Wendy Macklin, PhD

Publications

• Jaini R, Popescu DC, Flask CA, Macklin WB, Tuohy VK. Myelin antigen load influences antigen presentation and severity of central nervous system autoimmunity. J Neuroimmunol. 2013 Jun 15;259(1-2):37-46. PubMed PMID: 23601904
• Dutta R, Chomyk AM, Chang A, Ribaudo MV, Deckard SA, Doud MK, Edberg DD, Bai B, Li M, Baranzini SE, Fox RJ, Staugaitis SM, Macklin WB, Trapp BD. Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol. 2013 May;73(5):637-45. PubMed PMID: 23595422
• Ahrendsen JT, Macklin W. Signaling mechanisms regulating myelination in the central nervous system. Neurosci Bull. 2013 Apr;29(2):199-215. PubMed PMID: 23558589
• Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB. mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development. ASN Neuro. 2013 Mar 19;5(1):e00108. PubMed PMID: 23421405
• Hussain R, Ghoumari AM, Bielecki B, Steibel J, Boehm N, Liere P, Macklin WB, Kumar N, Habert R, Mhaouty-Kodja S, Tronche F, Sitruk-Ware R, Schumacher M, Ghandour MS. The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination. Brain. 2013 Jan;136(Pt 1):132-46. PubMed PMID: 23365095
• Hu X, Schlanger R, He W, Macklin WB, Yan R. Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression. FASEB J. 2013 May;27(5):1868-73. PubMed PMID: 23335052
• Sachs HH, Bercury KK, Popescu DC, Narayanan SP, Macklin WB. A new model of cuprizone-mediated demyelination/remyelination. ASN Neuro. 2014;6(5). PubMed PMID: 25290063
• Dai J, Bercury KK, Macklin WB. Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation. Glia. 2014 Dec;62(12):2096-109. PubMed PMID: 25060812
• Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 3;2(6):825-37. PubMed PMID: 24936469
• Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2349-55. PubMed PMID: 24843159
• Dai J, Bercury KK, Jin W, Macklin WB. Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development. J Neurosci. 2015 Dec 2;35(48):15875-93. PubMed PMID: 26631469
• Bercury KK, Dai J, Sachs HH, Ahrendsen JT, Wood TL, Macklin WB. Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination. J Neurosci. 2014 Mar 26;34(13):4466-80. PubMed PMID: 24671993
• Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury. J Biol Chem. 2015 Nov 30. [Epub ahead of print] PubMed PMID: 26620563
• Wahl SE, McLane LE, Bercury KK, Macklin WB, Wood TL. Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination. J Neurosci. 2014 Mar 26;34(13):4453-65. PubMed PMID: 24671992
• Zhao X, Dai J, Ma Y, Mi Y, Cui D, Ju G, Macklin WB, Jin W. Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation. Glia. 2014 Jun;62(6):914-26. PubMed PMID: 24615693
• Harlow DE, Saul KE, Culp CM, Vesely EM, Macklin WB. Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination. J Neurosci. 2014 Jan 22;34(4):1333-43. PubMed PMID: 24453324
• Harlow DE, Saul KE, Komuro H, Macklin WB. Myelin Proteolipid Protein Complexes with av Integrin and AMPA Receptors In Vivo and Regulates AMPA-Dependent Oligodendrocyte Progenitor Cell Migration through the Modulation of Cell-Surface GluR2 Expression. J Neurosci. 2015 Aug 26;35(34):12018-32. PubMed PMID: 26311781
• Harlow DE, Macklin WB. Inhibitors of myelination: ECM changes, CSPGs and PTPs. Exp Neurol. 2014 Jan;251:39-46. PubMed PMID: 24200549
• Dai J, Bercury KK, Ahrendsen JT, Macklin WB. Olig1 function is required for oligodendrocyte differentiation in the mouse brain. J Neurosci. 2015 Mar 11;35(10):4386-402. PubMed PMID: 25762682
