David Irwin, PhD

Publications

• Radiloff DR, Shan S, Zhao Y, Boico A, Wu C, Shan S, Palmer G, Hamilton KL, Hanna G, Irwin DC, Piantadosi CA, Schroeder T. Evidence for synergism between theophylline and endothelin receptor antagonists to improve exercise performance of rats under simulated high altitude. 2012; JAP 113(8): 1243-1252
• Hanna G, Fontanella A, Palmer G, Shan S, Radiloff DR, Zhao Y, Irwin DC, Hamilton KL, Dewhirst M, McMahon T, Schroeder T. Automated measurment of blood flow velocity, direction and hemoglobin oxygen saturation in the rat lung, using intravital microscopy. 2012; AJP Lung cell Mol physiol. Epub Nov 16
• Danielle J Reuland; Shadi Khademi; Christopher J Castle; David C Irwin; Joe M McCord; Benjamin F Miller; Karyn L Hamilton. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. 2012, FRMB epub Dec
• Zoe Loomis, Christina Lisk, Joe McCord, Karyn Hamilton, Thies Schroeder, Ian Conner, and David Irwin (2012) Evidence for the drugs used treat acute mountain sickness and have an off-target effect on Nrf2 induction may be more efficacious then those that don’t. Keystone, Hypoxia conference, Banff Canada
• Polymerized bovine hemoglobin infusion does not induce acute lung damage in a rat model. Robert Jacobs,Martha C Tissot Van Patot, Molly P White, Ben Foreman, Robert W Gotshall, David C Irwin and Karyn Hamilton.
• Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats. Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW. Am J Respir Cell Mol Biol. 2010 Feb;42(2):200-9
• Tissot Van Patot, Engebretsen BJ, Irwin DC "HIF-mediated proteins EPO and VEGF are elevated during adaptation to acute hypoxia and maladaptation to chronic hypoxia in an in-vivo rat model. Keystone Symposia-hypoxia
• Polymerized bovine hemoglobin infusion does not induce acute lung damage in a rat model. Robert Jacobs, Martha TissotvanPatot, Molly P White, Ben Foreman, Robert Gotshall, David C. Irwin, Karyn Hamilton. Open physiology journal
• Clark MB, WRite, R. Irwin, D, Bose,S, Van Rheen Z, Birari R, Stenmark KR, McCord JM, Nozik-Grayck E (2010) Sustained lung activity of a novel chimeric protien SOD 2/3, after intratracheal administration. Free rad Med&Biol. Oct 4 epub
• Evidence for drugs used to treat acute mountain sickness and have an off target effect on Nrf2 induction may be more efficaious then those that don't. Christin Lisk, Joe McCord, Karyn Hamilton, Thies Schroder, Ian Conner, Elena Forchielli and David Irwin
• Evidence for cell free hemoglobin induction of HIF-1a through a toll like recetpor - NF-kB signaling pathway. Christina Lisk, Doug Kominsky, Ian Connor , Elena Forchielli, Paul Buehler and David Irwin
• Christina Lisk and David Irwin (2012) Hemoglobin, endothelial cells and TLRs, common connection? American Heart Association, Hypertension conference, Washington D.C.
• Evidence that cell free hemoglobin induces rat pulmonary arterial smooth muscle cell proliferation by decreasing nuclear cylcic AMP response binding element(CREB) protein content by a mechanism other then oxidative stress. Christina lisk, Ian Connor, Elena Forchielli, Dwight Klemm, Chrystelle Garat and David Irwin
• Voluntary physical activity does not improve with attenuated vascular permeability in a model of acute mountain sickness. Karyn Hamilton, Laurie Biela, Natalie Rea, Thies Schroeder, Joe McCord and David Irwin
• Systemic enhancement of blood flow as a potential therapeutic strategy to counteract high altitude related health problems. Daniel Radiloff,Yulin Zhao, Siging Shan, David Irwin, Karyn Hamilton, Thies SChroeder
• Measuring drug effects on exercise endurance under extreme enviornmental conditions in rats using motorized wheels Daniel Radiloff,Chan Wu, Yulin Zhao, Siging Shan,Gabi Hanna, David Irwin, Karyn Hamilton, Thies SChroeder
• G.L Peltonen, R.L. Scalzo, S.E. Binns, A.L. Klochak, S.E. Szallar, L.M. Wood, D. Irwin, T. Schroeder, K.L. Hamilton, C. Bell. (2012) A Single Bout of Sprint Interval Training Does Not Improve Endurance Exercise Performance in Hypoxia, Integrative Biology Exercise.
