Katheleen Gardiner, PhD, MS
Clinical Professor, Pediatrics-Clinical Genetics and Metabolism
Publications
- Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Ahmed M, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ. Hum Mol Genet. 2013 Jan 24. [Epub ahead of print]
- Expression of trisomic proteins in Down syndrome model systems. Spellman C, Ahmed MM, Dubach D, Gardiner KJ. Gene. 2013 Jan 10;512(2):219-25. doi: 10.1016/j.gene.2012.10.051. Epub 2012 Oct 26.
- Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome. Ahmed MM, Sturgeon X, Ellison M, Davisson MT, Gardiner KJ. J Proteome Res. 2012 Feb 3;11(2):1251-63. doi: 10.1021/pr2011582. Epub 2012 Jan 25.
- RCDA: a highly sensitive and specific alternatively spliced transcript assembly tool featuring upstream consecutive exon structures. Sturgeon XH, Gardiner KJ. Genomics. 2012 Dec;100(6):357-62. doi: 10.1016/j.ygeno.2012.08.004. Epub 2012 Aug 20.
- Pathways to cognitive deficits in Down syndrome. Sturgeon X, Le T, Ahmed MM, Gardiner KJ. Prog Brain Res. 2012;197:73-100. doi: 10.1016/B978-0-444-54299-1.00005-4.
- Thanh Le, Tom Altman and Katheleen Gardiner, 2012, Probability-based imputation method for fuzzy cluster analysis of gene expression microarray data, Proc. Intl' Conf. on Information Technology-New Generations, pp. 42-47, Las Vegas, NV, USA. 04/2012.
- Thanh Le, Tom Altman and Katheleen Gardiner, 2012, Density-based imputation method for fuzzy cluster analysis of gene expression microarray data, Proc. Intl' Conf. on Bioinformatics and Computational Biology, pp. 190-195, Las Vegas, NV, USA. 03/2012.
- Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EMC, Tybulewizc VLJ, Gardiner KJ. (2013) Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Hu Molec Genet 22:1709-24
- Ahmed MM, Dhanasekaran AR, Block A, Costa AC, Gardiner KJ. (2014) Protein profiles associated with context fear conditioning and their modulation by memantine. Molec Cell Proteomics, in press.
- Block A, Dhanasekaran AR, Ahmed MD, Gardiner KJ. (2014) Abnormal protein profiles in hippocampus of mouse models of Down syndrome: similarities with Alzheimer’s Disease. J Alzheimer’s Disease and Parkinsonism, in press
- Busciglio J, Capone G, O’Bryan JP, Gardiner KJ (2013) Down syndrome: genes, model systems, and progress towards pharmacotherapies and clinical trials for cognitive deficits. Cytogenet Genome Res 141:260-271.
- Gardiner KJ. Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Des Devel Ther. 2015;9:103-125. PubMed PMID: 25552901
- Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2014 Dec 12. [Epub ahead of print] PubMed PMID: 25510383
- Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Gardiner KJ. Protein profiles associated with context fear conditioning and their modulation by memantine. Mol Cell Proteomics. 2014 Apr;13(4):919-37. PubMed PMID: 24469516
- Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Stasko M, Gardiner KJ. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome, PLoSONe
- Higuera C, Gardiner KJ, Cios KJ. Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS One. 2015;10(6):e0129126. PubMed PMID: 26111164
- Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Stasko M, Gardiner KJ. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome. PLoS One. 2015;10(3):e0119491. PubMed PMID: 25793384
- Gardiner KJ. Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Des Devel Ther. 2015;9:103-25. PubMed PMID: 25552901
- Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun;11(6):700-9. PubMed PMID: 25510383
- Aaron Block, Md. Mahiuddin Ahmed, A. Ranjitha Dhanasekaran, Suhong Tong, Katheleen J. Gardiner. Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome. Biology of Sex Differences, 2015 Nov 9;6:24.
- Mouse models of Down syndrome: gene content and consequences. Gupta M, Dhanasekaran AR, Gardiner KJ. Mamm Genome. 2016 Aug 18. [Epub ahead of print]
- A. RANJITHA DHANASEKARAN*,†,# and KATHELEEN J. GARDINER. RPPAware: A Software Suite to Preprocess, Analyze and Visualize Reverse Phase Protein Array Data. J Bioinformatics and Computational Biology
- Mahiuddin Ahmed, Aaron Block, Muriel T. Davisson, Katheleen J. Gardiner. Age exacerbates abnormal protein expression in a mouse model of Down syndrome. Md. Neurobiol Aging
- Angela L. Rachubinski; Susan Hepburn; Ellen R. Elias; Katheleen Gardiner; Tamim H. Shaikh. The co-occurrence of Down syndrome and autism spectrum disorder: is it due to additional genetic variations? Prenatal Diagnosis
- J. Delabar, B. Allinquant, D. Bianchi, T. Blumenthal, A. Dekker, J. Edgin, J. O’Bryan, M. Dierssen, M-C. Potier, F. Wiseman, F. Guedj, N. Créau, R. Reeves , K. Gardiner, and J. Busciglio. Changing paradigms in Down syndrome. The First International Conference of the Trisomy 21 Research Society. Molecular Syndromology
Practice Locations
Hospital Affiliation- Children's Hospital Colorado