Peter Buttrick, MD
Professor, Medicine-Cardiology

Professional Titles

• Division Head, Cardiology
• Senior Associate Dean for Academic Affairs
• S. Gilbert Blount Endowed Professor

Recognition & Awards

• Best physicians in America, Kiplinger (2019)
• Elected member, American Association of Physicians (2009)
  
• Elected member and past president, Association of University Cardiologists (1999)
• Member and past president, Association of Professors of Cardiology (1997)

Research Interests

Teaching

Publications

• Felker GM, Buttrick P, Rosenzweig A, Abel ED, Allen LA, Bristow M, Das S, DeVore AD, Drakos SG, Fang JC, Freedman JE, Hernandez AF, Li DY, McKinsey TA, Newton-Cheh C, Rogers JG, Shah RV, Shah SH, Stehlik J, Selzman CH. Heart Failure Strategically Focused Research Network: Summary of Results and Future Directions. J Am Heart Assoc. 2022 Sep 20;11(18):e025517. PubMed PMID: 36073647
• Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
• Riching AS, Danis E, Zhao Y, Cao Y, Chi C, Bagchi RA, Klein BJ, Xu H, Kutateladze TG, McKinsey TA, Buttrick PM, Song K. Suppression of canonical TGF-ß signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. J Mol Cell Cardiol. 2020 Dec 24;153:44-59. [Epub ahead of print] PubMed PMID: 33359755
• Allen LA, Venechuk G, McIlvennan CK, Page Ii RL, Knoepke CE, Helmkamp LJ, Khazanie P, Peterson PN, Pierce K, Harger G, Thompson JS, Dow TJ, Richards L, Huang J, Strader JR, Trinkley KE, Kao DP, Magid DJ, Buttrick P, Matlock DD. An Electronically Delivered, Patient-Activation Tool for Intensification of Medications for Chronic Heart Failure with Reduced Ejection Fraction: The EPIC-HF Trial. Circulation. 2020 Nov 17. [Epub ahead of print] PubMed PMID: 33201741
• Venechuk GE, Khazanie P, Page RL 2nd, Knoepke CE, Helmkamp LJ, Peterson PN, Pierce K, Thompson JS, Huang J, Strader JR, Dow TJ, Richards L, Trinkley KE, Kao DP, McIlvennan CK, Magid DJ, Buttrick PM, Matlock DD, Allen LA. An Electronically delivered, Patient-activation tool for Intensification of medications for Chronic Heart Failure with reduced ejection fraction: Rationale and design of the EPIC-HF trial. Am Heart J. 2020 Nov;229:144-155. PubMed PMID: 32866454
• Buttrick P. A Modern Library of Babel. J Card Fail. 2020 Aug;26(8):643-644. PubMed PMID: 32854926
• Bristow MR, Zisman LS, Altman NL, Gilbert EM, Lowes BD, Minobe WA, Slavov D, Schwisow JA, Rodriguez EM, Carroll IA, Keuer TA, Buttrick PM, Kao DP. Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium. JACC Basic Transl Sci. 2020 Sep;5(9):871-883. PubMed PMID: 32838074
• Cornwell WK, Tran T, Cerbin L, Coe G, Muralidhar A, Hunter K, Altman N, Ambardekar AV, Tompkins C, Zipse M, Schulte M, O'Gean K, Ostertag M, Hoffman J, Pal JD, Lawley JS, Levine BD, Wolfel E, Kohrt WM, Buttrick P. New insights into resting and exertional right ventricular performance in the healthy heart through real-time pressure-volume analysis. J Physiol. 2020 Jul;598(13):2575-2587. PubMed PMID: 32347547
• Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019;14(10):e0224389. PubMed PMID: 31639152
• Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019;14(8):e0221519. PubMed PMID: 31469842
• Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 Aug 6;28(6):1471-1484.e11. PubMed PMID: 31390562
• Bruns DR, Tatman PD, Kalkur RS, Brown RD, Stenmark KR, Buttrick PM, Walker LA. The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation. PLoS One. 2019;14(8):e0220573. PubMed PMID: 31374110
• Buttrick P. Research Integrity. J Card Fail. 2019 May;25(5):401-403. PubMed PMID: 30974162
• Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K. LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):556-565. PubMed PMID: 30584088
• Leary PJ, Kronmal RA, Bluemke DA, Buttrick PM, Jones KL, Kao DP, Kawut SM, Krieger EV, Lima JA, Minobe W, Ralph DD, Tedford RJ, Weiss NS, Bristow MR. Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Am J Cardiol. 2018 Jan 15;121(2):256-261. PubMed PMID: 29191567
• Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
• Buttrick P. Neprilysin Inhibition: What We Know and What We Don't Know. J Card Fail. 2018 Apr;24(4):276-277. PubMed PMID: 29378257
• Buttrick P. Should We Be More Interested in the Question or the Answer?. J Card Fail. 2017 Mar;23(3):207-208. PubMed PMID: 28115290
• Bruns DR, Buttrick PM, Walker LA. Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15;310(6):L542-50. PubMed PMID: 26747780
• Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L158-67. PubMed PMID: 25416385
• Thoemmes SF, Stutzke CA, Du Y, Browning MD, Buttrick PM, Walker LA. Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation. J Immunol Methods. 2014 Jan 31;403(1-2):66-71. PubMed PMID: 24291343
• Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. Am J Physiol Heart Circ Physiol. 2013 Jun 15;304(12):H1644-50. PubMed PMID: 23564307
• Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013 Feb 1;9(1):73-81. PubMed PMID: 23092273
• Zhao L, Chen CN, Hajji N, Oliver E, Cotroneo E, Wharton J, Wilkins MR, Wang D, Li M, Stenmark KR, McKinsey TA, Buttrick P. Response to letter regarding article, “histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid”. Circulation. 2013 Apr 9;127(14):e540. PubMed PMID: 23691553
• Vitello AM, Du Y, Buttrick PM, Walker LA. Serendipitous discovery of a novel protein signaling mechanism in heart failure. Biochem Biophys Res Commun. 2012 May 11;421(3):431-5. PubMed PMID: 22503978
• Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 2;110(5):739-48. PubMed PMID: 22282194
• Ambardekar AV, Dorosz JL, Cleveland JC Jr, Lindenfeld J, Buttrick PM. Longitudinal left ventricular structural and functional imaging during full support with continuous-flow ventricular assist devices: a retrospective, preliminary analysis. J Heart Lung Transplant. 2012 Dec;31(12):1311-3. PubMed PMID: 23063323
• Walker LA, Walker JS, Glazier A, Brown DR, Stenmark KR, Buttrick PM. Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H832-40. PubMed PMID: 21622821
• Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 6;43(19):1087-95. PubMed PMID: 21771878
• Ambardekar AV, Buttrick PM. Reverse remodeling with left ventricular assist devices: a review of clinical, cellular, and molecular effects. Circ Heart Fail. 2011 Mar;4(2):224-33. PubMed PMID: 21406678
• Walker LA, Medway AM, Walker JS, Cleveland JC Jr, Buttrick PM. Tissue procurement strategies affect the protein biochemistry of human heart samples. J Muscle Res Cell Motil. 2011 Mar;31(5-6):309-14. PubMed PMID: 21184256
• Ambardekar AV, Walker JS, Walker LA, Cleveland JC Jr, Lowes BD, Buttrick PM. Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail. 2011 Jul;4(4):425-32. PubMed PMID: 21540356
• Walker JS, Walker LA, Margulies K, Buttrick P, de Tombe P. Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils. Am J Physiol Heart Circ Physiol. 2011 Jul;301(1):H138-46. PubMed PMID: 21498779
• Scruggs SB, Reisdorph R, Armstrong ML, Warren CM, Reisdorph N, Solaro RJ, Buttrick PM. A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain. Mol Cell Proteomics. 2010 Sep;9(9):1804-18. PubMed PMID: 20445002
