Chad Pearson, PhD

Publications

• Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants. Mol Biol Cell. 2024 Mar 1;35(3):ar39. PubMed PMID: 38170584
• Lo HG, Goering R, Kocere A, Lo J, Pockalny MC, White LK, Ramirez H, Martinez A, Jacobson S, Spitale RC, Pearson CG, Resendiz MJE, Mosimann C, Taliaferro JM. Quantification of subcellular RNA localization through direct detection of RNA oxidation. bioRxiv. 2024 Nov 12. PubMed PMID: 39605352
• Li S, Fernandez JJ, Ruehle MD, Howard-Till RA, Fabritius A, Pearson CG, Agard DA, Winey ME. The Structure of Cilium Inner Junctions Revealed by Electron Cryo-tomography. bioRxiv. 2024 Sep 9. PubMed PMID: 39314311
• Martinez A, Stemm-Wolf AJ, Sheridan RM, Taliaferro MJ, Pearson CG. The Unkempt RNA binding protein reveals a local translation program in centriole overduplication. bioRxiv. 2024 Jul 30. PubMed PMID: 39131325
• Ruehle MD, Li S, Agard DA, Pearson CG. Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections. J Cell Biol. 2024 Aug 5;223(8). PubMed PMID: 38743010
• Everman JL, Sajuthi SP, Liegeois MA, Jackson ND, Collet EH, Peters MC, Chioccioli M, Moore CM, Patel BB, Dyjack N, Powell R, Rios C, Montgomery MT, Eng C, Elhawary JR, Mak ACY, Hu D, Huntsman S, Salazar S, Feriani L, Fairbanks-Mahnke A, Zinnen GL, Michel CR, Gomez J, Zhang X, Medina V, Chu HW, Cicuta P, Gordon ED, Zeitlin P, Ortega VE, Reisdorph N, Dunican EM, Tang M, Elicker BM, Henry TS, Bleecker ER, Castro M, Erzurum SC, Israel E, Levy BD, Mauger DT, Meyers DA, Sumino K, Gierada DS, Hastie AT, Moore WC, Denlinger LC, Jarjour NN, Schiebler ML, Wenzel SE, Woodruff PG, Rodriguez-Santana J, Pearson CG, Burchard EG, Fahy JV, Seibold MA. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma. Nat Commun. 2024 May 9;15(1):3900. PubMed PMID: 38724552
• Lo HG, Pearson CG, Taliaferro JM. Differential subcellular localization of ASPM RNA and protein. MicroPubl Biol. 2024;2024. PubMed PMID: 38344067
• Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and nonciliary phenotypes of IFT-A mutants. Mol Biol Cell. 2024 Mar 1;35(3):ar39. PubMed PMID: 38170584
• Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 Jan 19;12. PubMed PMID: 36656118
• Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023 Jan 11;:mbcE22110508. [Epub ahead of print] PubMed PMID: 36630324
• Sun H, Soh AWJ, Mitchell LE, Pearson CG, Murphy RF. Basal body organization and cell geometry during the cell cycle in Tetrahymena thermophila. Mol Biol Cell. 2023 May 15;34(6):ar53. PubMed PMID: 36630324
• Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 Jan 19;12. PubMed PMID: 36656118
• Leggere JC, Hibbard JVK, Papoulas O, Lee C, Pearson CG, Marcotte EM, Wallingford JB. Label-free proteomic comparison reveals ciliary and non-ciliary phenotypes of IFT-A mutants. bioRxiv. 2023 Mar 9. PubMed PMID: 36945534
• Ruehle MD, Li S, Agard DA, Pearson CG. Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections. bioRxiv. 2023 Nov 28. PubMed PMID: 38014135
• Junker AD, Woodhams LG, Soh AWJ, O'Toole ET, Bayly PV, Pearson CG. Basal bodies bend in response to ciliary forces. Mol Biol Cell. 2022 Dec 1;33(14):ar146. PubMed PMID: 36287828
• Soh AWJ, Woodhams LG, Junker AD, Enloe CM, Noren BE, Harned A, Westlake CJ, Narayan K, Oakey JS, Bayly PV, Pearson CG. Intracellular connections between basal bodies promote the coordinated behavior of motile cilia. Mol Biol Cell. 2022 Sep 15;33(11):br18. PubMed PMID: 35767367
• McCurdy BL, Jewett CE, Stemm-Wolf AJ, Duc HN, Joshi M, Espinosa JM, Prekeris R, Pearson CG. Trisomy 21 increases microtubules and disrupts centriolar satellite localization. Mol Biol Cell. 2022 Jul 1;33(8). PubMed PMID: 35476505
