Judith Blaine, MD, PhD

Professor, Medicine-Renal Med Diseases/Hypertension

FacultyPhoto
Medical School
  • MD, University of Colorado Denver School of Medicine (2001)
Graduate School
  • PhD, University of Colorado Denver (1999)
Undergraduate School
  • BA, Harvard University (MA) (1992)
Internship
  • University of Colorado (University Hospital) Program (2002)
Residency
  • University of Colorado (University Hospital) Program, Internal Medicine (2004)
Fellowships
  • University of Colorado (University Hospital) Program, Nephrology (2008)
Languages
English
Department
Medicine-Renal Med Diseases/Hypertension

Publications

  • Blaine J, Okamura K, Giral , Breusegem SY, Caldas Y, Millard A, Barry N, Levi M. PTH Induced Internalization of Apical Membrane NaPi2a: Role of Actin and Myosin VI. Am J Physiol Renal Physiol. 2009 Dec 297 (6): C1339-46. Epub 2009 Sep 23.
  • Breusegem SY, Takahashi H, Giral-Arnal H, Wang X, Jiang T, Verlander J, Wilson P, Miyazaki-Anzai S, Sutherland E, Caldas Y, Blaine JT, Segawa H, Miyamoto K, Barry NP, Levi M. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc and Pit-2 in dietary potassium deficiency. Am J Physiol Renal Physiol. 2009 Aug;297(2):F350-61. Epub 2009 Jun 3.
  • Giral H, Caldas Y, Sutherland E, Wilson P, Breusegem SY, Barry N, Blaine J, Jiang T, Wang XX, Levi M. Regulation of the rat intenstinal Na-dependent phosphate transporters by dietary phosphate. Am J Physiol Renal Physiol. 2009 Nov 297(5): F1466-75. Epub 2009 Aug 12.
  • Blaine J, Lanzano L, Giral H, caldas Y, Levi M, Gratton E, Moldovan R, Lei T. Dynamic Imaging of the NaPi Transporters. Adv Chronic Kidney Dis. Accepted.
  • Okamura K, Dummer P, Kopp J, Qiu L, Faubel S, Levi M, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS ONE 2013 013;8(1):e54817. PMCID: PMC3557279
  • Blaine J, Giral H, Jelen S, Levi M. Hypophosphatemia and Hyperphosphatemia. Oxford Textbook of Clinical Nephrology, accepted.
  • Blaine J, Weinman E, Cunningham R. The Regulation of Renal Phosphate Transport. Adv. Chronic Kidney Dis. Accepted.
  • Blaine J. Disorders of Phosphate Homeostasis. Clinical Support Decision Making digital program on Nephrology and Hypertension , 2013.
  • Lanzano L, Lei T, Okamura K, Giral H, Caldas YA, Masihzadeh O, Gratton E, Levi M, Blaine J. Differential Modulation of the Molecular Dynamics of the Type IIa And IIc Sodium Phosphate Cotransporters by Parathyroid Hormone. Am J Physiol Cell Physiol. 2011 Oct 301(4):C850-61.
  • Caldas Y, Giral H,Cortazar M, Sutherland S, Okamura K, Blaine J, Sorribas V, Koepsell H, Levi M. Liver X Receptor (LXR) Activating Ligands Modulate Renal and Intestinal Phosphate (Na-Pi) Transporters. Kidney Int. 2011 Sep 80(5):535-44
  • Blaine J, Chonchol M, Levi M. Renal Control of Calcium, Phosphate, and Magnesium Homeostasis. Clin J Am Soc Nephrol. 2014 Oct 6. [Epub ahead of print] PubMed PMID: 25287933
  • Hung KW, Blaine J, Faubel S. Dual therapy difficulties in angiotensin blockade for proteinuria: a teachable moment. JAMA Intern Med. 2014 Sep;174(9):1429-30. PubMed PMID: 25089763
  • Giral H, Lanzano L, Caldas Y, Blaine J, Verlander J, Gratton E, Levi M. Role of PDZ Interactions in Regulation of NaPi-2c Apical Membrane Expression in the Renal Proximal Tubule. J Biol Chem. 2011, 286(17):15032-42.
  • Carson JM, Okamura K, Wakashin H, McFann K, Dobrinskikh E, Kopp JB, Blaine J. Podocytes degrade endocytosed albumin primarily in lysosomes. PLoS One. 2014;9(6):e99771. PubMed PMID: 24924335