• Bercury KK, Macklin WB. Dynamics and mechanisms of CNS myelination. Dev Cell. 2015 Feb 23;32(4):447-58. PubMed PMID: 25710531
• Preston MA, Macklin WB. Zebrafish as a model to investigate CNS myelination. Glia. 2015 Feb;63(2):177-93. PubMed PMID: 25263121
• Hussain R, Macklin WB. Integrin linked kinase (ILK) deletion disrupts oligodendrocyte development by altering cell cycle. J Neurosci. 2016 Dec 2. [Epub ahead of print] PubMed PMID: 27913589
• Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica. J Neuroinflammation. 2016 Dec 1;13(1):301. PubMed PMID: 27905992
• Verden D, Macklin WB. Neuroprotection by central nervous system remyelination: Molecular, cellular, and functional considerations. J Neurosci Res. 2016 Dec;94(12):1411-1420. PubMed PMID: 27618492
• Turcotte R, Rutledge DJ, Bélanger E, Dill D, Macklin WB, Côté DC. Intravital assessment of myelin molecular order with polarimetric multiphoton microscopy. Sci Rep. 2016 Aug 19;6:31685. PubMed PMID: 27538357
• Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB. Juvenile striatal white matter is resistant to ischemia-induced damage. Glia. 2016 Nov;64(11):1972-86. PubMed PMID: 27463063
• Bai CB, Sun S, Roholt A, Benson E, Edberg D, Medicetty S, Dutta R, Kidd G, Macklin WB, Trapp B. A mouse model for testing remyelinating therapies. Exp Neurol. 2016 Sep;283(Pt A):330-40. PubMed PMID: 27384502
• Li Y, Dunphy JM, Pedraza CE, Lynch CR, Cardona SM, Macklin WB, Lynch WP. Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence. J Virol. 2016 Jan 13;90(7):3385-99. PubMed PMID: 26764005
• Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI. SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY. J Biol Chem. 2016 Jan 22;291(4):1957-73. PubMed PMID: 26620563
• Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 Jul;60:1-12. PubMed PMID: 27267556
• Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. J Cereb Blood Flow Metab. 2017 Jan 1;:271678X17750761. [Epub ahead of print] PubMed PMID: 29283314
• Ahrendsen JT, Harlow DE, Finseth LT, Bourne JN, Hickey SP, Gould EA, Culp CM, Macklin WB. The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J Neurosci. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29217681
• Abi Ghanem C, Degerny C, Hussain R, Liere P, Pianos A, Tourpin S, Habert R, Macklin WB, Schumacher M, Ghoumari AM. Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor. PLoS Genet. 2017 Nov;13(11):e1007049. PubMed PMID: 29107990
• Peschl P, Schanda K, Zeka B, Given K, Böhm D, Ruprecht K, Saiz A, Lutterotti A, Rostásy K, Höftberger R, Berger T, Macklin W, Lassmann H, Bradl M, Bennett JL, Reindl M. Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination. J Neuroinflammation. 2017 Oct 25;14(1):208. PubMed PMID: 29070051
• Ryan DP, Gould EA, Seedorf GJ, Masihzadeh O, Abman SH, Vijayaraghavan S, Macklin WB, Restrepo D, Shepherd DP. Automatic and adaptive heterogeneous refractive index compensation for light-sheet microscopy. Nat Commun. 2017 Sep 20;8(1):612. PubMed PMID: 28931809
• McLane LE, Bourne JN, Evangelou AV, Khandker L, Macklin WB, Wood TL. Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination. J Neurosci. 2017 Aug 2;37(31):7534-7546. PubMed PMID: 28694334
• Liu Y, Given KS, Harlow DE, Matschulat AM, Macklin WB, Bennett JL, Owens GP. Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathol Commun. 2017 Mar 24;5(1):25. PubMed PMID: 28340598
• Hussain R, Macklin WB. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017 Jan 11;37(2):397-412. PubMed PMID: 28077718