• Soh AWJ, Pearson CG. Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates. J Eukaryot Microbiol. 2022 Sep;69(5):e12880. PubMed PMID: 34897878
• Soh AWJ, Pearson CG. Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates. J Eukaryot Microbiol. 2021 Dec 12;:e12880. [Epub ahead of print] PubMed PMID: 34897878
• Junker AD, Jacob S, Philippe H, Legrand D, Pearson CG. Plastic cell morphology changes during dispersal. iScience. 2021 Aug 20;24(8):102915. PubMed PMID: 34430806
• Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG. The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis. Mol Biol Cell. 2021 Oct 1;32(20):ar4. PubMed PMID: 34406792
• Jewett CE, Pearson CG. Cancer biology: Messages in extracellular vesicles depend on centrosome number. Curr Biol. 2021 Apr 12;31(7):R337-R340. PubMed PMID: 33848487
• Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021 Feb 8;56(3):325-340.e8. PubMed PMID: 33561422
• Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R. RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis. Dev Cell. 2021 Feb 8;56(3):325-340.e8. PubMed PMID: 33561422
• Sankaran DG, Stemm-Wolf AJ, McCurdy BL, Hariharan B, Pearson CG. A semi-automated machine learning-aided approach to quantitative analysis of centrosomes and microtubule organization. J Cell Sci. 2020 Jul 30;133(14). PubMed PMID: 32591487
• Ruehle MD, Stemm-Wolf AJ, Pearson CG. Sas4 links basal bodies to cell division via Hippo signaling. J Cell Biol. 2020 Aug 3;219(8). PubMed PMID: 32435796
• Soh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CG. Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. J Cell Biol. 2020 Jan 6;219(1). PubMed PMID: 31740506
• Soh AWJ, van Dam TJP, Stemm-Wolf AJ, Pham AT, Morgan GP, O'Toole ET, Pearson CG. Ciliary force-responsive striated fibers promote basal body connections and cortical interactions. J Cell Biol. 2020 Jan 6;219(1). PubMed PMID: 31740506
• Junker AD, Soh AWJ, O'Toole ET, Meehl JB, Guha M, Winey M, Honts JE, Gaertig J, Pearson CG. Microtubule glycylation promotes attachment of basal bodies to the cell cortex. J Cell Sci. 2019 Aug 7;132(15). PubMed PMID: 31243050
• Ganapathi Sankaran D, Stemm-Wolf AJ, Pearson CG. CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells. Mol Biol Cell. 2019 May 1;30(10):1230-1244. PubMed PMID: 30811267
• Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW. Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein. J Cell Sci. 2019 Jan 22;132(2). PubMed PMID: 30584065
• Idiopathic Scoliosis Families Highlight Actin-Based and Microtubule-Based Cellular Projections and Extracellular Matrix in Disease Etiology. Baschal EE, Terhune EA, Wethey CI, Baschal RM, Robinson KD, Cuevas MT, Pradhan S, Sutphin BS, Taylor MRG, Gowan K, Pearson CG, Niswander LA, Jones KL, Miller NH. G3 (Bethesda). 2018 Jul 31;8(8):2663-2672. doi: 10.1534/g3.118.200290. PMID: 29930198 Free PMC Article Similar articles
• Trisomy 21 Represses Cilia Formation and Function. Galati DF, Sullivan KD, Pham AT, Espinosa JM, Pearson CG. Dev Cell. 2018 Sep 10;46(5):641-650.e6. doi: 10.1016/j.devcel.2018.07.008. Epub 2018 Aug 9. PMID: 30100262
• Proteins that control the geometry of microtubules at the ends of cilia. Louka P, Vasudevan KK, Guha M, Joachimiak E, Wloga D, Tomasi RF, Baroud CN, Dupuis-Williams P, Galati DF, Pearson CG, Rice LM, Moresco JJ, Yates JR 3rd, Jiang YY, Lechtreck K, Dentler W, Gaertig J. J Cell Biol. 2018 Dec 3;217(12):4298-4313. doi: 10.1083/jcb.201804141. Epub 2018 Sep 14.
• Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein. Han KJ, Wu Z, Pearson CG, Peng J, Song K, Liu CW. J Cell Sci. 2019 Jan 22;132(2). pii: jcs221663. doi: 10.1242/jcs.221663. PMID: 30584065
• Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24;8(4):6742-6762. PubMed PMID: 28039486
• Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, Alessandro AD, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2016 Dec 27. [Epub ahead of print] PubMed PMID: 28039486
• Galati DF, Mitchell BJ, Pearson CG. Subdistal Appendages Stabilize the Ups and Downs of Ciliary Life. Dev Cell. 2016 Nov 21;39(4):387-389. PubMed PMID: 27875681
• Bayless BA, Galati DF, Junker AD, Backer CB, Gaertig J, Pearson CG. Asymmetrically localized proteins stabilize basal bodies against ciliary beating forces. J Cell Biol. 2016 Nov 21;215(4):457-466. PubMed PMID: 27807131
• Wall KP, Pagratis M, Armstrong G, Balsbaugh JL, Verbeke E, Pearson CG, Hough LE. Molecular Determinants of Tubulin's C-Terminal Tail Conformational Ensemble. ACS Chem Biol. 2016 Nov 18;11(11):2981-2990. PubMed PMID: 27541566
• Ruehle MD, Orias E, Pearson CG. Tetrahymena as a Unicellular Model Eukaryote: Genetic and Genomic Tools. Genetics. 2016 Jun;203(2):649-65. PubMed PMID: 27270699
• Meehl JB, Bayless BA, Giddings TH Jr, Pearson CG, Winey M. Tetrahymena Poc1 ensures proper intertriplet microtubule linkages to maintain basal body integrity. Mol Biol Cell. 2016 Aug 1;27(15):2394-403. PubMed PMID: 27251062
• Hudish LI, Galati DF, Ravanelli AM, Pearson CG, Huang P, Appel B. miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling. Development. 2016 Jul 1;143(13):2292-304. PubMed PMID: 27226318
• Garcia G 3rd, Finnigan GC, Heasley LR, Sterling SM, Aggarwal A, Pearson CG, Nogales E, McMurray MA, Thorner J. Assembly, molecular organization, and membrane-binding properties of development-specific septins. J Cell Biol. 2016 Feb 29;212(5):515-29. PubMed PMID: 26929450
• Bayless BA, Galati DF, Pearson CG. Tetrahymena basal bodies. Cilia. 2016 Jan 19;5:1. PubMed PMID: 26793300
• Bayless BA, Galati DF, Pearson CG. Tetrahymena basal bodies. Cilia. 2015;5:1. PubMed PMID: 26793300
• Galati DF, Abuin DS, Tauber GA, Pham AT, Pearson CG. Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays. Biol Open. 2015 Dec 23;5(1):20-31. PubMed PMID: 26700722
• Dahl KD, Sankaran DG, Bayless BA, Pinter ME, Galati DF, Heasley LR, Giddings TH Jr, Pearson CG. A Short CEP135 Splice Isoform Controls Centriole Duplication. Curr Biol. 2015 Oct 5;25(19):2591-6. PubMed PMID: 26412126
• Galati DF, Bonney S, Kronenberg Z, Clarissa C, Yandell M, Elde NC, Jerka-Dziadosz M, Giddings TH, Frankel J, Pearson CG. DisAp-dependent striated fiber elongation is required to organize ciliary arrays. J Cell Biol. 2014 Dec 22;207(6):705-15. PubMed PMID: 25533842
• Pearson CG. Choosing sides--asymmetric centriole and basal body assembly. J Cell Sci. 2014 Jul 1;127(Pt 13):2803-10. PubMed PMID: 24895399
• Mark Winey, Alexander J. Stemm-Wolf, Thomas H Giddings Jr., and Chad G. Pearson (2012) Cytological Analysis of Tetrahymena thermophila. Methods Cell Biol. 109:357-378
• 1. Chelsea B. Backer, Jennifer H. Gutzman, Chad G. Pearson, and Iain M. Cheeseman. (2012) CSAP is targeted to polyglutamylated microtubules to promote proper cilia function and zebrafish development Mol. Biol. Cell. IN PRESS.
• Brian A. Bayless, Thomas H. Giddings Jr., Mark Winey, Chad G. Pearson. (2012) Bld10/Cep135 stabilizes basal bodies to resist cilia generated forces. Mol. Biol. Cell. 23(24):4820-4832.
• Chelsea B. Backer, Jennifer H. Gutzman, Chad G. Pearson, and Iain M. Cheeseman. (2012) CSAP is targeted to polyglutamylated microtubules to promote proper cilia function and zebrafish development Mol. Biol. Cell. 23:2122-2130.
• Mark Winey, Alexander J. Stemm-Wolf, Thomas H Giddings Jr., and Chad G. Pearson (2012) Cytological Analysis of Tetrahymena thermophila. Methods Cell Biol. 109:357-378.
• Chad G. Pearson (2011) A Kinesin in Command of Primary Ciliogenesis. Cell 145(6) 817-819.
• Robert S Coyne, Linda Hannick, Dhanasekaran Shanmugam, Jessica B Hostetler, Daniel Brami, Vinita S Joardar, Justin Johnson, Diana Radune, Irtisha Singh, Ujjwal Kumar, Milton Saier, Yufeng Wang, Hong Cai, Jianying Gu, Michael W Mather, Akhil B Vaidya, David E Wilkes, Vidyalakshmi Rajagopalan, David J Asai, Chad G Pearson, Robert C Findly, Harry W Dickerson, Jonathan H Badger, Martin Wu, Cindy Martens, Yves Van de Peer, David S Roos, Donna M Cassidy-Hanley and Theodore G Clark (2011) Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control. Genome Biology. 12(10):R100.