Kelly Knupp, MD

Publications

• Barberio M, Reiter PD, Kaufman J, Knupp K, Dobyns EL. Continuous infusion pentobarbital for refractory status epilepticus in children. J Child Neurol. 2012 Jun;27(6):721-6. PubMed PMID: 22156786
• Knupp K, Koh S, Park K. Pediatric Epilepsy: Five new things. Neurology: clinical practice. 2012 March; 40(2):40-47.
• Gertsch E and Knupp, K, Do children “outgrow” epilepsy? in Licht, Daniel, Ryan, Nichole and Kotlar, Carrie, Curbside Consultation in Pediatric Neurology: 49 clinical questions.
• Knupp K, Wirrell E. Progressive myoclonic epilepsies: It takes a village to make a diagnosis. Neurology. 2014 Feb 4;82(5):378-9. PubMed PMID: 24384640
• Knupp K and Theile E, Vigabatrin. In: Elaine Wyllie E, Gidal B Goodkin B, Sirven J and Loddenkemper T editors. Wyllie’s Treatment of Epilepsy: Principles and Practice – 6th edition, in press
• Knupp K, Wirrell E. Progressive myoclonic epilepsies: it takes a village to make a diagnosis. Neurology. 2014 Feb 4;82(5):378-9. PubMed PMID: 24384640
• Knupp, K and Tuxhorn I. Infantile Spasms. In: Elaine Wyllie E, Gidal B Goodkin B, Sirven J and Loddenkemper T editors. Wyllie’s Treatment of Epilepsy: Principles and Practice – 6th edition, in press
• Kedia S, Knupp K, Schreiner T, Yang, M, Levisohn P, and Moe P. Chap 25 Neurologic and Muscle Disorders in Hay, Levin, Deterding, Abzug (eds) Current Diagnosis and Treatment 22nd edition, McGraw Hill/Lange , in press
• Kumar RM, Koh S, Knupp K, Handler MH, O'Neill BR. Surgery for infants with catastrophic epilepsy: an analysis of complications and efficacy. Childs Nerv Syst. 2015 Sep;31(9):1479-91. PubMed PMID: 26022500
• Press CA, Knupp KG, Chapman KE. Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy. Epilepsy Behav. 2015 Apr;45:49-52. PubMed PMID: 25845492
• Knupp K and Brooks-Kayal A. Channelopathies in Swaiman's Pediatric Neurology sixth edition, eds Ashwal et al
• Knupp K, Wirrell E. Progressive myoclonic epilepsies: it takes a village to make a diagnosis. Neurology. 2014 Feb 4;82(5):378-9. PubMed PMID: 24384640
• Knupp K and Tuxhorn I. Epileptic Spasms in Wyllie’s Treatment of Epilepsy: Principles and Practice Sixth Edition eds Elaine Wyllie
• Knupp K and Thiele I.Vigabatrin in Wyllie’s Treatment of Epilepsy: Principles and Practice Sixth Edition eds Elaine Wyllie
• Wirrell EC, Shellhaas RA, Joshi C, Keator C, Kumar S, Mitchell WG. How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium. Epilepsia. 2015 Apr;56(4):617-25. PubMed PMID: 25779538
• Treat L, Chapman KE, Colborn KL, Knupp KG. Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2016 Nov 18. [Epub ahead of print] PubMed PMID: 27859038
• Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 Nov;57(11):1834-1842. PubMed PMID: 27615012
• Gertsch, Emily and Knupp, K. Do Children Outgrow Epilepsy in Curbside Consultation in Pediatric Neurology, SLACK inc, Thorofare NJ
• Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar;79(3):475-84. PubMed PMID: 26704170
• Eschbach K, Scarbro S, Juarez-Colunga E, Allen V, Hsu S, Knupp K. Growth and endocrine function in children with Dravet syndrome. Seizure. 2017 Sep 29;52:117-122. [Epub ahead of print] PubMed PMID: 29031192