• Liu Y, Given KS, Owens GP, Macklin WB, Bennett JL. Distinct patterns of glia repair and remyelination in antibody-mediated demyelination models of multiple sclerosis and neuromyelitis optica. Glia. 2018 Dec;66(12):2575-2588. PubMed PMID: 30240044
• Rodgers KM, Ahrendsen JT, Patsos OP, Strnad FA, Yonchek JC, Traystman RJ, Macklin WB, Herson PS. Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia. Neuroscience. 2018 Jun 1;380:1-13. PubMed PMID: 29649514
• Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018;11:57. PubMed PMID: 29599706
• Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB. Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife. 2018 Feb 13;7. PubMed PMID: 29436368
• Ahrendsen JT, Harlow DE, Finseth LT, Bourne JN, Hickey SP, Gould EA, Culp CM, Macklin WB. The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination. J Neurosci. 2018 Jan 24;38(4):787-802. PubMed PMID: 29217681
• Liu Y, Given KS, Dickson EL, Owens GP, Macklin WB, Bennett JL. Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo. Exp Neurol. 2019 Aug;318:32-41. PubMed PMID: 31029597
• Dingman AL, Rodgers KM, Dietz RM, Hickey SP, Frazier AP, Clevenger AC, Yonchek JC, Traystman RJ, Macklin WB, Herson PS. Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice. Dev Neurosci. 2019 Mar 12;:1-16. [Epub ahead of print] PubMed PMID: 30861520
• Brown TL, Macklin WB. The Actin Cytoskeleton in Myelinating Cells. Neurochem Res. 2019 Mar 7. [Epub ahead of print] PubMed PMID: 30847860
• Ishii A, Furusho M, Macklin W, Bansal R. Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood. Glia. 2019 Jul;67(7):1277-1295. PubMed PMID: 30761608
• Preston MA, Finseth LT, Bourne JN, Macklin WB. A novel myelin protein zero transgenic zebrafish designed for rapid readout of in vivo myelination. Glia. 2019 Apr;67(4):650-667. PubMed PMID: 30623975
• Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. J Cereb Blood Flow Metab. 2019 Jun;39(6):1005-1014. PubMed PMID: 29283314
• Brown TL, Macklin WB. The Actin Cytoskeleton in Myelinating Cells. Neurochem Res. 2020 Mar;45(3):684-693. PubMed PMID: 30847860
• Ornelas IM, Khandker L, Wahl SE, Hashimoto H, Macklin WB, Wood TL. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. 2020 Jun;68(6):1274-1290. PubMed PMID: 31904150
• Musah AS, Brown TL, Jeffries MA, Shang Q, Hashimoto H, Evangelou AV, Kowalski A, Batish M, Macklin WB, Wood TL. Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination. J Neurosci. 2020 Apr 8;40(15):2993-3007. PubMed PMID: 32139584
• Bargagna-Mohan P, Schultz G, Rheaume B, Trakhtenberg EF, Robson P, Pal-Ghosh S, Stepp MA, Given KS, Macklin WB, Mohan R. Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers. J Neurosci Res. 2020 Nov 16. [Epub ahead of print] PubMed PMID: 33197966
• Vicentini FA, Keenan CM, Wallace LE, Woods C, Cavin JB, Flockton AR, Macklin WB, Belkind-Gerson J, Hirota SA, Sharkey KA. Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia. Microbiome. 2021 Oct 26;9(1):210. PubMed PMID: 34702353
• Jeffries MA, McLane LE, Khandker L, Mather ML, Evangelou AV, Kantak D, Bourne JN, Macklin WB, Wood TL. mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model. J Neurosci. 2021 Oct 6;41(40):8321-8337. PubMed PMID: 34417330
• Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizu T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021 Jul 13;36(2):109362. PubMed PMID: 34260928
