Peter Baker, MD

Professional Titles

• Clinical Medical Director, Clinical Genetics and Metabolism
• Program Director, Medical Biochemical Genetics Fellowship

Publications

• Peter Baker, Kristen Boyle, Joe Houmard, Deborah Muoio, Jacob Friedman “Metabolic Inflexibility of MCAD and the TCA Cycle in Obese Subjects Exposed to a High Fat Diet”. Obesity
• Thierno Diallo, Dobromir Slavov, Rene Begay, Sharon L Graw, Theresa Boyle, and Matthew R. G. Taylor, Peter R Baker II, “A novel microdeletion affecting SNRPN but preserving distal gene expression leads to Prader-Willi Syndrome” American Society of Human Genetics, San Diego, CA, October 18-22, 2014
• P.R. Baker, K.E. Boyle, A.L. Butti, D. Dabelea, L.A. Barbour, J.E. Friedman, “Stem Cells from Offspring of Mothers Demonstrate Evidence for Developmental Programming in Obesity” American Society of Human Genetics, San Diego, CA, October 18-22, 2014
• Ross Ian, Babu Sunanda, Yu Liping, Armstrong Taylor, Zhang Li, Schatz Desmond, Pugliese Alberto, Eisenbarth George, Baker Peter, “HLA Genotype is influenced by 21-hydroxylase Autoantibody Positivity in South African Patients with Addison’s Disease” European Congress of Endocrinology, Wroclaw, Poland, May 5-7, 2014
• Boyle KE, Patinkin ZW, Shapiro AL, Baker PR 2nd, Dabelea D, Friedman JE. Mesenchymal Stem Cells from Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2015 Dec 2. [Epub ahead of print] PubMed PMID: 26631736
• Peter R. Baker II, Marisa W. Friederich, Michael A. Swanson, Tamim Shaikh, Kaustuv Bhattacharya, Gunter H. Scharer, Joseph Aicher, Geralyn Creadon-Swindell, Elizabeth Geiger, Kenneth N. MacLean, Wang-Tso Lee, Charu Deshpande, Mary-Louise Freckmann, Ling-Yu Shih, Melissa Wasserstein, Malene B. Rasmussen, Allan M. Lund, Peter Procopis, Jessie M. Cameron, Brian H. Robinson, Garry K. Brown, Ruth M. Brown, Alison G. Compton, Carol L. Dieckmann, Renata Collard, Curtis R. Coughlin II, Elaine Spector, Michael F. Wempe and Johan L.K. Van Hove. “Variant nonketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5.” Brain, 2014 Feb;137(Pt 2):366-79. PMID 24334290
• Ian Ross, Sunanda Babu, Taylor Armstrong, Li Zhang, Desmond Schatz, Alberto Pugliese, George Eisenbarth, and Peter Baker. “Evaluation of HLA and 21-hydroxylase Autoantibody Positivity in South African Autoimmune Addison’s Disease”. Tissue Antigens. 2014 Oct;84(4):361-9. PMID 25040682
• James D. Weisfeld-Adams and Peter R. Baker II “Co-occurrence of the Poland anomaly in a patient with the cobalamin C defect: more than just a coincidence?” J Inherit Metab Dis. 2014 Nov 12. PMID 25388550
• Heinrich Kahles, Pamela R. Fain, Peter Baker, George Eisenbarth, and Klaus Badenhoop “Genetics of autoimmune thyroiditis in type 1 diabetes reveals a novel association with DPB1*0201: data from the Type 1 Diabetes Genetics consortium (T1DGC)”. (In Press, Diabetes Care).
• Peter Baker and Jacob Friedman “Fetal Origins of Adult Disease: Placental and Intrauterine Environment” Fetal and Neonatal Physiology, 5th Ed, Edited by Seven Abman and Richard Polin, Elsevier, 2015 (in press)
• Peter Baker and Jacob Friedman “Critical Importance of the Perinatal Period in the Development of Obesity.” Treatment of the Obese Patient 2nd Edition, edited by Kushner, R.F. and Bessesen, D.H., Springer Science. 2014.
• Peter Baker “Pathophysiology of Metabolic Disease” Nutrition Treatment of Inherited Metabolic Diseases: Lessons from Metabolic University, Springer Press, 1st Ed. 2014
• Peter Baker, Andrea DeBarber, and Robert Steiner “Cerebrotendinous Xanthomatosis” (review), E-medicine: Published 2008, Last updated 2014.
