Virginia Sarapura, MD

Professor, Medicine-Endocrinology/Metabolism/Diabetes


FacultyPhoto
Medical School
  • MD, University of Buenos Aires (1981)
Residency
  • Tulane University Program, Internal Medicine (1986)
Fellowships
  • University of Colorado (University Hospital) Program, Endocrinology, Diabetes and Metabolism (1990)
Languages
English, Spanish
Department
Medicine-Endocrinology/Metabolism/Diabetes

Professional Titles

  • Professor of Medicine

Research Interests

My research interests have involved the molecular basis of pituitary gene expression and regulation, primarily thyroid stimulating hormone (TSH), and more recently, the mechanisms underlying thyroid autoimmunity, focusing on the genetic and immunological development of disease.

Publications

  • Sarapura VD, Wood WM, Woodmansee WW, Haakinson DJ, Dowding JM, Gordon DF, and Ridgway EC. Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. Pituitary 2006, in press.
  • Kerr JM, Gordon DF, Woodmanse WW, Sarapura VD, Ridgway EC and Wood WM. Growth arrest of thyrotropic tumors by thyroid hormone is correlated with novel changes in Wnt-10A. Mol. Cell. Endocrinol., 238:57-67,2005.
  • Sarapura VD, Wood WM, Woodmansee WW, Haakinson DJ, Dowding JM, Gordon DF, and Ridgway EC. Pituitary tumors arising from glycoprotein hormone alpha-subunit-deficient mice contain transcription factors and receptors present in thyrotropes. Pituitary 9:11-18, 2006
  • Sarapura VD. Prolactin-secreting pituitary tumors. In: McDermott MT (ed), Endocrinology secrets, p.102-105, Hanley and Belfus / Mosby, Philadelphia, PA, 1994 (1st edition), 1997 (2nd edition, revised) 2001 (3rd edition, revised), 2005 (4th edition, extensively revised), and 2008 (5th edition, revised)
  • Sarapura VD. Prolactin-secreting pituitary tumors. In: McDermott MT (ed), Endocrinology secrets, p.102-105, Hanley and Belfus / Mosby, Philadelphia, PA, 2005 (4th edition, extensively revised), and 2009 (5th edition, revised)
  • David F. Gordon, Virginia D. Sarapura, Mary H. Samuels and E. Chester Ridgway. Thyroid-stimulating Hormone Physiology and Secretion. In: DeGroot & Jameson (ed.), Endocrinology, Chapter 73, Elsevier, Amsterdam, The Netherlands, 2009 (6th edition)
  • Sarapura VD, Gordon DF and Samuels MH. Thyroid stimulating hormone. Chapter 6, in: Melmed S (ed), The Pituitary, Blackwell Scientific Publications, Oxford, UK, 2010 (3rd edition, extensively revised)
  • Gordon DF, Sarapura VD, Samuels MH and Ridgway EC. Thyroid-stimulating Hormone Physiology and Secretion. Chapter 73, in: Jameson JL and De Groot LJ (eds.), Endocrinology Adult and Pediatric, Elsevier, Amsterdam, The Netherlands, 2010 (6th edition)
  • Sarapura VD. Prolactin-secreting pituitary tumors. In: McDermott MT (ed), Endocrinology secrets, p.102-105, Hanley and Belfus / Mosby, Philadelphia, PA, 2013 (6th edition, revised)
  • Book title & edition number : The Pituitary Editor : Shlomo Melmed Authors : Shira Berman, Drouin, Ben-Shlomo, Majzoub, Soto-Rivera, Bonert, Binart, Sarapura, Samuels, Kaiser, Bichet, Giustina, Mortini, Spina, Frara, Carmichael, Fleseriu, Bronstein, Glezer, Stalla, Sievers, Chanson, Maiter, Wass, Karavitaki, Zada, Donoho, Beckers, Daly, Syro, Rotondo, Moshkin, Kovacs, Maya, Pressman, Fahlbusch, Buchfelder, Newell-Price & Greenman ISBN : 978-0-12-804169-7 Date book posted : 07 January 2017
  • Sarapura VD. Chapter 20: Prolactin-secreting pituitary tumors. In: McDermott MT (ed), Endocrinology secrets, p.102-105, Hanley and Belfus / Mosby, Philadelphia, PA, 2013 (6th edition, revised)
  • Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2017 Dec 9. [Epub ahead of print] PubMed PMID: 29233566
  • Sarapura VD and Samuels MH. Thyroid stimulating hormone. Chapter 6, in: Melmed S (ed), The Pituitary, Elsevier, 2017 (4th edition, extensively revised)
  • Smith MJ, Rihanek M, Coleman BM, Gottlieb PA, Sarapura VD, Cambier JC. Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients. J Autoimmun. 2018 May;89:82-89. PubMed PMID: 29233566
  • Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 7;4(3). [Epub ahead of print] PubMed PMID: 30728334
  • Smith MJ, Ford BR, Rihanek M, Coleman BM, Getahun A, Sarapura VD, Gottlieb PA, Cambier JC. Elevated PTEN expression maintains anergy in human B cells and reveals unexpectedly high repertoire autoreactivity. JCI Insight. 2019 Feb 7;4(3). [Epub ahead of print] PubMed PMID: 30728334
  • Stensland ZC, Coleman BM, Rihanek M, Baxter RM, Gottlieb PA, Hsieh EWY, Sarapura VD, Simmons KM, Cambier JC, Smith MJ. Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD. iScience. 2022 Jan 21;25(1):103626. PubMed PMID: 35005561

Practice Locations

UCHealth Diabetes and Endocrinology Clinic - Anschutz Medical Campus
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2650

Denver Health
777 Bannock St
Denver, CO 80204
303-436-6000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Endocrinology, Diabetes and Metabolism, Board Certification (1992)
  • Internal Medicine, Board Certification
Conditions & Treatments
  • Endocrine System (Hormones)
Clinical Interests
My clinical interests include primarily thyroid, pituitary, and metabolic bone disorders, particularly abnormal thyroid function, thyroid nodules and cancer, disorders of prolactin secretion, pituitary tumors, disorders of calcium metabolism and osteoporosis.

Care Philosophy
I strive to understand the unique circumstances surrounding my patient's endocrine disorder and propose a solution that best adapts to my patient's needs.