Natarajan Balasubramaniyan, PhD

Publications

• Grayck MR, McCarthy WC, Solar M, Balasubramaniyan N, Zheng L, Orlicky DJ, Wright CJ. Implications of neonatal absence of innate immune mediated NF?B/AP1 signaling in the murine liver. Pediatr Res. 2024 Jun;95(7):1791-1802. PubMed PMID: 38396130
• Grayck MR, McCarthy WC, Solar M, Golden E, Balasubramaniyan N, Zheng L, Sherlock LG, Wright CJ. GSK3ß/NF-?B -dependent transcriptional regulation of homeostatic hepatocyte Tnf production. Am J Physiol Gastrointest Liver Physiol. 2024 Apr 1;326(4):G374-G384. PubMed PMID: 38193163
• Shearn CT, Anderson AL, Miller CG, Noyd RC, Devereaux MW, Balasubramaniyan N, Orlicky DJ, Schmidt EE, Sokol RJ. Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury. Hepatol Commun. 2023 Jan 1;7(1):e0020. PubMed PMID: 36633484
• Shearn CT, Anderson AL, Miller CG, Noyd RC, Devereaux MW, Balasubramaniyan N, Orlicky DJ, Schmidt EE, Sokol RJ. Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury. Hepatol Commun. 2023 Jan 1;7(1):e0020. PubMed PMID: 36633484
• El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):1096-1106. PubMed PMID: 34664730
• El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice. Hepatology. 2022 Feb;75(2):252-265. PubMed PMID: 34387888
• El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition-associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2022 Jul;46(5):1096-1106. PubMed PMID: 34664730
• El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice. Hepatology. 2022 Feb;75(2):252-265. PubMed PMID: 34387888
• Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ, Suchy FJ. miR-199a-5p inhibits the expression of ABCB11 in obstructive cholestasis. J Biol Chem. 2021 Dec;297(6):101400. PubMed PMID: 34774795
• El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2021 Oct 19. [Epub ahead of print] PubMed PMID: 34664730
• El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic Activation of Hepatic Farnesoid X Receptor Prevents Parenteral Nutrition Associated Cholestasis in Mice. Hepatology. 2021 Aug 13. [Epub ahead of print] PubMed PMID: 34387888
• Natarajan Balasubramaniyan, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol, and Frederick J. Suchy. miR-199a-5p Regulates the Expression of ABCB11 in Obstructive Cholestasis (2021). Journal of Biological Chemistry-Accepted
• Azeltine MW, Chavez EJ, Nemec KM, Bednarek JM, Asokan R, Balasubramaniyan N, Zgheib C, Mack CL, Roach JP. Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia. J Surg Res. 2020 Dec;256:663-672. PubMed PMID: 32818799
• Azeltine MW, Chavez EJ, Nemec KM, Bednarek JM, Asokan R, Balasubramaniyan N, Zgheib C, Mack CL, Roach JP. Inflammation Drives MicroRNAs to Limit Hepatocyte Bile Acid Transport in Murine Biliary Atresia. J Surg Res. 2020 Aug 17;256:663-672. [Epub ahead of print] PubMed PMID: 32818799
• Balasubramaniyan N, Devereaux MW, Orlicky DJ, Sokol RJ, Suchy FJ. Up-regulation of miR-let7a-5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis. Hepatol Commun. 2019 Dec;3(12):1674-1686. PubMed PMID: 31832574
• Up-regulation of miR-let7a-5p Leads to Decreased Expression of ABCC2 in Obstructive Cholestasis. Natarajan Balasubramaniyan,Michael W. Devereaux,David J. Orlicky Ronald J. Sokol,Frederick J. Suchy.Hepatology Communications First published: 27 September 2019 https://doi.org/10.1002/hep4.1433
• Inflammation Drives miRNAs to Limit Hepatocyte Bile Acid Transport in Murine BiliaryAtresia .Mark W. Azeltine , Emily J. Chavez , Kelsey M. Nemec , Joseph M. Bednarek , Natarajan Balasubramaniyan , Carlos Zgheib , Cara L. Mack and Jonathan P.Roach (2019) Journal of Surgical Research-submitted
• El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 Apr 11;9(1):1393. PubMed PMID: 29643332
• Balasubramaniyan N, Devereaux MW, Sokol RJ, Suchy FJ .MicroRNA let-7a-5p Controls the Expression of the Multidrug Resistance-associated Protein 2 (ABCC2/MRP2).(2018) Under preparation
• El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 Apr 11;9(1):1393. PubMed PMID: 29643332
• Karim C. El Kasmi, Padade M. Vue, Aimee L. Anderson, Michael W. Devereaux, Swati Ghosh, Natarajan Balasubramaniyan, Sophie A. Fillon, Carola Dahrenmoeller, Ayed Allawzi, Crystal Woods, Sarah McKenna, Clyde J. Wright, Linda Johnson, Angelo D’Alessandro, Julie Reisz, Eva Nozik-Grayck, Frederick J. Suchy, and Ronald J. Sokol.Macrophage-derived IL-1beta/NFkB signaling mediates Parenteral Nutrition Associated Cholestasis.(2017) Nature Communications, under revision
• Aguilo F, Li S, Balasubramaniyan N, Sancho A, Benko S, Zhang F, Vashisht A, Rengasamy M, Andino B, Chen CH, Zhou F, Qian C, Zhou MM, Wohlschlegel JA, Zhang W, Suchy FJ, Walsh MJ. Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1a. Cell Rep. 2016 Jan 26;14(3):479-92. PubMed PMID: 26774474
• Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Nuclear factor-?B regulates the expression of multiple genes encoding liver transport proteins. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G618-28. PubMed PMID: 26867564
• Obeticholic acid markedly attenuates liver injury and reverses repressive epigenetic marks in the common bile duct ligated mouse. Natarajan Balasubramaniyan, Michael W.Devereaux, David J. Orlicky, and Frederick J. Suchy. Department of Pediatrics, Children’s Hospital Colorado Research Institute, University of Colorado School of Medicine, Aurora, CO 80045. AASLD,Boston,Nov 11-15,2016-Oral presentation.
