James Maloney, MD

Professional Titles

• Medical Director, UCH Pulmonary Ward
• Elected Member, UCH Medical Board

Research Interests

Pulmonary Hypertension High Altitude Medicine Pulmonary Embolism

Publications

• Am J Respir Cell Mol Biol. 2006;34(4):487-95.
• Am J Respir Crit Care Med. 2006; [Epub ahead of print]
• Clinics in Chest Medicine: The Lung in Extreme Environments, 2005; 26(3): 395-404.
• ATS abstract; VEGF SNP in AMS
• Pulmonary Hypertension and Interstitial Lung Disease; accepted, Treatments in Respiratory Medicine.
• Am J Respir Crit Care Med. 2005;171(4):361-70.
• LK Boshkov, JP Maloney, Z Mehdizadehkhashi, S Bieber CC Silliman.Two cases of transfusion-related acute lung injury caused by one unit of apheresis platelets, Submitted, Transfusion.
• L Gao, A Grant, N Rafaels, P Chi, P Gao, M Muñoz, M Stockton-Porter, H Watson, N Hansel, G Dunston, A Togias, RA Mathias, R Brower, J Sevransky, JP Maloney, M Moss, C Shanholtz, JGN Garcia, TH Beaty, and KC Barnes. Variants in the myosin light chain kinase (MYLK) gene that confer risk of severe sepsis are associated with a lower risk of asthma. In Press, Journal of Allergy and Clinical Immunology
• Macrophage Migration Inhibitory Factor in Acute Lung Injury: Expression, Biomarker and Associations. Li Gao, Carlos Flores, Shwu-Fan Ma, Edmund J. Miller, Jaideep Moitra, Liliana Moreno, Raj Wadgaonkar, Brett Simon, Bryan McVerry, Roy Brower, Jonathan Sevransky, Rubin M. Tuder, James P. Maloney, Marc Moss, Carl Shanholtz, C. Ryan Yates, Gianfranco Umberto Meduri, Shui Q. Ye, Kathleen C. Barnes and Joe G.N. Garcia.Journal of Translational Research 2006.
• Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med. 2006 Jun 15;173(12):1335-41. PMID: 16528020
• Submitted 2007, Am Jnl Resp Crit Care Med.
• Macrophage Migration Inhibitory Factor in Acute Lung Injury: Expression, Biomarker and Associations. Li Gao, Carlos Flores, Shwu-Fan Ma, Edmund J. Miller, Jaideep Moitra, Liliana Moreno, Raj Wadgaonkar, Brett Simon, Bryan McVerry, Roy Brower, Jonathan Sevransky, Rubin M. Tuder, James P. Maloney, Marc Moss, Carl Shanholtz, C. Ryan Yates, Gianfranco Umberto Meduri, Shui Q. Ye, Kathleen C. Barnes and Joe G.N. Garcia. Translational Research 2007; 150(1):18–29
• L Gao, A Grant, N Rafaels, P Chi, P Gao, M Muñoz, M Stockton-Porter, H Watson, N Hansel, G Dunston, A Togias, RA Mathias, R Brower, J Sevransky, JP Maloney, M Moss, C Shanholtz, JGN Garcia, TH Beaty, and KC Barnes. Variants in the myosin light chain kinase (MYLK) gene that confer risk of severe sepsis are associated with a lower risk of asthma. J Allergy Clin Immunol 2007;119: 1111-8
• Arcaroli J, Sankoff J, Liu N, Allison DB, Maloney J, Abraham E. Association between Urokinase Haplotypes and Outcome from Infection-Associated Acute Lung Injury. Intensive Care Med. 2008; 34(2):2046-52.
• Boé DM, Schwarz MI, Groshong SD, Maloney JP.A 64-year-old woman with a history of rheumatoid arthritis and new cavitary lung lesions. Chest. 2007;132(6):2046-52
• TLR polymorphisms are a key modulator of variability in human innate immune responses and confer increased mortality in sepsis. Wufel, MM, Gordon AC, Holden TD, Maloney JP, et al. Submitted, J Exp Med 2008
• Polymorphism in the Acute Lung Candidate Gene Pre-B- cell Colony Enhancing Factor are associated with human neutrophil responses. JB Stansberry, J Nick, K Poch, E Abraham, M tripp-Addison. D Calabrese, and JP Maloney. Accepted ATS Meeting, Toronto, May 2008
• Polymorphism in the Acute Lung Candidate Gene Pre-B- cell Colony Enhancing Factor are associated with human neutrophil responses. JB Stansberry, J Nick, K Poch, E Abraham, M tripp-Addison. D Calabrese, and JP Maloney. Jnl Investig Med 2008; 56(1):a142
• Simonneau G, Rubin LJ, Galiè N, Barst RJ, Fleming TR, Frost AE, Engel PJ, Kramer MR, Burgess G, Collings L, Cossons N, Sitbon O, Badesch DB; PACES Study Group. Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann Intern Med. 2008;149(8):521-30.
