Daniel Chan, PhD, MS

Publications

• Argast G.M., Croy C.H., Couts, K.L., Zhang Z.Y., Litman E., Chan, D.C. and Ahn, N.G.: Plexin B1 is repressed by oncogeneic B-Raf signaling and functions as a tumor suppressor in melanoma cells. Oncogene 28:2697-2710, 2009.
• Yukihito Kabuyama, Elizabeth S. Litman, Paul Templeton, Sandra Sousa1, Eric Witze,Gretchen M. Argast, Stephen J. Langer, Kirsi Polvinen, Yiqun Shellman, Daniel Chan,John B. Shabb, James E. Fitzpatrick, Katheryn A. Resing, Marcelo C. Sousa, and Natalie G. Ahn: A mediator of Rho-dependent signaling in melanoma has dual function as a methionine salvage enzyme. J. Thoracic Oncology 4: 1455-1465, 2009.
• Barthel B, Zhang Z, Rudnicki, DL, Coldren CD, Polinkovsky M, Sun H, Koch GG, Chan DC and Koch T. Preclinical efficacy of a carboxylesterase 2 activated prodrug of doxazolidine. J Medicinal Chemistry 52: 7678-7688, 2009
• Kabuyama Y, Litman ES, Templeton P, Sousal S, Witze E, Argast G, Langer SJ, Polvinen, K, Shellman, Y, Chan D, Shabb J. Fotz[atrocl JE, Resing K, Sousa M, and Ahn N. A mediator of Pho dependent signaling in melanoma has dual function as a methionine salvage enzyme. Molecular Cellular Proteomics 8: 2308, 2009.
• Helfrich B, Raben D, Varella-Garcia, Gustafson D, Chan DC, Coldren C, Baron a, Zeng C, Franklin W, Hirsch F, Gazdar A, Minna J and Bunn PA Jr: Antitumor activity of the EGFR tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in NSCLC cell lines and xenografts correlates with gene copy number and EGFR mutations but not EGFR protein levels. Clinical Cancer Research 12(23): 7117-7125, 2006.
• Di Zheng, Zhiyong Zhang, Tiffany Chan, Hong Wang, Natalie Ahn, Kate Horwitz, Paul Bunn, Lewis Lanier and Daniel C Chan: A novel mechanism of Immune escape?an old trick of impersonation. Pending
• Witta, Samir, Helfrich B, Hirsch FR, Coldren C, Hedman K, Chan Z. Chan DC, Ravdel L, Baron A, Franklin W, Drabkin HA, Minna JD, Gemmill RM, Bunn PA Jr: Restoring E-cadherin expression increases sensitivity to EGFR inhibitors in lung cancer cell lines. Cancer Research 66(2) 944-950, 2006.
• Terry W. Moody, Marc J. Berna, Samuel Mantey, Veronica Sancho, Lisa Ridnour, David A. Wink, Daniel Chan, Giuseppe Giaccone, Robert T. Jensen. Inhibition of Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells. European J of Pharmacology 637: 38-45, 2010.
• Moody TW, Nakagawa T, Kang Y, Jakowlew S, Chan DC and Jensen RT: Bombesin/Gastrin releasing peptide receptor antagonists increase the ability of histone deacetylase inhibitors to reduce lung cancer proliferation. J Mol Neurosci 28(3): 231-238, 2006.
• Thomas S M, Bhola N, Zhang Q, Wentzel AL, Freilina M, Gooding WE, Siegfried JM, Chan DC, Grandis JR: Cross-talk between G-protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. Cancer Research 66(24) 11831-11839, 2006.
• Brauweiler A, Lorick K, Lee JP, Tsai Y, Chan DC, Weissman A, Drabkin H, and Gemmill RM: RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. Oncogene (in press, 2006).
• Witta, S. Girard, L. Zheng, D. Zhang, ZY, Peyton M, Danenberg, KD, Minna J, Bunn PA Jr, Chan, DC, and Hirsch FR: Predicting response to cetuximab and enhancing its activity with entinostat in non-small cell lung cancer (2011).
• Ghosh R, Arevalo, NE, Garcia GE, Williams KL, Yeh IT, Troyer DA, Chan DC, and Kumar AP: Antioxidant combination blocks progression of prostatic intraepithelial neoplasia
• Brechbuhl, Heather, Kachadourian R, Min E, Chan, D, and Day, BJ. Chrysin enhances doxorubicin-induced cytotoxicity in several human lung epithelial cancer cell lines: the role of glutathione. (submitted for publication, 2011).