• Induction of non-cardiogenic pulmonary edema following cerebral hypoxia in a canine model Shadi Khademi, Melinda Fryie, Kimberly Jeckel, David Irwin, Karyn Hamilton, Eric Monnet
• Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism Maria A. Cavasin, Kim Demos-Davies, Todd R. Horn, Lori A. Walker, Douglas D. Lemon, Nicholas Birdsey, Mary C.M. Weiser-Evans, Julie Harral, David C. Irwin, Adil Anwar, Michael E. Yeager, Min Li, Peter A. Watson, Raphael A. Nemenoff, Peter M. Buttrick, Kurt R. Stenmark, and Timothy A. McKinsey Circulation Research. 2012;110:739-748, published online before print January 26 2012, doi:10.1161/CIRCRESAHA.111.258426 Selective Class I Histone Deacetylase Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Antiproliferative Mechanism Maria A. Cavasin, Kim Demos-Davies, Todd R. Horn, Lori A. Walker, Douglas D. Lemon, Nicholas Birdsey, Mary C.M. Weiser-Evans, Julie Harral, David C. Irwin, Adil Anwar, Michael E. Yeager, Min Li, Peter A. Watson, Raphael A. Nemenoff, Peter M. Buttrick, Kurt R. Stenmark, and Timothy A. McKinsey Circulation Research. 2012;110:739-748, published online before print January 26 2012, doi:10.1161/CIRCRESAHA.111.258426
• R.L. Scalzo, G.L. Peltonen,S.E. Binns, A.L. Klochak, M.M. Schweder, S.E. Szallar, L.M. Wood, D. Irwin, T. Schroeder, K.L. Hamilton, M.S. Hickey, C. Bell. (2012) Hypoxic Exercise Performance Following Intravenous Glucose Administration: Influence of Sympathetic Inhibition Integrative Biology Exercise.
• Yanaira Alonso Caraballo, Christina Lisk, David Irwin. (2012). Can haptoglobin attenuate hemoglobin-induced vascular damage? Annual Biomedical Research Conference for Minority Students (ABRCMS
• Thies Schroeder, David Irwin, Karyn Hamilton, Alina boico, gert Blueschke; (2013) Combinied aminophylline and ambrisentande is a poetentially safe treatment of health complications after rapid ascent to high alitutde. EB
• Pelton, G.L., Scalzo, R.L. Schweder, M.M, Larson, Luckasen, G.J. Irwin, D., Hamilton,K.L., Schroeder, T and Bell, C Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans. Journal Physiology, accepted February 28, 2012
• Nrf2 activators decrease high altitude induced cerebral vascular leak. Zoe Loomis, Christina Lisk, Ian Connor, Joe McCord, Thies Schroeder, Karyn Hamilton and David Irwin Keystone Hypoxia conference 2012
• Cell free hemoglobin activates HIF through NF-kb by a MyD88 dependent pathway. Christina Lisk, Ian connor, Doug Kominsky, Tim Sullivan, and David Irwin Experimental biology conference
• Treatment with Theophylline, but not all adenosine receptor antagonists, increases voluntary physical activity in hypobaric hypoxia. BW Soloncyze, LM Biela, NA Rea, DM Warro, C Bell, T Schroeder, D Irwin and KL Hamilton Experimental Biology
• Blood pressure stabilization as a therapeutic approach to reverse high altitude induced loss of physical activity. Thies schroeder, Chris Bell, Karyn Hamilton, David Irwin Experimental Biology 2012
• 28. Scott Marshall, Michael Russell, Rodney Coldren, Kathryn Marshall, Marleigh Erickson, Kathrerine Brazaitis, David Irwin, Steve Sharp and Louis Frenc. (2013) Cognitive performance of recreational climbes, Hypoxia
• Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through antiproliferatvie mechanism. 2012; Circ Res. 110(5): 739-48
• Peltonen GL, Scalzo RL, Schweder MM, Larson DG, Luckasen GJ, Irwin DC, Hamilton KL, Schroeder T and Bell C. Sympathetic Inhibition attenuates hypoxia induced insulin resistance. 2012 J Phys. 590(Pt11) 2801-2809
• Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky DJ, Majka S, Stenmark KR Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: Evidence of inflammatory mechanism. 2012; AJP Lung Cell Mol Physiol. 303(4) 312-326
• Danielle J Reuland; Shadi Khademi; Christopher J Castle; David C Irwin; Joe M McCord; Benjamin F Miller; Karyn L Hamilton. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. 2013, Free Radic Med 56:102-111 .
