Paul Rozance, MD

Recognitions

• Dean’s Academic Honor Roll, University of California at Berkeley (1994)
  
• Faustino R. Suarez Award, Georgetown University School of Medicine (1998)
  
• William H. Homer Award, Georgetown University School of Medicine (1998)
  
• Oscar Bentwood Hunter Award , Georgetown University School of Medicine (1998)
  
• Association of Pathology Chairs Honor Society, Georgetown University School of Medicine (1996)
  
• American Society of Clinical Pathologists Award for Academic Excellence and Achievement, Georgetown University School of Medicine (1996)
  
• Outstanding Clinical Research Training Program Student Award, University of Colorado Health Sciences Center (2004)
  
• President’s Award for Working Together , University of Colorado Health Sciences Center (2007)
  
• Pediatric Loan Repayment Award, National Institutes of Health (2003)
  
• Rising Investigator, Perinatal Research Society (2008)
  
• Young Investigator Research Award, Western Society for Pediatric Research (2011)
  
• Hypoglycemia Awareness Award, Congenital Hyperinsulinism International (2015)
• President, Western Society for Pediatric Research, WSPR (2015)
• Recognized as one of the best UpToDate authors, “Pathogenesis, Screening, and Diagnosis of Neonatal Hypoglycemia” and “Management and Outcome of Neonatal Hypoglycemia.” (2016)

Research Interests

My research interests are focused on how the fetuses senses the nutrient supply from the placenta and translates that information into appropriate signals for growth.