• Walker LA, Walker JS, Ambler SK, Buttrick PM. Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice. J Mol Cell Cardiol. 2010 Jun;48(6):1180-6. PubMed PMID: 19799909
• Walker JS, Li X, Buttrick PM. Analysing force-pCa curves. J Muscle Res Cell Motil. 2010 Jul;31(1):59-69. PubMed PMID: 20490629
• Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease. Curr Cardiol Rev. 2009 Jan;5(1):22-8. PubMed PMID: 20066144
• Scruggs SB, Hinken AC, Thawornkaiwong A, Robbins J, Walker LA, de Tombe PP, Geenen DL, Buttrick PM, Solaro RJ. Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem. 2009 Feb 20;284(8):5097-106. PubMed PMID: 19106098
• Lowes BD, Buttrick PM. Genetic determinants of drug response in heart failure. Curr Cardiol Rep. 2008 May;10(3):176-81. PubMed PMID: 18489860
• Goldspink P, Ruch S, Los T, Buttrick P, García J. Maladaptation of calcium homoeostasis in aging cardiac myocytes. Pflugers Arch. 2008 Jun;456(3):479-87. PubMed PMID: 18172603
• Hankiewicz JH, Goldspink PH, Buttrick PM, Lewandowski ED. Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H330-6. PubMed PMID: 17965277
• Lewandowski ED, O'donnell JM, Scholz TD, Sorokina N, Buttrick PM. Recruitment of NADH shuttling in pressure-overloaded and hypertrophic rat hearts. Am J Physiol Cell Physiol. 2007 May;292(5):C1880-6. PubMed PMID: 17229809
• Xiao L, Zhao Q, Du Y, Yuan C, Solaro RJ, Buttrick PM. PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo. Biochemistry. 2007 Jun 12;46(23):7054-61. PubMed PMID: 17503784
• Sorokina N, O'Donnell JM, McKinney RD, Pound KM, Woldegiorgis G, LaNoue KF, Ballal K, Taegtmeyer H, Buttrick PM, Lewandowski ED. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation. 2007 Apr 17;115(15):2033-41. PubMed PMID: 17404155
• Jweied E, deTombe P, Buttrick PM. The use of human cardiac tissue in biophysical research: the risks of translation. J Mol Cell Cardiol. 2007 Apr;42(4):722-6. PubMed PMID: 17350034
• Buttrick P. The regulation of heat shock protein expression: how, when and where. J Mol Cell Cardiol. 2006 Nov;41(5):785-6. PubMed PMID: 16982066
• Nazarloo HP, Buttrick PM, Saadat H, Dunn AJ. The roles of corticotropin-releasing factor-related peptides and their receptors in the cardiovascular system. Curr Protein Pept Sci. 2006 Jun;7(3):229-39. PubMed PMID: 16787262
• Zampino M, Yuzhakova M, Hansen J, McKinney RD, Goldspink PH, Geenen DL, Buttrick PM. Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H957-64. PubMed PMID: 16603692
• Scruggs SB, Walker LA, Lyu T, Geenen DL, Solaro RJ, Buttrick PM, Goldspink PH. Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol. 2006 Apr;40(4):465-73. PubMed PMID: 16445938
• Montgomery DE, Rundell VL, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM. Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1881-8. PubMed PMID: 15951344
• Jweied EE, McKinney RD, Walker LA, Brodsky I, Geha AS, Massad MG, Buttrick PM, de Tombe PP. Depressed cardiac myofilament function in human diabetes mellitus. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2478-83. PubMed PMID: 16085678
• Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM. Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo. Am J Physiol Heart Circ Physiol. 2004 Jun;286(6):H2089-95. PubMed PMID: 14726296
• Rundell VL, Geenen DL, Buttrick PM, de Tombe PP. Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H408-13. PubMed PMID: 15001437
• Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM. Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res. 2004 Aug 20;95(4):424-32. PubMed PMID: 15242976
• Solaro RJ, Montgomery DM, Wang L, Burkart EM, Ke Y, Vahebi S, Buttrick P. Integration of pathways that signal cardiac growth with modulation of myofilament activity. J Nucl Cardiol. 2002 Sep-Oct;9(5):523-33. PubMed PMID: 12360133
• Shizukuda Y, Reyland ME, Buttrick PM. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1625-34. PubMed PMID: 11959624
• Montgomery DE, Wolska BM, Pyle WG, Roman BB, Dowell JC, Buttrick PM, Koretsky AP, Del Nido P, Solaro RJ. alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI. Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2397-405. PubMed PMID: 12003851
• Shizukuda Y, Buttrick PM. Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. J Mol Cell Cardiol. 2002 Jul;34(7):823-31. PubMed PMID: 12099721
• Shizukuda Y, Buttrick PM. Isoprotrenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation. 2002 Jan 15;105(2):E9. PubMed PMID: 11790716
• Shizukuda Y, Buttrick PM. Coronary flow reserve or brachial artery flow to assess endothelial dysfunction: is it time to look at the heart again?. Am J Cardiol. 2002 Jan 1;89(1):113. PubMed PMID: 11779545
• Shizukuda Y, Buttrick PM. Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. Am J Physiol Heart Circ Physiol. 2002 Jan;282(1):H320-7. PubMed PMID: 11748077
• Shizukuda Y, Buttrick PM. Oxygen free radicals and heart failure: new insight into an old question. Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L237-8. PubMed PMID: 12114183
• Alden KJ, Goldspink PH, Ruch SW, Buttrick PM, García J. Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. Am J Physiol Cell Physiol. 2002 Apr;282(4):C768-74. PubMed PMID: 11880265
• Nwogu JI, Geenen D, Bean M, Brenner MC, Huang X, Buttrick PM. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation. 2001 Oct 30;104(18):2216-21. PubMed PMID: 11684634
• Goldspink PH, McKinney RD, Kimball VA, Geenen DL, Buttrick PM. Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats. Mol Cell Biochem. 2001 Oct;226(1-2):83-8. PubMed PMID: 11768242
• Shizukuda Y, Buttrick PM. Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity. J Mol Cell Cardiol. 2001 Oct;33(10):1791-803. PubMed PMID: 11603922
• Roman BB, Geenen DL, Leitges M, Buttrick PM. PKC-beta is not necessary for cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2264-70. PubMed PMID: 11299230
• Huang L, Wolska BM, Montgomery DE, Burkart EM, Buttrick PM, Solaro RJ. Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta. Am J Physiol Cell Physiol. 2001 May;280(5):C1114-20. PubMed PMID: 11287324
• Medin JA, Buttrick PM. Gene transfer in the cardiovascular system: update 2000. Heart Dis. 2000 Nov-Dec;2(6):409-21. PubMed PMID: 11728292
• Tian R, Miao W, Spindler M, Javadpour MM, McKinney R, Bowman JC, Buttrick PM, Ingwall JS. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13536-41. PubMed PMID: 10557356
• Yan SF, Lu J, Zou YS, Soh-Won J, Cohen DM, Buttrick PM, Cooper DR, Steinberg SF, Mackman N, Pinsky DJ, Stern DM. Hypoxia-associated induction of early growth response-1 gene expression. J Biol Chem. 1999 May 21;274(21):15030-40. PubMed PMID: 10329706
• Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, Sonnenblick EH. beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol. 1998 Sep;275(3):H961-8. PubMed PMID: 9724301
• Geenen DL, Malhotra A, Scheuer J, Buttrick PM. Repeated catecholamine surges alter cardiac isomyosin expression but not protein synthesis in the rat heart. J Mol Cell Cardiol. 1997 Oct;29(10):2711-6. PubMed PMID: 9344765
• Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest. 1997 Nov 1;100(9):2189-95. PubMed PMID: 9410895
• Malhotra A, Nakouzi A, Bowman J, Buttrick P. Expression and regulation of mutant forms of cardiac TnI in a reconstituted actomyosin system: role of kinase dependent phosphorylation. Mol Cell Biochem. 1997 May;170(1-2):99-107. PubMed PMID: 9144323
• Spencer RG, Buttrick PM, Ingwall JS. Function and bioenergetics in isolated perfused trained rat hearts. Am J Physiol. 1997 Jan;272(1 Pt 2):H409-17. PubMed PMID: 9038963
• Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, Buttrick PM. Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade. Circ Res. 1997 Dec;81(6):1027-33. PubMed PMID: 9400384
• Rybin VO, Buttrick PM, Steinberg SF. PKC-lambda is the atypical protein kinase C isoform expressed by immature ventricle. Am J Physiol. 1997 Apr;272(4 Pt 2):H1636-42. PubMed PMID: 9139945
• Kang PM, Nakouzi A, Simpson T, Scheuer J, Buttrick PM. Role of endogenous renin-angiotensin system in c-fos activation and PKC-epsilon translocation in adult rat hearts. Am J Physiol. 1996 Jun;270(6 Pt 2):H2177-83. PubMed PMID: 8764271
• Geenen DL, Malhotra A, Buttrick PM. Angiotensin receptor 1 blockade does not prevent physiological cardiac hypertrophy in the adult rat. J Appl Physiol (1985). 1996 Aug;81(2):816-21. PubMed PMID: 8872651
• Wiese S, Askanazi J, Manner T, Katz DP, Buttrick P. Effect of substrate manipulation on reducing ischemia/reperfusion injury in isolated perfused rat hearts. Clin Nutr. 1995 Apr;14(2):123-8. PubMed PMID: 16843910
• Kaplan ML, Cheslow Y, Vikstrom K, Malhotra A, Geenen DL, Nakouzi A, Leinwand LA, Buttrick PM. Cardiac adaptations to chronic exercise in mice. Am J Physiol. 1994 Sep;267(3 Pt 2):H1167-73. PubMed PMID: 8092282
• Kass-Eisler A, Falck-Pedersen E, Elfenbein DH, Alvira M, Buttrick PM, Leinwand LA. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther. 1994 Nov;1(6):395-402. PubMed PMID: 7584105
• De Leon JR, Buttrick PM, Fishman GI. Functional analysis of the connexin43 gene promoter in vivo and in vitro. J Mol Cell Cardiol. 1994 Mar;26(3):379-89. PubMed PMID: 8028021
• Buttrick PM, Kaplan M, Leinwand LA, Scheuer J. Alterations in gene expression in the rat heart after chronic pathological and physiological loads. J Mol Cell Cardiol. 1994 Jan;26(1):61-7. PubMed PMID: 8196070
• Geenen DL, Malhotra A, Buttrick PM, Scheuer J. Ventricular pacing attenuates but does not reverse cardiac atrophy and an isomyosin shift in the rat heart. Am J Physiol. 1994 Dec;267(6 Pt 2):H2149-54. PubMed PMID: 7810714
• Fishman GI, Kaplan ML, Buttrick PM. Tetracycline-regulated cardiac gene expression in vivo. J Clin Invest. 1994 Apr;93(4):1864-8. PubMed PMID: 8163686
• Fisher SA, Buttrick PM, Sukovich D, Periasamy M. Characterization of promoter elements of the rabbit cardiac sarcoplasmic reticulum Ca(2+)-ATPase gene required for expression in cardiac muscle cells. Circ Res. 1993 Oct;73(4):622-8. PubMed PMID: 8370120
• Buttrick PM, Kaplan ML, Kitsis RN, Leinwand LA. Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results. Circ Res. 1993 Jun;72(6):1211-7. PubMed PMID: 8495550
• Buttrick P, Kaplan M, Camargo MJ, deSimone G, Laragh JH, Wallerson D, Devereux RB. The influence of dietary salt and plasma renin activity on myosin heavy chain gene expression in rat hearts. Am J Hypertens. 1993 Jul;6(7 Pt 1):579-85. PubMed PMID: 8397998