• Knupp KG, Scarbro S, Wilkening G, Juarez-Colunga E, Kempe A, Dempsey A. Parental Perception of Comorbidities in Children With Dravet Syndrome. Pediatr Neurol. 2017 Jun 20. [Epub ahead of print] PubMed PMID: 28982531
• Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct;75:73-79. PubMed PMID: 28807611
• Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 Sep 1;171(9):863-871. PubMed PMID: 28759667
• Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct;39(5):556-564. PubMed PMID: 28640062
• Ziobro J, Eschbach K, Sullivan JE, Knupp KG. Current Treatment Strategies and Future Treatment Options for Dravet Syndrome. Curr Treat Options Neurol. 2018 Oct 13;20(12):52. PubMed PMID: 30315507
• Wallace A, Allen V, Park K, Knupp K. Infantile Spasms and Injuries of Prematurity: Short-Term Treatment-Based Response and Long-Term Outcomes. J Child Neurol. 2017 Sep;32(10):861-866. PubMed PMID: 28635418
• Knupp KG. Hormonal therapy with vigabatrin is superior to hormonal therapy alone in infantile spasms. J Pediatr. 2017 May;184:235-238. PubMed PMID: 28434569
• Jensen MP, Brunklaus A, Dorris L, Zuberi SM, Knupp KG, Galer BS, Gammaitoni AR. The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research. Epilepsy Behav. 2017 May;70(Pt A):104-109. PubMed PMID: 28431364
• Tolete P, Knupp K, Karlovich M, DeCarlo E, Bluvstein J, Conway E, Friedman D, Dugan P, Devinsky O. Lorcaserin therapy for severe epilepsy of childhood onset: A case series. Neurology. 2018 Oct 30;91(18):837-839. PubMed PMID: 30258026
• Bramswig NC, Lüdecke HJ, Hamdan FF, Altmüller J, Beleggia F, Elcioglu NH, Freyer C, Gerkes EH, Demirkol YK, Knupp KG, Kuechler A, Li Y, Lowenstein DH, Michaud JL, Park K, Stegmann APA, Veenstra-Knol HE, Wieland T, Wollnik B, Engels H, Strom TM, Kleefstra T, Wieczorek D. Heterozygous HNRNPU variants cause early onset epilepsy and severe intellectual disability. Hum Genet. 2017 Jul;136(7):821-834. PubMed PMID: 28393272
• Wirrell EC, Laux L, Donner E, Jette N, Knupp K, Meskis MA, Miller I, Sullivan J, Welborn M, Berg AT. Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel. Pediatr Neurol. 2017 Mar;68:18-34.e3. PubMed PMID: 28284397
• Coryell J, Gaillard WD, Shellhaas RA, Grinspan ZM, Wirrell EC, Knupp KG, Wusthoff CJ, Keator C, Sullivan JE, Loddenkemper T, Patel A, Chu CJ, Massey S, Novotny EJ Jr, Saneto RP, Berg AT. Neuroimaging of Early Life Epilepsy. Pediatrics. 2018 Sep;142(3). PubMed PMID: 30089657
• Griffin A, Hamling KR, Knupp K, Hong S, Lee LP, Baraban SC. Clemizole and modulators of serotonin signalling suppress seizures in Dravet syndrome. Brain. 2017 Mar 1;140(3):669-683. PubMed PMID: 28073790
• Treat L, Chapman KE, Colborn KL, Knupp KG. Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients. Epilepsia. 2017 Jan;58(1):123-127. PubMed PMID: 27859038
• Knupp KG, Wirrell EC. Correction to: Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Aug;32(8):783. PubMed PMID: 30027402
• Kelley SA, Knupp KG. Infantile Spasms-Have We Made Progress?. Curr Neurol Neurosci Rep. 2018 Apr 19;18(5):27. PubMed PMID: 29671077
• Knupp KG, Wirrell EC. Treatment Strategies for Dravet Syndrome. CNS Drugs. 2018 Apr;32(4):335-350. PubMed PMID: 29594870