• Adams KL, Dahl KD, Gallo V, Macklin WB. Intrinsic and extrinsic regulators of oligodendrocyte progenitor proliferation and differentiation. Semin Cell Dev Biol. 2021 Aug;116:16-24. PubMed PMID: 34110985
• Kapitza C, Chunder R, Scheller A, Given KS, Macklin WB, Enders M, Kuerten S, Neuhuber WL, Wörl J. Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens. Int J Mol Sci. 2021 Mar 22;22(6). PubMed PMID: 33810144
• Brown TL, Hashimoto H, Finseth LT, Wood TL, Macklin WB. PAK1 Positively Regulates Oligodendrocyte Morphology and Myelination. J Neurosci. 2021 Mar 3;41(9):1864-1877. PubMed PMID: 33478987
• Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem. 2022 Sep;162(5):430-443. PubMed PMID: 35560167
• Khandker L, Jeffries MA, Chang YJ, Mather ML, Evangelou AV, Bourne JN, Tafreshi AK, Ornelas IM, Bozdagi-Gunal O, Macklin WB, Wood TL. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell Rep. 2022 Mar 1;38(9):110423. PubMed PMID: 35235799
• Bargagna-Mohan P, Schultz G, Rheaume B, Trakhtenberg EF, Robson P, Pal-Ghosh S, Stepp MA, Given KS, Macklin WB, Mohan R. Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers. J Neurosci Res. 2021 Mar;99(3):731-749. PubMed PMID: 33197966
• Benardais K, Ornelas IM, Fauveau M, Brown TL, Finseth LT, Panic R, Deboux C, Macklin WB, Wood TL, Nait-Oumesmar B. p70S6 kinase regulates oligodendrocyte differentiation and is active in remyelinating lesions. Brain Commun. 2022;4(1):fcac025. PubMed PMID: 35224490
• George NM, Gentile Polese A, Merle L, Macklin WB, Restrepo D. Excitable Axonal Domains Adapt to Sensory Deprivation in the Olfactory System. J Neurosci. 2022 Feb 23;42(8):1491-1509. PubMed PMID: 35022219
• Owens GP, Fellin TJ, Matschulat A, Salas V, Schaller KL, Given KS, Ritchie AM, Navarro A, Blauth K, Hughes EG, Macklin WB, Bennett JL. Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains. J Clin Invest. 2023 Oct 2;133(19). PubMed PMID: 37561592
• Almeida AR, Macklin WB. Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate. Elife. 2023 Apr 20;12. PubMed PMID: 37078701
• Frazier AP, Mitchell DN, Given KS, Hunn G, Burch AM, Childs CR, Moreno-Garcia M, Corigilano MR, Quillinan N, Macklin WB, Herson PS, Dingman AL. Chronic changes in oligodendrocyte sub-populations after middle cerebral artery occlusion in neonatal mice. Glia. 2023 Jun;71(6):1429-1450. PubMed PMID: 36794545
• Jewett CE, McCurdy BL, O'Toole ET, Stemm-Wolf AJ, Given KS, Lin CH, Olsen V, Martin W, Reinholdt L, Espinosa JM, Sullivan KD, Macklin WB, Prekeris R, Pearson CG. Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. Elife. 2023 Jan 19;12. PubMed PMID: 36656118
• Bubak AN, Merle L, Niemeyer CS, Baxter BD, Gentile Polese A, Ramakrishnan V, Gomez J, Madrigal L, Villegas-Lanau A, Lopera F, Macklin W, Frietze S, Nagel MA, Restrepo D. Signatures for viral infection and inflammation in the proximal olfactory system in familial Alzheimer's disease. Neurobiol Aging. 2023 Mar;123:75-82. PubMed PMID: 36638683
• Woods C, Flockton AR, Wallace LE, Keenan CM, Macklin WB, Sharkey KA, Belkind-Gerson J. Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse. Am J Physiol Gastrointest Liver Physiol. 2023 Feb 1;324(2):G115-G130. PubMed PMID: 36511517
• Dahl KD, Almeida AR, Hathaway HA, Bourne J, Brown TL, Finseth LT, Wood TL, Macklin WB. mTORC2 Loss in Oligodendrocyte Progenitor Cells Results in Regional Hypomyelination in the Central Nervous System. J Neurosci. 2023 Jan 25;43(4):540-558. PubMed PMID: 36460463