• Aguilo F, Li S, Balasubramaniyan N, Sancho A, Benko S, Zhang F, Vashisht A, Rengasamy M, Andino B, Chen CH, Zhou F, Qian C, Zhou MM, Wohlschlegel JA, Zhang W, Suchy FJ, Walsh MJ. Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1a. Cell Rep. 2016 Jan 26;14(3):479-492. PubMed PMID: 26774474
• Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Nuclear factor-?B regulates the expression of multiple genes encoding liver transport proteins. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 15;310(8):G618-28. PubMed PMID: 26867564
• Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Nuclear factor ?B Regulates the Expression of Multiple Genes Encoding Liver Transport Proteins. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 11;:ajpgi.00363.2015. [Epub ahead of print] PubMed PMID: 26867564
• CHD6 REGULATES THE TOPOLOGICAL ARRANGEMENT OF THE CFTR LOCUS. Ana Sancho, SiDe Li, Thankam Paul, Fan Zhang, Francesca Aguilo, Ajay Vashisht, Natarajan Balasubramaniyan, Neal S. LeLeiko, Frederick J. Suchy, James A. Wohlschlegel, Weijia Zhang and Martin J. Walsh. Human Molecular Genetics, under revision
• Systemic inflammatory stress induces hepatic macrophage ET-1 expression via an IkBalpha/ NFkB dependent mechanism Sarah McKenna, Megan Gossling, Alejandro Bugarini, Ray Rancourt, Natarajan Balasubramaniyan, Karim El-Kasmi, Clyde J. Wright.Submited to JCI
• McKenna S, Gossling M, Bugarini A, Hill E, Anderson AL, Rancourt RC, Balasubramaniyan N, El Kasmi KC, Wright CJ. Endotoxemia Induces IkBß/NF-kB-Dependent Endothelin-1 Expression in Hepatic Macrophages. J Immunol. 2015 Oct 15;195(8):3866-79. PubMed PMID: 26342031
• Sancho A, Li S, Paul T, Zhang F, Aguilo F, Vashisht A, Balasubramaniyan N, Leleiko NS, Suchy FJ, Wohlschlegel JA, Zhang W, Walsh MJ. CHD6 regulates the topological arrangement of the CFTR locus. Hum Mol Genet. 2015 May 15;24(10):2724-32. PubMed PMID: 25631877
• Francesca Aguilo, SiDe Li, Natarajan Balasubramaniyan, Ana Sancho, Sabina Benko,Fan Zhang, Ajay Vashisht, Madhumitha Rengasamy, Blanca Andino, Chih-hung Chen,Felix Zhou, Chengmin Qian, Ming-Ming Zhou, James A. Wohlschlegel, Weijia Zhang,Frederick J. Suchy, and Martin J. Walsh.(2015) EPI-TRANSCRIPTOMIC CONTROL OF ENHANCER RNA FUNCTION BY THE PGC-1a CO-ACTIVATOR.Cell Reports.(Accepted for the publication)
• The role of NF-kB in inflammation-induced and obstructive cholestasis Natarajan Balasubramaniyan1, Meena Ananthanarayanan2, and Frederick J. Suchy1 1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO and 2Dept of Internal Medicine,Yale University School of Medicine, New Haven, CT. AASLD ,Boston
• SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes Natarajan Balasubramaniyan,Yuhuan Luo,An-Qiang Sun and Frederick J. Suchy
• Identification of functional relevant lysine residues that modulate human farnesoid x receptor (hFXR) activation An-Qiang Sun,Yuhuan Luo,shuhua Xu,Natarajan Balasubramaniyan and Frederick J. Suchy
• Balasubramaniyan N, Luo Y, Sun AQ, Suchy FJ. SUMOylation of the farnesoid X receptor (FXR) regulates the expression of FXR target genes. J Biol Chem. 2013 May 10;288(19):13850-62. PubMed PMID: 23546875
• Sun AQ, Luo Y, Backos DS, Xu S, Balasubramaniyan N, Reigan P, Suchy FJ. Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation. Mol Pharmacol. 2013 May;83(5):1078-86. PubMed PMID: 23462506
• Nair VD, Ge Y, Balasubramaniyan N, Kim J, Okawa Y, Chikina M, Troyanskaya O, Sealfon SC. Involvement of histone demethylase LSD1 in short-time-scale gene expression changes during cell cycle progression in embryonic stem cells. Mol Cell Biol. 2012 Dec;32(23):4861-76. PubMed PMID: 23028048
• Sundaram RK, Balasubramaniyan N, Sundaram P. Protein stains and applications. Methods Mol Biol. 2012;869:451-64. PubMed PMID: 22585510
• Balasubramaniyan N, Ananthanarayanan M, Suchy FJ. Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes. Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G937-47. PubMed PMID: 22345554