss of prdm1a accelerates melanoma onset and progression. Mol Carcinog. 2020 Sep;59(9):1052-1063. PubMed PMID: 32562448

Andres-Hernando A, Kuwabara M, Orlicky DJ, Vandenbeuch A, Cicerchi C, Kinnamon SC, Finger TE, Johnson RJ, Lanaspa MA. Sugar causes obesity and metabolic syndrome in mice independently of sweet taste. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E276-E290. PubMed PMID: 32574112

Dhar D, Raina K, Kumar D, Wempe MF, Bagby SM, Pitts TM, Orlicky DJ, Agarwal C, Messersmith WA, Agarwal R. Bitter melon juice intake with gemcitabine intervention circumvents resistance to gemcitabine in pancreatic patient-derived xenograft tumors. Mol Carcinog. 2020 Oct;59(10):1227-1240. PubMed PMID: 32816368

Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jirón Tamburini BA. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2020 Sep 19. [Epub ahead of print] PubMed PMID: 32961356

Ghosh S, Devereaux MW, Anderson AL, Gehrke S, Reisz JA, D'Alessandro A, Orlicky DJ, Lovell M, El Kasmi KC, Shearn CT, Sokol RJ. NF-?B Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis. Hepatology. 2021 Jul 26. [Epub ahead of print] PubMed PMID: 34310734

Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2020 Oct 1. [Epub ahead of print] PubMed PMID: 33004979

Petrash JM, Shieh B, Ammar DA, Pedler MG, Orlicky DJ. Diabetes-Independent Retinal Phenotypes in an Aldose Reductase Transgenic Mouse Model. Metabolites. 2021 Jul 10;11(7). PubMed PMID: 34357344

Golla JP, Kandyliari A, Tan WY, Chen Y, Orlicky DJ, Thompson DC, Shah YM, Vasiliou V. Interplay between APC and ALDH1B1 in a newly developed mouse model of colorectal cancer. Chem Biol Interact. 2020 Nov 1;331:109274. PubMed PMID: 33007288

El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic Activation of Hepatic Farnesoid X Receptor Prevents Parenteral Nutrition Associated Cholestasis in Mice. Hepatology. 2021 Aug 13. [Epub ahead of print] PubMed PMID: 34387888

Thompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. Ocul Surf. 2021 Oct;22:190-203. PubMed PMID: 34425299

Andres-Hernando A, Cicerchi C, Kuwabara M, Orlicky DJ, Sanchez-Lozada LG, Nakagawa T, Johnson RJ, Lanaspa MA. Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation. Nat Metab. 2021 Sep;3(9):1189-1201. PubMed PMID: 34552272

Tuttle KD, Waugh KA, Araya P, Minter R, Orlicky DJ, Ludwig M, Andrysik Z, Burchill MA, Tamburini BAJ, Sempeck C, Smith K, Granrath R, Tracy D, Baxter J, Espinosa JM, Sullivan KD. JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell Rep. 2020 Nov 17;33(7):108407. PubMed PMID: 33207208

McMahan RH, Najarro KM, Mullen JE, Paul MT, Orlicky DJ, Hulsebus HJ, Kovacs EJ. A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age. Immun Ageing. 2021 Sep 23;18(1):37. PubMed PMID: 34556145

Orlicky DJ, Guess MK, Bales ES, Rascoff LG, Arruda JS, Hutchinson-Colas JA, Johnson J, Connell KA. Using the Novel Pelvic Organ Prolapse Histology Quantification System to Identify Phenotypes in Uterosacral Ligaments in Women with Pelvic Organ Prolapse. Am J Obstet Gynecol. 2020 Oct 29. [Epub ahead of print] PubMed PMID: 33130030

Nordeen SK, Su LJ, Osborne GA, Hayman PM, Orlicky DJ, Wessells VM, van Bokhoven A, Flaig TW. Titration of Androgen Signaling: How Basic Studies Have Informed Clinical Trials Using High-Dose Testosterone Therapy in Castrate-Resistant Prostate Cancer. Life (Basel). 2021 Aug 27;11(9). PubMed PMID: 34575033

Dobrinskikh E, Al-Juboori SI, Zarate MA, Zheng L, De Dios R, Balasubramaniyan D, Sherlock LG, Orlicky DJ, Wright CJ. Pulmonary implications of acetaminophen exposures independent of hepatic toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L941-L953. PubMed PMID: 34585971

