James McManaman, PhD

Publications

• Heterotrimerization of ErbB3/ErbB2/IGF-1R in trastuzumab-resistant breast cancer cells, Cancer Research 70:1204-1214, 2010
• Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis, BMC Dev Biol 10:(epub)2010
• Strong foreign promoters contribute to innate inflammatory responses induced by adenovirus transducing vectors, Virol. 312:28-35, 2011
• The adipophilin C-terminus is a self-folding membrane binding domain that is important for milk lipid secretion. J. Biol.Chem. 286:23254-23265, 2011
• Chronic ethanol consumption in mice alters lipid droplet properties. Alcholism: Clinc. Expt. Res. 35:1020-1033, 2011
• Adipophilin regulates cytoplasmic lipid droplet accumulation and alveolar maturation in differentiating nulliparous mouse mammary glands J. Cell Sci. 124:3247-3253, 2011
• Impact of obesity on energy balance and fuel utilization during the metabolic challenge of lactation, Obesity 20:65-75
• Physiology of lactation, In: Fetal and Neonatal Physiology, (Polin,Fox,Abman eds), 4th edition, harcort Health Sciences, 2011 (in press)
• Physiology of Lactation, In: Encyclopedia of Human Nutrition, 3rd Edition, Elsevier Science, London, in press 2011
• Determinants of adipophilin function in milk lipid formation and secretion. Trends Endocrinol. Metab. 22:211-217-2011
• The Role of Lipid Droplets in Metabolic Disease in Rodents and Humans. J. Clini. Invest. 121:2102-2110, 2011
• Secretion and Fluid Transport Mechanisms, Dietary and Nutritional Aspects of Human Breast Milk, (in press, 2012)
• Milk Lipid Secretion, Biomolecular Aspects, Biomolecular concepts (in press 2012)
• Neville, M.C., Anderson, S.M. McManaman, J.L. et al. Lactation and neonatal nutrition: defining and refining the critical questions. J. Mammary Gland Biol. Neoplasia, 17: 167-188, 2012
• McManaman, J.L. and Neville, M.C., Physiology of Lactation, In: Encyclopedia of Human Nutrition, 3nd Edition, Elsevier Science, London, (In Press), 2012
• Monks, J. and McManaman, J.L. Secretion and Fluid Transport Mechanisms. Dietary and Nutritional Aspects of Human Breast Milk, (In press, 2012)
• McManaman, J.L. Milk Lipid Secretion, Biomolecular Aspects . BioMol Concepts, 3: 581-591, 2012
• McManaman, JL, Bales, ES, Orlicky, DJ, Jackman, M, MacLean, PS, Cain, S, Crunk, AE, Mansur, A, Graham, CE, Bowman, TA, Greenber, AS. Perilipin-2 Null Mice are Protected Against Diet-Induced Obesity, Adipose Inflammation and Fatty Liver Disease. J Lipid Res., doi: 10.1194/jlr.M035063, 2013
• McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May;54(5):1346-59. PubMed PMID: 23402988
• Orlicky DJ, Monks J, Stefanski AL, McManaman JL. Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion. PLoS One. 2013;8(6):e66837. PubMed PMID: 23825572
• Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL. Dynamic regulation of hepatic lipid droplet properties by diet. PLoS One. 2013;8(7):e67631. PubMed PMID: 23874434
• Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434. PubMed PMID: 24022321
• McManaman, J.L. and Neville, M.C. Lactation. In: Encyclopedia of Human Nutrition, 3rd Edition. Allen, L. and Prentice, A. eds. Elsevier, Amersterdam, 2013
• Monks, J. and McManaman, J.L. Handbook of dietary and nutritional aspects of human breast milk. Wageningen Academic Publishers, 2013, Chapt. 2 Secretion and fluid transport mechanisms in the mammary gland; p. 35-56
• McManaman JL. Lipid Transport in the Lactating Mammary Gland. J Mammary Gland Biol Neoplasia. 2014 Feb 25. [Epub ahead of print] PubMed PMID: 24567110
• Saben JL, Bales ES, Jackman MR, Orlicky D, MacLean PS, McManaman JL. Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis. PLoS One. 2014;9(5):e98066. PubMed PMID: 24849657
• McGowan EM, Simpson A, McManaman J, Boonyaratanakornkit V, Hardikar AA. Hijacking of Endocrine and Metabolic Regulation in Cancer and Diabetes. Biomed Res Int. 2015;2015:386203. PubMed PMID: 26240821
• McManaman JL. Lipid transport in the lactating mammary gland. J Mammary Gland Biol Neoplasia. 2014 Mar;19(1):35-42. PubMed PMID: 24567110
• Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL. Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine. PLoS One. 2015;10(7):e0131944. PubMed PMID: 26147095
• McManaman, J.L. Fetal and Neonatal Physiology 5th ed. Elsevier, (Polin, R.A., Abman, S.H., Rowitch, D, and Benitz, W.E. eds.) Physiology of Lactation, Chapt. 27, pp 279-285, 2016
• Libby AE, Bales E, Orlicky DJ, McManaman JL. Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. J Biol Chem. 2016 Nov 11;291(46):24231-24246. PubMed PMID: 27679530
