Linda Barlow, PhD
Professor, Cell & Developmental Biology

Publications

• Shechtman, L.A., J.K. Scott, E.D. Larson, T.J. Isner, B.J. Johnson, D. Gaillard, P.J. Dempsey and L.A. Barlow. 2023. High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. bioRxiv doi:https://doi.org/10.1101/2022.06.30.498302 Development. In press.
• High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. Shechtman LA, Scott JK, Larson ED, Isner TJ, Johnson BJ, Gaillard D, Dempsey PJ, Barlow LA. Development. 2023 Feb 15;150(4):dev201375. doi: 10.1242/dev.201375. Epub 2023 Feb 16. PMID: 36794954
• Barlow, L.A. 2022. The Sense of Taste: Development, Regeneration and Disease. WIREs Mechanisms of Disease. WIREs Mech Dis. Epub 2021 Nov 30:e1547. doi: 10.1002/wsbm.1547. Online ahead of print. PMID: 34850604
• Finger, T.E.* and L.A. Barlow*. 2021. Cellular Diversity and Regeneration in Taste Buds. Curr Opinion Phys. Invited review. In press. *Co-corresponding authors.
• Gaillard, D. and L.A. Barlow. 2021. A mechanistic overview of taste bud maintenance and impairment in cancer therapies. Invited Review for special issue Booesveldt and Johanson. In press.
• Shechtman, L.A.*, C.M. Piarowski*, J.K. Scott, D. Gaillard and L.A. Barlow. 2021. Generation and culture of lingual organoids derived from adult mouse taste progenitor cells. *Co-1st authors J Vis Exp. Apr 5;(170). PMID: 33871462 PMC8336305
• Golden, E.J., E.D. Larson, L.A. Shechtman, G.D. Trahan, D. Gaillard, T.J. Fellin, K.L. Jones, and L.A. Barlow. 2021. Onset of taste cell renewal starts at birth and coincides with a shift in SHH function. bioRxiv doi: https://doi.org/10.1101/2020.10.12.336602. eLife. May 19;10:e64013. doi: 10.7554/eLife.64013. Online ahead of print. PMID: 34009125
• Finger, T.E.* and L.A. Barlow*. 2021. Cellular Diversity and Regeneration in Taste Buds. Curr Opinion Phys. Invited review. *Co-corresponding authors. Apr;20:146-153. doi: 10.1016/j.cophys.2021.01.003
• Shechtman, L.A.*, C.M. Piarowski*, J.K. Scott, D. Gaillard and L.A. Barlow. 2020. Generation and culture of lingual organoids derived from adult mouse taste progenitor cells. JoVE. Under revision. *Co-1st authors
• Gaillard, D.* and L.A. Barlow. 2021. A mechanistic overview of taste bud maintenance and impairment in cancer therapies. Chemical Senses. Invited Review for special issue Booesveldt and Johanson. *Corresponding author. DOI: 10.1093/chemse/bjab011
• Barlow, L.A. 2021. The Sense of Taste: Development, Regeneration and Disease. WIREs Mechanisms of Disease. WIREs Mech Dis. 2021 Nov 30:e1547. doi: 10.1002/wsbm.1547. Online ahead of print. PMID: 34850604
• Cooper, K.W.†, D.H. Brann†, M.C. Farruggia, S. Bhutani, R. Pellegrino, T. Tsukahara, C. Weinreb, P.V. Joseph, E.D. Larson, V. Parma, M. Albers, L.A. Barlow*, S.R. Datta* and A. Di Pizio*. 2020. COVID-19 and the chemical senses: supporting players take center stage. Neuron. 107(2):219-233. Co-corresponding authors*. PMID: 32640192 PMC7328585
• Mainland, J.D., L.A. Barlow, S. Munger, S., S.E. Millar, M.N. Vergara, P. Jiang, J. Schwob, B.J. Goldstein, S.E. Boye, J.R. Martens, D. Leopold, L. Bartoshuk, R. Doty, T. Hummel, J. Pinto, C. Trimmer, C. Kelly, E. Pribitkin, D.R. Reed. 2020. Identifying treatments for taste and smell disorders: gaps and opportunities. Chem Senses. 45(7):493-502. PMID: 32556127 PMC7545248
• Golden, E.J., E.D. Larson, L.A. Shechtman, G.D. Trahan, D. Gaillard, T.J. Fellin, K.L. Jones, and L.A. Barlow. 2020. Onset of taste cell renewal starts at birth and coincides with a shift in SHH function. bioRxiv doi: https://doi.org/10.1101/2020.10.12.336602. Under revision at eLife.
• Jewkes BC, Barlow LA, Delay ER. Effect of Radiation on Sucrose Detection Thresholds of Mice. Chem Senses. 2017 Dec 25;43(1):53-58. PubMed PMID: 29053803
• Gaillard D, Bowles SG, Salcedo E, Xu M, Millar SE, Barlow LA. ß-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice. PLoS Genet. 2017 Aug;13(8):e1006990. PubMed PMID: 28846687
• Castillo-Azofeifa D, Losacco JT, Salcedo E, Golden EJ, Finger TE, Barlow LA. Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development. 2017 Sep 1;144(17):3054-3065. PubMed PMID: 28743797
• Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 7;8:15397. PubMed PMID: 28589954
• Barlow LA. Progress and renewal in gustation: new insights into taste bud development. Development. 2015 Nov 1;142(21):3620-9. PubMed PMID: 26534983
• Thirumangalathu S, Barlow LA. ß-Catenin signaling regulates temporally discrete phases of anterior taste bud development. Development. 2015 Dec 15;142(24):4309-17. PubMed PMID: 26525674
• Gaillard D, Xu M, Liu F, Millar SE, Barlow LA. ß-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates. PLoS Genet. 2015 May;11(5):e1005208. PubMed PMID: 26020789
• Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015;111:401-19. PubMed PMID: 25662267