Chen Y, Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Wan F, Ginsberg G, Thompson DC, Vasiliou V. Oxidative stress and genotoxicity in 1,4-dioxane liver toxicity as evidenced in a mouse model of glutathione deficiency. Sci Total Environ. 2021 Sep 30;:150703. [Epub ahead of print] PubMed PMID: 34600989

Bertol BC, Bales ES, Calhoun JD, Mayberry A, Ledezma ML, Sams S, Orlicky DJ, Donadi EA, Haugen BR MD, French J. Lenvatinib plus Anti-PD-1 Combination Therapy for Advanced Cancers: Defining Mechanisms of Resistance in an Inducible Transgenic Model of Thyroid Cancer. Thyroid. 2021 Oct 12. [Epub ahead of print] PubMed PMID: 34641722

El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2021 Oct 19. [Epub ahead of print] PubMed PMID: 34664730

Sherlock LG, Balasubramaniyan D, Zheng L, Grayck M, McCarthy WC, De Dios RC, Zarate MA, Orlicky DJ, De Dios R, Wright CJ. APAP-induced I?Bß/NF?B signaling drives hepatic IL6 expression and associated sinusoidal dilation. Toxicol Sci. 2021 Nov 2. [Epub ahead of print] PubMed PMID: 34726736

Orlicky DJ, Guess MK, Bales ES, Rascoff LG, Arruda JS, Hutchinson-Colas JA, Johnson J, Connell KA. Using the novel pelvic organ prolapse histologic quantification system to identify phenotypes in uterosacral ligaments in women with pelvic organ prolapse. Am J Obstet Gynecol. 2021 Jan;224(1):67.e1-67.e18. PubMed PMID: 33130030

Andres-Hernando A, Jensen TJ, Kuwabara M, Orlicky DJ, Cicerchi C, Li N, Roncal-Jimenez CA, Garcia GE, Ishimoto T, Maclean PS, Bjornstad P, Sanchez-Lozada LG, Kanbay M, Nakagawa T, Johnson RJ, Lanaspa MA. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight. 2021 Jan 11;6(1). PubMed PMID: 33320834

Miller CG, Kundert JA, Prigge JR, Amato JA, Perez AE, Coppo L, Rizzo GN, Kavanaugh MP, Orlicky DJ, Shearn CT, Schmidt EE. Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption. Antioxidants (Basel). 2021 Feb 27;10(3). PubMed PMID: 33673577

Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Toxicol Sci. 2021 Sep 28;183(2):338-351. PubMed PMID: 33693819

Dobrinskikh E, Sherlock LG, Orlicky DJ, Zheng L, De Dios R, Balasubramaniyan D, Sizemore T, Butler B, Wright CJ. The developing murine lung is susceptible to acetaminophen toxicity. Am J Physiol Lung Cell Mol Physiol. 2021 May 1;320(5):L969-L978. PubMed PMID: 33759579

Niemeyer CS, Mescher T, Griggs R, Orlicky DJ, Wilkerson GK, Bubak AN, Hassell JE Jr, Feia B, Mahalingam R, Traina-Dorge V, Nagel MA. Histopathological Analysis of Adrenal Glands after Simian Varicella Virus Infection. Viruses. 2021 Jun 26;13(7). PubMed PMID: 34206909

Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ, Suchy FJ. miR-199a-5p inhibits the Expression of ABCB11 in Obstructive Cholestasis. J Biol Chem. 2021 Nov 11;:101400. [Epub ahead of print] PubMed PMID: 34774795

Bertol BC, Bales ES, Calhoun JD, Mayberry A, Ledezma ML, Sams SB, Orlicky DJ, Donadi EA, Haugen BR, French JD. Lenvatinib Plus Anti-PD-1 Combination Therapy for Advanced Cancers: Defining Mechanisms of Resistance in an Inducible Transgenic Model of Thyroid Cancer. Thyroid. 2022 Feb;32(2):153-163. PubMed PMID: 34641722

El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):1096-1106. PubMed PMID: 34664730

Sherlock LG, Balasubramaniyan D, Zheng L, Grayck M, McCarthy WC, De Dios RC, Zarate MA, Orlicky DJ, De Dios R, Wright CJ. APAP-Induced I?Bß/NF?B Signaling Drives Hepatic Il6 Expression and Associated Sinusoidal Dilation. Toxicol Sci. 2022 Jan 24;185(2):158-169. PubMed PMID: 34726736

