Brian Graham, MD

Publications

• Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Hassoun PM, Bandeira AP, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of IL-13 signaling. Am J Pathol. 2010;177(3):1549-61. PMID: 20671265
• Kolosionek E, Graham BB, Tuder RM, Butrous G. Pulmonary vascular disease associated with parasitic infection – the role of schistosomiasis. Clin Microbiol Infect. 2010 Jul 15. [Epub ahead of print]. PMID: 20636425
• Tuder RM, Davis LA, Graham BB. Targeting Energetic Metabolism: a New Frontier in the Pathogenesis and Treatment of Pulmonary Hypertension. Am J Respir Crit Care Med. epub 2011 Nov 10.
• Graham BB et al. Identificaton of parasite antigens in human schistosomiasis associated pulmonary hypertension. Pulmonary Circulation 2012 (accepted for publication)
• Tuder RM, Robinson JC, Graham BB. Fat and cardiotoxicity in hereditary pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 1;189(3):247-9. PubMed PMID: 24484329
• Modern age pathology of pulmonary arterial hypertension. Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM. Am J Respir Crit Care Med. 2012 Aug 1;186(3):261-72. doi: 10.1164/rccm.201201-0164OC. Epub 2012 Jun 7.
• Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension. Asosingh K, Farha S, Lichtin A, Graham B, George D, Aldred M, Hazen SL, Loyd J, Tuder R, Erzurum SC. Blood. 2012 Aug 9;120(6):1218-27. doi: 10.1182/blood-2012-03-419275. Epub 2012 Jun 28.
• Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB. Pathology of pulmonary hypertension. Clin Chest Med. 2013 Dec;34(4):639-50. PubMed PMID: 24267295
• Macht M, Robinson JC, Graham BB. Updated approach for the assessment of ventilator-associated pneumonia. Crit Care Med. 2013 Nov;41(11):2641-2. PubMed PMID: 24162675
• Hunt JM, Bethea B, Liu X, Gandjeva A, Mammen PP, Stacher E, Gandjeva MR, Parish E, Perez M, Smith L, Graham BB, Kuebler WM, Tuder RM. Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15;305(10):L725-36. PubMed PMID: 24039255
• Kolosionek E, King J, Rollinson D, Schermuly RT, Grimminger F, Graham BB, Morrell N, Butrous G. Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study. Pulm Circ. 2013 Apr;3(2):356-62. PubMed PMID: 24015336
• Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, Tuder RM. Transforming growth factor-ß signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation. 2013 Sep 17;128(12):1354-64. PubMed PMID: 23958565
• Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Dec;49(6):951-9. PubMed PMID: 23815102
• Dorosz JL, Fonseca BM, Kay JD, Graham BB, Salcedo EE, Quaife RA. A sinus venosus atrial septal defect is diagnosed by echocardiography with an unusual bubble study. Echocardiography. 2013 Jul;30(6):E182-3. PubMed PMID: 23551148
• Lundgrin EL, Park MM, Sharp J, Tang WH, Thomas JD, Asosingh K, Comhair SA, DiFilippo FP, Neumann DR, Davis L, Graham BB, Tuder RM, Dostanic I, Erzurum SC. Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. Ann Am Thorac Soc. 2013 Feb;10(1):1-9. PubMed PMID: 23509326
• Ghosh MC, Zhang DL, Jeong SY, Kovtunovych G, Ollivierre-Wilson H, Noguchi A, Tu T, Senecal T, Robinson G, Crooks DR, Tong WH, Ramaswamy K, Singh A, Graham BB, Tuder RM, Yu ZX, Eckhaus M, Lee J, Springer DA, Rouault TA. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2a. Cell Metab. 2013 Feb 5;17(2):271-81. PubMed PMID: 23395173
• Qi X, Hong J, Chaves L, Zhuang Y, Chen Y, Wang D, Chabon J, Graham B, Ohmori K, Li Y, Huang H. Antagonistic regulation by the transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity. 2013 Jul 25;39(1):97-110. PubMed PMID: 23871207
• Chow K, Fessel JP, Kaoriihida-Stansbury, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH Jr, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan;3(1):31-49. PubMed PMID: 23662173
• Graham BB, Kumar R. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Pulm Circ. 2014 Sep;4(3):353-62. PubMed PMID: 25621148
• Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep;184(9):2382-9. PubMed PMID: 25016184
• Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014 Jun;4(2):289-99. PubMed PMID: 25006448
• Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 3;13(5):1016-32. PubMed PMID: 26565914
• Robinson JC, Graham BB, Rouault TC, Tuder RM. The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension. Am J Respir Cell Mol Biol. 2014 Dec;51(6):721-9. PubMed PMID: 24988529
• Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15;192(8):998-1008. PubMed PMID: 26192556
• Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 1;309(5):L435-40. PubMed PMID: 26115672
• White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Mar 30;7(6):695-713. PubMed PMID: 25825391
• Graham BB, Kumar R. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Pulm Circ. 2014 Sep;4(3):353-62. PubMed PMID: 25621148
• Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep;184(9):2382-9. PubMed PMID: 25016184
• Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014 Jun;4(2):289-99. PubMed PMID: 25006448
• Robinson JC, Graham BB, Rouault TC, Tuder RM. The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension. Am J Respir Cell Mol Biol. 2014 Dec;51(6):721-9. PubMed PMID: 24988529
• Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug;124(8):3514-28. PubMed PMID: 24960162
• El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15;193(2):597-609. PubMed PMID: 24928992
• Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA 3rd, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. PubMed PMID: 24605778
• Tuder RM, Robinson JC, Graham BB. Fat and cardiotoxicity in hereditary pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 1;189(3):247-9. PubMed PMID: 24484329
• Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug 1;124(8):3514-28. PubMed PMID: 24960162
• El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15;193(2):597-609. PubMed PMID: 24928992
• Graham BB, Robinson JC, Tuder RM. Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle. Am J Respir Crit Care Med. 2016 Sep 15;194(6):655-6. PubMed PMID: 27628075
• Xu W, Ghosh S, Comhair SA, Asosingh K, Janocha AJ, Mavrakis DA, Bennett CD, Gruca LL, Graham BB, Queisser KA, Kao CC, Wedes SH, Petrich JM, Tuder RM, Kalhan SC, Erzurum SC. Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016 Jul 1;126(7):2465-81. PubMed PMID: 27214549
• Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA 3rd, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. PubMed PMID: 24605778
• Tuder RM, Robinson JC, Graham BB. Fat and cardiotoxicity in hereditary pulmonary hypertension. Am J Respir Crit Care Med. 2014 Feb 1;189(3):247-9. PubMed PMID: 24484329
• Ali Z, Kosanovic D, Kolosionek E, Schermuly RT, Graham BB, Mathie A, Butrous G. Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling. Pulm Circ. 2017 Mar;7(1):244-252. PubMed PMID: 28680583
• Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30;8:15494. PubMed PMID: 28555642
• Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR. A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. J Immunol. 2017 Jun 15;198(12):4802-4812. PubMed PMID: 28500078
• Graham BB, Koyanagi D, Kandasamy B, Tuder RM. Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology. Am J Respir Crit Care Med. 2017 Oct 15;196(8):1075-1077. PubMed PMID: 28278380
• Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW. Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. Am J Respir Cell Mol Biol. 2018 Dec 18. [Epub ahead of print] PubMed PMID: 30562042
• Gu S, Kumar R, Lee MH, Mickael C, Graham BB. Common genetic variants in pulmonary arterial hypertension. Lancet Respir Med. 2018 Dec 5. [Epub ahead of print] PubMed PMID: 30527955
• Mickael C, Lee MH, Gu S, Graham BB. Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective. Cardiovasc Res. 2018 Dec 4. [Epub ahead of print] PubMed PMID: 30517607
• Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB. Paclitaxel blocks Th2-mediated TGF-ß activation in Schistosoma mansoni-induced pulmonary hypertension. Pulm Circ. 2019 Jan-Mar;9(1):2045894018820813. PubMed PMID: 30511588
• Graham BB, Yu PB. Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019 Jan 1;199(1):9-11. PubMed PMID: 30130137
• Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 Jun 13;10(445). PubMed PMID: 29899023
• Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM. Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2018 Oct;59(4):479-489. PubMed PMID: 29851508
• Stenmark KR, Graham BB. Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy?. Cardiovasc Res. 2018 Jul 1;114(8):1057-1059. PubMed PMID: 29800416
• Tamosiuniene R, Manouvakhova O, Mesange P, Saito T, Qian J, Sanyal M, Lin YC, Nguyen LP, Luria A, Tu AB, Sante JM, Rabinovitch M, Fitzgerald DJ, Graham BB, Habtezion A, Voelkel NF, Aurelian L, Nicolls MR. Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension. Circ Res. 2018 Jun 8;122(12):1689-1702. PubMed PMID: 29545367
• Stenmark KR, Frid MG, Graham BB, Tuder RM. Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension. Cardiovasc Res. 2018 Mar 15;114(4):551-564. PubMed PMID: 29385432
• Kumar R, Graham B. How does inflammation contribute to pulmonary hypertension?. Eur Respir J. 2018 Jan;51(1). PubMed PMID: 29371392
• Kumar R, Graham B. IL-33-HIF1a Axis in Hypoxic Pulmonary Hypertension. EBioMedicine. 2018 Jul;33:8-9. PubMed PMID: 30049389

Professional Memberships

• American Thoracic Society (ATS), Member
• American College of Chest Physicians, Associate
• American College of Physicians (ACP), Associate

Specialty Information

• Internal Medicine, Board Certification (2007)
• Pulmonary Disease and Critical Care Medicine, Board Certification (2010)
• Critical Care Medicine, Board Certification (, 2010)

• Lungs and Breathing - Pulmonary Hypertension
• Hereditary Hemorrhagic Telangiectasia (HHT)
• Lungs and Breathing
• Critical Care