• Monks J, Dzieciatkowska M, Bales ES, Orlicky DJ, Wright RM, McManaman JL. Xanthine oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion. J Physiol. 2016 Oct 15;594(20):5899-5921. PubMed PMID: 27357166
• Skaznik-Wikiel ME, Swindle DC, Allshouse AA, Polotsky AJ, McManaman JL. High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice. Biol Reprod. 2016 May;94(5):108. PubMed PMID: 27030045
• Xiong X, Bales ES, Ir D, Robertson CE, McManaman JL, Frank DN, Parkinson J. Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine. Microbiome. 2017 Sep 6;5(1):117. PubMed PMID: 28877764
• Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. An autonomous metabolic role for Spen. PLoS Genet. 2017 Jun;13(6):e1006859. PubMed PMID: 28640815
• Orlicky DJ, Libby AE, Bales ES, McMahan RH, Monks J, La Rosa FG, McManaman JL. Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. J Physiol. 2018 Dec 8. [Epub ahead of print] PubMed PMID: 30536914
• Libby AE, Bales ES, Monks J, Orlicky DJ, McManaman JL. Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature. J Lipid Res. 2018 Aug;59(8):1482-1500. PubMed PMID: 29866659
• Monks J, Orlicky DJ, Stefanski AL, Libby AE, Bales ES, Rudolph MC, Johnson GC, Sherk VD, Jackman MR, Williamson K, Carlson NE, MacLean PS, McManaman JL. Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction. Nutr Diabetes. 2018 Apr 25;8(1):18. PubMed PMID: 29695710
• Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. Correction: An autonomous metabolic role for Spen. PLoS Genet. 2018 Mar;14(3):e1007266. PubMed PMID: 29509756
• Xiong X, Bales ES, Ir D, Robertson CE, McManaman JL, Frank DN, Parkinson J. Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine. Microbiome. 2017 Sep 6;5(1):117. PubMed PMID: 28877764
• Hazegh KE, Nemkov T, D'Alessandro A, Diller JD, Monks J, McManaman JL, Jones KL, Hansen KC, Reis T. An autonomous metabolic role for Spen. PLoS Genet. 2017 Jun;13(6):e1006859. PubMed PMID: 28640815
• Ladinsky MS, Mardones GA, Orlicky DJ, Howell KE, McManaman JL. Electron Tomography Revels that Milk Lipids Originate from Endoplasmic Reticulum Domains with Novel Structural Features. J Mammary Gland Biol Neoplasia. 2019 Dec;24(4):293-304. PubMed PMID: 31709487
• Orlicky DJ, Libby AE, Bales ES, McMahan RH, Monks J, La Rosa FG, McManaman JL. Perilipin-2 promotes obesity and progressive fatty liver disease in mice through mechanistically distinct hepatocyte and extra-hepatocyte actions. J Physiol. 2019 Mar;597(6):1565-1584. PubMed PMID: 30536914
• Monks, J. Ladinsky, M. and McManaman, J.L. Organellar contacts of milk lipid droplets, Contact, In press, 10.1177/2515256419897226
• Martin Carli JF, Trahan GD, Jones KL, Hirsch N, Rolloff KP, Dunn EZ, Friedman JE, Barbour LA, Hernandez TL, MacLean PS, Monks J, McManaman JL, Rudolph MC. Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework for Investigating Human Lactation Physiology. J Mammary Gland Biol Neoplasia. 2020 Nov 20. [Epub ahead of print] PubMed PMID: 33216249
• Monks J, Ladinsky MS, McManaman JL. Organellar Contacts of Milk Lipid Droplets. Contact (Thousand Oaks). 2020 Jan-Dec;3. PubMed PMID: 32232194
• Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M. Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice. J Biol Chem. 2020 Apr 3;295(14):4733-4747. PubMed PMID: 32075905
• McManaman J.L., Martin Carli J.F. and Monks. J. Human Milk Lipids in Human Milk (1st Ed). McGuire M. and O'Connor D. Eds. Academic Press. 2020
• McManaman J.L. Lipid Transport Across the Mammary Gland. In: Ion Transport Across Epithelia Tissues and Disease. Vol 2. (Hamilton K.L. and Devore D.C. Eds.) p.p. 241-247. Springer 2020
• Smilowitz, J.T. et al. Breastmilk Ecology and the Genesis of Infant Nutrition (the “BEGIN Project”) Part 4: Ecologies, Synergies, and Systems Shaping Human Milk Composition. J. Nutrition.
• Wang XX, Xie C, Libby AE, Ranjit S, Levi J, Myakala K, Bhasin K, Jones BA, Orlicky DJ, Takahashi S, Dvornikov A, Kleiner DE, Hewitt SM, Adorini L, Kopp JB, Krausz KW, Rosenberg A, McManaman JL, Robertson CE, Ir D, Frank DN, Luo Y, Gonzalez FJ, Gratton E, Levi M. The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice. J Biol Chem. 2022 Nov;298(11):102530. PubMed PMID: 36209823
• Monks J, Orlicky DJ, Libby AE, Dzieciatkowska M, Ladinsky MS, McManaman JL. Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland. Front Cell Dev Biol. 2022;10:958566. PubMed PMID: 36158190
• Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, Swinnen JV, Haidar M, Bogie JFJ, Hendriks JJA. Perilipin-2 limits remyelination by preventing lipid droplet degradation. Cell Mol Life Sci. 2022 Sep 13;79(10):515. PubMed PMID: 36100764