David Irwin, PhD
Professor, Medicine-Cvp-Pulmonary

Publications

• Lisk C, Cendali F, Pak DI, Swindle D, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkeley sickle cell anemia mice. Front Med (Lausanne). 2023;10:1149005. PubMed PMID: 37502360
• Thangaraju K, Setua S, Lisk C, Swindle D, Stephenson D, Dzieciatkowska M, Lamb DR, Moitra P, Pak D, Hassell K, George G, Nuss R, Davizon-Castillo P, Stenmark KR, D'Alessandro A, Irwin DC, Buehler PW. Extracellular Vesicle Size Reveals Cargo Specific to Coagulation and Inflammation in Pediatric and Adult Sickle Cell Disease. Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231186144. PubMed PMID: 37469147
• Cendali FI, Nemkov T, Lisk C, Lacroix IS, Nouraie SM, Zhang Y, Gordeuk VR, Buehler PW, Irwin D, D'Alessandro A. Metabolic correlates to critical speed in murine models of sickle cell disease. Front Physiol. 2023;14:1151268. PubMed PMID: 37007990
• Irwin DC, Ferguson SK. Adding a youthful perspective to high-altitude research. J Physiol. 2022 Nov;600(22):4777-4778. PubMed PMID: 36321641
• Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L355-L371. PubMed PMID: 35763400
• Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
• Yalamanoglu A, Dubach IL, Schulthess N, Ingoglia G, Swindle DC, Humar R, Schaer DJ, Buehler PW, Irwin DC, Vallelian F. Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice. Front Immunol. 2021;12:627944. PubMed PMID: 33763072
• Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 Nov 29;10(12). PubMed PMID: 34943862
• Weigand MRH, Gómez-Pastora J, Kim J, Kurek MT, Hickey RJ, Irwin DC, Buehler PW, Zborowski M, Palmer AF, Chalmers JJ. Magnetophoretic and spectral characterization of oxyhemoglobin and deoxyhemoglobin: Chemical versus enzymatic processes. PLoS One. 2021;16(9):e0257061. PubMed PMID: 34478473
• Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107. PubMed PMID: 34478834
• Karoor V, Swindle D, Pak DI, Strassheim D, Fini MA, Dempsey E, Stenmark KR, Hassell K, Nuss R, Buehler PW, Irwin DC. Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia. Pulm Circ. 2021 Oct-Dec;11(4):20458940211056806. PubMed PMID: 34777787
• Buehler PW, Swindle D, Pak DI, Fini MA, Hassell K, Nuss R, Wilkerson RB, D'Alessandro A, Irwin DC. Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features. Pulm Circ. 2021 Oct-Dec;11(4):20458940211055996. PubMed PMID: 34777785
• Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 Nov 29;10(12). PubMed PMID: 34943862
• • Ryan C. Hunt1, Upendra K. Katneni1, Ayla Yalamanoglu2, Kathryn Hassell3, Katie Redinius4, David C. Irwin4, Paul W. Buehler2,5 and Chava Kimchi-Sarfaty1 Investigation of ADAMTS13-independent cleavage and regulation of von Willebrand Factor BIC conference 2021
• •Paul Buehler and David C Irwin Modeling the effects of moderate hypoxia for the progression of pulmonary vascular hypertension in sickle cell disease. International Society of Oxygen Transport to Tissue (ISOTT) Conference, July 2021
• • Orlando Esparza, Giovanny Hernandez, Rachelle Nuss, David Irwin, Marguerite Kelher, Christopher C. Silliman, Katheryn L. Hassell, Pavel Davizon-Castillo The Therapeutic Modalities of Sickle Cell Disease Reprogram the Platelet Functional-Bioenergetic Profile ASH Dec 11 2021
• • Claudia Mickael, Linda A. Sanders, Michael H. Lee, Rahul Kumar, Amy McKee, David Irwin, Delaney Swindle, Kurt Stenmark, Brian Graham, Rubin Tuder Classical Dendritic Cells Are Determinant in Driving and Maintaining Hypoxia-Induced Pulmonary Hypertension ATS May 2022
• • Authors: Sue Gu MD, Claudia Mickael PhD, Linda Sanders BA, Ronald Vagnozzi PhD, Delaney Swindle MS David Irwin PhD, Peter Henson PhD, Kurt Stenmark MD Hypoxic pulmonary hypertension results in expansion of right ventricular CCR2+ macrophages ATS May 2022