• JP Maloney. Genetic Factors Impacting Therapy in Acute Lung Injury/ARDS. Jrnl Investig Med. 2009; Sep 16, EPub ahead of print; PMID: 18827716
• TLR1 polymorphisms confer higher innate immune responses and susceptibility to death in sepsis. Wurfel, MM, Gordon AC, Holden TD, Maloney JP, et al. Am Jnl Resp Crit Care Med 2008;178(7):710-20.
• Maloney JP. Genetic factors impacting therapy in acute lung injury/acute respiratory distress syndrome. J Investig Med. 2009 Dec;57(8):865-9.
• Hodgin KE, Maloney JP.Risk of major adverse cardiovascular events with inhaled anticholinergics in patients with chronic obstructive pulmonary disease. JAMA 2009 Mar 25;301(12):1224
• Thrombospondin-1 Mutations in Familial PAH; revision submitted to Journal of Clinical Investigation 3/'11
• James P. Maloney, TM Bull, DW Calabrese, ML Tripp-Addison, MJ Wick, A Chuckran, R Stearman, U Broeckel, IM Robbins, LA Wheeler, JD Cogan, and JE Loyd.Loss of Function Thrombospondin-1 Mutations in Familial Pulmonary Hypertension. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2012. PMID 22198906
• SeungHye Han, Greg S Martin, James P Maloney, Carl Shanholtz, Kathleen C Barnes, Stacey Murray and Jonathan E Sevransky. Short women with severe sepsis-related acute lung injury receive lung protective ventilation less frequently: an observational cohort study. In Press, Critical Care, 2012; PMID 22044724
• Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H; for the Trauma ALI SNP Consortium (TASC) investigators. Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma. PLoS ONE 2012; 7(1): e28268
• James P. Maloney, Robert S. Stearman, Todd M. Bull, David W. Calabrese,Megan L. Tripp-Addison, Marilee J. Wick, Ulrich Broeckel, Ivan M. Robbins, Lisa A. Wheeler, Joy D. Cogan, and James E. Loyd Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 302: L541–L554, 2012.
• Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, Maloney JP, Hakonarson H; for the Trauma ALI SNP Consortium (TASC) investigators. Genome Wide Association Identifies PPFIA1 as a Candidate Gene for Acute Lung Injury Risk Following Major Trauma. PLoS ONE 2012; 7(1): e28268
• J.P. Maloney, D. R. Ambruso, N. F. Voelkel, and C. C. Silliman. Platelet VEGF is a Potential Mediator of Transfusion-related Acute Lung Injury. Pulmonary & Respiratory Medicine, 2014; 4(6): 1-7.
• National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5;370(23):2191-2000.
• National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Fluid Management With a Simplified Conservative Protocol for the Acute Respiratory Distress Syndrome*. Crit Care Med. 2015 Feb; 43(2):288-295.
• Maloney JP, Gao L. Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells. Mediators Inflamm. 2015;2015:387842. PubMed PMID: 26424968
• Maloney JP, Narasimhan J, Biller J. Decreased TGF-ß1 and VEGF Release in Cystic Fibrosis Platelets: Further Evidence for Platelet Defects in Cystic Fibrosis. Lung. 2016 Oct;194(5):791-8. PubMed PMID: 27423781
• James P. Maloney, Brian R. Branchford Gary L. Brodsky, Maxwell S. Cosmic, David W. Calabrese, Christina L. Aquilante, Kelly W. Maloney, Joseph R. Gonzalez, Weiming Zhang, Kerrie L Moreau, Kerri L. Wiggins, Nicholas L. Smith, Ulrich Broeckel, and Jorge Di Paola. The ENTPD1 Promoter Polymorphism -860 A>G (rs3814159) is Associated with Increased Gene Transcription, Protein Expression, CD39/NTPDase1 Enzymatic Activity, and Thromboembolism Risk. FASEB Journal, 2017, 31: 2771–2784,. DOI 10.1096
• Rahul Kumar, Claudia Mickael, Biruk Kassa, Liya Gebreab, Jeffery Robinson, Daniel Koyanagi, Linda Sanders, Lea Barthel, Christina Meadows, Daniel Fox, David Irwin, Min Li, B. Mckeown, Suzette R. Riddle, R. Dale Brown, Leslie Morgan, Christopher Evans, Daniel Hernandez-Saavedra, Angela Bandeira, James Maloney, Todd Bull, William Janssen, Kurt Stenmark, Rubin Tuder, and Brian Graham. TGF-ß Activation by Thrombospondin-1 Causes Schistosoma- and Hypoxia-Induced Pulmonary Hypertension. Nature Communications 2017, 8: 15494. Doi 10.1038/ncomms15494.