• Xiang Ling, Xiang He, Felicia Cao, Hak-Ryul Kim, Daniel C. F. Chan and Fengzhi Li: Combination of cisplatin with AITC down regulates the expression of surviving/ Bcl-2, inhibits cancer cell growth and induces apoptosis. (submitted for publication, 2011).
• Daniel C. Chan, Samir E. Witta, Di Zheng, Veronika Franekova, Xiaomei Sui, Peter Ordentlich, Paul A. Bunn, Jr., Fred R. Hirsch. Characterization of the class 1 histone deacetylase inhibitor entinostat in EGFRi acquired resistance models and in combination with cetuximab in NSCLC. AACR Proceeding 51: 1319, #5439, 2010.
• Zhiyong Zhang, Hong Wang#, Xiaomei Sui, Tiffany Chan, Paul A. Bunn Jr, Natalie Ahn#, Lewis L. Lanier*, and Daniel C. Chan: Role of Natural Killer-cell Immunoglobulin-like receptors (KIR) in Immune Resistance. AACR proceeding 51: 326, #1357, 2010.
• Yan Chao, Shieh B, Regan P, Zhang ZY, Colucci M, Chilloux a, Newsome J, Siegel D, Chan DC Moody CJ, Ross D. Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer. AACR Proceeding 51: 1102, #4544, 2010.
• Zhiyong Zhang, Tiffany Chan, Joseph Phillips, Paul A Bunn, Jr, Lewis Lanier and Daniel Chan: Anti-KIR antibodies augmented NK killings of cancer cells with aberrant expression of KIRs. AACR 2011
• Argast, G.M., Croy, C.H., Litman, E.S, Zhang, J., Chan, DC., Ahn, N.G. Suppression of Plexin B1 by MEK/ERK in melanoma contributes to primary tumor growth and metastatic potential.
• Chan, D, Gara L, Helfrich, B, Zhang ZZ, Eckhardt, Stewart JM, and Bunn PA Jr: Preclinical development of bradykinin receptor antagonist dimer CU201 for lung cancer therapy. Lung Cancer SPORE Winter Meeting: Abstract #28, 2006.
• Daniel Chan, Victor Chen, Barbara Helfrich, Zhiyong Zhang, Fred Hirsch, Doreen Ma, and Paul Bunn, Jr. Preclinical studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancers. AACR 2006, Vol 47: pp. 1278, Abstract # 5441.
• Rita Ghosh, Daniel C Chan, Dean A Troyer and Addanki Pratap Kumar: Combination of antioxidants prevent the development of PIN in Noble rats. AACR 2006, Vol 47: pp. 162, Abstract #680.
• Alpna Tyagi, Anil Tyagi, Daniel Chan, Chapla Agarwal, and Rajesh Agarwal Grape Seed Extract Sensitizes Human Breast Carcinoma MDA-MB468 and MDA-MB231 cells to chemotherapy agents-induced Growth Inhibition and Apoptotic Death via cytochrome C release and caspase 3 activation pathway. AACR 2006, Vol 47: pp. 1283abstract #5460.
• PEP02, liposomal irinotecan, effectively inhibited lung xenografts in subcutaneous and orthotopic models. 16th World Conference on Lung Cancer, July 14, 2011, Holland.
• Gemmill Robert, Brauweiler A, Lee JP, Chan DC, Hooper JE, Lorick K, Weissman A, Drabkin HA: TRC8 (RNF139), the t(3;8) hereditary RCC gene, is a sterol-regulated polytopic RING protein whose ubiquitin ligase activity is necessary for tumor suppression. AACR 2006, Vol 47: pp. 781, Abstract # 3323.
• Brechbuhl, Heather, Kachadourian R, Min E, Chan, D, and Day, BJ. Chrysin enhances doxorubicin-induced cytotoxicity in several human lung epithelial cancer cell lines: the role of glutathione. Toxicology an Applied Pharmacology, 258, 2012
• Patricia A Burke, Xiaoru Chen, Cassandra L. Waters, Glenn M. Swartz, Steven J. Strawn, Daniel C. Chan and Theresa M. LaVallee. ENMD-1198 is a microtubule destabilizing agent and inhibits HIF-1?, NF-?B and Stat3, transcription factors that promote tumorigenesis. AACR 2006, Vol 47: pp. 116, Abstract #491.