Publications

• Limesand SW, Rozance PJ, Macko AR, Anderson MJ, Kelly AC, Hay WW Jr. Reductions in Insulin Concentrations and ß-Cell Mass Precede Growth Restriction in Sheep Fetuses with Placental Insufficiency. Am J Physiol Endocrinol Metab. 2012 Dec 31. [Epub ahead of print] PubMed PMID: 23277186
• Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. INCREASED AMINO ACID SUPPLY POTENTIATES GLUCOSE STIMULATED INSULIN SECRETION BUT DOES NOT INCREASE BETA CELL MASS IN FETAL SHEEP. Am J Physiol Endocrinol Metab. 2012 Dec 4. [Epub ahead of print] PubMed PMID: 23211516
• Dodson RB, Rozance PJ, Fleenor BS, Petrash CC, Shoemaker LG, Hunter KS, Ferguson VL. Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep. Pediatr Res. 2012 Nov 15. [Epub ahead of print] PubMed PMID: 23154756
• Lavezzi JR, Thorn SR, O'Meara MC, Loturco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan;304(1):R50-8. PubMed PMID: 23135788
• Frost MS, Zehri AH, Limesand SW, Hay WW Jr, Rozance PJ. Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic ß-Cells. J Pregnancy. 2012;2012:812094. PubMed PMID: 23133755
• Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
• Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW Jr, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15;303(8):R861-9. PubMed PMID: 22933022
• Rozance PJ, Hay WW Jr. Neonatal hypoglycemia--answers, but more questions. J Pediatr. 2012 Nov;161(5):775-6. PubMed PMID: 22809663
• Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E352-64. PubMed PMID: 22649066
• Chen X, Rozance PJ, Hay WW Jr, Limesand SW. Insulin-like growth factor and fibroblast growth factor expression profiles in growth-restricted fetal sheep pancreas. Exp Biol Med (Maywood). 2012 May 1;237(5):524-9. PubMed PMID: 22581814
• Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1483-92. PubMed PMID: 22454287
• Delaney CA, Rozance PJ, Sandoval JA, Bealer JF, Kinsella JP. Late onset diaphragmatic hernia complicated by intestinal strangulation. Curr Opin Pediatr. 2012 Apr;24(2):274-6. PubMed PMID: 22327952
• Rozance PJ, Rosenberg AA. “The Neonate.” In Obstetrics: Normal and Problem Pregnancies, 6th edition. Gabbe, Niebyl, Simpson, Landon, Galan, Jauniaux, and Driscoll, editors, Elsevier. 2012.
• Dodson RB, Rozance PJ, Petrash CC, Hunter KS, Ferguson VL. Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted (IUGR) fetal sheep. Am J Physiol Heart Circ Physiol. 2013 Dec 6. [Epub ahead of print] PubMed PMID: 24322609
• Dodson RB, Rozance PJ, Reina-Romo E, Ferguson VL, Hunter KS. Hyperelastic remodeling in the intrauterine growth restricted (IUGR) carotid artery in the near-term fetus. J Biomech. 2013 Mar 15;46(5):956-63. PubMed PMID: 23332229
• Limesand SW, Rozance PJ, Macko AR, Anderson MJ, Kelly AC, Hay WW Jr. Reductions in insulin concentrations and ß-cell mass precede growth restriction in sheep fetuses with placental insufficiency. Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E516-23. PubMed PMID: 23277186
• Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW Jr, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E352-62. PubMed PMID: 23211516
• Dodson RB, Rozance PJ, Fleenor BS, Petrash CC, Shoemaker LG, Hunter KS, Ferguson VL. Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep. Pediatr Res. 2013 Feb;73(2):147-54. PubMed PMID: 23154756
• Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW Jr, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 1;304(1):R50-8. PubMed PMID: 23135788
• Thorn SR, Brown LD, Rozance PJ, Hay WW Jr, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan;62(1):65-73. PubMed PMID: 22933111
• Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2014 Dec 16;:ajpendo.00396.2014. [Epub ahead of print] PubMed PMID: 25516551
• Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. PubMed PMID: 26224688
• Thornton PS, Stanley CA, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Rozance PJ, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI. Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children. J Pediatr. 2015 Aug;167(2):238-45. PubMed PMID: 25957977