• 24. Christina Lisk, Joe McCord, Swapan Bose, Ian Conner, Tim Sullivan, Zoe Loomis, Eva Nozik-Grayck, Thies Schroeder, Karyn Hamilton, and David Irwin Nrf2 Activation: A potential strategy for the prevention of Acute Mountain Sickness. 2013, Free Radical Med 63: 264-73
• West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. Am J Physiol Cell Physiol. 2014 Sep 1;307(5):C415-30. PubMed PMID: 24871858
• Blueschke G, Hanna G, Fontanella AN, Palmer GM, Boico A, Min H, Dewhirst MW, Irwin DC, Zhao Y, Schroeder T. Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats. J Vis Exp. 2014 Nov 30;(93):e51630. PubMed PMID: 25490280
• Radiloff D, Zhao Y, Boico A, Blueschke G, Palmer G, Fontanella A, Dewhirst M, Piantadosi CA, Noveck R, Irwin D, Hamilton K, Klitzman B, Schroeder T. Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude. PLoS One. 2014;9(6):e99309. PubMed PMID: 24960187
• Eigenberger P, Faino A, Maltzahn J, Lisk C, Frank E, Frank A, Loomis Z, Schroeder T, Strand M, Irwin D. A retrospective study of acute mountain sickness on Mt. Kilimanjaro using trekking company data. Aviat Space Environ Med. 2014 Nov;85(11):1125-9. PubMed PMID: 25329946
• 23. Lisk C, Kominsky D, Ehrentraut S, Connor I, Bonaventura J, Nozik-Grayck C, and Irwin DC. Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism 2013, Am J Respir Cell Mol Biol (49)4: 619-26
• Irwin DC, Garat CV, Crossno JT Jr, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulm Circ. 2014 Dec;4(4):638-53. PubMed PMID: 25610600
• Goodman J, Hassell K, Irwin D, Witkowski EH, Nuss R. The splenic syndrome in individuals with sickle cell trait. High Alt Med Biol. 2014 Dec;15(4):468-71. PubMed PMID: 25361178
• Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 1;307(11):L868-76. PubMed PMID: 25326578
• Paul Eigenberger, zoe loomis, Joanne Maltzhan, Malcolm Anderson and David Irwin. (2014) Hemoglobin induced lipid peroxidation and TLR9 activation in vitro. SFRBM.
• Paul Buehler, Paul Eigenberger, Zoe Loomis, Joanne Maltzhan, Malcolm Anderson, Christina Lisk and David Irwin; (2014) Hemoglobin Induced Vasoconstriction and Oxidative Stress are Prevented by Haptoglobin. SFRBM
• Rebecca L. Scalzo, Scott E. Binns, Anna L. Klochak, Gregory R. Giordano, Hunter LR. Paris, Kyle J. Sevits, Joseph W. Beals, Dennis G. Larson, Gary J. Luckasen, David Irwin, Theis Schroeder, Karyn L. Hamilton, Christopher Bell. Co-administration of Neptazane and Aminophylline to men abrogates the decline in endurance exercise performance in simulated high-altitude. Submitted for 2014 Experimental Biology (EB) conference.