Koelmel JP, Tan WY, Li Y, Bowden JA, Ahmadireskety A, Patt AC, Orlicky DJ, Mathé E, Kroeger NM, Thompson DC, Cochran JA, Golla JP, Kandyliari A, Chen Y, Charkoftaki G, Guingab-Cagmat JD, Tsugawa H, Arora A, Veselkov K, Kato S, Otoki Y, Nakagawa K, Yost RA, Garrett TJ, Vasiliou V. Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage. Hepatol Commun. 2022 Mar;6(3):513-525. PubMed PMID: 34811964

Schaefer REM, Callahan RC, Atif SM, Orlicky DJ, Cartwright IM, Fontenot AP, Colgan SP, Onyiah JC. Disruption of monocyte-macrophage differentiation and trafficking by a heme analog during active inflammation. Mucosal Immunol. 2022 Feb;15(2):244-256. PubMed PMID: 34916594

Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, McCullough RL, Fritz KS. Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker. Alcohol. 2022 Mar;99:35-48. PubMed PMID: 34923085

Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chem Biol Interact. 2022 Mar 1;355:109804. PubMed PMID: 35123994

Paudel S, Raina K, Tiku VR, Maurya A, Orlicky DJ, You Z, Rigby CM, Deep G, Kant R, Raina B, Agarwal C, Agarwal R. Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch /- mice. Carcinogenesis. 2022 Jun 27;43(6):557-570. PubMed PMID: 35184170

Andres-Hernando A, Orlicky DJ, Kuwabara M, Cicerchi C, Pedler M, Petrash MJ, Johnson RJ, Tolan DR, Lanaspa MA. Endogenous Fructose Production and Metabolism Drive Metabolic Dysregulation and Liver Disease in Mice with Hereditary Fructose Intolerance. Nutrients. 2023 Oct 16;15(20). PubMed PMID: 37892451

Shearn CT, Anderson AL, Devereaux MW, El Kasmi KC, Orlicky DJ, Sokol RJ. Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition. PLoS One. 2023;18(8):e0290385. PubMed PMID: 37647292

Khair S, Walrath TM, Curtis BJ, Orlicky DJ, McMahan RH, Kovacs EJ. Ethanol exacerbates pulmonary complications after burn injury in mice, regardless of frequency of ethanol exposures. Burns. 2023 Jul 26. [Epub ahead of print] PubMed PMID: 37574341

Walrath T, Najarro KM, Giesy LE, Khair S, Frank DN, Robertson CE, Orlicky DJ, Quillinan N, Idrovo JP, McMahan RH, Kovacs EJ. REMOTE BURN INJURY IN AGED MICE INDUCES COLONIC LYMPHOID AGGREGATE EXPANSION AND DYSBIOSIS OF THE FECAL MICROBIOME WHICH CORRELATES WITH NEUROINFLAMMATION. Shock. 2023 Oct 1;60(4):585-593. PubMed PMID: 37548929

Okamura K, Lu S, He Z, Altmann C, Montford JR, Li AS, Lucia MS, Orlicky DJ, Weiser-Evans M, Faubel S. IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model. Am J Physiol Renal Physiol. 2023 Sep 1;325(3):F328-F344. PubMed PMID: 37471421

Ghosh S, Devereaux MW, Orlicky DJ, Sokol RJ. Publisher Correction: Pharmacologic inhibition of HNF4a prevents parenteral nutrition associated cholestasis in mice. Sci Rep. 2023 Jul 19;13(1):11673. PubMed PMID: 37468479

Orlicky DJ, Smith EE, Bok R, Guess MK, Rascoff LG, Arruda JS, Hutchinson-Colas JA, Johnson J, Connell KA. Estrogen and Androgen Receptor Status in Uterosacral Ligaments of Women with Pelvic Organ Prolapse Stratified by the Pelvic Organ Prolapse Histology Quantification System. Reprod Sci. 2023 Jul 10. [Epub ahead of print] PubMed PMID: 37430099

Davidson EA, Chen Y, Singh S, Orlicky DJ, Thompson B, Wang Y, Charkoftaki G, Furnary TA, Cardone RL, Kibbey RG, Shearn CT, Nebert DW, Thompson DC, Vasiliou V. Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype. bioRxiv. 2023 Jun 26. PubMed PMID: 37398356

