Derek Strassheim, PhD

Publications

• PMID: 27856430
• C/EBPß Deletion Promotes Expansion of Functionally Poor Intestinal Regulatory T Cells. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. J Crohns Colitis. 2019 Jan 9. doi: 10.1093/ecco-jcc/jjy194. [Epub ahead of print] No abstract available. PMID: 30624617 Similar articles Select item 30085016 2. C/EBPß Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells. Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF. J Crohns Colitis. 2018 Nov 28;12(12):1475-1485. doi: 10.1093/ecco-jcc/jjy105. PMID: 30085016 Similar articles
• Review Open Access Strassheim et al. Vessel Plus 2018;2:29 DOI: 10.20517/2574-1209.2018.44 Vessel Plus © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention Derek Strassheim1 , Vijaya Karoor1,2, Kurt Stenmark2,3, Alexander Verin4, Evgenia Gerasimovskaya2,3 1 Departments of Medicine, University of Colorado Denver, Aurora, CO 80045, USA. 2 Cardiovascular and Pulmonary Research laboratories, University of Colorado Denver, Aurora, CO 80045, USA. 3 Department of Pediatrics, Pulmonary and Critical Care Medicine, University of Colorado Denver, Aurora, CO 80045, USA. 4Vascular Biology Center, Augusta University, Augusta, GA 30912, USA. Correspondence to: Dr. Derek Strassheim, Departments of Medicine, University of Colorado Denver, 12700 E. 19th Avenue, Box B131, Research 2, Room 6470D, Aurora, CO 80045, USA. E-mail: derek.strassheim@ucdenver.edu How to cite this article: Strassheim D, Karoor V, Stenmark K, Verin A, Gerasimovskaya E. A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention. Vessel Plus 2018;2:29. http://dx.doi.org/10.20517/2574-1209.2018.44 Received: 8 Jun 2018 First Decision: 23 Jul 2018 Revised: 29 Aug 2018 Accepted: 30 Aug 2018 Published: 30 Sep 2018 Science Editor: Alexander D. Verin Copy Editor: Cai-Hong Wang Production Editor: Zhong-Yu Guo Abstract Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertrophy, vascular inflammation, and abnormal angiogenesis in pulmonary circulation. G protein-coupled receptors (GPCRs) are the largest family in the genome and widely expressed in cardiovascular system. They regulate all aspects of PH pathophysiology and represent therapeutic targets. We overview GPCRs function in vasoconstriction, vasodilation, vascular inflammation-driven remodeling and describe signaling cross talk between GPCR, inflammatory cytokines, and growth factors. Overall, the goal of this review is to emphasize the importance of GPCRs as critical signal transducers and targets for drug development in PH.