• Berg AT, Chakravorty S, Koh S, Grinspan ZM, Shellhaas RA, Saneto RP, Wirrell EC, Coryell J, Chu CJ, Mytinger JR, Gaillard WD, Valencia I, Knupp KG, Loddenkemper T, Sullivan JE, Poduri A, Millichap JJ, Keator C, Wusthoff C, Ryan N, Dobyns WB, Hegde M. Why West? Comparisons of clinical, genetic and molecular features of infants with and without spasms. PLoS One. 2018;13(3):e0193599. PubMed PMID: 29518120
• Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 Apr 1;172(4):352-360. PubMed PMID: 29435578
• Campbell JD, Whittington MD, Kim CH, VanderVeen GR, Knupp KG, Gammaitoni A. Assessing the impact of caring for a child with Dravet syndrome: Results of a caregiver survey. Epilepsy Behav. 2018 Mar;80:152-156. PubMed PMID: 29414545
• Whittington MD, Knupp KG, Vanderveen G, Kim C, Gammaitoni A, Campbell JD. The direct and indirect costs of Dravet Syndrome. Epilepsy Behav. 2018 Mar;80:109-113. PubMed PMID: 29414539
• McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2019 Nov 26;:883073819886244. [Epub ahead of print] PubMed PMID: 31769329
• Sorin LM, Knupp KG, Berg AT. New-onset seizure survey of epilepsy centers in the United States. Epilepsy Behav. 2019 Dec;101(Pt A):106579. PubMed PMID: 31677582
• Knupp KG, Rice JD, Helmkamp LJ, Galinkin J, Sempio C, Jost K, Chapman KE. Prospective evaluation of oral cannabis extracts in children with epilepsy. Seizure. 2019 Sep 16;72:23-27. [Epub ahead of print] PubMed PMID: 31550641
• Berg AT, Wusthoff C, Shellhaas RA, Loddenkemper T, Grinspan ZM, Saneto RP, Knupp KG, Patel A, Sullivan JE, Kossoff EH, Chu CJ, Massey S, Valencia I, Keator C, Wirrell EC, Coryell J, Millichap JJ, Gaillard WD. Immediate outcomes in early life epilepsy: A contemporary account. Epilepsy Behav. 2019 Aug;97:44-50. PubMed PMID: 31181428
• Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2019 May 21;:1-5. [Epub ahead of print] PubMed PMID: 31111749
• Eschbach K, Knupp KG. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. PubMed PMID: 31017478
• Daniels D, Knupp K, Benke T, Wolter-Warmerdam K, Moran M, Hickey F. Infantile Spasms in Children With Down Syndrome: Identification and Treatment Response. Glob Pediatr Health. 2019;6:2333794X18821939. PubMed PMID: 30671494
• Van Nuland A, Ivanenko A, Meskis MA, Villas N, Knupp KG, Berg AT. Sleep in Dravet syndrome: A parent-driven survey. Seizure. 2021 Jan 7;85:102-110. [Epub ahead of print] PubMed PMID: 33453590
• Berg AT, Gaebler-Spira D, Wilkening G, Zelko F, Knupp K, Dixon-Salazar T, Villas N, Meskis MA, Harwell V, Thompson T, Sims S, Nesbitt G. Nonseizure consequences of Dravet syndrome, KCNQ2-DEE, KCNB1-DEE, Lennox-Gastaut syndrome, ESES: A functional framework. Epilepsy Behav. 2020 Oct;111:107287. PubMed PMID: 32759067
• Wirrell EC, Grinspan ZM, Knupp KG, Jiang Y, Hammeed B, Mytinger JR, Patel AD, Nabbout R, Specchio N, Cross JH, Shellhaas RA. Care Delivery for Children With Epilepsy During the COVID-19 Pandemic: An International Survey of Clinicians. J Child Neurol. 2020 Nov;35(13):924-933. PubMed PMID: 32666891
• Pellinen J, Snyder E, Knupp KG. The language of seizure identification: A qualitative investigation. Epilepsy Behav. 2021 Dec 13;126:108484. [Epub ahead of print] PubMed PMID: 34915429
• Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL. Management of Infantile Spasms During the COVID-19 Pandemic. J Child Neurol. 2020 Oct;35(12):828-834. PubMed PMID: 32576057