• Peter R. Baker II, Kristen Boyle, Allison Shapiro, Zach Patinkin, Dana Dabelea, and Jacob E. Friedman “Maternal Obesity and Newborn Adiposity Correlate with Amino acid and Acylcarnitine Metabolism in Mesenchymal Stem Cells” Society for Inherited Metabolic Disease, Salt Lake City, UT, 3/24/2015-3/28/2015
• Peter R. Baker II, Kristen Boyle, Allison Shapiro, Zach Patinkin, Dana Dabelea, and Jacob E. Friedman “Maternal Obesity Influences Amino Acid Metabolism in Offspring Umbilical Derived Stem Cells” Keystone Symposia: Diabetes and Metabolic Dysfunction, Santa Fe, NM , 1/27/2015-2/1/2015
• Capitena CE, Wagoner HJ, Ruzas CM, Bennett TD, Baker PR 2nd, Jung JL, Weisfeld-Adams JD. Rapid resolution of infantile lipemia retinalis following exchange transfusion. J Inherit Metab Dis. 2016 Nov;39(6):889-890. PubMed PMID: 27518769
• Lemas DJ, Young BE, Baker PR 2nd, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr. 2016 May;103(5):1291-300. PubMed PMID: 27140533
• Boyle KE, Patinkin ZW, Shapiro AL, Baker PR 2nd, Dabelea D, Friedman JE. Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project. Diabetes. 2016 Mar;65(3):647-59. PubMed PMID: 26631736
• Peter Baker and Jacob Friedman “Fetal Origins of Adult Disease: Placental and Intrauterine Environment” Fetal and Neonatal Physiology, 5th Ed, Edited by Steven Abman and Richard Polin, Elsevier, 2016
• Baker PR 2nd, Patinkin Z, Shapiro AL, De La Houssaye BA, Woontner M, Boyle KE, Vanderlinden L, Dabelea D, Friedman JE. Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism. JCI Insight. 2017 Nov 2;2(21). [Epub ahead of print] PubMed PMID: 29093265
• Baker PR 2nd, Patinkin ZW, Shapiro ALB, de la Houssaye BA, Janssen RC, Vanderlinden LA, Dabelea D, Friedman JE. Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain. Sci Rep. 2017 Dec 22;7(1):18095. PubMed PMID: 29273781
• Baker P II, Ayres L, Gaughan S, Weisfeld-Adams J. Hereditary Fructose Intolerance. . 2015. PubMed PMID: 26677512
• Janet Thomas, Johan Van Hove, Peter Baker II “Inborn Errors of Metabolism” Current Opinions in Pediatrics, Edited by Steven Abman and Bill Hay
• Kahles H, Fain PR, Baker P, Eisenbarth G, Badenhoop K. Genetics of Autoimmune Thyroiditis in Type 1 Diabetes Reveals a Novel Association With DPB1*0201: Data From the Type 1 Diabetes Genetics Consortium. Diabetes Care. 2015 Oct;38 Suppl 2:S21-8. PubMed PMID: 26405068
• Brorsson CA, Onengut S, Chen WM, Wenzlau J, Yu L, Baker P, Williams AJ, Bingley PJ, Hutton JC, Eisenbarth GS, Concannon P, Rich SS, Pociot F. Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes. Diabetes. 2015 Aug;64(8):3017-27. PubMed PMID: 25829454
• Bush D, Sremba L, Lomax K, Lipsett J, Ketteridge D, Bratkovic D, Enchautegui-Colon Y, Weisfeld-Adams J, Galambos C, Lummus S, Wartchow E, Weinman J, Liptzin DR, Baker P 2nd. Neonatal Onset Interstitial Lung Disease as a Primary Presenting Manifestation of Mucopolysaccharidosis Type I. JIMD Rep. 2018 Apr 14. [Epub ahead of print] PubMed PMID: 29654546
• Larson AA, Baker PR 2nd, Milev MP, Press CA, Sokol RJ, Cox MO, Lekostaj JK, Stence AA, Bossler AD, Mueller JM, Prematilake K, Tadjo TF, Williams CA, Sacher M, Moore SA. TRAPPC11 and GOSR2 mutations associate with hypoglycosylation of a-dystroglycan and muscular dystrophy. Skelet Muscle. 2018 May 31;8(1):17. PubMed PMID: 29855340
• Borengasser SJ, Baker PR 2nd, Kerns ME, Miller LV, Palacios AP, Kemp JF, Westcott JE, Morrison SD, Hernandez TL, Garces A, Figueroa L, Friedman JE, Hambidge KM, Krebs NF. Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese. Nutrients. 2018 Sep 11;10(9). PubMed PMID: 30208589
• Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41. PubMed PMID: 30337225
• Baker PR 2nd, Friedman JE. Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease. J Clin Invest. 2018 Aug 31;128(9):3692-3703. PubMed PMID: 30168806
• Janet Thomas, Johan Van Hove, Peter Baker II “Inborn Errors of Metabolism” Current Opinions in Pediatrics, 24th Ed, Edited by Steven Abman, Bill Hay, Myron Melvin, and Robin Deterding, 2018
• Weisfeld-Adams JD, Baker PR. Co-occurrence of the Poland sequence in a patient with the cobalamin C defect: more than just a coincidence?. J Inherit Metab Dis. 2015 Mar;38(2):365-6. PubMed PMID: 25388550
• Peter Baker and Jacob Friedman “Critical Importance of the Perinatal Period in the Development of Obesity.” Treatment of the Obese Patient 2nd Edition, edited by Kushner, R.F. and Bessesen, D.H., Springer Science. 2015.
• Peter Baker and Jacob Friedman “Fetal Origins of Adult Disease: Placental and Intrauterine Environment” Fetal and Neonatal Physiology, 5th Ed, Edited by Steven Abman and Richard Polin, Elsevier, 2016
• Peter Baker “Pathophysiology of Metabolic Disease” Nutrition Treatment of Inherited Metabolic Diseases: Lessons from Metabolic University, Springer Press, 1st Ed. 2015
• Steiner RD, Baker PR, DeBarber AE. Cerebrotendinous Xanthomatosis. Medscape Reference. Updated May 12, 2015. Available at: http://emedicine.medscape.com/article/1418820-overview
• Baker PR 2nd, Boyle KE, Koves TR, Ilkayeva OR, Muoio DM, Houmard JA, Friedman JE. Metabolomic analysis reveals altered skeletal muscle amino acid and fatty acid handling in obese humans. Obesity (Silver Spring). 2015 May;23(5):981-8. PubMed PMID: 25864501
• Sremba L, McCandless S, Baker P 2nd. Concerning "Diagnostic Exome Sequencing and Tailored Bioinformatics of the Parents of a Deceased Child with Cobalamin Deficiency Suggests Digenic Inheritance of the MTR and LMBRD1 Genes" by Farwell Gonzalez et al. J Inherit Metab Dis. 2019 Aug 4. [Epub ahead of print] PubMed PMID: 31378948
• Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 Sep 4. [Epub ahead of print] PubMed PMID: 31483682
• Nicoli ER, Weston MR, Hackbarth M, Becerril A, Larson A, Zein WM, Baker PR 2nd, Burke JD, Dorward H, Davids M, Huang Y, Adams DR, Zerfas PM, Chen D, Markello TC, Toro C, Wood T, Elliott G, Vu M, Zheng W, Garrett LJ, Tifft CJ, Gahl WA, Day-Salvatore DL, Mindell JA, Malicdan MCV. Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification. Am J Hum Genet. 2019 Jun 6;104(6):1127-1138. PubMed PMID: 31155284
• Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41. PubMed PMID: 30337225
• Janet Thomas, Austin Larson, Johan Van Hove, Peter Baker II* “Inborn Errors of Metabolism” Current Diagnosis and Treatment: Pediatrics, 25th Ed, Edited by Bill Hay, Myron Melvin, Robin Deterding, and Mark Abzug, 2019 *Denotes communicating author
• E. Wright, GC and P. R. Baker II, MD, “Macrosomia as an Interfering Factor for Multiple Analytes on the Colorado State Newborn Screen” JCEM
• Bernstein LE, Burns C, Drumm M, Gaughan S, Sailer M, Baker PR 2nd. Impact on Isoleucine and Valine Supplementation When Decreasing Use of Medical Food in the Nutritional Management of Methylmalonic Acidemia. Nutrients. 2020 Feb 13;12(2). PubMed PMID: 32069872
• Wright EL, Baker PR. Neonatal Macrosomia is an Interfering Factor for Analytes on the Colorado State Newborn Screen. J Clin Endocrinol Metab. 2020 Mar 1;105(3). PubMed PMID: 32126138
