Philippa Marrack, PhD

Publications

• Stadinski, B., Delong, T., Reisdorph, N., Reisdorph, R., Powell, R., Armstrong, M., Piganelli, J., Barbour, G., Bradley, B., Marrrack, P., Mahata, S.K., Kappler, J. and Haskins, K. Chromogranin A is a Major T Cell Autoantigen in Type 1 Diabetes. Nat. Immunol. 11: 225-231, 2010
• McKee, A.S., MacLeod, M.K.L., Kappler, J.W. and Marrack, P. Immune mechanisms of protection: can adjuvants rise to the challenge? J. Biol. 8:37, 2010. PMC2864095.
• Dai, S., Murphy, G.A., Crawford, F., Mack, D.G., Falta, M.T., Marrack, P., Kappler, J.W. and Fontenot, A.P. Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc. Natl. Acad. Sci. 107:7425-7430, 2010. PMC2867715
• MacLeod, M.K., Kappler, J.W. and Marrack, P. Memory CD4 T cells: generation, reactivation and reassignment. Immunology 130:10-15, 2010. PMC2855788.
• Rubtsov, A.V., Rubtsova, K, Kappler, J.W. and Marrack, P. Genetic and hormonal factors in female-biased immunity. Autoimmun. Rev. 9:494-498, 2010. PMC in process
• Stadinski, B.D., Zhang, L., Crawford, F., Marrack, P., Eisenbarth, G.S. and Kappler, J. W., Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc. Natl. Acad. Sci. USA 107: 10978-10983, 2010. PMC 2890771.
• Munks, M.W., McKee, A.S., MacLeod, M.K.., Powell, R., Brinkmann, V., Zychlisky, A., Degen, J.L., Reisdorph, N.A., Kappler, J.W. and Marrack, P. Aluminum Adjuvants Elicit Fibrin-Dependent Extracellular Traps in vivo. Blood 116:5191-5199, 2010. PMC in process
• Marrack, P., Scott-Browne, J. and MacLeod, M.K. Terminating the immune response. Immunol. Rev. 236:5-10, 2010.
• Mallevaey, T., Clarke, A.J., Scott-Brown, J., Young, M.H., Pellicci, D.G., Onisha Patel, O., Matsuda, J.L., McCluskey, J., Godfrey, D.I., Marrack, P., Rossjohn, J. and Gapin, L. The molecular basis of NKT cell autoreactivity and recognition of self-CD1d. Immunity 34:315-326, 2011.
• MacLeod, M.K.L., McKee, A.S., David, A., Wang, J., Mason, R.J., Kappler, J.W. and Marrack, P. Vaccine adjuvants Aluminum and Monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proc. Natl. Acad. Sci. USA 108:7914-7919, 2011. PMC 3093483.
• Rubtsov, A.V., Rubtsova, K., Fischer, A., Meehan, R.T., Gillis, J.,Z., Kappler, J.W. and Marrack, P. Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B cell population is important for the development of autoimmunity. Blood 118:1305-1315, 2011. PMC in process.
• Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S and Kappler J.W. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers. Immunity. 35:23-33, 2011. PMC in process.
• Crawford F, Stadinski B, Jin N, Michels A, Nakayama M, Pratt P, Marrack P, Eisenbarth G, Kappler JW. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci U S A. 108:16729-34, 2011. PMC3189014.
• Scott-Browne, J. P., Crawford, F., Young, M.H., Kappler, J.W., Marrack, P*. and Gapin, L.* Evolutionarily conserved features of the ?? T cell receptor contribute to its MHC specificity. Immunity 35:526-535, 2011. PMC in process. * These authors contributed equally to the work.
• Rubtsova K, Marrack P, Rubtsov AV. Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women? Expert Rev. Clin. Immunol. 8:5-7, 2012. Free article PMC in process
• Bedel R, Matsuda J, Brigl M, White J, Kappler J, Marrack P and Gapin L. The structure of the TRAJ18 locus in TRAJ18 deficient mice leads to an unexpectedly severe reduction in the T cell receptor repertoire diversity. Nature Immunol. 13:705-6, 2012.