• Pellinen J, French J, Knupp KG. Diagnostic Delay in Epilepsy: the Scope of the Problem. Curr Neurol Neurosci Rep. 2021 Nov 24;21(12):71. PubMed PMID: 34817723
• Andrade DM, Berg AT, Hood V, Knupp KG, Koh S, Laux L, Meskis MA, Miller I, Perry MS, Scheffer IE, Sullivan J, Villas N, Wirrell E. Dravet syndrome: A quick transition guide for the adult neurologist. Epilepsy Res. 2021 Nov;177:106743. PubMed PMID: 34624600
• Helms JA, Smith J, Clark S, Knupp K, Haddad NM. Ant Communities and Ecosystem Services in Organic Versus Conventional Agriculture in the U.S. Corn Belt. Environ Entomol. 2021 Dec 17;50(6):1276-1285. PubMed PMID: 34554252
• Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Pomeroy SL, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL. Crisis Standard of Care: Management of Infantile Spasms during COVID-19. Ann Neurol. 2020 Aug;88(2):215-217. PubMed PMID: 32445204
• Messer R, Knupp KG. Infantile Spasms: Opportunities to Improve Care. Semin Neurol. 2020 Apr;40(2):236-245. PubMed PMID: 32143232
• Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. PubMed PMID: 32048179
• Nabbout R, Mistry A, Zuberi S, Villeneuve N, Gil-Nagel A, Sanchez-Carpintero R, Stephani U, Laux L, Wirrell E, Knupp K, Chiron C, Farfel G, Galer BS, Morrison G, Lock M, Agarwal A, Auvin S. Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens: A Randomized Clinical Trial. JAMA Neurol. 2020 Mar 1;77(3):300-308. PubMed PMID: 31790543
• McGarry L, Messer R, Cree-Green M, Ray K, Knupp K. Incidence of Hypertension Among Children Treated With Adrenocorticotropic Hormone (ACTH) or Prednisolone for Infantile Spasms. J Child Neurol. 2020 Mar;35(3):215-220. PubMed PMID: 31769329
• Isom LL, Knupp KG. Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy. Neurotherapeutics. 2021 Jul;18(3):1524-1534. PubMed PMID: 34378168
• Gil-Nagel A, Sullivan J, Ceulemans B, Wirrell E, Devinsky O, Nabbout R, Knupp KG, Scott Perry M, Polster T, Davis R, Lock M, Cortes RM, Gammaiton AR, Farfel G, Galer BS, Agarwal A. Treatment with fenfluramine in patients with Dravet syndrome has no long-term effects on weight and growth. Epilepsy Behav. 2021 Sep;122:108212. PubMed PMID: 34352670
• Min JY, Knupp KG, Patel AD, Shellhaas RA, Zhang M, Grinspan ZM. Medication selection, health services outcomes, and cost trajectories for Medicaid beneficiaries with infantile spasms. Epilepsy Res. 2021 Oct;176:106733. PubMed PMID: 34333373
• Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell E, Valencia I, Singhal NS, Nordli DR, Mytinger JR, Mitchell W, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Jul 15. [Epub ahead of print] PubMed PMID: 34266919
• Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 Feb;58(2):124-128. PubMed PMID: 31111749
• Nelson JA, Demarest S, Thomas J, Juarez-Colunga E, Knupp KG. Evolution of Infantile Spasms to Lennox-Gastaut Syndrome: What Is There to Know?. J Child Neurol. 2021 Aug;36(9):752-759. PubMed PMID: 33764203
• Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids bY LC-MS-MS in Human Plasma. J Anal Toxicol. 2021 Mar 23. [Epub ahead of print] PubMed PMID: 33754154
• Van Nuland A, Ivanenko A, Meskis MA, Villas N, Knupp KG, Berg AT. Sleep in Dravet syndrome: A parent-driven survey. Seizure. 2021 Feb;85:102-110. PubMed PMID: 33453590
