Edward Janoff, MD

Professional Titles

• Director, Mucosal and Vaccine Research Colorado (MAVRC

Publications

• Janoff EN. The microbiome and human disease pathogenesis: how do you do what you do to me …?. Transl Res. 2017 Jan;179:1-6. PubMed PMID: 27832935
• Malarkey CS, Gustafson CE, Saifee JF, Torres RM, Churchill ME, Janoff EN. Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production. PLoS One. 2016 Jun 9;11(6):e0157157. PubMed PMID: 27280778
• Meya DB, Manabe YC, Boulware DR, Janoff EN. The immunopathogenesis of cryptococcal immune reconstitution inflammatory syndrome: understanding a conundrum. Curr Opin Infect Dis. 2016 Feb;29(1):10-22. PubMed PMID: 26658650
• Signoracci GM, Stearns-Yoder KA, Holliman BD, Huggins JA, Janoff EN, Brenner LA. Listening to Our Patients: Learning About Suicide Risk and Protective Factors From Veterans With HIV/AIDS. J Holist Nurs. 2016 Dec;34(4):318-328. PubMed PMID: 26578552
• Lynch AM, Wagner BD, Deterding RR, Giclas PC, Gibbs RS, Janoff EN, Holers VM, Santoro NF. The relationship of circulating proteins in early pregnancy with preterm birth. Am J Obstet Gynecol. 2016 Apr;214(4):517.e1-8. PubMed PMID: 26576488
• Chi YC, Rahkola JT, Kendrick AA, Holliday MJ, Paukovich N, Roberts TS, Janoff EN, Eisenmesser EZ. Streptococcus pneumoniae IgA1 protease: A metalloprotease that can catalyze in a split manner in vitro. Protein Sci. 2016 Dec 28. [Epub ahead of print] PubMed PMID: 28028839
• McFarland EJ, Powell TM, Onyango-Makumbi C, Zhang W, Melander K, Naluyima P, Okurut S, Eller MA, Fowler MG, Janoff EN. Ontogeny of CD4 T Lymphocytes with Phenotypic Susceptibility to HIV-1 during Exclusive and Non-Exclusive Breastfeeding in HIV-1-exposed Ugandan Infants. J Infect Dis. 2016 Dec 8. [Epub ahead of print] PubMed PMID: 27932619
• Delayed Antiretroviral Therapy after Cryptococcal Meningitis Improves Survival. N Engl J Med 2014; in press Boulware DR, Meya DB, ...Janoff EN, Bohjanen PR, Meintjes G.
• Limited expression of APRIL and its receptors prior to intestinal IgA plasma cell development during human infancy. Gustafson CE, Higbee D, Yeckes AR, Wilson CC, De Zoeten EF, Jedlicka P, Janoff EN. Mucosal Immunol. 2013 Sep 18. doi: 10.1038/mi.2013.64. [Epub ahead of print] PMID: 24045575
• Pneumococcal IgA1 protease subverts specific protection by human IgA1. Janoff EN, Rubins JB, Fasching C, Charboneau D, Rahkola JT, Plaut AG, Weiser JN. Mucosal Immunol. 2014 Mar;7(2):249-56. doi: 10.1038/mi.2013.41. Epub 2013 Jul 3. PMID: 23820749
• Decreased mutation frequencies among immunoglobulin G variable region genes during viremic HIV-1 infection. Bowers E, Scamurra RW, Asrani A, Beniguel L, MaWhinney S, Keays KM, Thurn JR, Janoff EN. PLoS One. 2014 Jan 7;9(1):e81913. doi: 10.1371/journal.pone.0081913. PMID: 24409278
• Janoff EN, Musher DM. Streptococcus pneumoniae. (Chapter 200) In: Mandell, Gordon, Douglas and Bennett. Principles and Practice of Infectious Disease. Churchill Livingston Elsevier. 8th Ed. 2014.
• Nicholson, L, Janoff, EN. 2014. Respiratory Bacterial Vaccines, in: Mestecky, J., Strober,W., Russell, M.W., Cheroutre, H., Kelsall, B.L., and Lambrecht, B.N. (Eds.), Mucosal Immunology, Third Edition. Elsevier, Waltham, in press.