• Marrack, P. and Kappler, JW. Do MHCII presented neo-antigens drive type-1 diabetes and other autoimmune diseases? Cold Spring Harbor Prospectives in Biology Diabetes CSH Laboratory Press Bluestone J., Editor. In press 2012.
• Rubtsov AV, Rubtsova KV, Kappler JW and Marrack P. TLR7 drives accumulation of ABCs and autoantibody production in autoimmune prone mice. Immunol. Res. 55:210-216, 2013.
• Garcia, KC, Gapin, L, Adams, J, Birnbaum, M, Scott-Browne, J, Kappler, J and Marrack, P. A closer look at TCR germline recognition. Immunity 36:887-888, 2012.
• Yin, L., Dai, S., Clayton, G., Gao, W., Wang, Y., Kappler, J. and Marrack, P. Recognition of self and altered self by T cells in autoimmunity and allergy. Protein and Cell 4:8-16, 2013
• Yin, L., Crawford, F., Marrack, P., Kappler, J. and Dai, S. T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. Proc. Natl. Acad. Sci, USA 109:18517-18522, 2012
• Collins BC, Clambey ET, Scott-Browne J, Marrack P, Hagman J and Kappler JW. Ikaros promotes secondary rearrangement of T cell receptor alpha genes. Eur. J. Immunol. 43:521-32, 2013
• Young MH, U’Ren L, Huang S, Mallevaey T, Scott-Browne J, Crawford F, Lantz O, Hansen TH, Kappler J, Marrack, P and Gapin, L. MAIT cell recognition of MR1 on bacterially infected and uninfected cells. PLoS One 8:e53789, 2013 PMC3544856
• Sosinowski T, Haluszczak C,,White JT, Cross E, Marrack P, Gapin L and Kedl RM. CD8a+ DC trans-presentation of IL-15 to naïve CD8+ T cells produces antigen inexperienced T cells in the periphery with memory phenotype and function. J. Immunol. 190: 1936-47, 2013
• Amy S. McKee1, Matthew A. Burchill2,3, Michael W. Munks2,3, Lei Jin3, John Kappler2,3,4, Rachel S. Friedman3, Jordan Jacobelli3, and Philippa Marrack2,3,5 Host DNA released in response to aluminum adjuvant prolongs CD4 T cell interactions with dendritic cells. Proc. Natl. Acad. Sci, USA 110:E1122-31, 2013
• Clambey ET, Collins B, Young MH, Eberlein J, David A, Kappler JW, Marrack P. "The Ikaros Transcription Factor Regulates Responsiveness to IL-12 and Expression of IL-2 Receptor Alpha in Mature, Activated CD8 T Cells." PLoS One. 2013: 8: e57435, 2013
• Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell. 2014 Jul 3;158(1):132-42. PubMed PMID: 24995984
• Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8553-8. PubMed PMID: 24912188
• Clambey ET, Davenport B, Kappler JW, Marrack P, Homann D. Molecules in medicine mini review: the aß T cell receptor. J Mol Med (Berl). 2014 Jul;92(7):735-41. PubMed PMID: 24848996
• David A, Crawford F, Garside P, Kappler JW, Marrack P, MacLeod M. Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7735-40. PubMed PMID: 24821788
• David A, Trigunaite A, Macleod MK, Johnson AC, Marrack P, Jørgensen TN. Intrinsic autoimmune capacities of hematopoietic cells from female New Zealand hybrid mice. Genes Immun. 2014 Apr-May;15(3):153-61. PubMed PMID: 24477163
• Bedel R, Berry R, Mallevaey T, Matsuda JL, Zhang J, Godfrey DI, Rossjohn J, Kappler JW, Marrack P, Gapin L. Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E119-28. PubMed PMID: 24344267
• Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3216-24. PubMed PMID: 23922396
• Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP. Identification of beryllium-dependent peptides recognized by CD4 T cells in chronic beryllium disease. J Exp Med. 2013 Jul 1;210(7):1403-18. PubMed PMID: 23797096
• Macleod MK, David A, Jin N, Noges L, Wang J, Kappler JW, Marrack P. Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence. PLoS One. 2013;8(4):e61775. PubMed PMID: 23613928