• Bishop KI, Isquith PK, Gioia GA, Knupp KG, Scheffer IE, Nabbout R, Specchio N, Sullivan J, Auvin S, Helen Cross J, Guerrini R, Farfel G, Galer BS, Gammaitoni AR. Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment. Epilepsy Behav. 2023 Jan;138:108994. PubMed PMID: 36463826
• Sullivan J, Wirrell E, Knupp KG, Chen D, Zafar M, Flamini R, Stutely J, Brathwaite C, Ventola P, Avendaño J, Parkerson KA, Wyant N, Ticho B. Interim results of adaptive functioning and neurodevelopment in BUTTERFLY - An observational study of children and adolescents with Dravet syndrome. Epilepsy Behav. 2022 Dec;137(Pt A):108955. PubMed PMID: 36332561
• Knupp KG, Scheffer IE, Ceulemans B, Sullivan J, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Agarwal A, Lock M, Dai D, Farfel GM, Galer BS, Gammaitoni AR, Polega S, Davis R, Gil-Nagel A. Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study. Epilepsia. 2023 Jan;64(1):139-151. PubMed PMID: 36196777
• Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2022 Jun 1;79(6):554-564. PubMed PMID: 35499850
• Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J. International consensus on diagnosis and management of Dravet syndrome. Epilepsia. 2022 Jul;63(7):1761-1777. PubMed PMID: 35490361
• Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, Wusthoff CJ, Wirrell EC, Yozawitz E, Knupp KG, Shellhaas RA, Grinspan ZM. Inequities in Therapy for Infantile Spasms: A Call to Action. Ann Neurol. 2022 Jul;92(1):32-44. PubMed PMID: 35388521
• Hood V, Berg AT, Knupp KG, Koh S, Laux L, Meskis MA, Zulfiqar-Ali Q, Perry MS, Scheffer IE, Sullivan J, Wirrell E, Andrade DM. COVID-19 vaccine in patients with Dravet syndrome: Observations and real-world experiences. Epilepsia. 2022 Jul;63(7):1778-1786. PubMed PMID: 35383912
• Knupp KG, Coryell J, Singh RK, Gaillard WD, Shellhaas RA, Koh S, Mitchell WG, Harini C, Millichap JJ, May A, Dlugos D, Nickels K, Mytinger JR, Keator C, Yozawitz E, Singhal N, Lockrow J, Thomas JF, Juarez-Colunga E. Comparison of Cosyntropin, Vigabatrin, and Combination Therapy in New-Onset Infantile Spasms in a Prospective Randomized Trial. J Child Neurol. 2022 Mar;37(3):186-193. PubMed PMID: 35044272
• Pellinen J, Snyder E, Knupp KG. The language of seizure identification: A qualitative investigation. Epilepsy Behav. 2022 Jan;126:108484. PubMed PMID: 34915429
• Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids by LC-MS-MS in Human Plasma. J Anal Toxicol. 2022 Apr 21;46(4):383-392. PubMed PMID: 33754154
• Sullivan J, Lagae L, Cross JH, Devinsky O, Guerrini R, Knupp KG, Laux L, Nikanorova M, Polster T, Talwar D, Ceulemans B, Nabbout R, Farfel GM, Galer BS, Gammaitoni AR, Lock M, Agarwal A, Scheffer IE. Fenfluramine in the treatment of Dravet syndrome: Results of a third randomized, placebo-controlled clinical trial. Epilepsia. 2023 Oct;64(10):2653-2666. PubMed PMID: 37543865
• Nelson JA, Knupp KG. Lennox-Gastaut Syndrome: Current Treatments, Novel Therapeutics, and Future Directions. Neurotherapeutics. 2023 Sep;20(5):1255-1262. PubMed PMID: 37353676
• Smith KM, Wirrell EC, Andrade DM, Choi H, Trenité DK, Jones H, Knupp KG, Mugar J, Nordli DR Jr, Riva A, Stern JM, Striano P, Thiele EA, Zawar I. Clinical presentation and evaluation of epilepsy with eyelid myoclonia: Results of an international expert consensus panel. Epilepsia. 2023 Sep;64(9):2330-2341. PubMed PMID: 37329145