• Ferguson SK, Redinius KM, Harral JW, Pak DI, Swindle DC, Hirai DM, Blackwell JR, Jones AM, Stenmark KR, Buehler PW, Irwin DC. The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease. J Appl Physiol (1985). 2020 Sep 1;129(3):474-482. PubMed PMID: 32702277
• Kopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SM. Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice. Pulm Circ. 2020 Jan-Mar;10(1):2045894020912937. PubMed PMID: 32206308
• Ayla Yalamanoglu, Irina L. Dubach, Nadja Schulthess, Giada Ingoglia, Delaney C. Swindle, Dominik J. Schaer, Paul W. Buehler, David C. Irwin and Florence Vallelian Agonistic anti-CD40 antibody triggers an acute liver crisis with systemic inflammation in humanized sickle cell disease mice Frontiers in Biology, Immunology
• P.W. Buehler and D.C. Irwin Modelling the effects of moderate hypoxia on the progression of pulmonary hypertension in sickle cell disease International society on transport of oxygen to tissue
• Ferguson et al; Impact of cell-free hemoglobin on exercising muscle vascular control in rats: ACSM conference
• Ferguson SK, Pak DI, Hopkins JL, Harral JW, Redinius KM, Loomis Z, Stenmark KR, Borden MA, Schroeder T, Irwin DC. Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases. Drug Deliv. 2019 Dec;26(1):147-157. PubMed PMID: 30822171
• Strassheim D, Gerasimovskaya E, Irwin D, Dempsey EC, Stenmark K, Karoor V. RhoGTPase in Vascular Disease. Cells. 2019 Jun 6;8(6). PubMed PMID: 31174369
• Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 Aug 8;4(15). PubMed PMID: 31391342
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017 Feb 2;12(2):e0171219. PubMed PMID: 28152051
• Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. PubMed PMID: 26694989
• Khademi S, Frye MA, Jeckel KM, Schroeder T, Monnet E, Irwin DC, Cole PA, Bell C, Miller BF, Hamilton KL. Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow. BMC Physiol. 2015 Oct 9;15:4. PubMed PMID: 26449218
• Scalzo RL, Peltonen GL, Binns SE, Klochak AL, Szallar SE, Wood LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. The Effects of Sympathetic Inhibition on Metabolic and Cardiopulmonary Responses to Exercise in Hypoxic Conditions. Wilderness Environ Med. 2015 Dec;26(4):520-4. PubMed PMID: 26183071
• Scalzo RL, Binns SE, Klochak AL, Giordano GR, Paris HL, Sevits KJ, Beals JW, Biela LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. Methazolamide Plus Aminophylline Abrogates Hypoxia-Mediated Endurance Exercise Impairment. High Alt Med Biol. 2015 Dec;16(4):331-42. PubMed PMID: 26680684
• Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling During Hemolysis. Am J Respir Crit Care Med. 2015 Dec 22. [Epub ahead of print] PubMed PMID: 26694989
• West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C415-30. PubMed PMID: 24871858
• Blueschke G, Hanna G, Fontanella AN, Palmer GM, Boico A, Min H, Dewhirst MW, Irwin DC, Zhao Y, Schroeder T. Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats. J Vis Exp. 2014 Nov 30;(93):e51630. PubMed PMID: 25490280
• Radiloff D, Zhao Y, Boico A, Blueschke G, Palmer G, Fontanella A, Dewhirst M, Piantadosi CA, Noveck R, Irwin D, Hamilton K, Klitzman B, Schroeder T. Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. PLoS One. 2014;9(6):e99309. PubMed PMID: 24960187
• Eigenberger P, Faino A, Maltzahn J, Lisk C, Frank E, Frank A, Loomis Z, Schroeder T, Strand M, Irwin D. A retrospective study of acute mountain sickness on Mt. Kilimanjaro using trekking company data. Aviat Space Environ Med. 2014 Nov;85(11):1125-9. PubMed PMID: 25329946
• Irwin DC, Garat CV, Crossno JT Jr, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulm Circ. 2014 Dec;4(4):638-53. PubMed PMID: 25610600
• Goodman J, Hassell K, Irwin D, Witkowski EH, Nuss R. The splenic syndrome in individuals with sickle cell trait. High Alt Med Biol. 2014 Dec;15(4):468-71. PubMed PMID: 25361178
• Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L868-76. PubMed PMID: 25326578