• Stanley CA, Rozance PJ, Thornton PS, De Leon DD, Harris D, Haymond MW, Hussain K, Levitsky LL, Murad MH, Simmons RA, Sperling MA, Weinstein DA, White NH, Wolfsdorf JI. Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management. J Pediatr. 2015 Jun;166(6):1520-5.e1. PubMed PMID: 25819173
• Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14. PubMed PMID: 25516551
• Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;156(1):367-76. PubMed PMID: 25343274
• Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;1(1):367-76. PubMed PMID: 25343274
• Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW. Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep. Diabetes. 2015 Feb;64(2):555-64. PubMed PMID: 25249573
• Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW. Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep. Diabetes. 2014 Sep 23. [Epub ahead of print] PubMed PMID: 25249573
• Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18;2(6). PubMed PMID: 24944291
• Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014;5(1):28. PubMed PMID: 24917928
• Houin S, Rozance PJ. 50 years ago in the Journal of pediatrics: The incidence of neonatal hypoglycemia in a nursery for premature infants. J Pediatr. 2014 Jun;164(6):1485. PubMed PMID: 24855928
• Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW Jr, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct;157(10):3788-3799. PubMed PMID: 27501184
• Kamath-Rayne BD, Rozance PJ, Goldenberg RL, Jobe AH. Antenatal corticosteroids beyond 34 weeks gestation: What do we do now?. Am J Obstet Gynecol. 2016 Oct;215(4):423-30. PubMed PMID: 27342043
• Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R200-8. PubMed PMID: 27170658
• Rozance PJ, Hay WW Jr. New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol. 2016 May 10;2:3. PubMed PMID: 27168942
• Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW Jr, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 Jun;157(6):2447-60. PubMed PMID: 27049667
• Dodson RB, Rozance PJ, Petrash CC, Hunter KS, Ferguson VL. Thoracic and abdominal aortas stiffen through unique extracellular matrix changes in intrauterine growth restricted fetal sheep. Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H429-37. PubMed PMID: 24322609
• Hay WW Jr, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug;105(8):881-9. PubMed PMID: 27028695
• Rozance PJ. 50 Years Ago in The Journal of Pediatrics: Perinatal Stress and the Premature Neonate. II. Effect of Fluid and Calorie Deprivation on Blood Glucose. J Pediatr. 2016 Mar;170:89. PubMed PMID: 26922762
• Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW Jr. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 Apr;241(8):839-47. PubMed PMID: 26873920
• Rozance PJ, Hay WW Jr. Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses. Mol Cell Endocrinol. 2016 Nov 5;435:78-84. PubMed PMID: 26820125
• Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar;170:10-2. PubMed PMID: 26746122
• Houin SS, Rozance PJ, Brown LD, Hay WW Jr, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15;308(4):E306-14. PubMed PMID: 25516551
• Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW Jr, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan;156(1):367-76. PubMed PMID: 25343274
• Rozance PJ, Anderson M, Martinez M, Fahy A, Macko AR, Kailey J, Seedorf GJ, Abman SH, Hay WW Jr, Limesand SW. Placental insufficiency decreases pancreatic vascularity and disrupts hepatocyte growth factor signaling in the pancreatic islet endothelial cell in fetal sheep. Diabetes. 2015 Feb;64(2):555-64. PubMed PMID: 25249573
• Rozance PJ. Update on neonatal hypoglycemia. Curr Opin Endocrinol Diabetes Obes. 2014 Feb;21(1):45-50. PubMed PMID: 24275620
• Bourque SL, Rozance PJ, Hay WW. 50 Years Ago in The Journal of Pediatrics: Diazoxide Treatment for Idiopathic Hypoglycemia of Infancy. J Pediatr. 2017 Oct;189:53. PubMed PMID: 28947056
• Hernandez TL, Hay WW Jr, Rozance PJ. Continuous glucose monitoring in the neonatal intensive care unit: not quite ready for 'plug and play'. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. [Epub ahead of print] PubMed PMID: 30425111