• Neutralization of HIV subtypes A and D by breast milk IgG from women with HIV infection in Uganda. Palaia JM, McConnell M, Achenbach JE, Gustafson CE, Stoermer KA, Nolan M, Guay LA, Leitner TK, Matovu F, Taylor AW, Fowler MG, Janoff EN. J Infect. 2014 Mar;68(3):264-72. doi: 10.1016/j.jinf.2013.11.002. Epub 2013 Nov 13. PMID: 24239588
• Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Pujanauski LM, Janoff EN, McCarter MD, Pelanda R, Torres RM. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1422-7. PMID: 23288906
• Aizire J, McConnell MS, Mudiope P, Mubiru M, Matovu F, Parsons TL, Elbireer A, Nolan M, Janoff EN, Fowler MG. Kinetics of nevirapine and its impact on HIV-1 RNA levels in maternal plasma and breast milk over time after perinatal single dose nevirapine. J Acquir Immune Defic Syndr. 2012; 15;60:483-8 (PMID: 22217678)
• Frank DN, Manigart O, Leroy V, Meda N, Valéa D, Zhang W, Dabis F, Pace NR, Van de Perre P, Janoff EN. Altered vaginal microbiota are assocaited with perinatal mother-to-child tranmission in African women from Burkina Faso. J Acquir Immune Defic Syndr. 2012; 60:299-306 (PMID: 22343176)
• The world within: living with our microbial guests and guides. Janoff EN, Gustafson C, Frank DN. Transl Res. 2012 Oct;160(4):239-45. doi: 10.1016/j.trsl.2012.05.005. Epub 2012 Jun 22. No abstract available. PMID: 22732305
• Wahl SM, Redford M, Christensen S, Mack W, Cohn J, Janoff EN, Mestecky J, Jenson HB, Navazesh M, Cohen M, Reichelderfer P, Kovacs A for the DATRI 009 Study Group. Systemic and mucosal differences in HIV burden, immune and therapeutic responses. J AIDS 2011; in press. (PMID: 21239996) .
• Janoff EN, Frank D. Pathogen-specific Antibodies: Co-Dependent No Longer. J Clin Invest 2010; 120:1039-42. (PMID: 20335652)
• 105. High KP, Aquila RT, Fuldner RA, Gerding DN, Halter JB, Haynes L, Hazzard WR, Jackson LA, Janoff EN, et. al. Workshop on Immunizations in Older Adults: Identifying Future Research Agendas. J Amer Geriatr Soc (JAGS) 2010; in press
• Boulware DR, Shulamith C. Bonham, Meya DB, Wiesner DL, Park GS, Kambugu A, Janoff, EN, Bohjanen PR. Paucity of Initial Cerebrospinal Fluid Inflammation in Cryptococcal Meningitis is associated with subsequent Immune Reconstitution Inflammatory Syndrome. J Infect Dis 2010; in press.
• Frank DN, Bessesen M, Price C, Janoff EN, PAce NR. The Human Nasal Microbiome and Staphylococcus aureus Carriage. PLoS One 2010; in press.
• Janoff EN, Frank DN. Pathogen-specific Antibodies: Co-dependent no longer.
• High KP, Aquila RT, Fuldner RA, Gerding DN, Halter JB, Haynes L, Hazzard WR, Jackson LA, Janoff EN, et. al. Workshop on Immunizations in Older Adults: Identifying Future Research Agendas. J Amer Geriatr Soc (JAGS) 2010; 58:765–776.
• Boulware DR, Shulamith C. Bonham, Meya DB, Wiesner DL, Park GS, Kambugu A, Janoff EN, Bohjanen PR. Paucity of Initial Cerebrospinal Fluid Inflammation in Cryptococcal Meningitis is associated with subsequent Immune Reconstitution Inflammatory Syndrome. J Infect Dis 2010; 202:962-70. (PMID: 20677939)
• Frank DN, Bessesen M, Price C, Janoff EN, Pace NR. The Human Nasal Microbiome and Staphylococcus aureus Carriage. PLoS One 2010; 5(5):e10598. (PMID: 20498722)