• Kass-Eisler A, Falck-Pedersen E, Alvira M, Rivera J, Buttrick PM, Wittenberg BA, Cipriani L, Leinwand LA. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11498-502. PubMed PMID: 8265580
• Buttrick P, Scheuer J. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation. 1992 Oct;86(4):1336-8. PubMed PMID: 1394941
• Geenen DL, Malhotra A, Buttrick PM, Scheuer J. Increased heart rate prevents the isomyosin shift after cardiac transplantation in the rat. Circ Res. 1992 Mar;70(3):554-8. PubMed PMID: 1531621
• Cowley AW Jr, Dzau V, Buttrick P, Cooke J, Devereux RB, Grines CL, Haidet GC, Thames MD. Working group on noncoronary cardiovascular disease and exercise in women. Med Sci Sports Exerc. 1992 Jun;24(6 Suppl):S277-87. PubMed PMID: 1352614
• Buttrick PM, Kass A, Kitsis RN, Kaplan ML, Leinwand LA. Behavior of genes directly injected into the rat heart in vivo. Circ Res. 1992 Jan;70(1):193-8. PubMed PMID: 1309314
• Amin M, Gabelman G, Buttrick P. Cocaine-induced myocardial infarction. A growing threat to men in their 30s. Postgrad Med. 1991 Sep 15;90(4):50-5. PubMed PMID: 1891433
• Kitsis RN, Buttrick PM, McNally EM, Kaplan ML, Leinwand LA. Hormonal modulation of a gene injected into rat heart in vivo. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4138-42. PubMed PMID: 2034660
• Buttrick P, Malhotra A, Factor S, Greenen D, Leinwand L, Scheuer J. Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart. Circ Res. 1991 Mar;68(3):645-52. PubMed PMID: 1835908
• Rosen S, Lahorra M, Cohen MV, Buttrick P. Ventricular fibrillation threshold is influenced by left ventricular stretch and mass in the absence of ischaemia. Cardiovasc Res. 1991 Jun;25(6):458-62. PubMed PMID: 1889059
• Buttrick P, Perla C, Malhotra A, Geenen D, Lahorra M, Scheuer J. Effects of chronic dobutamine on cardiac mechanics and biochemistry after myocardial infarction in rats. Am J Physiol. 1991 Feb;260(2 Pt 2):H473-9. PubMed PMID: 1996690
• Malhotra A, Buttrick P, Scheuer J. Effects of sex hormones on development of physiological and pathological cardiac hypertrophy in male and female rats. Am J Physiol. 1990 Sep;259(3 Pt 2):H866-71. PubMed PMID: 2144404
• Amin M, Gabelman G, Karpel J, Buttrick P. Acute myocardial infarction and chest pain syndromes after cocaine use. Am J Cardiol. 1990 Dec 15;66(20):1434-7. PubMed PMID: 2251988
• Rubin SA, Buttrick P, Malhotra A, Melmed S, Fishbein MC. Cardiac physiology, biochemistry and morphology in response to excess growth hormone in the rat. J Mol Cell Cardiol. 1990 Apr;22(4):429-38. PubMed PMID: 2143788
• Eghbali M, Blumenfeld OO, Seifter S, Buttrick PM, Leinwand LA, Robinson TF, Zern MA, Giambrone MA. Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol. 1989 Jan;21(1):103-13. PubMed PMID: 2716064
• McNally EM, Buttrick PM, Leinwand LA. Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension. Nucleic Acids Res. 1989 Apr 11;17(7):2753-67. PubMed PMID: 2717409
• Geenen D, Buttrick P, Scheuer J. Cardiovascular and hormonal responses to swimming and running in the rat. J Appl Physiol (1985). 1988 Jul;65(1):116-23. PubMed PMID: 3403456
• Buttrick P, Malhotra A, Factor S, Geenen D, Scheuer J. Effects of chronic dobutamine administration on hearts of normal and hypertensive rats. Circ Res. 1988 Jul;63(1):173-81. PubMed PMID: 2968193
• Buttrick PM, Malhotra A, Scheuer J. Effects of systolic overload and swim training on cardiac mechanics and biochemistry in rats. J Appl Physiol (1985). 1988 Apr;64(4):1466-71. PubMed PMID: 2967813

Professional Memberships

• American College of Cardiology, Fellow
• American Heart Association (AHA), Inaugural Fellow