Jennifer Armstrong, MD, MPH/MSPH

Professional Titles

• Medical Director for Inpatient Services, Child Neurology
• Justice, Equity, Diversity, and Inclusion (JEDI) Program Director, Child Neurology
• Program Director, Perinatal Stroke and Neonatal Neurology Clinics
• Colorado Multiple Institution Review Board (COMIRB) Chair

Recognitions

• Best Doctors in the US - Neonatal Neurology, Best Doctors (2015)
  2015-present
• University of Colorado President's Diversity Award Nominee, CU (2019)
• Woman of the Year, Alpha Chi Omega National Sorority (2016)
• Fellow of the American Heart Association, American Heart Association/American Stroke Association (2013)

Research Interests

Publications

• Kedia S, Stence N, Manco-Johnson M, Armstrong-Wells J, Bernard TJ. Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke?. Headache. 2012 Apr;52(4):674-8. PubMed PMID: 22404149
• Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260102
• Bernard TJ, Armstrong-Wells J, Goldenberg NA. The Institution-Based Prospective Inception Cohort Study: Design, Implementation, and Quality Assurance in Pediatric Thrombosis and Stroke Research. Semin Thromb Hemost. 2012 Dec 26. [Epub ahead of print] PubMed PMID: 23269572
• Bernard TJ, Manco-Johnson MJ, Lo W, MacKay MT, Ganesan V, DeVeber G, Goldenberg NA, Armstrong-Wells J, Dowling MM, Roach ES, Tripputi M, Fullerton HJ, Furie KL, Benseler SM, Jordan LC, Kirton A, Ichord R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke. 2012 Feb;43(2):371-7. PubMed PMID: 22156694
• Saver JL, Warach S, Janis S, Odenkirchen J, Becker K, Benavente O, Broderick J, Dromerick AW, Duncan P, Elkind MS, Johnston K, Kidwell CS, Meschia JF, Schwamm L, National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element Working Group. Standardizing the structure of stroke clinical and epidemiologic research data: the National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element (CDE) project. Stroke. 2012 Apr;43(4):967-73. PubMed PMID: 22308239
• Joachim E, Goldenberg NA, Bernard TJ, Armstrong-Wells J, Stabler S, Manco-Johnson MJ. The methylenetetrahydrofolate reductase polymorphism (MTHFR c.677C>T) and elevated plasma homocysteine levels in a U.S. pediatric population with incident thromboembolism. Thromb Res. 2013 Aug;132(2):170-4. PubMed PMID: 23866722
• Armstrong-Wells J, Post MD, Donnelly M, Manco-Johnson MJ, Fisher BM, Winn VD. Patterns of placental pathology in preterm premature rupture of membranes. J Dev Orig Health Dis. 2013 Jun;4(3):249-255. PubMed PMID: 23828732
• Goldenberg NA, Bernard TJ, Hillhouse J, Armstrong-Wells J, Galinkin J, Knapp-Clevenger R, Jacobson L, Marcovina SM, Manco-Johnson MJ. Elevated lipoprotein (a), small apolipoprotein (a), and the risk of arterial ischemic stroke in North American children. Haematologica. 2013 May;98(5):802-7. PubMed PMID: 23349301
• Bernard TJ, Armstrong-Wells J, Goldenberg NA. The institution-based prospective inception cohort study: design, implementation, and quality assurance in pediatric thrombosis and stroke research. Semin Thromb Hemost. 2013 Feb;39(1):10-4. PubMed PMID: 23269572
• Armstrong-Wells J, Ferriero DM. Diagnosis and acute management of perinatal arterial ischemic stroke. Neurol Clin Pract. 2014 Oct;4(5):378-385. PubMed PMID: 25317375
• Armstrong-Wells J, Donnelly M, Post MD, Manco-Johnson MJ, Winn VD, Sébire G. Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. Am J Obstet Gynecol. 2014 Sep 16. [Epub ahead of print] PubMed PMID: 25223243
• Sabry A, Hauk PJ, Jing H, Su HC, Stence NV, Mirsky DM, Nagel MA, Abbott JK, Dragone LL, Armstrong-Wells J, Curtis DJ, Cohrs R, Schmid DS, Gilden D, Gelfand EW. Vaccine strain varicella-zoster virus-induced central nervous system vasculopathy as the presenting feature of DOCK8 deficiency. J Allergy Clin Immunol. 2014 Apr;133(4):1225-7. PubMed PMID: 24418481
• Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-dimer, and risk of poor neurologic outcome in childhood-onset arterial ischemic stroke. J Pediatr. 2013 May;162(5):1041-6.e1. PubMed PMID: 23260102
• Stence NV, Mirsky DM, Deoni SC, Armstrong-Wells J. Paradoxical centrally increased diffusivity in perinatal arterial ischemic stroke. Pediatr Radiol. 2015 Aug 4. [Epub ahead of print] PubMed PMID: 26238967
• Stence NV, Mirsky DM, Deoni SC, Armstrong-Wells J. Paradoxical centrally increased diffusivity in perinatal arterial ischemic stroke. Pediatr Radiol. 2016 Jan;46(1):82-6. PubMed PMID: 26238967
• Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016 Oct;47(10):2443-9. PubMed PMID: 27633024
• Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016 Oct;47(10):2443-9. PubMed PMID: 27633024
• Stence NV, Mirsky DM, Deoni SC, Armstrong-Wells J. Paradoxical centrally increased diffusivity in perinatal arterial ischemic stroke. Pediatr Radiol. 2016 Jan;46(1):82-6. PubMed PMID: 26238967
• Fox CK, Mackay MT, Dowling MM, Pergami P, Titomanlio L, Deveber G. Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk. Dev Med Child Neurol. 2017 Jan;59(1):38-44. PubMed PMID: 27422813
• Howell K, Armstrong J. Vascular Endothelial Growth Factor (VEGF) in Neurodevelopmental Disorders. Curr Behv Neurosci Rep doi:10.1007/S40473-017-0130-9 [Epub ahead of print]
• Fox CK, Jordan LC, Beslow LA, Armstrong J, Mackay MT, deVeber G. Children with post-stroke epilepsy have poorer outcomes one year after stroke. Int J Stroke. 2018 Oct;13(8):820-823. PubMed PMID: 29956597
• Fox CK, Mackay MT, Dowling MM, Pergami P, Titomanlio L, Deveber G. Prolonged or recurrent acute seizures after pediatric arterial ischemic stroke are associated with increasing epilepsy risk. Dev Med Child Neurol. 2016 Jul 16. [Epub ahead of print] PubMed PMID: 27422813
• Ryan J. Felling, MD, PhD*, Sahar M.A. Hassanein, MD, PhD*, Jennifer Armstrong, MD, Luis Aversa, MD, Lori Billinghurst, MD, Neil A. Goldenberg, MD, PhD, Jo Ellen Lee, CPNP, Emily C. Maxwell, PhD, Michael J. Noetzel, MD, and Warren Lo, MD, on behalf of the International Pediatric Stroke Study Group.Neurology: Clinical Practice September 12, 2019, DOI: https://doi.org/10.1212/CPJ.0000000000000720
• Cain DW, Dingman AL, Armstrong J, Stence NV, Jensen AM, Mirsky DM. Subpial Hemorrhage of the Neonate. Stroke. 2020 Jan;51(1):315-318. PubMed PMID: 31694507
• Felling RJ, Hassanein SMA, Armstrong J, Aversa L, Billinghurst L, Goldenberg NA, Lee JE, Maxwell EC, Noetzel MJ, Lo W. Treatment and outcome of childhood cerebral sinovenous thrombosis. Neurol Clin Pract. 2020 Jun;10(3):232-244. PubMed PMID: 32642325
• Salehi Omran S, Parikh NS, Poisson S, Armstrong J, Merkler AE, Prabhu M, Navi BB, Riley LE, Fink ME, Kamel H. Association between Pregnancy and Cervical Artery Dissection. Ann Neurol. 2020 Jun 11. [Epub ahead of print] PubMed PMID: 32525238
• Smith N, Warren BB, Smith J, Jacobson L, Armstrong J, Kim J, Di Paola J, Manco-Johnson M. Antithrombin deficiency: A pediatric disorder. Thromb Res. 2021 Jun;202:45-51. PubMed PMID: 33725558
• Giamberardino W, Winn VD, Armstrong J. Risk Factors for Clinically Significant Intraventricular Hemorrhage in Pregnancies Complicated by Preterm Premature Rupture of Membranes. J Preg Neo Med, 2021
• Penn AA, Wintermark P, Chalak LF, Armstrong J, Redline R, Scher MS, Nelson KB on behalf of the Newborn Brain Society Guidelines and Publications Committee. Placental Contributions to Neonatal Encephalopathy. SFNM. 2021
• CU-Anschutz/Denver COMIRB Guidance on Research in Pregnant Women
• CU-Anschutz/Denver COMIRB Guidance on Placental/Fetal/Neonatal Research
• Armstrong J, Lakin A, Blumberg-Romero L, Campbell T, Heldens J, Lieu C, Neiman J, Sandene E, Steinbeiss M, Thompson D, Tregellas J, Flaig T, Higgins J. Clinical Research Reactivation During the COVID-19 Pandemic: An Academic Center Process and Lessons for the Future. J Trans Sci, 2022 8:1-8, DOI: 10.15761/JTS.1000468
• What That Temporary Pause in J&J Vaccine Means for Neurology , Neurology Today, May 6, 2021