• Kripps K, Kierstein J, Nicklas D, Nelson J, Yang M, Collins A, Troy E, Escolar M, Maloney J, Neuberger I, Stence N, Baker PR 2nd. Unusual Neuroimaging in a Case of Rapidly Progressive Juvenile-Onset Krabbe Disease. J Child Neurol. 2020 Sep;35(10):649-653. PubMed PMID: 32484059
• Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 Oct;247(1):115-126. PubMed PMID: 32756000
• Danielle E. Soranno, Lara Kirkbride-Romeo, Sara A. Wennersten, Kathy Ding, Maria A. Cavasin, Peter Baker II, Christopher Altmann, Rushita A. Bagchi, Korey Haefner, John Montford, Katja Gist, Timothy A. McKinsey, Sarah Faubel “Acute kidney injury results in diastolic dysfunction in male but not female mice, and histone deacetylase inhibition prevents the dysfunction”
• Sophia L. Ambruso, Hyo-Wook Gil, Benjamin Fox, Bryan Park, Christopher Altmann, Rushita A. Bagchi, Peter R. Baker II, Sarah Faubel “Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion”
• Soranno, Danielle; Baker, Peter; Kirkbride-Romeo, Lara; Wennersten, Sara; Ding, Kathy; Keith, Brysen; Cavasin, Maria; Altmann, Christopher; Bagchi, Rushita; Haefner, Korey; Montford, John; Gist, Katja; McKinsey, Timothy; Faubel, Sarah. “Female sex protects against diastolic dysfunction but not hypertension after acute kidney injury in mice”
• Sommer Gaughan, Lachlan Ayres, and Peter Baker II, “Hereditary Fructose Intolerance” Gene Reviews
• Janet Thomas, Austin Larson, Johan Van Hove, Peter Baker II* “Inborn Errors of Metabolism” Current Diagnosis and Treatment: Pediatrics, 25th Ed, Edited by Bill Hay, Myron Melvin, Robin Deterding, and Mark Abzug
• Peter Baker “Fetal Origins of Adult Disease: Placental and Intrauterine Environment” Fetal and Neonatal Physiology, 6th Ed, Edited by Steven Abman and Richard Polin, Elsevier
• Danielle E. Soranno, Lara Kirkbride-Romeo, Sara A. Wennersten, Kathy Ding, Maria A. Cavasin, Peter Baker II, Christopher Altmann, Rushita A. Bagchi, Korey Haefner, John Montford, Katja Gist, Timothy A. McKinsey, Sarah Faubel “Acute kidney injury results in diastolic dysfunction in male but not female mice, and histone deacetylase inhibition prevents the dysfunction” The Journal of Experimental Medicine
• Sophia L. Ambruso, Hyo-Wook Gil, Benjamin Fox, Bryan Park, Christopher Altmann, Rushita A. Bagchi, Peter R. Baker II, Sarah Faubel “Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion” AJP Lung
• Kimberly A. Kripps, MD; Peter R. Baker, MD; Janet A. Thomas, MD; Heather E. Skillman; Laurie Bernstein; Sommer Gaughan; Casey Burns; Curtis R. Coughlin; Shawn E. McCandless, MD; Austin A. Larson, MD; Aaina Kochar, MD; Chelsey Stillman; Erica Wymore, MD; Ellie Hendricks; Michael Woontner, PhD, Dr Johan Van Hove “Practical strategies to maintain anabolism by intravenous nutritional management in children with inborn metabolic diseases.” Molecular Genetics and Metabolism
• Jane Stremming, Eileen Chang, Leslie Knaub, Michael Armstrong, Peter Baker, Stephanie Wesolowski, Nichole Reisdorph, Jane Reusch, and Laura Brown. "Mitochondrial respiration is intact despite lower citrate synthase activity and fewer oxidative myofibers in skeletal muscle from growth restricted fetal sheep" American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
• Kimberly A. Kripps, MD, Leighann Sremba, GC, Austin A. Larson, MD, Johan L.K. Van Hove, MD, PhD, Hoanh Nguyen, MD, Erica L. Wright, MS, David M. Mirsky, MD, David Watkins, David S. Rosenblatt, MDCM, David Ketteridge, MBBS, Susan A. Berry, MD, Shawn E. McCandless, MD, Peter R. Baker II, MD “Methionine synthase deficiency: Variable Clinical Presentation and Benefit of Early diagnosis and Treatment” Journal of Inherited Metabolic Disease