• Thomas SU, Zhang Q, Kalyankrishna S, Wentzel A, Freilijno M, Gubish C, Gooding WE, Siefgried, Daniel Chan, JM, Grandis JR: Head and neck squamous cell carcinoma express receptors for PGE2 and bradykinin that trans-activate the EGFR signaling axis increasing tumor invasion and proliferation. AACR 2006, Vol 47: pp. 1131, Abstract # 4819.
• Daniel Chan, Victor J. Chen, Zhiyong Zhang, Barbara Helfrich, Fred Hirsch, Doreen Ma, and Paul Bunn, Jr. Studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancer models. J. Clinical Oncology, 24(18s), part 1, P.676s, #17114, ASCO 2006
• Mara Gladstone, Barbara Frederick, Di Zheng, Anthony Edwards, Petros Yoon, Stefanie Stickel, Tessie DeLaney, Daniel C Chan, David Raben, and Tin Tin Su: A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer. Disease Model and Mechanism 5: 342-350, 2012.
• Matias Casas Selves, Jihye Kim, Yhiyong Zhang, Barbara Helfrich, Dexiang Gao, Christopher C. Porter, Paul Bunn, Daniel Chan, Aik Choon Tan, James DeGregori: Tankyrase and the Canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Research, 72: 1-11, 2012.
• Brechbuhl, Heather, Kachadourian R, Min E, Chan, D, and Day, BJ. Chrysin enhances doxorubicin-induced cytotoxicity in several human lung epithelial cancer cell lines: the role of glutathione. Toxicology an Applied Pharmacology, 258, 2012
• Mara Gladstone, Barbara Frederick, Di Zheng, Anthony Edwards, Petros Yoon, Stefanie Stickel, Tessie DeLaney, Daniel C Chan, David Raben, and Tin Tin Su: A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer. Disease Model and Mechanism 5: 342-350, 2012.
• Eiji Nakajima, Barbara A. Helfrich, Dan Chan, Zhiyong Zhang, Fred R. Hirsch, Paul A. Bunn Jr. Enzastaurin a Protein Kinase C?-Selective Inhibitor, Inhibits the Growth of SCLC and NSCLC Cell Lines. J Clinical Oncology, 24 (18s), Part 1, p. 612s, #13138.
• Matias Casas Selves, Jihye Kim, Yhiyong Zhang, Barbara Helfrich, Dexiang Gao, Christopher C. Porter, Paul Bunn, Daniel Chan, Aik Choon Tan, James DeGregori: Tankyrase and the Canonical Wnt pathway protect lung cancer cells from EGFR inhibition. Cancer Research, 72: 1-11, 2012.
• Samiha Mateen, Komal Raina, Anil Jain, Chapla Agarwal, Daniel Chan, Rajesh Agarwal: "Epigenetic Modifications and p21-cyclin B1 Nexus in Anti-cancer Effect of Histone Deacetylase Inhibitors in Combination with Silibinin on Non-Small Cell Lung Cancer Cells". Epigenetics 7(10): 1161-1172, 2012
• Samiha Mateen, Komal Raina, Chapla, Agarwal, Daniel Chan and Rajesh Agarwal: Silibinin synergizes with histone deacetylase and DNA methytransferase inhibitors in up-regulating E-Cadherin expression in non-small cell lung cancer cells. J. Pharmacology and Experimental Therapeutics, March 5,2013. DOI:10.1123/jpet.113.203471.
• Chan, DC, Gera, L, Zhang ZZ, Zheng D, Hodges, R, Stewart, JM, Bunn, P Jr; Development of novel NSAID conjugated molecules for lung cancer therapy. Proc AACR, 53: 472, #1941, 2012
• Mateen, S, Paina, K, Agarwal C, Chan D and Agarwal R: Silibinin synergizes with histone deactylase (HDAC) inhibitors in upregulating E-Cadherin expression in NSCLC cells. Proc AACR, 53: 390, #1608, 2012.
• Gera, L, Chan, DC, Bunn, PA and Hodges RS: Design and synthesis of small molecule peptidomimetics as broad spectrum anticancer drug candidates. 23rd American Peptide Symposium, Aug 13, 2013.
• Witta S, Bunn PA Jr., Drabkin H, Gemmill B and Chan DC: Histone Deacetylase inhibitors sensitize cancer cells to epidermal growth factor inhibitors”, US Patent Application US2012/0141479 A1, June 7 2012.