• Smith KM, Wirrell EC, Andrade DM, Choi H, Trenité DK, Jones H, Knupp KG, Mugar J, Nordli DR Jr, Riva A, Stern JM, Striano P, Thiele EA, Zawar I. Management of epilepsy with eyelid myoclonia: Results of an international expert consensus panel. Epilepsia. 2023 Sep;64(9):2342-2350. PubMed PMID: 37326215
• Smith KM, Wirrell EC, Andrade DM, Choi H, Trenité DK, Knupp KG, Nordli DR Jr, Riva A, Stern JM, Striano P, Thiele EA, Zawar I. A comprehensive narrative review of epilepsy with eyelid myoclonia. Epilepsy Res. 2023 Jul;193:107147. PubMed PMID: 37121024
• Bishop KI, Isquith PK, Gioia GA, Knupp KG, Scheffer IE, Nabbout R, Specchio N, Sullivan J, Auvin S, Helen Cross J, Guerrini R, Farfel G, Galer BS, Gammaitoni AR. Fenfluramine treatment is associated with improvement in everyday executive function in preschool-aged children (<5 years) with Dravet syndrome: A critical period for early neurodevelopment. Epilepsy Behav. 2023 Jan;138:108994. PubMed PMID: 36463826
• Sullivan J, Wirrell E, Knupp KG, Chen D, Zafar M, Flamini R, Stutely J, Brathwaite C, Ventola P, Avendaño J, Parkerson KA, Wyant N, Ticho B. Interim results of adaptive functioning and neurodevelopment in BUTTERFLY - An observational study of children and adolescents with Dravet syndrome. Epilepsy Behav. 2022 Dec;137(Pt A):108955. PubMed PMID: 36332561
• Knupp KG, Scheffer IE, Ceulemans B, Sullivan J, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Agarwal A, Lock M, Dai D, Farfel GM, Galer BS, Gammaitoni AR, Polega S, Davis R, Gil-Nagel A. Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study. Epilepsia. 2023 Jan;64(1):139-151. PubMed PMID: 36196777
• Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2022 Jun 1;79(6):554-564. PubMed PMID: 35499850
• Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J. International consensus on diagnosis and management of Dravet syndrome. Epilepsia. 2022 Jul;63(7):1761-1777. PubMed PMID: 35490361
• Baumer FM, Mytinger JR, Neville K, Briscoe Abath C, Gutierrez CA, Numis AL, Harini C, He Z, Hussain SA, Berg AT, Chu CJ, Gaillard WD, Loddenkemper T, Pasupuleti A, Samanta D, Singh RK, Singhal NS, Wusthoff CJ, Wirrell EC, Yozawitz E, Knupp KG, Shellhaas RA, Grinspan ZM. Inequities in Therapy for Infantile Spasms: A Call to Action. Ann Neurol. 2022 Jul;92(1):32-44. PubMed PMID: 35388521
• Hood V, Berg AT, Knupp KG, Koh S, Laux L, Meskis MA, Zulfiqar-Ali Q, Perry MS, Scheffer IE, Sullivan J, Wirrell E, Andrade DM. COVID-19 vaccine in patients with Dravet syndrome: Observations and real-world experiences. Epilepsia. 2022 Jul;63(7):1778-1786. PubMed PMID: 35383912
• Knupp KG, Coryell J, Singh RK, Gaillard WD, Shellhaas RA, Koh S, Mitchell WG, Harini C, Millichap JJ, May A, Dlugos D, Nickels K, Mytinger JR, Keator C, Yozawitz E, Singhal N, Lockrow J, Thomas JF, Juarez-Colunga E. Comparison of Cosyntropin, Vigabatrin, and Combination Therapy in New-Onset Infantile Spasms in a Prospective Randomized Trial. J Child Neurol. 2022 Mar;37(3):186-193. PubMed PMID: 35044272
• Pellinen J, Snyder E, Knupp KG. The language of seizure identification: A qualitative investigation. Epilepsy Behav. 2022 Jan;126:108484. PubMed PMID: 34915429
• Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids by LC-MS-MS in Human Plasma. J Anal Toxicol. 2022 Apr 21;46(4):383-392. PubMed PMID: 33754154
• Starosta RT, Larson AA, Meeks NJL, Gracie S, Friederich MW, Gaughan SM, Baker PR 2nd, Knupp KG, Michel CR, Reisdorph R, Hock DH, Stroud DA, Wood T, Van Hove JLK. An integrated multi-omics approach allowed ultra-rapid diagnosis of a deep intronic pathogenic variant in PDHX and precision treatment in a neonate critically ill with lactic acidosis. Mitochondrion. 2024 Oct 15;79:101973. [Epub ahead of print] PubMed PMID: 39413893
• Pellinen J, Sillau S, Morrison C, Maruff P, O'Brien TJ, Penovich P, French J, Knupp KG, Meador KJ. Engagement in online cognitive testing with the Cogstate brief battery among a multinational cohort of people with focal epilepsy. Epilepsy Behav. 2024 Oct;159:109953. PubMed PMID: 39121756
• Gil-Nagel A, Cross JH, Devinsky O, Ceulemans B, Lagae L, Knupp K, Schoonjans AS, Ryvlin P, Thiele EA, Polega S, Lothe A, Nabbout R. Comprehensive scoping review of fenfluramine's role in managing generalized tonic-clonic seizures in developmental and epileptic encephalopathies. Epilepsia. 2024 Aug;65(8):2186-2199. PubMed PMID: 39030735
• Abbott MJ, Knupp KG. SCN8A modified Delphi commentary. Epilepsia. 2024 Aug;65(8):2339-2340. PubMed PMID: 38943498
• Mason JA, Juarez-Colunga E, Knupp KG. Electrographic screening for infantile epileptic spasms syndrome in a single sleep-wake cycle. Epilepsia. 2024 Jun;65(6):1737-1743. PubMed PMID: 38572956
• Snyder E, Sillau S, Knupp KG, French J, Khanna A, Birlea M, Nair K, Pellinen J. Testing the diagnostic accuracy of common questions for seizure diagnosis: Challenges and future directions. Epilepsy Behav. 2024 Apr;153:109686. PubMed PMID: 38401417
• Sullivan J, Wirrell E, Knupp KG, Chen D, Flamini R, Zafar M, Ventola P, Avendaño J, Wang F, Parkerson KA, Ticho B. Adaptive functioning and neurodevelopment in patients with Dravet syndrome: 12-month interim analysis of the BUTTERFLY observational study. Epilepsy Behav. 2024 Feb;151:109604. PubMed PMID: 38219604
• Auvin S, Arzimanoglou A, Brambilla I, French J, Knupp KG, Lagae L, Perucca E, Trinka E, Dlugos D. Call for the use of the ILAE terminology for seizures and epilepsies by health care professionals and regulatory agencies to benefit patients and caregivers. Epilepsia. 2024 Feb;65(2):283-286. PubMed PMID: 38105624
• Perry MS, Scheffer IE, Sullivan J, Brunklaus A, Boronat S, Wheless JW, Laux L, Patel AD, Roberts CM, Dlugos D, Holder D, Knupp KG, Lallas M, Phillips S, Segal E, Smeyers P, Lal D, Wirrell E, Zuberi S, Brünger T, Wojnaroski M, Maru B, O'Donnell P, Morton M, James E, Vila MC, Huang N, Gofshteyn JS, Rico S. Severe communication delays are independent of seizure burden and persist despite contemporary treatments in SCN1A Dravet syndrome: Insights from the ENVISION natural history study. Epilepsia. 2024 Feb;65(2):322-337. PubMed PMID: 38049202

Practice Locations

• Children's Hospital Colorado
• University of Colorado Hospital

• ACCORDS (COHO)
• Center for Neuroscience

Specialty Information

• Child Neurology, Board Certification (2004, 2013)
• Clinical Neurophysiology, Board Certification (2007, 2018)
• Epilepsy, Board Certification (2014)

• Child and Teen Health
• Brain and Nervous System - Epilepsy
• Brain and Nervous System