Waugh KA, Minter R, Baxter J, Chi C, Galbraith MD, Tuttle KD, Eduthan NP, Kinning KT, Andrysik Z, Araya P, Dougherty H, Dunn LN, Ludwig M, Schade KA, Tracy D, Smith KP, Granrath RE, Busquet N, Khanal S, Anderson RD, Cox LL, Estrada BE, Rachubinski AL, Lyford HR, Britton EC, Fantauzzo KA, Orlicky DJ, Matsuda JL, Song K, Cox TC, Sullivan KD, Espinosa JM. Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model. Nat Genet. 2023 Jun;55(6):1034-1047. PubMed PMID: 37277650

Andres-Hernando A, Orlicky DJ, Cicerchi C, Kuwabara M, Garcia GE, Nakagawa T, Sanchez-Lozada LG, Johnson RJ, Lanaspa MA. High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in Obese Mice with Metabolic Syndrome. Biomolecules. 2023 Apr 30;13(5). PubMed PMID: 37238651

McMahan RH, Hulsebus HJ, Najarro KM, Giesy LE, Frank DN, Orlicky DJ, Kovacs EJ. Age-Related Intestinal Dysbiosis and Enrichment of Gut-specific Bacteria in the Lung Are Associated With Increased Susceptibility to Streptococcus pneumoniae Infection in Mice. Front Aging. 2022;3. PubMed PMID: 35392033

Ghosh S, Devereaux MW, Orlicky DJ, Sokol RJ. Pharmacologic inhibition of HNF4a prevents parenteral nutrition associated cholestasis in mice. Sci Rep. 2023 May 12;13(1):7752. PubMed PMID: 37173326

Hazleton KZ, Martin CG, Orlicky DJ, Arnolds KL, Nusbacher NM, Moreno-Huizar N, Armstrong M, Reisdorph N, Lozupone CA. Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice. NPJ Biofilms Microbiomes. 2022 Apr 1;8(1):15. PubMed PMID: 35365681

Andres-Hernando A, Cicerchi C, Garcia GE, Orlicky DJ, Stenvinkel P, Johnson RJ, Lanaspa MA. Phosphate depletion in insulin-insensitive skeletal muscle drives AMPD activation and sarcopenia in chronic kidney disease. iScience. 2023 Apr 21;26(4):106355. PubMed PMID: 36994079

Charkoftaki G, Tan WY, Berrios-Carcamo P, Orlicky DJ, Golla JP, Garcia-Milian R, Aalizadeh R, Thomaidis NS, Thompson DC, Vasiliou V. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice. Chem Biol Interact. 2022 Jun 1;360:109931. PubMed PMID: 35429548

Hulsebus HJ, Najarro KM, McMahan RH, Boe DM, Orlicky DJ, Kovacs EJ. Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection. Front Immunol. 2022;13:884719. PubMed PMID: 35603143

McCarthy WC, Sherlock LG, Grayck MR, Zheng L, Lacayo OA, Solar M, Orlicky DJ, Dobrinskikh E, Wright CJ. Innate Immune Zonation in the Liver: NF-?B (p50) Activation and C-Reactive Protein Expression in Response to Endotoxemia Are Zone Specific. J Immunol. 2023 May 1;210(9):1372-1385. PubMed PMID: 36946778

Gillen AE, Epperson LE, Orlicky DJ, Fu R, Martin SL. Adrenal gene expression dynamics support hibernation in 13-lined ground squirrels. Physiol Genomics. 2023 Apr 1;55(4):155-167. PubMed PMID: 36847440

Sasai F, Rogers KL, Orlicky DJ, Stem A, Schaeffer J, Garcia G, Fox J, Ray MS, Butler-Dawson J, Gonzalez-Quiroz M, Leiva R, Taduri G, Anutrakululchai S, Venugopal V, Madero M, Glaser J, Wijkstrom J, Wernerson A, Brown JM, Johnson RJ, Roncal-Jimenez CA. Inhaled silica nanoparticles cause chronic kidney disease in rats. Am J Physiol Renal Physiol. 2022 Jul 1;323(1):F48-F58. PubMed PMID: 35635324