• Wai SG, Rozance PJ, Wesolowski SR, Hay WW Jr, Brown LD. Prolonged amino acid infusion into intrauterine growth restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 Sep 11. [Epub ahead of print] PubMed PMID: 30205012
• White A, Louey S, Chang EI, Boehmer BH, Goldstrohm D, Jonker SS, Rozance PJ. A 1 week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep. Physiol Rep. 2018 Sep;6(17):e13840. PubMed PMID: 30175552
• Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW Jr, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940557
• Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. Pulsatile hyperglycemia increases insulin secretion but not pancreatic ß-cell mass in intrauterine growth-restricted fetal sheep. J Dev Orig Health Dis. 2018 Oct;9(5):492-499. PubMed PMID: 29973299
• Kaiser JR, Bai S, Rozance PJ. Reply to the Letter to the Editor "The Postnatal Glucose Concentration Nadir Is Not Abnormal and Does Not Need to Be Treated". Neonatology. 2018;114(2):164. PubMed PMID: 29894996
• Hay WW Jr, Rozance PJ. Neonatal Hyperglycemia-Causes, Treatments, and Cautions. J Pediatr. 2018 Sep;200:6-8. PubMed PMID: 29753545
• Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L348-L359. PubMed PMID: 29722560
• Rozance PJ, Wright CJ. Preparing for the first breath: in the developing lung, maternal overnutrition takes centre stage. J Physiol. 2017 Nov 1;595(21):6595-6596. PubMed PMID: 28925540
• Kaiser JR, Bai S, Rozance PJ. Newborn Plasma Glucose Concentration Nadirs by Gestational-Age Group. Neonatology. 2018;113(4):353-359. PubMed PMID: 29510404
• Boehmer BH, Limesand SW, Rozance PJ. The impact of IUGR on pancreatic islet development and ß-cell function. J Endocrinol. 2017 Nov;235(2):R63-R76. PubMed PMID: 28808079
• Bourque SL, Rozance PJ. Does dextrose gel prevent treatment failure in infants with neonatal hypoglycaemia?. Acta Paediatr. 2017 Jul;106(7):1201. PubMed PMID: 28220533
• Beune IM, Bloomfield FH, Ganzevoort W, Embleton ND, Rozance PJ, van Wassenaer-Leemhuis AG, Wynia K, Gordijn SJ. Consensus Based Definition of Growth Restriction in the Newborn. J Pediatr. 2018 May;196:71-76.e1. PubMed PMID: 29499988
• Limesand SW, Rozance PJ. Fetal adaptations in insulin secretion result from high catecholamines during placental insufficiency. J Physiol. 2017 Aug 1;595(15):5103-5113. PubMed PMID: 28194805
• Brown LD, Kohn JR, Rozance PJ, Hay WW Jr, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R654-R663. PubMed PMID: 28179229
• Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW Jr, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R492-R500. PubMed PMID: 28100476
• Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 Mar;232(3):475-491. PubMed PMID: 28053000
• Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 4. [Epub ahead of print] PubMed PMID: 31483682
• Qiao L, Wattez JS, Lim L, Rozance PJ, Hay WW Jr, Shao J. Prolonged Prepregnant Maternal High-Fat Feeding Reduces Fetal and Neonatal Blood Glucose Concentrations by Enhancing Fetal ß-Cell Development in C57BL/6 Mice. Diabetes. 2019 Aug;68(8):1604-1613. PubMed PMID: 31127056
• Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW Jr, Limesand SW, Wesolowski SR. Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E1-E10. PubMed PMID: 30964701
• Rozance PJ, Wolfsdorf JI. Hypoglycemia in the Newborn. Pediatr Clin North Am. 2019 Apr;66(2):333-342. PubMed PMID: 30819340
• Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. PubMed PMID: 30758974
• Hay WW Jr, Rozance PJ. Alert Newborn Infants Are Ready to Feed and Raise Their Glucose Concentration. Neonatology. 2019;115(3):239-241. PubMed PMID: 30669150
• Hernandez TL, Hay WW Jr, Rozance PJ. Continuous glucose monitoring in the neonatal intensive care unit: not quite ready for 'plug and play'. Arch Dis Child Fetal Neonatal Ed. 2019 Jul;104(4):F344-F345. PubMed PMID: 30425111
• Ali A, Swanepoel CM, Winger QA, Rozance PJ, Anthony RV. Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization. J Endocrinol. 2020 Dec;247(3):169-180. PubMed PMID: 33108344
• Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
• Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct;247(1):115-126. PubMed PMID: 32756000