• Zoe Loomis, Paul Eigenberger, Joanne Maltzhan, Malcolm Anderson, Christina Lisk and David Irwin (2014) Evidence that Cell Free Hemoglobin Directly and Indirectly Activates Smooth Muscle Cells. SFRBM
• Irwin D, Grayck E, Hassell k, Nuss R, Stenmark K, et al. Hypoxic pulmonary hypertension and the role of extra-cellular hemoglobin in perivascular macrophage accumulation. Macrophage. 2015 July 06; 2(2
• Khademi S, Frye MA, Jeckel KM, Schroeder T, Monnet E, Irwin DC, Cole PA, Bell C, Miller BF, Hamilton KL. Hypoxia mediated pulmonary edema: potential influence of oxidative stress, sympathetic activation and cerebral blood flow. BMC Physiol. 2015 Oct 9;15:4. PubMed PMID: 26449218
• Scalzo RL, Peltonen GL, Binns SE, Klochak AL, Szallar SE, Wood LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. The Effects of Sympathetic Inhibition on Metabolic and Cardiopulmonary Responses to Exercise in Hypoxic Conditions. Wilderness Environ Med. 2015 Dec;26(4):520-4. PubMed PMID: 26183071
• Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. PubMed PMID: 26694989
• Scalzo RL, Binns SE, Klochak AL, Giordano GR, Paris HL, Sevits KJ, Beals JW, Biela LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. Methazolamide Plus Aminophylline Abrogates Hypoxia-Mediated Endurance Exercise Impairment. High Alt Med Biol. 2015 Dec;16(4):331-42. PubMed PMID: 26680684
• Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017 Feb 2;12(2):e0171219. PubMed PMID: 28152051
• Tarshis, Samanth; Maltzahn, Joanne, Loomis, Zoe, Irwin, David C Preventing High Altitude Cerebral Edema in Rats with Repurposed Anti-Angiogenesis Pharmacotherapy Aerospace Medicine and Human Performance 87(12):1031-1035 · December 2016
• Scott K. Ferguson, Zoe Loomis, Jules Harral, Katherine Redinius, Kandice Dixon, Malcolm Anderson, Thies Schroeder, David Irwin Therapeutic Role of Ambrisentan for the Treatment of Hypoxic Pulmonary Vasoconstriction: Impact of Intrapulmonary Delivery (2016) Experimental Biology Conference
• Scott K. Ferguson, Zoe Loomis, Jules Harral, Katherine Redinius, Kandice Dixon, Malcolm Anderson, Thies Schroeder, David Irwin hemoglobin induced lipid peroxidation as an initiating factor in pulmonary hypertension (2016) Experimental biology conference
• Vijaya Karoor, Zoe Loomis, Timothy Sullivan, Louis B. Hersh, David Irwin , Edward C. Dempsey. Sustained Activation of RhoGTPases Promote a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. (2016) American Thoracic Society (ATS) Conference.
• Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling During Hemolysis. Am J Respir Crit Care Med. 2015 Dec 22. [Epub ahead of print] PubMed PMID: 26694989
• Scott. K. Ferguson, Katie Redinius, Zoe Loomis, Kurt Stenmark, Paul W. Buehler, David C. Irwin Impaired Critical Speed in Mice with Sickle Cell Anemia: Implications for Therapeutic Development 2016 UK sports science meeting
• 44. Scott Ferguson, Zoe Loomis, Jules Harral, Katherin Radinius, Kandice Dixon, Malcolm Anderson, Thies Schroederm and David Irwin Therapuetic role of Ambrisentan for the treatment of hypoxic pulmonary vasoconstriction: Impact of Intrapulmonary Delivery. (2016) Military health System Research Symposium
• Thies Schroeder, Claude A. Piantadosi, David Irwin, Robert Noveck The combination of aminophyilline and ambrisentan is safe and potentially effective in reversing high altitude induced health decrements in humans. (2016) Military health System Research Symposium
• Integration of RNA-Seq Transcriptome and Variant Detection, Association and Pathway Analyses Link ECHS1 to Drug Refractory Dilated Cardiomyopathy, NIH bio-bioinformatics conference
• Exercise (in) tolerance in sickle cell disease: potential disruptive role of free hemoglobin on skeletal muscle oxygen delivery utlization mataching and functional capacity APS Physiological and Pathophysiological consequencese of SCD
• Impaired critical speed in mice with sickle cell anemia:implicantions for therapeutic development. (2017) ACSM annual meeting; Med Sci Sports Exer, May; 49(5 suppl.1) 407-8
• Ryan Hunt, Ayla Yalamanoglu, Kathryn Hassell, Katie Redinius, David C. Irwin, Paul W. Buehler2 and Chava Kimchi-Sarfaty Assay-dependent results of ADAMTS13 activity in sickle cell disease (2017) APS conference on Sickle cell disease
• Ferguson SK, Harral JW, Pak DI, Redinius KM, Stenmark KR, Schaer DJ, Buehler PW, Irwin DC. Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics. Nitric Oxide. 2018 Mar 8;76:29-36. doi: 10.1016/j.niox.2018.03.005. [Epub ahead of print] PubMed PMID: 29526566
• Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2018 Jun 21. doi: 10.1113/JP275810. [Epub ahead of print] PubMed PMID: 29931797.
