Linda Barlow, PhD

Publications

• Barlow, L.A. 2025. Development of Ectodermal and Endodermal Taste Buds. Dev Biol Special Issue - Development and Regeneration of Ectodermal Organs. 518:20-27.
• Piarowski, C.M., T.J. Isner and L.A. Barlow. 2025. Developing and Regenerating a Sense of Taste. Curr. Topics Dev. Biol. Special Issue: Development of the Senses.
• High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. Shechtman LA, Scott JK, Larson ED, Isner TJ, Johnson BJ, Gaillard D, Dempsey PJ, Barlow LA. Development. 2023 Feb 15;150(4):dev201375. doi: 10.1242/dev.201375. Epub 2023 Feb 16. PMID: 36794954
• Shechtman, L.A., J.K. Scott, E.D. Larson, T.J. Isner, B.J. Johnson, D. Gaillard, P.J. Dempsey and L.A. Barlow. 2023. High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. bioRxiv doi:https://doi.org/10.1101/2022.06.30.498302 Development. In press.
• Barlow, L.A. 2022. The Sense of Taste: Development, Regeneration and Disease. WIREs Mechanisms of Disease. WIREs Mech Dis. Epub 2021 Nov 30:e1547. doi: 10.1002/wsbm.1547. Online ahead of print. PMID: 34850604
• Finger, T.E.* and L.A. Barlow*. 2021. Cellular Diversity and Regeneration in Taste Buds. Curr Opinion Phys. Invited review. In press. *Co-corresponding authors.
• Gaillard, D. and L.A. Barlow. 2021. A mechanistic overview of taste bud maintenance and impairment in cancer therapies. Invited Review for special issue Booesveldt and Johanson. In press.
• Shechtman, L.A.*, C.M. Piarowski*, J.K. Scott, D. Gaillard and L.A. Barlow. 2020. Generation and culture of lingual organoids derived from adult mouse taste progenitor cells. JoVE. Under revision. *Co-1st authors
• Shechtman, L.A.*, C.M. Piarowski*, J.K. Scott, D. Gaillard and L.A. Barlow. 2021. Generation and culture of lingual organoids derived from adult mouse taste progenitor cells. *Co-1st authors J Vis Exp. Apr 5;(170). PMID: 33871462 PMC8336305
• Golden, E.J., E.D. Larson, L.A. Shechtman, G.D. Trahan, D. Gaillard, T.J. Fellin, K.L. Jones, and L.A. Barlow. 2021. Onset of taste cell renewal starts at birth and coincides with a shift in SHH function. bioRxiv doi: https://doi.org/10.1101/2020.10.12.336602. eLife. May 19;10:e64013. doi: 10.7554/eLife.64013. Online ahead of print. PMID: 34009125
• Finger, T.E.* and L.A. Barlow*. 2021. Cellular Diversity and Regeneration in Taste Buds. Curr Opinion Phys. Invited review. *Co-corresponding authors. Apr;20:146-153. doi: 10.1016/j.cophys.2021.01.003
• Gaillard, D.* and L.A. Barlow. 2021. A mechanistic overview of taste bud maintenance and impairment in cancer therapies. Chemical Senses. Invited Review for special issue Booesveldt and Johanson. *Corresponding author. DOI: 10.1093/chemse/bjab011
• Barlow, L.A. 2021. The Sense of Taste: Development, Regeneration and Disease. WIREs Mechanisms of Disease. WIREs Mech Dis. 2021 Nov 30:e1547. doi: 10.1002/wsbm.1547. Online ahead of print. PMID: 34850604
• Cooper, K.W.†, D.H. Brann†, M.C. Farruggia, S. Bhutani, R. Pellegrino, T. Tsukahara, C. Weinreb, P.V. Joseph, E.D. Larson, V. Parma, M. Albers, L.A. Barlow*, S.R. Datta* and A. Di Pizio*. 2020. COVID-19 and the chemical senses: supporting players take center stage. Neuron. 107(2):219-233. Co-corresponding authors*. PMID: 32640192 PMC7328585
• Mainland, J.D., L.A. Barlow, S. Munger, S., S.E. Millar, M.N. Vergara, P. Jiang, J. Schwob, B.J. Goldstein, S.E. Boye, J.R. Martens, D. Leopold, L. Bartoshuk, R. Doty, T. Hummel, J. Pinto, C. Trimmer, C. Kelly, E. Pribitkin, D.R. Reed. 2020. Identifying treatments for taste and smell disorders: gaps and opportunities. Chem Senses. 45(7):493-502. PMID: 32556127 PMC7545248
• Golden, E.J., E.D. Larson, L.A. Shechtman, G.D. Trahan, D. Gaillard, T.J. Fellin, K.L. Jones, and L.A. Barlow. 2020. Onset of taste cell renewal starts at birth and coincides with a shift in SHH function. bioRxiv doi: https://doi.org/10.1101/2020.10.12.336602. Under revision at eLife.
• Gaillard D, Shechtman LA, Millar SE, Barlow LA. Fractionated head and neck irradiation impacts taste progenitors, differentiated taste cells, and Wnt/ß-catenin signaling in adult mice. Sci Rep. 2019 Nov 29;9(1):17934. doi: 10.1038/s41598-019-54216-9.