• Crum-Cianflone NF, Roediger MP, Huppler Hullsiek K, Ganesan A, Patel S, Landrum M, Rahkola JT, Weintrob A, Agan BA, Medina S, Hale BR, Janoff EN. A Randomized Clinical Trial Comparing Revaccination with Pneumococcal Conjugate Vaccine (PCV) to Polysaccharide Vaccine (PPV) among HIV-Infected Adults. J Infect Dis 2010; 202:1114-25. (PMID: 20795819)
• Boulware DR, Meya DB, Bergemann TL, Williams D, Vlasova IA, Rhein J, Staddon J, Kambugu A, Janoff EN, and Bohjanen PR. Antiretroviral Therapy Down-regulates Immune Activation and Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa. J Acquir Immune Defic Syndr. 2010; 55(4):428-438. (PMID: 20838227)
• Crum-Cianflone NF, Roediger MP, Huppler Hullsiek K, Ganesan A, Patel S, Landrum M, Rahkola JT, Weintrob A, Agan BA, Medina S, Hale BR, Janoff EN. The Association of Ethnicity with Antibody Responses to Pneumococcal Vaccination among Adults with HIV Infection. Vaccine 2010; 28; 7583-8. (PMID: 20887830)
• Bryan CL, Beard KS, Pott GB, Rahkola J, Gardner EM, Janoff EN, Shapiro L. HIV infection is associated with reduced serum alpha-1-antitrypsin concentrations. Clin Invest Med. 2010;33:E384. (PMID: 21134340)
• Boulware DR, Meya DB, Bergemann TL, Wiesner DL, Rhein J, Musubire A, Lee SJ, Kambugu A, Janoff EN, Bohjanen PR. Clinical features and Serum biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: a Prospective Cohort Study. PLoS Medicine 2010; 7: e1000384. (doi:10.1371/journal.pmed.1000384)
• Kunisake KM, Janoff EN. Influenza in the immunodeficient patient. Lancet Infectious Disease.
• Working Group. Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents: Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR 2009; 58: RR-4.
• Infectious Disease Society of America. Grinding to a Halt: The Effects of the Increasing Regulatory Burden on Research and Quality. Clin Infect Dis 2009; 49:328–35
• Kunisake K, Janoff EN. Influenza in the Immunocompromised Host. Lancet Infectious Diseases 2009; 9:493-504.
• 104. Hammitt LL, Bartlett JP, Li S, Rahkola J, Lang N, Janoff EN, Levin MJ, Weinberg A. Kinetics of Viral Shedding and Immune Responses in Adults Following Administration of Cold-Adapted Influenza Vaccine. Vaccine 2009; 27:7359-66.
• Rubins JB, Boulware D, Janoff EN. Pneumococcal disease in adults. In: Pneumococcal Vaccines: The Impact of Conjugate Vaccine. Siber GR, Klugman KP, and Mäkelä PH, eds. ASM Press, Washington DC.
• Smith PD, Janoff EN. Intestinal complications of AIDS and other immunodeficiency states. (Chapter) In: Textbook of Gastroenterology. Yamada T, Alpers DH, Kaplowitz N, Owyang C, Powell DW, Kalloo A, eds. Blackwell Publishing, Oxford, UK.
• Smith PD, Jhala NC, Wilcox CM, Janoff EN. Complications of AIDS and other immunodeficiency states. In: Atlas of Gastroenterology. Yamada T, Alpers DH, Kaplowitz N, Owyang C, Powell DW, Kalloo A, eds. Blackwell Publishing, Oxford, UK.
• Cooper JE, Janoff EN. Mucosal Control of Streptococcus pneumoniae infections. In: Immunity Against Mucosal Pathogens. Vadjy M, ed. Springer Publishing, Heidelberg/New York.