  • Blaine J and Levi M. Albuminuria or CKD Stage as Best Marker of CVD in Diabetes? Nat Rev Nephrol. 8(7):376-77, 2012.
  • Dobrinskikh E, Okamura K, Kopp JB, Doctor RB, Blaine J. Human podocytes perform polarized, caveolae-dependent albumin endocytosis. Am J Physiol Renal Physiol. 2014 May 1;306(9):F941-51. PubMed PMID: 24573386
  • Okamura K, Dummer P, Kopp J, Qiu L, Faubel S, Levi M, Blaine J. Endocytosis of albumin by podocytes elicits an inflammatory response and induces apoptotic cell death. PLoS ONE, 013;8(1):e54817
  • Kempson S, Anderson B, Levi M, Blaine J. Nitric Oxide Activates Plasma Membrane Insertion of the Betaine/GABA Transporter in Renal Epithelial Cells.Research in Cell Biology. 2014; 2(1):1-7.
  • Blaine J, Chonchol M, Levi M. Correction. Renal control of calcium, phosphate, and magnesium homeostasis. Clin J Am Soc Nephrol. 2015 Oct 7;10(10):1886-7. PubMed PMID: 26384363
  • Dobrinskikh E, Lewis L, Brian Doctor R, Okamura K, Lee MG, Altmann C, Faubel S, Kopp JB, Blaine J. Shank2 Regulates Renal Albumin Endocytosis. Physiol Rep. 2015 Sep;3(9). PubMed PMID: 26333830
  • Podocyte-specific knockout of the neonatal Fc receptor (FcRn) reduces crescent formation in immune complex mediated glomerular disease. Dylewski J, Dobrinskikh E, Lewis L, Garcia G, Jat P, Blaine J. Scientific Reports, Under Revision
  • The Glomerulus: The parts that form the greater whole. Dylewski J and Blaine J. Kidney News, American Society of Nephrology, 2016
  • Evaluation of Proteinuria. Blaine J in Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer, 2016
  • Glomerular Mechanisms of Proteinuria. Dobrinskikh E and Blaine J in Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer, 2016
  • Pathophysiology of Focal Segmental Glomerulosclerosis and its Treatment. Dylewski J and Blaine J in Proteinuria: Basic Mechanisms, Pathophysiology and Clinical Relevance. Springer, 2016
  • Dylewski J, Dobrinskikh E, Lewis L, Tonsawan P, Miyazaki M, Jat P and Blaine J. Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo. PLOS ONE, under revision.
  • Wilson NA, Dylewski J, Degner KR, O'Neill MA, Reese SR, Hidalgo LG, Blaine J, Panzer SE. An in vitro model of antibody-mediated injury to glomerular endothelial cells: Upregulation of MHC class II and adhesion molecules. Transpl Immunol. 2019 Dec 27;:101261. [Epub ahead of print] PubMed PMID: 31887408
  • Tonsawan P, Dylewski J, Lewis L, Blaine J. Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton. Am J Physiol Cell Physiol. 2019 Nov 1;317(5):C1048-C1060. PubMed PMID: 31553647
  • Dylewski J, Dobrinskikh E, Lewis L, Tonsawan P, Miyazaki M, Jat PS, Blaine J. Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo. PLoS One. 2019;14(2):e0209732. PubMed PMID: 30811433
  • Blaine J. Generating a podocyte-specific FcRn knockout mouse". Mouse Genetics, Methods in Molecular Biology, Springer. Accepted
  • Dylewski JF, Tonsawan P, Garcia G, Lewis L, Blaine J. Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis. PLoS One. 2020;15(12):e0230401. PubMed PMID: 33370294
  • Dylewski JF, Wilson N, Lu S, Jat P, Weiser-Evans M, Panzer SE, Blaine J. Isolation, purification, and conditional immortalization of murine glomerular endothelial cells of microvascular phenotype. MethodsX. 2020;7:101048. PubMed PMID: 32944514
  • Blaine J, Dylewski J. Regulation of the Actin Cytoskeleton in Podocytes. Cells. 2020 Jul 16;9(7). PubMed PMID: 32708597
  • Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 May;97(5):966-979. PubMed PMID: 32081304