• Barb Helfrich, Eji Nakajima, Dan Chan, Zhiyong Zhang, Fred R. Hirsch, Paul A. Bunn. Pemetrexed inhibits the in vitro growth of SCLC Cell Lines. ASCO 2006.
• B.D. Kavanagh, R.P. Steffen, B. Frederick, B Solomon, D. Chan. The influence of Efaproxiral on tumor hypoxia and HIF-1-alpha expression in a breast cancer xenograft. J Clinical Oncology, 24 (18S) Part 1, p.565s, #10102, ASCO 2006.
• Chan DC, Chen V et al: Enzastaurin for lung cancer therapy, AACR 2007.
• Charu Gupta, Girish Sharma and Daniel Chan: “Resveratrol: a chemopreventative agent with diverse applications” in Phytochemicals of Nutraceutical Importance, Editors: Dhan Prakash and Girish Sharma, Chapter 4, p. 47-60, CABI Publisher (2013).
• Jingjing Gong, Amanda R Muñoz, Daniel Chan, Rita Ghosh and Addanki P Kumar: Stat3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth: Role of Nexrutine : Cell Death and Differentiation (in press, 2014)
• . L Gera, D.C. Chan, P.A. Bunn, Jr., R.S. Hodges. Design and synthesis of small molecule peptidomimetics as broad spectrum anticancer candidates. Abstracts, 23rd American Peptide Symposium, 2013, P257 (Biopolymers, 100(3): 303-304, 2013).
• Terry Moody, Daniel Chan, Samuel A Mantey, Paola Moreno, and Robert T Jensen: SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner. Life Sciences (in press, 2014).
• Zhang Lei, Chan DC, Wiseman A, Balamurugan A, Serkova N and Chan L: Short report on NMR imaging on human islet labeled with nanoparticles. American Transplant Conference, 2007.
• Terry Moody, Daniel Chan, Samuel A Mantey, Paola Moreno, and Robert T Jensen: SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner. Life Sciences 100(1) 25-34, 2014.
• Jingjing Gong, Amanda R Muñoz, Daniel Chan, Rita Ghosh and Addanki P Kumar: Stat3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth: Role of Nexrutine : Oncotarget, 5: 1-13, 2014.
• Helfrich B, Raben D, Varella-Garcia, Gustafson D, Chan DC, Coldren C, Baron a, Zeng C, Franklin W, Hirsch F, Gazdar A, Minna J and Bunn PA Jr: Antitumor activity of the EGFR tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in NSCLC cell lines and xenografts correlates with gene copy number and EGFR mutations but not EGFR protein levels. Clinical Cancer Research 12(23): 7117-7125, 2006.
• Witta, Samir, Helfrich B, Hirsch FR, Coldren C, Hedman K, Chan Z. Chan DC, Ravdel L, Baron A, Franklin W, Drabkin HA, Minna JD, Gemmill RM, Bunn PA Jr: Restoring E-cadherin expression increases sensitivity to EGFR inhibitors in lung cancer cell lines. Cancer Research 66(2) 944-950, 2006.
• Moody TW, Nakagawa T, Kang Y, Jakowlew S, Chan DC and Jensen RT: Bombesin/Gastrin releasing peptide receptor antagonists increase the ability of histone deacetylase inhibitors to reduce lung cancer proliferation. J Mol Neurosci 28(3): 231-238, 2006.
• Thomas S M, Bhola N, Zhang Q, Wentzel AL, Freilina M, Gooding WE, Siegfried JM, Chan DC, Grandis JR: Cross-talk between G-protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell carcinoma. Cancer Research 66(24) 11831-11839, 2006.
• Brauweiler A, Lorick K, Lee JP, Tsai Y, Chan DC, Weissman A, Drabkin H, and Gemmill RM: RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. Oncogene 26: 2263-2271, 2007.
• Frederick BA, Helfrich B, Coldren CD, Zheng D, Chan DC, Bunn PA jr, and Raben D: Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non-small cell lung cancer cell lines. Molecular Cancer Therapeutics 6(6): 2701-2710, 2007.
• Ghosh R, Arevalo, NE, Garcia GE, Williams KL, Yeh IT, Troyer DA, Chan DC, and Kumar AP: Antioxidant combination blocks progression of prostatic intraepithelial neoplasia (submitted for publication, 2007).