• Thornton PS, Rozance PJ, Sperling MA. The GLOW Study does not light up the true Pediatric Endocrine Society recommendations for management of hypoglycemia in newborns. J Pediatr. 2020 Oct;225:279. PubMed PMID: 32603688
• Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 Oct;26(7):549-564. PubMed PMID: 32538259
• Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
• Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na( ) K( ) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
• Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. PubMed PMID: 33427051
• Boehmer BH, Brown LD, Wesolowski SR, Rozance PJ. Chronic fetal leucine infusion does not potentiate glucose-stimulated insulin secretion or affect pancreatic islet development in late-gestation growth-restricted fetal sheep. Accepted J Nutr. October 2020
• Boehmer BH, Wesolowski SR, Brown LD, Rozance PJ. Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep. J Nutr. 2021 Feb 1;151(2):312-319. PubMed PMID: 33326574
• Tanner AR, Lynch CS, Ali A, Winger QA, Rozance PJ, Anthony RV. Impact of chorionic somatomammotropin RNA interference on uterine blood flow and placental glucose uptake in the absence of intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2021 Feb 1;320(2):R138-R148. PubMed PMID: 33146554
• Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2021 Oct 5. [Epub ahead of print] PubMed PMID: 34611848
• Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep;9(18):e15033. PubMed PMID: 34558219
• Zarate MA, De Dios RK, Balasubramaniyan D, Zheng L, Sherlock LG, Rozance PJ, Wright CJ. The Acute Hepatic NF-?B-Mediated Proinflammatory Response to Endotoxemia Is Attenuated in Intrauterine Growth-Restricted Newborn Mice. Front Immunol. 2021;12:706774. PubMed PMID: 34539638
• Tanner AR, Lynch CS, Kennedy VC, Ali A, Winger QA, Rozance PJ, Anthony RV. CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction. Int J Mol Sci. 2021 Jul 29;22(15). PubMed PMID: 34360913
• Rozance PJ, Wesolowski SR, Jonker SS, Brown LD. Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2021 Sep 1;321(3):R352-R363. PubMed PMID: 34287074
• Dinu D, Rozance P. Real-time continuous glucose monitoring in preterm infants (react): An International, open-label, randomised, controlled trial. Acta Paediatr. 2021 Sep;110(9):2656-2657. PubMed PMID: 34121224
• White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1138-E1147. PubMed PMID: 33938236
• Cilvik SN, Wesolowski SR, Anthony RV, Brown LD, Rozance PJ. Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth. J Physiol. 2021 Jul;599(13):3403-3427. PubMed PMID: 33878802
• Wright CJ, McKenna S, De Dios R, Boehmer BH, Nguyen L, Ghosh S, Sandoval J, Rozance PJ. Lower threshold to NF?B activity sensitizes murine ß-cells to streptozotocin. J Endocrinol. 2021 May 6;249(3):163-175. PubMed PMID: 33764312
• Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. PubMed PMID: 33427051
• Boehmer BH, Wesolowski SR, Brown LD, Rozance PJ. Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep. J Nutr. 2021 Feb 1;151(2):312-319. PubMed PMID: 33326574
• Tanner AR, Lynch CS, Ali A, Winger QA, Rozance PJ, Anthony RV. Impact of chorionic somatomammotropin RNA interference on uterine blood flow and placental glucose uptake in the absence of intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2021 Feb 1;320(2):R138-R148. PubMed PMID: 33146554
• Ali A, Swanepoel CM, Winger QA, Rozance PJ, Anthony RV. Chorionic somatomammotropin RNA interference alters fetal liver glucose utilization. J Endocrinol. 2020 Dec;247(3):251-262. PubMed PMID: 33108344
• Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW Jr, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 Oct 1;319(4):E721-E733. PubMed PMID: 32830555
• Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct;247(1):115-126. PubMed PMID: 32756000
• Thornton PS, Rozance PJ, Sperling MA. The GLOW Study does not light up the true Pediatric Endocrine Society recommendations for management of hypoglycemia in newborns. J Pediatr. 2020 Oct;225:279. PubMed PMID: 32603688