  • Wilson NA, Dylewski J, Degner KR, O'Neill MA, Reese SR, Hidalgo LG, Blaine J, Panzer SE. An in vitro model of antibody-mediated injury to glomerular endothelial cells: Upregulation of MHC class II and adhesion molecules. Transpl Immunol. 2020 Feb;58:101261. PubMed PMID: 31887408
  • Brown CN, Atwood D, Pokhrel D, Holditch SJ, Altmann C, Skrypnyk NI, Bourne J, Klawitter J, Blaine J, Faubel S, Thorburn A, Edelstein CL. Surgical procedures suppress autophagic flux in the kidney. Cell Death Dis. 2021 Mar 5;12(3):248. PubMed PMID: 33674554
  • Blaine J. Generating a Podocyte-Specific Neonatal F Receptor (FcRn) Knockout Mouse. Methods Mol Biol. 2021;2224:123-132. PubMed PMID: 33606211
  • Skrypnyk N, Gast K, Okamura K, Montford J, You Z, Yang H, Moldovan R, Bodoni E, Blaine J, Edelstein C, Soranno D, Kirkbride-Romeo L, Griffin B, Altmann C, Faubel S. Circulating IL-6 Mediates Hepatic NGAL Production Suring Acute Kidney Injury. Kidney International. Accepted.
  • Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Factor H related proteins modulate complement activation on kidney cells. Kidney Int. 2022 Dec;102(6):1331-1344. PubMed PMID: 36063874
  • Bauer C, Piani F, Banks M, Ordoñez FA, de Lucas-Collantes C, Oshima K, Schmidt EP, Zakharevich I, Segarra A, Martinez C, Roncal-Jimenez C, Satchell SC, Bjornstad P, Lucia MS, Blaine J, Thurman JM, Johnson RJ, Cara-Fuentes G. Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation. Kidney Int Rep. 2022 Apr;7(4):797-809. PubMed PMID: 35497798
  • Miyazaki-Anzai S, Keenan AL, Blaine J, Miyazaki M. Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification. J Am Soc Nephrol. 2022 Aug;33(8):1477-1486. PubMed PMID: 35459732
  • Kovitangkoon K, Lukkanalikitkul E, Wiangnon P, Chunghom T, Anutrakulchai S, Blaine J, Tonsawan P. Cefazolin Plus Ceftazidime versus Cefazolin Monotherapy in the Treatment of Culture-Negative Peritonitis: A Retrospective Cohort Study. Int J Nephrol Renovasc Dis. 2022;15:17-25. PubMed PMID: 35177925
  • Haddad G, Dylewski J, Evans R, Lewis L, Blaine J. Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. PLoS One. 2023;18(4):e0284636. PubMed PMID: 37071647
  • Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Factor H related proteins modulate complement activation on kidney cells. Kidney Int. 2022 Dec;102(6):1331-1344. PubMed PMID: 36063874
  • Dylewski J, Haddad G, Blaine J. Exploiting the neonatal Fc receptor to treat kidney disease. Kidney International, accepted
  • Dylewski JF, Haddad G, Blaine J. Exploiting the neonatal crystallizable fragment receptor to treat kidney disease. Kidney Int. 2024 Jan;105(1):54-64. PubMed PMID: 38707675
  • Haddad G, Blaine J. Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles. Cells. 2024 Mar 29;13(7). PubMed PMID: 38607033

Professional Memberships

  • American Society of Nephrology, Member
  • American Physiological Society, Member

Practice Locations

UCHealth Anschutz Outpatient Pavilion - Anschutz Medical Campus
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

UCHealth Anschutz Inpatient Pavilion - Anschutz Medical Campus
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Kidney Disease and Hypertension Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 7th floor
Aurora, CO 80045
720-848-0749

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2005)
  • Nephrology, Board Certification (2009)

School of Medicine

CU Anschutz
Fitzsimons Building

13001 East 17th Place

Aurora, CO 80045

303.724.5375

School
General
Students