• Ohira T, Kakihana M, Chan DC, Witta S, Roche J, Drabkin HA, Gemmill RM: Induction of E-Cadherin and Apoptosis by histone deacetylase inhibitors in lung cancer. Molecular Cancer Therapeutics, 2007.
• Argast, G.M., Croy, C.H., Litman, E.S, Zhang, J., Chan, DC., Ahn, N.G. Suppression of Plexin B1 by MEK/ERK in melanoma contributes to primary tumor growth and metastatic potential. (submitted for publication 2007).
• Chan DC, Zheng D and Zhang ZY: A novel mechanism of immunoescape and metastasis: an old trick of impersonation. Nature, Letter to Editor (submited 2008)
• Chan, D, Gara L, Helfrich, B, Zhang ZZ, Eckhardt, Stewart JM, and Bunn PA Jr: Preclinical development of bradykinin receptor antagonist dimer CU201 for lung cancer therapy. Lung Cancer SPORE Winter Meeting: Abstract #28, 2006.
• Daniel Chan, Victor Chen, Barbara Helfrich, Zhiyong Zhang, Fred Hirsch, Doreen Ma, and Paul Bunn, Jr. Preclinical studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancers. AACR 2006, Vol 47: pp. 1278, Abstract # 5441.
• Rita Ghosh, Daniel C Chan, Dean A Troyer and Addanki Pratap Kumar: Combination of antioxidants prevent the development of PIN in Noble rats. AACR 2006, Vol 47: pp. 162, Abstract #680.
• Alpna Tyagi, Anil Tyagi, Daniel Chan, Chapla Agarwal, and Rajesh Agarwal Grape Seed Extract Sensitizes Human Breast Carcinoma MDA-MB468 and MDA-MB231 cells to chemotherapy agents-induced Growth Inhibition and Apoptotic Death via cytochrome C release and caspase 3 activation pathway. AACR 2006, Vol 47: pp. 1283abstract #5460.
• Gemmill Robert, Brauweiler A, Lee JP, Chan DC, Hooper JE, Lorick K, Weissman A, Drabkin HA: TRC8 (RNF139), the t(3;8) hereditary RCC gene, is a sterol-regulated polytopic RING protein whose ubiquitin ligase activity is necessary for tumor suppression. AACR 2006, Vol 47: pp. 781, Abstract # 3323.
• Patricia A Burke, Xiaoru Chen, Cassandra L. Waters, Glenn M. Swartz, Steven J. Strawn, Daniel C. Chan and Theresa M. LaVallee. ENMD-1198 is a microtubule destabilizing agent and inhibits HIF-1?, NF-?B and Stat3, transcription factors that promote tumorigenesis. AACR 2006, Vol 47: pp. 116, Abstract #491.
• Thomas SU, Zhang Q, Kalyankrishna S, Wentzel A, Freilijno M, Gubish C, Gooding WE, Siefgried, Daniel Chan, JM, Grandis JR: Head and neck squamous cell carcinoma express receptors for PGE2 and bradykinin that trans-activate the EGFR signaling axis increasing tumor invasion and proliferation. AACR 2006, Vol 47: pp. 1131, Abstract # 4819.
• Daniel Chan, Victor J. Chen, Zhiyong Zhang, Barbara Helfrich, Fred Hirsch, Doreen Ma, and Paul Bunn, Jr. Studies of pemetrexed and gemcitabine, alone and in combinations, in human lung cancer models. J. Clinical Oncology, 24(18s), part 1, P.676s, #17114, ASCO 2006
• Eiji Nakajima, Barbara A. Helfrich, Dan Chan, Zhiyong Zhang, Fred R. Hirsch, Paul A. Bunn Jr. Enzastaurin a Protein Kinase C?-Selective Inhibitor, Inhibits the Growth of SCLC and NSCLC Cell Lines. J Clinical Oncology, 24 (18s), Part 1, p. 612s, #13138.
• Barb Helfrich, Eji Nakajima, Dan Chan, Zhiyong Zhang, Fred R. Hirsch, Paul A. Bunn. Pemetrexed inhibits the in vitro growth of SCLC Cell Lines. ASCO 2006.
• B.D. Kavanagh, R.P. Steffen, B. Frederick, B Solomon, D. Chan. The influence of Efaproxiral on tumor hypoxia and HIF-1-alpha expression in a breast cancer xenograft. J Clinical Oncology, 24 (18S) Part 1, p.565s, #10102, ASCO 2006.