Shearn CT, Anderson AL, Miller CG, Noyd RC, Devereaux MW, Balasubramaniyan N, Orlicky DJ, Schmidt EE, Sokol RJ. Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury. Hepatol Commun. 2023 Jan 1;7(1):e0020. PubMed PMID: 36633484

Anton P, Rutt LN, Capper C, Orlicky DJ, McCullough R. Profiling the Oxylipidome in Aged Mice after Chronic Ethanol Feeding: Identifying Lipid Metabolites as Drivers of Hepatocyte Stress. Alcohol. 2022 Sep 20. [Epub ahead of print] PubMed PMID: 36150611

Johnson J, Kim SY, Sam PK, Asokan R, Cari EL, Bales ES, Luu TH, Perez L, Kallen AN, Nel-Themaat L, Polotsky AJ, Post MD, Orlicky DJ, Jordan KR, Bitler BG. Expression and T cell regulatory action of the PD-1 immune checkpoint in the ovary and fallopian tube. Am J Reprod Immunol. 2023 Mar;89(3):e13649. PubMed PMID: 36394352

Monks J, Orlicky DJ, Libby AE, Dzieciatkowska M, Ladinsky MS, McManaman JL. Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland. Front Cell Dev Biol. 2022;10:958566. PubMed PMID: 36158190

Wang XX, Xie C, Libby AE, Ranjit S, Levi J, Myakala K, Bhasin K, Jones BA, Orlicky DJ, Takahashi S, Dvornikov A, Kleiner DE, Hewitt SM, Adorini L, Kopp JB, Krausz KW, Rosenberg A, McManaman JL, Robertson CE, Ir D, Frank DN, Luo Y, Gonzalez FJ, Gratton E, Levi M. The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J Biol Chem. 2022 Oct 7;298(11):102530. [Epub ahead of print] PubMed PMID: 36209823

Goldberg AR, Ferguson M, Pal S, Cohen R, Orlicky DJ, McCullough RL, Rutkowski JM, Burchill MA, Tamburini BAJ. Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. Front Physiol. 2022;13:1021038. PubMed PMID: 36338478

Shearn CT, Anderson AL, Devereux MW, Orlicky DJ, Michel C, Petersen DR, Miller CG, Harpavat S, Schmidt EE, Sokol RJ. The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease. PLoS One. 2022;17(11):e0276879. PubMed PMID: 36378690

Kim JS, Liu L, Kant S, Orlicky DJ, Uppalapati S, Margolis A, Davenport BJ, Morrison TE, Matsuda J, McClelland M, Jones-Carson J, Vazquez-Torres A. Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase. Cell Host Microbe. 2024 Mar 13;32(3):411-424.e10. PubMed PMID: 38307020

Johnson J, Kim SY, Sam PK, Asokan R, Cari EL, Bales ES, Luu TH, Perez L, Kallen AN, Nel-Themaat L, Polotsky AJ, Post MD, Orlicky DJ, Jordan KR, Bitler BG. Expression and T cell Regulatory Action of the PD-1 Immune Checkpoint in the Ovary and Fallopian Tube. Am J Reprod Immunol. 2022 Nov 17. [Epub ahead of print] PubMed PMID: 36394352

Grayck MR, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Orlicky DJ, Wright CJ. Implications of neonatal absence of innate immune mediated NF?B/AP1 signaling in the murine liver. Pediatr Res. 2024 Jun;95(7):1791-1802. PubMed PMID: 38396130

Callahan RC, Bhagavatula G, Curry J, Staley AW, Schaefer REM, Minhajuddin F, Zhou L, Neuhart R, Atif SM, Orlicky DJ, Cartwright IM, Gerich M, Theiss AL, Hall CHT, Colgan SP, Onyiah JC. Epithelial heme oxygenase-1 enhances colonic tumorigenesis by inhibiting ferroptosis. bioRxiv. 2024 Mar 8. PubMed PMID: 38496569

Burtis AEC, DeNicola DMC, Ferguson ME, Santos RG, Pinilla C, Kriss MS, Orlicky DJ, Tamburini BAJ, Gillen AE, Burchill MA. Antigen-driven CD8 ( ) T cell clonal expansion is a prominent feature of MASH in humans and mice. bioRxiv. 2024 Mar 22. PubMed PMID: 38562766

