Catherine Proenza, PhD

Publications

• Independent activation of sinoatrial HCN channels by cAMP and PKA. Channels (in press)
• Cellular context and multiple channel domains determine cAMP sensitivity of HCN4 channels: Ligand-independent relief of autoinhibition in HCN4. J Gen Physiol 2012 140:557.
• Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. PLoS One. 2013;8(11):e81633. PubMed PMID: 24278453
• Larson ED, St Clair JR, Sumner WA, Bannister RA, Proenza C. Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):18011-6. PubMed PMID: 24128759
• St Clair JR, Liao Z, Larson ED, Proenza C. PKA-independent activation of If by cAMP in mouse sinoatrial myocytes. Channels (Austin). 2013 Jun 11;7(4). [Epub ahead of print] PubMed PMID: 23756695
• Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10;6:8243. PubMed PMID: 26354680
• St Clair JR, Sharpe EJ, Proenza C. Culture and adenoviral infection of sinoatrial node myocytes from adult mice. Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H490-8. PubMed PMID: 26001410
• Sharpe EJ, Larson ED, Proenza C. Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes. J Gen Physiol. 2017 Jan 5. [Epub ahead of print] PubMed PMID: 28057842
• Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2016 Nov 13. [Epub ahead of print] PubMed PMID: 27861921
• Sharpe EJ, St Clair JR, Proenza C. Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice. J Vis Exp. 2016 Oct 23;(116). PubMed PMID: 27805586
• Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H. Mammalian ?2 AMPK regulates intrinsic heart rate. Nat Commun. 2017 Nov 2;8(1):1258. PubMed PMID: 29097735
• St Clair JR, Larson ED, Sharpe EJ, Liao Z, Proenza C. Phosphodiesterases 3 and 4 Differentially Regulate the Funny Current, I(f), in Mouse Sinoatrial Node Myocytes. J Cardiovasc Dev Dis. 2017 Sep;4(3). PubMed PMID: 28868308
• Rickert C, Proenza C. ParamAP: Standardized Parameterization of Sinoatrial Node Myocyte Action Potentials. Biophys J. 2017 Aug 22;113(4):765-769. PubMed PMID: 28834713
• Sharpe EJ, Larson ED, Proenza C. Cyclic AMP reverses the effects of aging on pacemaker activity and If in sinoatrial node myocytes. J Gen Physiol. 2017 Feb;149(2):237-247. PubMed PMID: 28057842
• Grandi E, Sanguinetti MC, Bartos DC, Bers DM, Chen-Izu Y, Chiamvimonvat N, Colecraft HM, Delisle BP, Heijman J, Navedo MF, Noskov S, Proenza C, Vandenberg JI, Yarov-Yarovoy V. Potassium channels in the heart: structure, function and regulation. J Physiol. 2017 Apr 1;595(7):2209-2228. PubMed PMID: 27861921
• Proenza C. Exploiting natural regulation. Elife. 2018 Aug 6;7. PubMed PMID: 30080138
• Peters CH, Sharpe EJ, Proenza C. Cardiac Pacemaker Activity and Aging. Annu Rev Physiol. 2019 Nov 22. [Epub ahead of print] PubMed PMID: 31756134
• Peters CH, Myers ME, Juchno J, Haimbaugh C, Bichraoui H, Du Y, Bankston JR, Walker LA, Proenza C. Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18079-18090. PubMed PMID: 32647060
• Peters CH, Sharpe EJ, Proenza C. Cardiac Pacemaker Activity and Aging. Annu Rev Physiol. 2020 Feb 10;82:21-43. PubMed PMID: 31756134
• Peters CH, Liu PW, Morotti S, Gantz SC, Grandi E, Bean BP, Proenza C. Bidirectional flow of the funny current (I(f)) during the pacemaking cycle in murine sinoatrial node myocytes. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28). PubMed PMID: 34260402
• Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. Intracellular Na( ) Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26;22(11). PubMed PMID: 34073281
• Peters CH, Rickert C, Morotti S, Grandi E, Aronow KA, Beam KG, Proenza C. The funny current If is essential for the fight-or-flight response in cardiac pacemaker cells. J Gen Physiol. 2022 Dec 5;154(12). PubMed PMID: 36305844
• Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, Proenza C, Chatfield KC, Tsai MF. Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex. Mol Cell. 2022 Oct 6;82(19):3661-3676.e8. PubMed PMID: 36206740
• Zhao Y, Riching AS, Knight WE, Chi C, Broadwell LJ, Du Y, Abdel-Hafiz M, Ambardekar AV, Irwin DC, Proenza C, Xu H, Leinwand LA, Walker LA, Woulfe KC, Bristow MR, Buttrick PM, Song K. Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714. PubMed PMID: 35862102
• Peters CH, Singh RK, Bankston JR, Proenza C. Regulation of HCN Channels by Protein Interactions. Front Physiol. 2022;13:928507. PubMed PMID: 35795651
• Contribution of the funny current to the fight-or-flight heart rate increase CH Peters, C Rickert, S Morotti, P Liu, S Gantz, BP Bean, E Grandi, ... Biophysical Journal 121 (3), 303a 2022
• Interactions of HCN4 with LRMP and IRAG C Proenza, CH Peters, D Jeffrey, J Bankston Biophysical Journal 121 (3), 438a
• Bankston JR, Proenza C, Peters CH, Singh RK, Langley AA, Nichols WG, Ferris HR, Jeffrey DA. LRMP inhibits the cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction. bioRxiv. 2024 Jan 24. PubMed PMID: 37693562
• Peters CH, Proenza C (2023) HCN Pacemaker Channels. Textbook of Ion Channels, 2nd edition, edited by Matthew Trudeau and Jie Zheng.