• Soranno, Danielle; Baker, Peter; Kirkbride-Romeo, Lara; Wennersten, Sara; Ding, Kathy; Keith, Brysen; Cavasin, Maria; Altmann, Christopher; Bagchi, Rushita; Haefner, Korey; Montford, John; Gist, Katja; McKinsey, Timothy; Faubel, Sarah. “Female and male mice have differential long term cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury” Scientific Reports
• Janet Thomas, Austin Larson, Johan Van Hove, Peter Baker II* “Inborn Errors of Metabolism” Current Diagnosis and Treatment: Pediatrics, 25th Ed, Edited by Bill Hay, Myron Melvin, Robin Deterding, and Mark Abzug,
• Peter Baker “Fetal Origins of Adult Disease: Placental and Intrauterine Environment” Fetal and Neonatal Physiology, 6th Ed, Edited by Steven Abman and Richard Polin, Elsevier, 2021
• Emily Shelkowitz, Austin Larson, Peter Baker “Inborn Errors of Metabolism” Developmental-Behavioral Pediatrics, 5th Ed, Edited by William B. Carey, Allen C. Crocker, Ellen Roy Elias, Heidi M. Feldman, and William L. Coleman
• Gaughan S, Ayres L, Baker PR II. Hereditary Fructose Intolerance. . 1993. PubMed PMID: 26677512
• Soranno DE, Baker P 2nd, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S. Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury. Sci Rep. 2022 Jan 12;12(1):643. PubMed PMID: 35022484
• “Recognizing and Managing a Metabolic Crisis” Pediatric Clinics of North America
• Shanlee M Davis, Rhianna Urban, Angelo D’Alessandro, Christine Chan, Megan Kelsey, Susan Howell, Nicole Tartaglia, Philip Zeitler, Peter Baker II, “Unique plasma metabolite signature for adolescents with Klinefelter syndrome reveals altered fatty acid metabolism” Endocrine Connections
• “Pathophysiology of Metabolic Disease” Nutrition Treatment of Inherited Metabolic Diseases: Lessons from Metabolic University, Springer
• Janet Thomas, Austin Larson, Johan Van Hove, Peter Baker II* “Inborn Errors of Metabolism” Current Diagnosis and Treatment: Pediatrics, 26th Ed
• Emily Shelkowitz, Austin Larson, Peter Baker “Inborn Errors of Metabolism” Developmental-Behavioral Pediatrics, 5th Ed
• Crenshaw MM, Thompson L, Piqué DG, Micke K, Saenz M, Baker PR 2nd. Congenital diaphragmatic hernia in siblings with PIGA-related congenital disorder of glycosylation. Am J Med Genet A. 2023 Dec;191(12):2860-2867. PubMed PMID: 37589195
• Crenshaw MM, Graw SL, Slavov D, Boyle TA, Piqué DG, Taylor M, Baker P 2nd. An Atypical 15q11.2 Microdeletion Not Involving SNORD116 Resulting in Prader-Willi Syndrome. Case Rep Genet. 2023;2023:4225092. PubMed PMID: 37736297
• Sewani S, Azamian MS, Mendelsohn BA, Mau-Them FT, Réda M, Nambot S, Isidor B, van der Smagt JJ, Shen JJ, Shillington A, White L, Elloumi HZ, Baker PR 2nd, Svihovec S, Brown K, Koopman-Keemink Y, Hoffer MJV, Lakeman IMM, Brischoux-Boucher E, Kinali M, Zhao X, Lalani SR, Scott DA. Neurodevelopmental and other phenotypes recurrently associated with heterozygous BAZ2B loss-of-function variants. Am J Med Genet A. 2023 Oct 23. [Epub ahead of print] PubMed PMID: 37872713
• Davis SM, Urban R, D'Alessandro A, Reisz JA, Chan CL, Kelsey M, Howell S, Tartaglia N, Zeitler P, Baker Ii P. Unique plasma metabolite signature for adolescents with Klinefelter syndrome reveals altered fatty acid metabolism. Endocr Connect. 2023 May 1;12(5). PubMed PMID: 36884262

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation

• Children's Hospital Colorado