• Chan DC, Chen V et al: PKC inhibitor for lung cancer therapy. 12th World Conference on Lung Cancer. J Thoracic Oncology, 2 (8), supplement 4: S460, PD3-1-4, 2007.
• Nakajima E, Sugita M, Helfrich B, Chan DC, Kato H, Bunn PA Jr, Franklin WA, and Hirsch FR: Putative biomarker genes for pemetrexed threatment in small and non-small cell lung cancer cell lines, detected by microarray analysis. J Thoracic Oncology, 2(8), Supplement S508, P2-047, 2007.
• Harry A. Drabkin, Barbara Helfrich, Dan Chan, Tzu Phang, Wilbur A. Franklin, , Paul Bunn and Robert M. “Gemmill. Mesenchymal conversion of lung cancer by ZEB1”. 2007 spore Summer Workshop.
• Harry A. Drabkin, Barbara Helfrich, Dan Chan, Tzu Phang, Wilbur A. Franklin, , Paul Bunn and Robert M. Gemmill. Strategy to Identify Genes Responsible for EGFR-inhibitor Resistance and Novel Biomarkers in Lung Cancer Univ. of Colorado Lung SPORE.
• L. Gera, D.C.Chan, V. Simkeviciene, P A. Bunn, Jr and J. M. Stewart: N-(Fluorenyl-9-methoxycarbonyl)amino acid amide derivatives as a new class of anti-cancer agents, Peptide Science, vol .88, 535, 2007.
• David Siegel, Phillip Reigan, Aurélie Chilloux, Marie A. Colucci, Cho Yan, Biehuoy Shieh, Zhiyong Zhang, Daniel Chan, Christopher J. Moody and David Ross: The development of indolequinone-based anticancer agents for the treatment of pancreatic cancer. AACR Molecular Targets (2007).
• Daniel Chan, ZY Zhang, D Zheng, A Dulude, E Nakajima, B Helfrich, F Hirsch, M Clay1, V Chen1, D Ma1 and P Bunn, Jr.:Enzastaurin (LY317615.HCl) inhibits human lung cancer cells in vitro and in vivo: a pharmacodynamic study. AACR 2007, Vol.47, pp. 358, #5408.
• Di Zheng, Zhiyong Zhang, Alexandra Dulude, Michio Sugita, Paul A. Bunn, Jr, and Daniel C. Chan. AACR 2008. Identification of genes modulated in lung cancer metastasis in orthotopic rat model.
• Michio Sugita, Jerry L. Haney, Zhiyong Zhang, Di Zheng, Lynne T. Bemis, Wilbur A. Franklin, Daniel C. Chan. New biomarkers for lung cancer by gene expression with xenograft tumor. AACR 2008.
• Rana P. Singh, Komal Raina, Gagan Deep, Daniel Chan and Rajesh Agarwal: Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via inhibition of STAT and activation of ERK1/2 signaling, AACR 2008.
• Rana P. Singh, Komal Raina, Gagan Deep, Daniel Chan and Rajesh Agarwal. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of ERK1/2 and inhibition of STAT signaling. Clinical Cancer Res 15(2):613-621, 2009.
• Ghosh R, Arevalo, NE, Garcia GE, Williams KL, Yeh IT, Troyer DA, Chan DC, and Kumar AP: Combination of 2-Methoxyestradiol (2-ME2) and Eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. The Journal of Steroid Biochemistry and Molecular Biology 113 25-35, 2009.
• Chao Yan, Biehuoy Shieh, Philip Reigan, Zhiyong Zhang, Marie A. Colucci, Aurélie Chilloux, Jeffery J. Newsome, David Siegel Daniel C.F. Chan, Christopher J. Moody, and David Ross. Indolequinone antitumor agents: in vitro and in vivo cytotoxicity against human pancreatic cancer, Cancer Research (submitted for publication, 2008).
• Terry W. Moody, Marc J. Berna, Samuel Mantey, Veronica Sancho, Nieves Gonzalez, Lisa Ridnour, David A. Wink, Daniel Chan, Giuseppe Giaccone, Robert T. Jensen. Inhibition of Neuromedin B mediated transactivation of EGF receptors in lung cancer cells enhances gefitinib sensitivity. Cancer Research (submitted for publication, 2008).