• Yalamanoglu A, Deuel JW, Hunt RC, Baek JH, Hassell K, Redinius K, Irwin DC, Schär DJ, Buehler PW. Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 26. doi: 10.1152/ajplung.00269.2018. [Epub ahead of print] PubMed PMID: 30047285
• Campbell NV, Weitzenkamp DA, Campbell IL, Schmidt RF, Hicks C, Morgan MJ, Irwin DC, Tentler JJ. "Omics" data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy. BMC Med Genomics. 2018 Dec 12;11(1):110. doi: 10.1186/s12920-018-0439-6. PubMed PMID: 30541556; PubMed Central PMCID: PMC6292014.
• Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. 2018 Am J Respir Cell Mol Biol. PMID 29851508
• Boulet LM, Teppema LJ, Hackett HK, Dominelli PB, Cheyne WS, Dominelli GS, Irwin DC, Buehler PW, Baek JH, Swenson ER, Foster GE. Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide. J Appl Physiol (1985). 2018 Sep 20;. doi: 10.1152/japplphysiol.00509.2018. [Epub ahead of print] PubMed PMID: 30236048.
• Heme-mediated oxidation of plasma lipids in sickle cell disease (2017) APS conference on Sickle cell disease
• Ferguson SK, Stenmark KR, Buehler PW, Irwin DC. Exercise (In)Tolerance in Sickle Cell Disease: Potential Disruptive Role of Free Hemoglobin on Skeletal Muscle Oxygen Delivery/Utilization Matching and Functional Capacity. APS Experimental biology meeting, 2018
• Harral G, Irwin N, Harral J, Redinius K, Pak D, Buehler PW, Irwin DC, Ferguson SK. Impact of chronic free hemoglobin infusion on skeletal muscle microvascular PO2 dynamics in rats. APS Experimental biology meeting, 2018
• Ferguson SK, Stenmark KR, Buehler PW, Irwin DC. Impact of cell-free hemoglobin on contracting skeletal muscle oxygen pressure dynamics: Potential therapeutic role of haptoglobin. APS Experimental biology meeting, 2018
• David I.Pak, Scott K Ferguson, Justin Hopkins, Julie W. Harral, Katherine M Redinius, Mark A. Borden, Thies Schroeder, David C Irwin. Pre-clinical application of aerosolized water-in-fluorocarbon emulsion intrapulmonary drug delivery system for targeting pulmonary vascular disease. APS Experimental biology meeting, 2018
• Exposure to moderate altitude enhances pulmonary vascular disease in Berkley sickle cell mice (2017) APS conference of Sickle cell disease.
• Schroeder T, Hamiltion K, Irwin DC Ergogenic effects and potential synergism of combined doxapram and acetazolamide in hypoxic rats APS Experimental biology meeting, 2018
• Zoe Loomis, Paul Eigenberger, Katherine Redinius, Christina Lisk,Vijaya Karoor, Eva Nozik-Grayck, Scott K. Ferguson, Kathryn Hassell, Rachelle Nuss, Kurt Stenmar, Paul Buehler, David C. Irwin Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle activation. PLoS One 2017 March 6; 12 (3) PMID 28152051
• Strand TE, Khiabani-Zare H, Boico A, Radiloff DR, Zhao Y, Hamilton K, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin DC, Schroeder T. The Novel Combination of Theophylline and Bambuterol as a Potential Treatment of Hypoxemia in Humans. Can J Physiol Pharmacol. 2017 May 3. doi: 10.1139/cjpp-2016-0635. [Epub ahead of print] PubMed PMID: 28467859.