Danielson SM, Lefferts AR, Norman E, Regner EH, Schulz HM, Sansone-Poe D, Orlicky DJ, Kuhn KA. Myeloid Cells and Sphingosine-1-Phosphate Are Required for TCRaß Intraepithelial Lymphocyte Recruitment to the Colon Epithelium. J Immunol. 2024 Jun 1;212(11):1843-1854. PubMed PMID: 38568091

Solar M, Grayck MR, McCarthy WC, Zheng L, Lacayo OA, Sherlock LG, Zhou R, Orlicky DJ, Wright CJ. Absence of I?Bß/NF?B signaling does not attenuate acetaminophen-induced hepatic injury. Anat Rec (Hoboken). 2022 Nov 25. [Epub ahead of print] PubMed PMID: 36426684

Uppalapati S, Kant S, Liu L, Kim JS, Orlicky D, McClelland M, Vazquez-Torres A. Prophage terminase with tRNase activity sensitizes Salmonella enterica to oxidative stress. Science. 2024 Apr 5;384(6691):100-105. PubMed PMID: 38574144

Baker PR 2nd, Li AS, Griffin BR, Gil HW, Orlicky DJ, Fox BM, Park B, Sparagna GC, Goff J, Altmann C, Elajaili H, Okamura K, He Z, Stephenson D, D'Alessandro A, Reisz JA, Nozik ES, Sucharov CC, Faubel S. Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice. Sci Rep. 2024 Jun 15;14(1):13862. PubMed PMID: 38879688

Orlicky DJ, Smith EE, Johnson J, Hilton AE, Guess MK, Rascoff LG, Arruda JS, Hutchinson-Colas JA, Yang I, Connell KA. Inflammatory Cells in Control and Prolapsed Uterosacral Ligament Tissue. Reprod Sci. 2024 Oct;31(10):3026-3038. PubMed PMID: 38907126

Schwab SK, Harris PS, Michel C, McGinnis CD, Nahomi RB, Assiri MA, Reisdorph R, Henriksen K, Orlicky DJ, Levi M, Rosenberg A, Nagaraj RH, Fritz KS. Quantifying Protein Acetylation in Diabetic Nephropathy from Formalin-Fixed Paraffin-Embedded Tissue. Proteomics Clin Appl. 2024 Jun 24;:e202400018. [Epub ahead of print] PubMed PMID: 38923810

Jiang L, Lunding LP, Webber WS, Beckmann K, Azam T, Falkesgaard Højen J, Amo-Aparicio J, Dinarello A, Nguyen TT, Pessara U, Parera D, Orlicky DJ, Fischer S, Wegmann M, Dinarello CA, Li S. An antibody to IL-1 receptor 7 protects mice from LPS-induced tissue and systemic inflammation. Front Immunol. 2024;15:1427100. PubMed PMID: 38983847

Maclean KN, Jiang H, Neill PD, Chanin RR, Hurt KJ, Orlicky DJ, Bottiglieri T, Roede JR, Stabler SP. Dysregulation of hepatic one-carbon metabolism in classical homocystinuria: Implications of redox-sensitive DHFR repression and tetrahydrofolate depletion for pathogenesis and treatment. FASEB J. 2024 Jul 15;38(13):e23795. PubMed PMID: 38984928

Andres-Hernando A, Orlicky DJ, Kuwabara M, Fini MA, Tolan DR, Johnson RJ, Lanaspa MA. Activation of AMPD2 drives metabolic dysregulation and liver disease in mice with hereditary fructose intolerance. Commun Biol. 2024 Jul 11;7(1):849. PubMed PMID: 38992061

Burtis AEC, DeNicola DMC, Ferguson ME, Santos RG, Pinilla C, Kriss MS, Orlicky DJ, Tamburini BAJ, Gillen AE, Burchill MA. Ag-driven CD8 T cell clonal expansion is a prominent feature of MASH in humans and mice. Hepatology. 2024 Jul 24. [Epub ahead of print] PubMed PMID: 39047085

Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson DC, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Arch Toxicol. 2024 Oct;98(10):3241-3257. PubMed PMID: 39192018

Walrath T, Najarro KM, Giesy LE, Khair S, Orlicky DJ, McMahan RH, Kovacs EJ. Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome. FASEB J. 2024 Sep 30;38(18):e70065. PubMed PMID: 39305117

Associate Professor, Pathology

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School of Medicine

CU Anschutz

Fitzsimons Building