• Rita Ghosh, John Schoolfield, I-Tien Yeh, Maxwell L. Smith, Stephen D, Hursting, Daniel C.F. Chan, M. Scott Lucia and Addanki P. Kumar. Loss of NADPH Quinone Oxidoreductase (NQO1) in the prostate and enhanced serum levels of cytokine-induced neutrophil chemoattractant-2 alpha (CINC-2alpha) in hormone stimulated Noble rats: potential role in PIN development. Translational Oncology (in press 2009).
• Yukihito Kabuyama, Elizabeth S. Litman, Paul Templeton, Sandra Sousa1, Eric Witze,Gretchen M. Argast, Stephen J. Langer, Kirsi Polvinen, Yiqun Shellman, Daniel Chan,John B. Shabb, James E. Fitzpatrick, Katheryn A. Resing, Marcelo C. Sousa, and Natalie G. Ahn: A mediator of Rho-dependent signaling in melanoma has dual function as a methionine salvage enzyme. (submitted for publication, 2008).
• Argast G.M., Croy C.H., Couts, K.L., Zhang Z.Y., Litman E., Chan, D.C. and Ahn, N.G.: Plexin B1 is repressed by oncogeneic B-Raf signaling and functions as a tumor suppressor in melanoma cells. Oncogene (submitted for publication).
• Xiang Ling, Xiang He, Felicia Cao, Hak-Ryul Kim, Daniel C. F. Chan and Fengzhi Li: Combination of cisplatin with AITC down regulates the expression of surviving/ Bcl-2, inhibits cancer cell growth and induces apoptosis. (submitted for publication).
• Di Zheng, Zhiyong Zhang, Tiffany Chan, Kate Horwitz, Paul Bunn and Daniel C Chan: A novel mechanism of Immune escape—an old trick of impersonation. (Submitted, 2009).
• 155. Di Zheng, Zhiyong Zhang, Alexandra Dulude, Michio Sugita, Paul A. Bunn, Jr, and Daniel C. Chan. AACR 2008. Identification of genes modulated in lung cancer metastasis in orthotopic rat model.
• Michio Sugita, Jerry L. Haney, Zhiyong Zhang, Di Zheng, Lynne T. Bemis, Wilbur A. Franklin, Daniel C. Chan. New biomarkers for lung cancer by gene expression with xenograft tumor. AACR 2008.
• 157. Rana P. Singh, Komal Raina, Gagan Deep, Daniel Chan and Rajesh Agarwal: Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via inhibition of STAT and activation of ERK1/2 signaling, AACR 2008, Late breaking abstracts LB317, p.87, 2008.
• Miyako Okamoto, Aki Tanaka, Daniel CF Chan, David A Norris, Charles A Dinarello and Mayumi Fujita,: Autocrine regulation of human melanoma by interleukin-1ß, Keystone symposium on “Inflammation, microenvironment and cancer”. Pp. 57, #132, March 30-Apirl 4, 2008, Snowbird, Utah.
• Rana P. Singh, Komal Raina, Gagan Deep, Daniel Chan and Rajesh Agarwal. Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of ERK1/2 and inhibition of STAT signaling. Clinical Cancer Res 15(2):613-621, 2009.
• Ghosh R, Arevalo, NE, Garcia GE, Williams KL, Yeh IT, Troyer DA, Chan DC, and Kumar AP: Combination of 2-Methoxyestradiol (2-ME2) and Eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. The Journal of Steroid Biochemistry and Molecular Biology 113 25-35, 2009.
• Chao Yan, Biehuoy Shieh, Philip Reigan, Zhiyong Zhang, Marie A. Colucci, Aur?lie Chilloux, Jeffery J. Newsome, David Siegel Daniel C.F. Chan, Christopher J. Moody, and David Ross. Indolequinone antitumor agents: in vitro and in vivo cytotoxicity against human pancreatic cancer, Molecular Pharmacology 76: 163-172, 2009.
• Rita Ghosh, John Schoolfield, I-Tien Yeh, Maxwell L. Smith, Stephen D, Hursting, Daniel C.F. Chan, M. Scott Lucia and Addanki P. Kumar. Loss of NADPH Quinone Oxidoreductase (NQO1) in the prostate and enhanced serum levels of cytokine-induced neutrophil chemoattractant-2 alpha (CINC-2alpha) in hormone stimulated Noble rats: potential role in PIN development. Translational Oncology 2: 65-72, 2009.