• Ferguson SK, Pak DI, Hopkins JL, Harral JW, Redinius KM, Loomis Z, Stenmark KR, Borden MA, Schroeder T, Irwin DC. Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases. Drug Deliv. 2019 Dec;26(1):147-157. PubMed PMID: 30822171
• Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30;8:15494. doi: 10.1038/ncomms15494. PubMed PMID: 28555642; PubMed Central PMCID: PMC5459967.
• Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia. Clin Pharmacol Ther. 2017 Aug 31. doi: 10.1002/cpt.860. [Epub ahead of print] PubMed PMID: 28857147
• Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC. Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):154-163. Epub 2017 Nov 30. PubMed PMID: 29191928; PubMed Central PMCID: PMC5746466
• Strassheim D, Gerasimovskaya E, Irwin D, Dempsey EC, Stenmark K, Karoor V. RhoGTPase in Vascular Disease. Cells. 2019 Jun 6;8(6). PubMed PMID: 31174369
• Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease. JCI Insight. 2019 Aug 8;4(15). PubMed PMID: 31391342
• Ferguson, Scott K.; Stenmark, Kurt R.; Nuss, Rachelle; Grayck, Eva; Bueher, Paul W.; Irwin, David C. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anemia. Hypoxia meeting 2019.
• Pressurized Metered Dose Inhalers As first Responder-Tools during Mass Casualty Scenarios. David Irwin and Theis Schroeder. MHSRS conference Orlando Florida, August 2019.
• Ferguson SK, Redinius KM, Harral JW, Pak DI, Swindle DC, Hirai DM, Blackwell JR, Jones AM, Stenmark KR, Buehler PW, Irwin DC. The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease. J Appl Physiol (1985). 2020 Sep 1;129(3):474-482. PubMed PMID: 32702277
• Kopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SM. Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice. Pulm Circ. 2020 Jan-Mar;10(1):2045894020912937. PubMed PMID: 32206308
• Ferguson et al; Impact of cell-free hemoglobin on exercising muscle vascular control in rats: ACSM conference
• Ayla Yalamanoglu, Irina L. Dubach, Nadja Schulthess, Giada Ingoglia, Delaney C. Swindle, Dominik J. Schaer, Paul W. Buehler, David C. Irwin and Florence Vallelian Agonistic anti-CD40 antibody triggers an acute liver crisis with systemic inflammation in humanized sickle cell disease mice Frontiers in Biology, Immunology
• P.W. Buehler and D.C. Irwin Modelling the effects of moderate hypoxia on the progression of pulmonary hypertension in sickle cell disease International society on transport of oxygen to tissue
• Yalamanoglu A, Dubach IL, Schulthess N, Ingoglia G, Swindle DC, Humar R, Schaer DJ, Buehler PW, Irwin DC, Vallelian F. Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice. Front Immunol. 2021;12:627944. PubMed PMID: 33763072
• Weigand MRH, Gómez-Pastora J, Kim J, Kurek MT, Hickey RJ, Irwin DC, Buehler PW, Zborowski M, Palmer AF, Chalmers JJ. Magnetophoretic and spectral characterization of oxyhemoglobin and deoxyhemoglobin: Chemical versus enzymatic processes. PLoS One. 2021;16(9):e0257061. PubMed PMID: 34478473
• Buehler PW, Swindle D, Pak DI, Ferguson SK, Majka SM, Karoor V, Moldovan R, Sintas C, Black J, Gentinetta T, Buzzi RM, Vallelian F, Wassmer A, Edler M, Bain J, Schu D, Hassell K, Nuss R, Schaer DJ, Irwin DC. Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease. Free Radic Biol Med. 2021 Nov 1;175:95-107. PubMed PMID: 34478834