• Maloney JP. Putting Some Skin in the Game: Dermis-derived Stem Cells Provide Insight into Familial Pulmonary Hypertension. Stem Cell Investigation Stem Cell Investig 2017; 4:35-36 doi: 10.21037/sci.2017.04.05
• Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. Interstitial Macrophage-Derived Thrombospondin-1 Contributes to Hypoxia-Induced Pulmonary Hypertension. Cardiovasc Res. 2019 Nov 9. [Epub ahead of print] PubMed PMID: 31710666
• Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan;146:110394. PubMed PMID: 33239231
• Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension. Cardiovasc Res. 2020 Oct 1;116(12):2021-2030. PubMed PMID: 31710666
• Histopathological correlation of acute on chronic eosinophilic pneumonitis caused by vaporized cannabis oil inhalation
• Lee MH, Cool CD, Maloney JP. Histopathological Correlation of Acute on Chronic Eosinophilic Pneumonitis Caused by Vaporized Cannabis Oil Inhalation. Chest. 2021 Mar;159(3):e137-e139. PubMed PMID: 33678280
• Bai X, Hippensteel J, Leavitt A, Maloney JP, Beckham D, Garcia C, Li Q, Freed BM, Ordway D, Sandhaus RA, Chan ED. Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19. Med Hypotheses. 2021 Jan;146:110394. PubMed PMID: 33239231
• Zagona-Prizio C, Pascoe MA, Corbisiero MF, Simon VC, Mann SE, Mayer KA, Maloney JP. Cadaveric emergency cricothyrotomy training for non-surgeons using a bronchoscopy-enhanced curriculum. PLoS One. 2023;18(3):e0282403. PubMed PMID: 36952528
• Vargas Barahona L, Molina KC, Pedraza-Arévalo LC, Sillau S, Tagawa A, Scherger S, Chastain DB, Shapiro L, Tuells J, Franco-Paredes C, Hawkins KL, Maloney JP, Thompson GR 3rd, Henao-Martínez AF. Previous corticosteroid exposure associates with an increased Pneumocystis jirovecii pneumonia mortality among HIV-negative patients: a global research network with a follow-up multicenter case-control study. Ther Adv Infect Dis. 2023 Jan-Dec;10:20499361231159481. PubMed PMID: 36938147
• Arguinchona LM, Zagona-Prizio C, Joyce ME, Chan ED, Maloney JP. Microvascular significance of TGF-ß axis activation in COVID-19. Front Cardiovasc Med. 2022;9:1054690. PubMed PMID: 36684608
• Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells. Front Immunol. 2022;13:988125. PubMed PMID: 36131937
• Castleman MJ, Stumpf MM, Therrien NR, Smith MJ, Lesteberg KE, Palmer BE, Maloney JP, Janssen WJ, Mould KJ, Beckham JD, Pelanda R, Torres RM. SARS-CoV-2 infection relaxes peripheral B cell tolerance. J Exp Med. 2022 Jun 6;219(6). PubMed PMID: 35420627
• Rhoads, S., Maloney, J., Mantha, A. et al. Pneumocystis jirovecii Pneumonia in HIV-Negative, Non-transplant Patients: Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention. Curr Fungal Infect Rep (2024). https://doi.org/10.1007/s12281-024-00482-8

Professional Memberships

• American Thoracic Society, Member
• American College of Chest Physicians, Fellow

Practice Locations

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Denver Veterans Affairs Medical Center
1055 Clermont St
Denver, CO 80220
1-888-336-8262

UCHealth Pulmonary Vascular Disease Clinic
(PH, PE/CTEPH, HHT, High Altitude) 
12505 E. 16th Ave, 3rd Floor, Inpatient Pavilion 2
Aurora, CO 80045
720-848-5300

Hospital Affiliation

• University of Colorado Hospital

Specialty Information

Specialties

• Pulmonary Disease and Critical Care Medicine, Board Certification (1994)
• Pulmonary Disease, Board Certification (1991)
• Critical Care Medicine, Board Certification (1995)

Conditions & Treatments

• Critical Care
• Lungs and Breathing - Lung Disease
• Lungs and Breathing - Pulmonary Embolism
• Lungs and Breathing
• Lungs and Breathing - Chronic Thromboembolic Pulmonary Hypertension (CTEPH)