Amy McKee, PhD

Assistant Professor, Medicine-Allergy/Clinical Immunology

FacultyPhoto
Graduate Schools
  • MS, Colorado State University (1998)
  • PhD, Cornell University (2004)
Undergraduate School
  • BS, Colorado State University (CO) (1997)
Department
Medicine-Allergy/Clinical Immunology

Professional Titles

  • Assistant Professor, Division of Clinical Immunology
  • Chief Development Officer, ClinImmune Cell and Gene Therapy

Publications

  • Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Proc Natl Acad Sci U S A. 2013 Feb 27.
  • Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. J Immunol. 2013 Feb 1;190(3):913-21.
  • Dai S, Falta MT, Bowerman NA, McKee AS, Fontenot AP. T cell recognition of beryllium. Curr Opin Immunol. 2013 Dec;25(6):775-80. PubMed PMID: 23978481
  • McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31. PubMed PMID: 23447566
  • Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 1;190(3):913-21. PubMed PMID: 23275606
  • Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8553-8. PubMed PMID: 24912188
  • McKee AS, Mack DG, Crawford F, Fontenot A. Keystone Symposium on Granulomas in Infectious and Non-infectious Diseases. January 22-27, 2015, Santa Fe Community Convention Center, Santa Fe, NM, USA. Invited talk: MyD88-dependence of beryllium-induced dendritic cell trafficking and CD4+ T cell priming.
  • Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 1;196(1):22-7. PubMed PMID: 26685315
  • McKee AS, Mack DG, Crawford F, Fontenot AP. MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4? T-cell priming. Mucosal Immunol. 2015 Nov;8(6):1237-47. PubMed PMID: 25760420
  • McKee AS, Fontenot AP. Interplay of innate and adaptive immunity in metal-induced hypersensitivity. Curr Opin Immunol. 2016 Oct;42:25-30. PubMed PMID: 27228132
  • Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 1;196(1):22-7. PubMed PMID: 26685315
  • McKee AS, Marrack P. Old and new adjuvants. Curr Opin Immunol. 2017 Aug;47:44-51. PubMed PMID: 28734174
  • Wade MF, Collins MK, Richards D, Mack DG, Martin AK, Dinarello CA, Fontenot AP, McKee AS. TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018 Oct 15;201(8):2232-2243. PubMed PMID: 30185516
  • Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA. IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease. Nat Immunol. 2019 Sep;20(9):1138-1149. PubMed PMID: 31427775
  • Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB. Th2 CD4( ) T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension. J Am Heart Assoc. 2019 Aug 6;8(15):e013111. PubMed PMID: 31339057
  • Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019 May 16;5. PubMed PMID: 31094704
  • Collins MK, Shotland AM, Wade MF, Atif SM, Richards DK, Torres-Llompart M, Mack DG, Martin AK, Fontenot AP, McKee AS. A role for TNF-a in alveolar macrophage damage-associated molecular pattern release. JCI Insight. 2020 May 7;5(9). PubMed PMID: 32255768
  • Shotland AM, Fontenot AP, McKee AS. Pulmonary Macrophage Cell Death in Lung Health and Disease. Am J Respir Cell Mol Biol. 2021 May;64(5):547-556. PubMed PMID: 33332993
  • McKee AS, Atif SM, Falta MT, Fontenot AP. Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease. J Immunol. 2022 Apr 15;208(8):1835-1843. doi: 10.4049/jimmunol.2101159. PMID: 35418504; PMCID: PMC9106315.
  • McKee AS, Atif SM, Falta MT, Fontenot AP. Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease. J Immunol. 2022 Apr 15;208(8):1835-1843. PubMed PMID: 35418504
  • MacLeod MK, McKee AS, David A, Wang J, Mason R, Kappler JW, Marrack P. Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7914-9. PubMed PMID: 21518876
  • MacLeod MK, David A, McKee AS, Crawford F, Kappler JW, Marrack P. Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. J Immunol. 2011 Mar 1;186(5):2889-96. PubMed PMID: 21270407
  • Munks MW, McKee AS, Macleod MK, Powell RL, Degen JL, Reisdorph NA, Kappler JW, Marrack P. Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood. 2010 Dec 9;116(24):5191-9. PubMed PMID: 20876456
  • McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol. 2009 Oct 1;183(7):4403-14. PubMed PMID: 19734227
  • Marrack P, McKee AS, Munks MW. Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol. 2009 Apr;9(4):287-93. PubMed PMID: 19247370
  • McKee AS, MacLeod M, White J, Crawford F, Kappler JW, Marrack P. Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. Int Immunol. 2008 May;20(5):659-69. PubMed PMID: 18343889
  • McKee AS, Munks MW, Marrack P. How do adjuvants work? Important considerations for new generation adjuvants. Immunity. 2007 Nov;27(5):687-90. PubMed PMID: 18031690
  • Pearce EJ, M Kane C, Sun J, J Taylor J, McKee AS, Cervi L. Th2 response polarization during infection with the helminth parasite Schistosoma mansoni. Immunol Rev. 2004 Oct;201:117-26. PubMed PMID: 15361236
  • McKee AS, Pearce EJ. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004 Jul 15;173(2):1224-31. PubMed PMID: 15240714
  • Kane CM, Cervi L, Sun J, McKee AS, Masek KS, Shapira S, Hunter CA, Pearce EJ. Helminth antigens modulate TLR-initiated dendritic cell activation. J Immunol. 2004 Dec 15;173(12):7454-61. PubMed PMID: 15585871
  • McKee AS, Dzierszinski F, Boes M, Roos DS, Pearce EJ. Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol. 2004 Aug 15;173(4):2632-40. PubMed PMID: 15294980
  • Straw AD, MacDonald AS, Denkers EY, Pearce EJ. CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J Immunol. 2003 Jan 15;170(2):727-34. PubMed PMID: 12517934
  • MacDonald AS, Straw AD, Dalton NM, Pearce EJ. Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J Immunol. 2002 Jan 15;168(2):537-40. PubMed PMID: 11777943
  • MacDonald AS, Straw AD, Bauman B, Pearce EJ. CD8- dendritic cell activation status plays an integral role in influencing Th2 response development. J Immunol. 2001 Aug 15;167(4):1982-8. PubMed PMID: 11489979
  • McKee AS, Atif SM, Falta MT, Fontenot AP. Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease. J Immunol. 2022 Apr 15;208(8):1835-1843. PubMed PMID: 35418504


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13001 East 17th Place

Aurora, CO 80045

303.724.5375

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