• Karoor V, Swindle D, Pak DI, Strassheim D, Fini MA, Dempsey E, Stenmark KR, Hassell K, Nuss R, Buehler PW, Irwin DC. Evidence supporting a role for circulating macrophages in the regression of vascular remodeling following sub-chronic exposure to hemoglobin plus hypoxia. Pulm Circ. 2021 Oct-Dec;11(4):20458940211056806. PubMed PMID: 34777787
• Buehler PW, Swindle D, Pak DI, Fini MA, Hassell K, Nuss R, Wilkerson RB, D'Alessandro A, Irwin DC. Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features. Pulm Circ. 2021 Oct-Dec;11(4):20458940211055996. PubMed PMID: 34777785
• Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 Nov 29;10(12). PubMed PMID: 34943862
• • Ryan C. Hunt1, Upendra K. Katneni1, Ayla Yalamanoglu2, Kathryn Hassell3, Katie Redinius4, David C. Irwin4, Paul W. Buehler2,5 and Chava Kimchi-Sarfaty1 Investigation of ADAMTS13-independent cleavage and regulation of von Willebrand Factor BIC conference 2021
• •Paul Buehler and David C Irwin Modeling the effects of moderate hypoxia for the progression of pulmonary vascular hypertension in sickle cell disease. International Society of Oxygen Transport to Tissue (ISOTT) Conference, July 2021
• • Orlando Esparza, Giovanny Hernandez, Rachelle Nuss, David Irwin, Marguerite Kelher, Christopher C. Silliman, Katheryn L. Hassell, Pavel Davizon-Castillo The Therapeutic Modalities of Sickle Cell Disease Reprogram the Platelet Functional-Bioenergetic Profile ASH Dec 11 2021
• • Claudia Mickael, Linda A. Sanders, Michael H. Lee, Rahul Kumar, Amy McKee, David Irwin, Delaney Swindle, Kurt Stenmark, Brian Graham, Rubin Tuder Classical Dendritic Cells Are Determinant in Driving and Maintaining Hypoxia-Induced Pulmonary Hypertension ATS May 2022
• • Authors: Sue Gu MD, Claudia Mickael PhD, Linda Sanders BA, Ronald Vagnozzi PhD, Delaney Swindle MS David Irwin PhD, Peter Henson PhD, Kurt Stenmark MD Hypoxic pulmonary hypertension results in expansion of right ventricular CCR2+ macrophages ATS May 2022
• Irwin DC, Ferguson SK. Adding a youthful perspective to high-altitude research. J Physiol. 2022 Nov;600(22):4777-4778. PubMed PMID: 36321641
• Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2022 Sep 1;323(3):L355-L371. PubMed PMID: 35763400
• Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
• Strassheim D, Sullivan T, Irwin DC, Gerasimovskaya E, Lahm T, Klemm DJ, Dempsey EC, Stenmark KR, Karoor V. Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases. Cells. 2021 Nov 29;10(12). PubMed PMID: 34943862
• Lisk C, Cendali F, Pak DI, Swindle D, Hassell K, Nuss R, George G, Davizon-Castillo P, Buehler PW, D'Alessandro A, Irwin DC. Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkeley sickle cell anemia mice. Front Med (Lausanne). 2023;10:1149005. PubMed PMID: 37502360
• Thangaraju K, Setua S, Lisk C, Swindle D, Stephenson D, Dzieciatkowska M, Lamb DR, Moitra P, Pak D, Hassell K, George G, Nuss R, Davizon-Castillo P, Stenmark KR, D'Alessandro A, Irwin DC, Buehler PW. Extracellular Vesicle Size Reveals Cargo Specific to Coagulation and Inflammation in Pediatric and Adult Sickle Cell Disease. Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231186144. PubMed PMID: 37469147
• Cendali FI, Nemkov T, Lisk C, Lacroix IS, Nouraie SM, Zhang Y, Gordeuk VR, Buehler PW, Irwin D, D'Alessandro A. Metabolic correlates to critical speed in murine models of sickle cell disease. Front Physiol. 2023;14:1151268. PubMed PMID: 37007990

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