• Zarate MA, Wesolowski SR, Nguyen LM, De Dios RK, Wilkening RB, Rozance PJ, Wright CJ. In utero inflammatory challenge induces an early activation of the hepatic innate immune response in late gestation fetal sheep. Innate Immun. 2020 Oct;26(7):549-564. PubMed PMID: 32538259
• Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 Aug 1;150(8):2061-2069. PubMed PMID: 32470982
• Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na( ) K( ) -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 Apr;598(8):1625-1639. PubMed PMID: 31909825
• Hord TK, Tanner AR, Kennedy VC, Lynch CS, Winger QA, Rozance PJ, Anthony RV. Impact of Chorionic Somatomammotropin In Vivo RNA Interference Phenotype on Uteroplacental Expression of the IGF Axis. Life (Basel). 2023 May 26;13(6). PubMed PMID: 37374044
• Swenson KS, Wang D, Jones AK, Nash MJ, O'Rourke R, Takahashi DL, Kievit P, Hennebold JD, Aagaard KM, Friedman JE, Jones KL, Rozance PJ, Brown LD, Wesolowski SR. Metformin Disrupts Signaling and Metabolism in Fetal Hepatocytes. Diabetes. 2023 Sep 1;72(9):1214-1227. PubMed PMID: 37347736
• Lynch CS, Kennedy VC, Tanner AR, Ali A, Winger QA, Rozance PJ, Anthony RV. Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation. Int J Mol Sci. 2022 Oct 19;23(20). PubMed PMID: 36293384
• Kyllo HM, Wang D, Lorca RA, Julian CG, Moore LG, Wilkening RB, Rozance PJ, Brown LD, Wesolowski SR. Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency. Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E556-E568. PubMed PMID: 37126847
• White A, Stremming J, Brown LD, Rozance PJ. Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets. J Dev Orig Health Dis. 2023 Jun;14(3):353-361. PubMed PMID: 37114757
• Rozance PJ, Boehmer BH, Chang EI, Wesolowski SR, Brown LD. Chronic Fetal Leucine Infusion Increases Rate of Leucine Oxidation but Not of Protein Synthesis in Late Gestation Fetal Sheep. J Nutr. 2023 Feb;153(2):493-504. PubMed PMID: 36894241
• Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ, Brown LD. Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep. Front Physiol. 2022;13:954948. PubMed PMID: 36091374
• Hernandez TL, Rozance PJ. Re-examination of the estimated average requirement for carbohydrate intake during pregnancy: Addition of placental glucose consumption. Am J Clin Nutr. 2023 Feb;117(2):227-234. PubMed PMID: 36811561
• Lynch CS, Kennedy VC, Tanner AR, Ali A, Winger QA, Rozance PJ, Anthony RV. Impact of Placental SLC2A3 Deficiency during the First-Half of Gestation. Int J Mol Sci. 2022 Oct 19;23(20). PubMed PMID: 36293384
• Stremming J, White A, Donthi A, Batt DG, Hetrick B, Chang EI, Wesolowski SR, Seefeldt MB, McCurdy CE, Rozance PJ, Brown LD. Sheep recombinant IGF-1 promotes organ-specific growth in fetal sheep. Front Physiol. 2022;13:954948. PubMed PMID: 36091374
• Stenhouse C, Halloran KM, Tanner AR, Suva LJ, Rozance PJ, Anthony RV, Bazer FW. Uptake of Phosphate, Calcium, and Vitamin D by the Pregnant Uterus of Sheep in Late Gestation: Regulation by Chorionic Somatomammotropin Hormone. Int J Mol Sci. 2022 Jul 14;23(14). PubMed PMID: 35887141
• Stenhouse C, Halloran KM, Tanner AR, Suva LJ, Rozance PJ, Anthony RV, Bazer FW. Uptake of Phosphate, Calcium, and Vitamin D by the Pregnant Uterus of Sheep in Late Gestation: Regulation by Chorionic Somatomammotropin Hormone. Int J Mol Sci. 2022 Jul 14;23(14). PubMed PMID: 35887141
• Tanner AR, Kennedy VC, Lynch CS, Hord TK, Winger QA, Rozance PJ, Anthony RV. In vivo investigation of ruminant placenta function and physiology-a review. J Anim Sci. 2022 Jun 1;100(6). PubMed PMID: 35648127
• Rozance PJ. Hypoglycemia in the Newborn and Neurodevelopmental Outcomes in Childhood. JAMA. 2022 Mar 22;327(12):1135-1137. PubMed PMID: 35315906
• Joss-Moore LA, Lane RH, Rozance PJ, Bird I, Albertine KH. Perinatal Research Society's Young Investigator Workshop Prepares the Next Generation of Investigators. Reprod Sci. 2022 Apr;29(4):1271-1277. PubMed PMID: 35020187
• Tanner AR, Kennedy VC, Lynch CS, Hord TK, Winger QA, Rozance PJ, Anthony RV. In vivo investigation of ruminant placenta function and physiology-a review. J Anim Sci. 2022 Jun 1;100(6). PubMed PMID: 35648127