• Sotiros A, Thornhill D, Post MD, Winn VD, Armstrong J. Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers. PLoS One. 2021;16(11):e0260094. PubMed PMID: 34780565
• Flume PA, Berbari EF, Viera L, Hess R, Higgins J, Armstrong J, Rice L, True L, Shaker R, Buse JB, Panettieri RA Jr. Managing the risks and benefits of clinical research in response to a pandemic. J Clin Transl Sci. 2021;5(1):e105. PubMed PMID: 35757679
• Paulson L, Thornhill D, Armstrong J. Clinic Follow up and Neurological Disability in Children Following Pregnancies Complicated by Preterm Rupture of Membranes and Preeclampsia. J Child Dev Disord. 2021;7(5). PubMed PMID: 35782107
• Hoffman JE, Ryan M, Wittenberg B, Armstrong J, Greenan K, Wilkinson C. Successful treatment of hemorrhagic brainstem cavernous malformation with hematoma evacuation and postoperative propranolol. Childs Nerv Syst. 2020 Sep;36(9):2109-2112. PubMed PMID: 32303833
• Sotiros A, Thornhill D, Post MD, Winn VD, Armstrong J. Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers. PLoS One. 2021;16(11):e0260094. PubMed PMID: 34780565
• Flume PA, Berbari EF, Viera L, Hess R, Higgins J, Armstrong J, Rice L, True L, Shaker R, Buse JB, Panettieri RA Jr. Managing the risks and benefits of clinical research in response to a pandemic. J Clin Transl Sci. 2021;5(1):e105. PubMed PMID: 35757679
• Smith N, Warren BB, Smith J, Jacobson L, Armstrong J, Kim J, Di Paola J, Manco-Johnson M. Antithrombin deficiency: A pediatric disorder. Thromb Res. 2021 Jun;202:45-51. PubMed PMID: 33725558
• Paulson L, Thornhill D, Armstrong J. Clinic Follow up and Neurological Disability in Children Following Pregnancies Complicated by Preterm Rupture of Membranes and Preeclampsia. J Child Dev Disord. 2021;7(5). PubMed PMID: 35782107
• Armstrong J, Lakin A, Blumberg-Romero L, Campbell T, Heldens J, Lieu C, Neiman J, Sandene E, Steinbeiss M, Thompson D, Tregellas J, Flaig T, Higgins J. Clinical research reactivation during the COVID-19 pandemic: An academic center process and lessons for the future. J Transl Sci. 2022 Feb;8(1). PubMed PMID: 37122588
• Armstrong J, Lakin A, Blumberg-Romero L, Campbell T, Heldens J, Lieu C, Neiman J, Sandene E, Steinbeiss M, Thompson D, Tregellas J, Flaig T, Higgins J. Clinical Research Reactivation During the COVID-19 Pandemic: An Academic Center Process and Lessons for the Future. J Trans Sci, 2022 8:1-8, DOI: 10.15761/JTS.1000468
• Giamberardino W, Winn VD, Armstrong J. Risk Factors for Clinically Significant Intraventricular Hemorrhage in Pregnancies Complicated by Preterm Premature Rupture of Membranes. J Preg Neo Med, 2021 5:4. PMCID PMC9224317
• Penn AA, Wintermark P, Chalak LF, Armstrong J, Redline R, Scher MS, Nelson KB on behalf of the Newborn Brain Society Guidelines and Publications Committee. Placental Contributions to Neonatal Encephalopathy. Semin Fetal Neonatal Med. 2021 Aug;26(4):101276. PMID 34420894, DOI: 10.1016/j/siny.2021.101276
• Wu Y, Sun T, Medina P, Narasimhan P, Stevenson DK, Von Versen-Höynck F, Armstrong J, Wu JC, Sayed N, Winn VD. A Novel Stem Cell Model to Study Preeclampsia Endothelial Dysfunction. Reprod Sci. 2024 Oct;31(10):2993-3003. PubMed PMID: 39179924

Professional Memberships

• American Academy of Neurology, Member
• American Academy of Neurology - Stroke Section, Member
• Child Neurology Society, Member
• American Heart Association/American Stroke Association, Member
• International Pediatric Stroke Study (IPSS), Member

Practice Locations

• Children's Hospital Colorado
• University of Colorado Hospital

• Hemophilia and Thrombosis Center

Specialty Information

• Child Neurology, Board Certification (2008)

• Brain and Nervous System - Cerebral Palsy
• Brain and Nervous System - Neurovascular Conditions
• Brain and Nervous System - Stroke
• Blood / Lymphatic System - Clotting Disorders
• Blood / Lymphatic System
• Brain and Nervous System