• Jewkes BC, Barlow LA, Delay ER. Effect of Radiation on Sucrose Detection Thresholds of Mice. Chem Senses. 2017 Dec 25;43(1):53-58. PubMed PMID: 29053803
• Gaillard D, Bowles SG, Salcedo E, Xu M, Millar SE, Barlow LA. ß-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice. PLoS Genet. 2017 Aug;13(8):e1006990. PubMed PMID: 28846687
• Castillo-Azofeifa D, Losacco JT, Salcedo E, Golden EJ, Finger TE, Barlow LA. Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development. 2017 Sep 1;144(17):3054-3065. PubMed PMID: 28743797
• Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 7;8:15397. PubMed PMID: 28589954
• SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. Development. 2018 Jul 17;145(14). pii: dev164889. doi: 10.1242/dev.164889. PMID:29945863
• Barlow LA. Progress and renewal in gustation: new insights into taste bud development. Development. 2015 Nov 1;142(21):3620-9. PubMed PMID: 26534983
• Thirumangalathu S, Barlow LA. ß-Catenin signaling regulates temporally discrete phases of anterior taste bud development. Development. 2015 Dec 15;142(24):4309-17. PubMed PMID: 26525674
• Gaillard D, Xu M, Liu F, Millar SE, Barlow LA. ß-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates. PLoS Genet. 2015 May;11(5):e1005208. PubMed PMID: 26020789
• Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015;111:401-19. PubMed PMID: 25662267
• Krimm, R.F., Thirumangalathu, S. and Barlow, L.A. 2014. Chapter 33: Development of the Taste System: Basic Neurobiology. In: Handbook of Olfaction and Gustation (3rd Edition): Modern Perspectives. R. Doty Ed. In press.
• 3. Miura, H., J.K. Scott, S. Harada and L.A. Barlow. 2014. Sonic hedgehog-expressing basal cells are general post-mitotic precursors of functional taste receptor cells. Developmental Dynamics Mar 2 [Epub ahead of print. 243(10):1286-1297. PMID:24590958 Cover image for Special Issue: Sensory Systems: Development, Disease & Regeneration
• 4. Castillo, D. K. Seidel, E. Salcedo, C. Ahn, F.J. De Sauvage, O.D. Klein and L.A. Barlow. 2014. Induction of ectopic tatse buds by SHH reveals the competency and plasticity of the adult lingual epithelium. Development 141:2993-3002. PMID: 24993944. Selected by Faculty of 1000 Biology: http://f1000.com/prime/718478050?subscriptioncode=6834a5af-eb6e-4f78-8742-7b34d78d818d
• 3. Krimm, R.F., Thirumangalathu, S. and Barlow, L.A. 2015. Chapter 33: Development of the Taste System: Basic Neurobiology. In: Handbook of Olfaction and Gustation (3rd Edition): Modern Perspectives. R. Doty Ed. In press.
• Kapsimali, M. and Barlow, L.A., 2013. Developing a Sense of Taste. Semin Cell Dev Biol. 24(3):200-9. PMC3604069 [Available on 2014/3/1]
• Krimm, R.F., Thirumangalathu, S. and Barlow, L.A. 2013. Chapter 33: Development of the Taste System: Basic Neurobiology. In: Handbook of Olfaction and Gustation (3rd Edition): Modern Perspectives. R. Doty Ed. In press.
• Kapsimali, M. and Barlow, L.A., 2012. Developing a Sense of Taste. Semin Cell Dev Biol, http://dx.doi.org/10.1016/j.semcdb.2012.11.002
• Castillo, D.#, K. Seidel#,, F. De Savage, C. Ahn, O.D. Klein*, and L.A. Barlow*. 2013. Molecular Induction of Taste Buds in the Absence of Innervation. Submitted. # co-first authors, * co-senior authors.
• Nguyen, H.M., M.E. Reyland and L.A.Barlow. 2012. Mechanisms of taste bud cell loss following head and neck irradiation. J. Neurosci. 32:3474.
• Peterson, C.I, A.H. Jheon, P. Mostiwfi, C. Charles, S. Ching, S. Thirumangalathu, L.A. Barlow and O.D. Klein. 2011. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genetics. Jun;7(6):e1002098. Epub 2011 Jun 2
• Gaillard, D. and L.A. Barlow. 2011. Taste bud cells in adult mice are responsive to Wnt/ß-catenin signaling: implications for the renewal of mature taste cells. Genesis. Article first published online 15 FEB 2011. DOI: 10.1002/dvg.20731
• Harlow, D.E., H. Yang, T. Williams and L.A. Barlow. 2011. Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev. Dynam. 240(2):309-23. Selected for "Highlights in DD".
• Nguyen, H.M. and L.A. Barlow. 2010. BMP4 transgene expression differs in anterior fungiform versus posterior circumvallate taste buds of mice. BMC Neurosci. 11:129.
• Miura, H. and Barlow, L.A. 2010. Taste bud regeneration, and the search for taste progenitor cells. Archives Italiennes de Biologie. 148:107-118.
• Castillo, D. and L.A. Barlow. 2016. Disassembling taste: peeling and dissociation of adult lingual epithelium to achieve single cell suspensions for use in cell sorting and high-throughput analysis methods in: Methods in Molecular Biology, Craniofacial Biology. F. Michon, Ed. In press.