• Jones AK, Wang D, Goldstrohm DA, Brown LD, Rozance PJ, Limesand SW, Wesolowski SR. Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E181-E196. PubMed PMID: 34957858
• Rozance PJ. Hypoglycemia in the Newborn and Neurodevelopmental Outcomes in Childhood. JAMA. 2022 Mar 22;327(12):1135-1137. PubMed PMID: 35315906
• Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2022 Jun;29(6):1776-1789. PubMed PMID: 34611848
• Joss-Moore LA, Lane RH, Rozance PJ, Bird I, Albertine KH. Perinatal Research Society's Young Investigator Workshop Prepares the Next Generation of Investigators. Reprod Sci. 2022 Apr;29(4):1271-1277. PubMed PMID: 35020187
• Jones AK, Wang D, Goldstrohm DA, Brown LD, Rozance PJ, Limesand SW, Wesolowski SR. Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep. Am J Physiol Endocrinol Metab. 2022 Feb 1;322(2):E181-E196. PubMed PMID: 34957858
• Gilley SP, Ruebel ML, Chintapalli SV, Wright CJ, Rozance PJ, Shankar K. Calorie restriction during gestation impacts maternal and offspring fecal microbiome in mice. Front Endocrinol (Lausanne). 2024;15:1423464. PubMed PMID: 39429739
• Cilvik SN, Boehmer B, Wesolowski SR, Brown LD, Rozance PJ. Chronic late gestation fetal hyperglucagonaemia results in lower insulin secretion, pancreatic mass, islet area and beta- and a-cell proliferation. J Physiol. 2024 Nov;602(22):6329-6345. PubMed PMID: 39383208
• Chang EI, Stremming J, Knaub LA, Wesolowski SR, Rozance PJ, Sucharov CC, Reusch JEB, Brown LD. Mitochondrial respiration is lower in the intrauterine growth-restricted fetal sheep heart. J Physiol. 2024 Jun;602(12):2697-2715. PubMed PMID: 38743350
• Kennedy VC, Lynch CS, Tanner AR, Winger QA, Gad A, Rozance PJ, Anthony RV. Fetal Hypoglycemia Induced by Placental SLC2A3-RNA Interference Alters Fetal Pancreas Development and Transcriptome at Mid-Gestation. Int J Mol Sci. 2024 Apr 27;25(9). PubMed PMID: 38731997
• Stremming J, Chang EI, White A, Rozance PJ, Brown LD. IGF-1 infusion increases growth in fetal sheep when euinsulinemia is maintained. J Endocrinol. 2024 Jul 1;262(1). PubMed PMID: 38727325
• Brown LD, Rozance PJ, Wang D, Eroglu EC, Wilkening RB, Solmonson A, Wesolowski SR. Increased hepatic glucose production with lower oxidative metabolism in the growth-restricted fetus. JCI Insight. 2024 Apr 30;9(10). PubMed PMID: 38687612
• Rozance PJ, Brown LD, Wesolowski SR. Absence of Metformin in Fetal Circulation Following Maternal Administration in Late Gestation Pregnant Sheep. Reprod Sci. 2024 Jun;31(6):1763-1766. PubMed PMID: 38653860
• Dinu D, Hagan JL, Rozance PJ. Variability in Diagnosis and Management of Hypoglycemia in Neonatal Intensive Care Unit. Am J Perinatol. 2024 Oct;41(14):1990-1998. PubMed PMID: 38565171
• Tanner AR, Kennedy VC, Lynch CS, Winger QA, Anthony RV, Rozance PJ. Increasing maternal glucose concentrations is insufficient to restore placental glucose transfer in chorionic somatomammotropin RNA interference pregnancies. Am J Physiol Endocrinol Metab. 2024 May 1;326(5):E602-E615. PubMed PMID: 38353640
• Gilley SP, Zarate MA, Zheng L, Jambal P, Yazza DN, Chintapalli SV, MacLean PS, Wright CJ, Rozance PJ, Shankar K. Metabolic and fecal microbial changes in adult fetal growth restricted mice. Pediatr Res. 2024 Feb;95(3):647-659. PubMed PMID: 37935884

Professional Memberships

• Alpha Omega Alpha, Member
• Western Society for Pediatric Research (WSPR), Member
• American Academy of Pediatrics (AAP), Fellow
• American Diabetes Association, Professional Member
• Society For Pediatric Research (SPR), Member
• Perinatal Research Society (PRS), Member
• American Physiological Society, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Highlands Ranch Hospital
1500 Park Central Drive
Highlands Ranch, CO 80129
720-516-1000

Hospital Affiliation

• Children's Hospital Colorado
• University of Colorado Hospital
• UCHealth Highlands Ranch Hospital

Center Affiliations

• Perinatal Research Center

Specialty Information

Specialties

• Neonatal-Perinatal Medicine, Board Certification (2005)

Conditions & Treatments

• Pregnancy and Reproduction - Neonatal Intensive Care
• Pregnancy and Reproduction