• Bliss SJ, O’Brien KL, Janoff EN, Cotton MF, Musoke P, Coovadia H, and Levine OS. The evidence for using conjugate vaccines to protect HIV-infected children against pneumococcal disease. Lancet Infect Dis 2008; 8:67-80
• D’Heilly, SJ Janoff EN, Nichol P, Nichol KL. Point of care diagnosis of influenza infection in older adults: Traditional and rapid culture compared with rapid antigen testing. J Clin Virol 2008; 42:124-8.
• Kambugu A, Meya DB, Rhein J, O’Brien M, Janoff EN, Ronald AR, Kamya MR, Mayanja-Kizza H, Sande MA, Bohjanen PR, Boulware DR. Outcomes of cryptococcal meningitis in Uganda before and after the availability of HAART. Clin Infect Dis 2008; 46: 1694-1701.
• Kunisaki KM, Rice KL, Janoff EN, Rector TS, Niewoehner DE. Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective study. Therapeutic Advances in Respiratory Disease 2008; 2:55-64.
• Effros RB, Fletcher C, Gebo K, Halter JB, Hazzard WR, McFarland Horne F, Huebner RE, Janoff EN, et. al. Workshop on HIV and Aging: What is Known and Future Research Directions. Clin Infect Dis 2008; 47:542-53.
• Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John L, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R; for the International Network for the Study of HIV-associated IRIS. Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis. 2008 Aug;8(8):516-523.
• Jackson LA, Janoff EN. Pneumococcal vaccination of elderly adults: new paradigms for protection. Clin Infect Dis 2008; 47:1328-38.
• Fasching CE, Grossman T, Corthesy B, Plaut AG, Weiser JN, Janoff EN. Impact of the molecular form of immunoglobulin a on functional activity in defense against Streptococcus pneumoniae. Infect Immun. 2007 Apr;75(4):1801-10. Epub 2007 Jan 29. PMID: 17261616
• Shapiro RL, Lockman S, Kim S, Smeaton L, Rahkola JT, Thior I, Wester C, Moffat C, Arimi P, Ndase P, Asmelash A, Stevens L, Montano M, Makhema J, Essex M, Janoff EN. Infant morbidity, mortality, and breast milk immunologic profiles among breastfeeding HIV-infected and HIV-uninfected women in Botswana. J Infect Dis 2007; In press.
• Mantis NJ, Palaia J, Hessell AJ, Mehta S, Zhu Z, Corthésy B, Neutra MR, Burton DR, Janoff EN. Inhibition of HIV-1 Infectivity and Epithelial Cell Transfer by Immunoglobulin A Monoclonal Antibody b12. J Immunol 2007; in press.
• Nguyen JT, Myers N, Palaia J, Georgopoulos A, Rubins JB, Janoff EN. Humoral responses to oxidized low-density lipoprotein and related bacterial antigens after pneumococcal vaccine. Translational Research 2007; in press.
• Natural history of pneumococcal pneumonia in adults. Pneumococcal Conjugate Vaccine. Ed. G. Siber.
• J Infect Dis 2005; 192: 1412
• Infect Dis 2005; 191: 1239

Practice Locations

UCHealth Infectious Disease Clinic - Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0191

Denver Veterans Affairs Medical Center
1055 Clermont St
Denver, CO 80220
1-888-336-8262

Hospital Affiliation

• University of Colorado Hospital
• Veterans Affairs Medical Center

Specialty Information

Specialties

• Infectious Disease, Board Certification (2005)
• Internal Medicine, Board Certification

Conditions & Treatments

• Infections - Viral Infections
• Infections - Sexually Transmitted Diseases
• Infections